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1. 发明授权

US4286341A Vascular prosthesis and method of making the same 失效
标题翻译：血管假体及其制作方法
公开(公告)号：US4286341A
公开(公告)日：1981-09-01
申请号：US041607
申请日：1979-05-23
申请人： Raymond T. Greer , Bradley H. Vale , Randall L. Knoll
发明人： Raymond T. Greer , Bradley H. Vale , Randall L. Knoll
IPC分类号： A61F2/00 , A61F2/06 , A61L27/14 , A61L33/06 , A61F1/24
CPC分类号： A61L27/14 , A61F2/06 , A61L33/064 , A61F2250/0023
摘要： A vascular prosthesis and its method of fabrication. The prosthesis takes the form of a flexible and conformable support tube having a luminal surface formed of a smooth, homogenous, and substantially non-thrombogenic hydrogel having relatively small pores or microvoids suitable for tissue ingrowth but resistant to thrombus formation, and having an outer surface formed of essentially the same hydrogel having a heterogenous microstructure which includes relatively large pores or macrovoids especially suitable for cellular ingrowth from perigraft sources and attachment sites. In one embodiment, the tubular substrate is foraminous and the inner and outer hydrogel layers merge through the interstices of the substrate to provide a unified ground substance characterized by strata having selectively different pore characteristics for promoting effective endothelialization and for reducing possibilities of thrombotic occlusion.
摘要翻译：血管假体及其制造方法。假体呈柔性且适形的支撑管的形式，其具有由光滑，均匀且基本上非血栓形成的水凝胶形成的腔表面，其具有适于组织向内生长但抗血栓形成但具有外表面的较小孔或微孔由具有异质微结构的基本上相同的水凝胶形成，其包含相对较大的孔或大孔，特别适合于来自围网源和附着位点的细胞向内生长。在一个实施方案中，管状基质是有孔的并且内部和外部水凝胶层合并通过基底的间隙以提供统一的研磨物质，其特征在于具有选择性不同的孔特性的层，用于促进有效的内皮化和减少血栓闭塞的可能性。

2. 发明授权

US5364367A Cannula anchor 失效
标题翻译：插管锚
公开(公告)号：US5364367A
公开(公告)日：1994-11-15
申请号：US55820
申请日：1993-04-30
申请人： Thomas F. Banks , Claude Vidal , Randall L. Knoll , Russell J. Redmond
发明人： Thomas F. Banks , Claude Vidal , Randall L. Knoll , Russell J. Redmond
IPC分类号： A61B17/34 , A61M25/02 , A61M5/32
CPC分类号： A61M25/02 , A61B2017/3419 , A61B2017/347 , A61B2017/3492 , A61M2025/024 , A61M2025/0266 , Y10S128/26
摘要： An anchor sheet and anchor body for holding a cannula within the abdominal cavity of a patient is described. The cannula is used during a laparoscopic surgical procedure. The anchor sheet and anchor body assist in holding the cannula in a preferred orientation relative to the abdominal cavity. An attachment mechanism such as a hook and loop fastener may be utilized to connect the anchor sheet to the anchor body.
摘要翻译：描述了用于在患者腹腔内保持插管的锚定片和锚固体。在腹腔镜手术过程中使用套管。锚固片和锚固体有助于相对于腹腔将插管保持在优选的取向。可以使用诸如钩和环紧固件的附接机构来将锚片连接到锚固体。

3. 发明授权

US4964206A Intraocular lens anchoring filament to lens element fixation method 失效
标题翻译：人工晶状体固定丝与透镜元件固定方法
公开(公告)号：US4964206A
公开(公告)日：1990-10-23
申请号：US507855
申请日：1990-04-12
申请人： Randall L. Knoll , James E. Aysta , Wilhelm Lewon
发明人： Randall L. Knoll , James E. Aysta , Wilhelm Lewon
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2002/1686 , Y10S623/901 , Y10T29/49812 , Y10T29/49885 , Y10T29/49945
摘要： Disclosed is an intraocular lens comprising a lens element and a plurality of haptics extending therefrom, at least one of the haptics having an anchoring filament with an enlarged complete or partial mushroom-shaped end fixedly disposed inside a passage in the lens element. Also disclosed is a method for fixing a haptic having an anchoring filament to a lens element in a soft intraocular lens comprising the steps of (a) forming in the lens element a passage having a width that is less than the greatest width of the anchoring filament, (b) lubricating the anchoring filament of the haptic, the passage in the lens element, or both, (c) inserting the anchoring filament end-first into the passage, and (d) washing the intraocular lens to remove the lubricant.
摘要翻译：公开了一种包括透镜元件和从其延伸的多个触觉件的眼内透镜，至少一个触觉件具有锚固细丝，其具有固定地设置在透镜元件的通道内的扩大的完整或部分蘑菇形端。还公开了一种用于将具有锚定细丝的触觉件固定到软性眼内透镜中的透镜元件的方法，包括以下步骤：（a）在透镜元件中形成宽度小于锚定细丝的最大宽度的通道，（b）润滑触觉件的锚固细丝，透镜元件中的通道或两者，（c）将锚定丝线首先插入通道中，以及（d）洗涤眼内透镜以除去润滑剂。

4. 发明授权

US5032131A Prosthesis holding device 失效
标题翻译：假体握持装置
公开(公告)号：US5032131A
公开(公告)日：1991-07-16
申请号：US163515
申请日：1988-03-02
申请人： James E. Aysta , John T. Capecchi , Carl Franzblau , Donald F. Gibbons , Randall L. Knoll , Howard M. Leibowitz , Vickery Trinkaus-Randall
发明人： James E. Aysta , John T. Capecchi , Carl Franzblau , Donald F. Gibbons , Randall L. Knoll , Howard M. Leibowitz , Vickery Trinkaus-Randall
IPC分类号： A61F2/00 , A61F2/14
CPC分类号： A61F2/14 , A61F2/0095 , Y10S623/92
摘要： A holding device for seeding cells on a surface of a prosthesis including chamber means for partially defining a first chamber with the first surface, and sealing means for providing a seal between the chamber means and the prosthesis so as to isolate the seeding surface from another portion of the prosthesis.
摘要翻译：一种用于在假体的表面上接种细胞的保持装置，包括用于部分地限定具有第一表面的第一腔室的腔室装置，以及用于在腔室装置和假体之间提供密封的密封装置，以便将接种表面与另一部分的假体。

5. 发明授权

US08676319B2 Implantable medical device with compressible fixation member 失效
标题翻译：具有可压缩固定构件的植入式医疗装置
公开(公告)号：US08676319B2
公开(公告)日：2014-03-18
申请号：US12915935
申请日：2010-10-29
申请人： Randall L. Knoll
发明人： Randall L. Knoll
IPC分类号： A61N1/375
CPC分类号： A61N1/375
摘要： An implantable medical device and method of implanting a medical device, the device including a housing surrounding an operative component and a resiliently deformable fixation member. The fixation member includes a ring shaped annulus circumscribing the housing and a plurality of elongated struts having a proximal end affixed to the housing and a distal end affixed to the annulus. The fixation member may be comprised of a hydrogel such that it may be in a smaller, dehydrated form during implantation, and then may absorb fluid to expand to a larger, hydrated form after insertion to engage the surrounding tissue.
摘要翻译：一种植入式医疗装置和植入医疗装置的方法，所述装置包括围绕操作部件的壳体和可弹性变形的固定部件。固定构件包括环绕壳体的环形环形空间和多个细长支柱，其具有固定到壳体的近端和固定到环形空间的远端。固定构件可以由水凝胶构成，使得其在植入期间可以处于较小的脱水形式，然后可以在插入之后吸收流体以扩大至更大的水合形式以接合周围组织。

6. 发明申请

US20080046037A1 Wireless Communication Network for an Implantable Medical Device System 审中-公开
标题翻译：无线通信网络，用于植入式医疗设备系统
公开(公告)号：US20080046037A1
公开(公告)日：2008-02-21
申请号：US11739283
申请日：2007-04-24
申请人： Gregory J. Haubrich , Sarah A. Audet , Gerard J. Hill , Randall L. Knoll , Javaid Masoud
发明人： Gregory J. Haubrich , Sarah A. Audet , Gerard J. Hill , Randall L. Knoll , Javaid Masoud
IPC分类号： A61N1/02
CPC分类号： H04B13/005 , A61B5/0028 , A61B5/0031 , A61N1/08 , A61N1/37211 , A61N1/37217 , G06F19/3418 , H04L25/03114 , H04L2025/03375 , H04L2025/0377
摘要： An implantable medical device system includes, in one embodiment, a first device including a first communication module coupled to a wireless communication network for transmitting data and a second device adapted for implantation in a patient's body including a second communication module coupled to the wireless communication network and adapted to receive data from the first device. The second device may include an equalizer coupled to the second communication module for reducing signal distortion of the data received wirelessly through the patient's body. The second device may convert a received signal to an acoustic or radio-frequency output signal.
摘要翻译：在一个实施例中，可植入医疗装置系统包括第一装置，其包括耦合到用于传输数据的无线通信网络的第一通信模块和适于植入患者体内的第二装置，其包括耦合到无线通信网络的第二通信模块并适于从第一设备接收数据。第二设备可以包括耦合到第二通信模块的均衡器，用于减少通过患者身体无线地接收的数据的信号失真。第二装置可以将接收的信号转换成声或射频输出信号。

7. 发明授权

US06290685B1 Microchanneled active fluid transport devices 失效
标题翻译：微通道活性流体输送装置
公开(公告)号：US06290685B1
公开(公告)日：2001-09-18
申请号：US09099269
申请日：1998-06-18
申请人： Thomas I. Insley , Raymond P. Johnston , Randall L. Knoll
发明人： Thomas I. Insley , Raymond P. Johnston , Randall L. Knoll
IPC分类号： A61M1100
CPC分类号： F28F21/065 , A61M1/008 , F28F2260/02 , Y10S366/03
摘要： An active fluid transport device (10, 40, 54, 60) that includes a layer (12) of polymeric material. The layer (12) has a structured surface (13) that includes a plurality of substantially discrete flow channels (16). The flow channels (16) have a minimum aspect ratio of about 10 to 1 and a hydraulic radius no greater than about 300 micrometers. The device may also include a connector (20, 55) that allows a potential source (14) external to the structured surface (13) to be placed in fluid communication with the discrete flow channels (16). The potential source (14) promotes fluid movement through the flow channels (16) from a first location to a second location.
摘要翻译：包括聚合物材料层（12）的主动流体输送装置（10,40,54,60）。层（12）具有包括多个基本上离散的流动通道（16）的结构化表面（13）。流动通道（16）具有约10比1的最小纵横比和不大于约300微米的液压半径。该装置还可以包括允许结构化表面（13）外部的潜在源（14）与离散流动通道（16）流体连通的连接器（20,55）。潜在源（14）促进流体通过流动通道（16）从第一位置运动到第二位置。

8. 发明授权

US07289850B2 System for enhanced cardiac function with combined PESP/NES 有权
标题翻译：使用PESP / NES组合增强心脏功能的系统
公开(公告)号：US07289850B2
公开(公告)日：2007-10-30
申请号：US11116941
申请日：2005-04-28
申请人： John E. Burnes , Lawrence J. Mulligan , Randall L. Knoll
发明人： John E. Burnes , Lawrence J. Mulligan , Randall L. Knoll
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36564
摘要： In some embodiments, a method of applying stimulation pulse therapy to excitable tissue may include one or more of the following steps: (a) delivering a PESP stimulation therapy to the excitable tissue for a cardiac cycle, (b) delivering a NES stimulation therapy to the excitable tissue during certain cardiac cycles, (c) determining physiologic demand of the patient based on at least one physiologic measurement, (d) determining physiologic demand being placed on a heart based on at least one physiologic measurement, and ceasing the delivery of the NES and PESP stimulation therapy when physiologic demand returns to a base level, and (e) determining physiologic demand being placed on a heart based on at least one physiologic measurement, and modulating the ratio of the number of cardiac cycles in which the NES stimulation therapy is delivered to the number of cardiac cycles in which the PESP stimulation therapy is delivered based on physiologic demand.
摘要翻译：在一些实施方案中，将刺激脉冲治疗应用于可兴奋组织的方法可以包括以下步骤中的一个或多个：（a）将PESP刺激疗法递送至心脏周期的可兴奋组织，（b）将NES刺激疗法递送至（c）基于至少一个生理测量来确定患者的生理需求，（d）基于至少一个生理测量来确定置于心脏上的生理需求，并且停止递送 NES和PESP刺激治疗，当生理需求恢复到基础水平时，以及（e）基于至少一个生理测量来确定置于心脏上的生理需求，以及调节NES刺激疗法的心脏周期数基于生理需求被传递到其中递送PESP刺激疗法的心脏周期数。

9. 发明授权

US5841081A Method of attenuating sound, and acoustical insulation therefor 失效
标题翻译：衰减声音及其隔音方法
公开(公告)号：US5841081A
公开(公告)日：1998-11-24
申请号：US669896
申请日：1996-06-21
申请人： Delton R. Thompson , Randall L. Knoll
发明人： Delton R. Thompson , Randall L. Knoll
IPC分类号： B29C43/22 , B60R11/00 , B60R11/02 , B60R13/08 , D04H1/00 , D04H1/54 , D04H1/56 , D04H13/00 , G10K11/162 , E04B1/82
CPC分类号： G10K11/162 , B29C43/006 , B60R13/0815 , D04H1/54 , D04H1/558 , D04H1/56 , B29C2043/025 , B29C2043/043 , B29C2043/3433 , B29C2043/3455 , B29C2043/461 , B29C43/22 , B29C43/222 , B29K2105/06 , B29L2031/3041 , B60R11/0217 , B60R13/083 , B60R13/0892 , B60R2011/0021 , Y10S428/903 , Y10T428/249939 , Y10T428/249943
摘要： Noise is attenuated through use of an acoustical insulation 10 that includes a molded, three-dimensional nonwoven web that contains organic microfibers 12 and heat activatable staple fibers 14 where the heat activatable staple fibers 14 are bonded to each other and to the microfibers 12 at various contact points. The web contains greater than 15 weight percent heat activatable staple fibers, has a thickness of about 0.5 centimeters or greater, and a density of less than 250 kilograms per cubic meter and preferably contains bulking staple fiber 16. The acoustical insulation is positioned between a source area and a receiving area such that a major face of the insulation intercepts and thereby significantly attenuates sound waves passing from the source area to the receiving area.
摘要翻译：噪声通过使用隔音10减弱，该隔音10包括模制的三维非织造纤维网，其包含有机微纤维12和可热活化的短纤维14，其中可热活化的短纤维14彼此结合并以各种方式结合到微纤维12 联络点。纤维网含有大于15重量％的可热活化的短纤维，其厚度为约0.5厘米或更大，密度小于250千克每立方米，并且优选含有填充短纤维16.声绝缘体位于源区域和接收区域，使得绝缘体的主面屏蔽截断，从而显着地衰减从源区域传递到接收区域的声波。

10. 发明授权

US5489300A Surgical method for implanting a corneal implant 失效
标题翻译：用于植入角膜植入物的手术方法
公开(公告)号：US5489300A
公开(公告)日：1996-02-06
申请号：US82261
申请日：1993-06-24
申请人： John T. Capecchi , Carl Franzblau , Donald F. Gibbons , William B. Isaacson , Manley R. Johnston , Randall L. Knoll , Howard M. Leibowitz , Vickery Trinkaus-Randall
发明人： John T. Capecchi , Carl Franzblau , Donald F. Gibbons , William B. Isaacson , Manley R. Johnston , Randall L. Knoll , Howard M. Leibowitz , Vickery Trinkaus-Randall
IPC分类号： A61L27/00 , A61F2/14 , A61L27/16
CPC分类号： A61F2/142 , A61L27/14 , A61L27/16 , A61L2430/16 , Y10S623/906
摘要： A corneal prosthesis including an optical element having an optically transparent central portion and an anterior surface capable of supporting a layer of epithelial cells, the optical element being made of optical material having water content between 50% and 90% and a tensile strength greater than 20 kg/cm.sup.2, and a porous outer skirt secured to the periphery of said element, said skirt being sufficiently porous to permit cell ingrowth and tissue attachment. Also disclosed are methods of making, seeding and using corneal implants having epithelial layers thereon and porous implant material of a coherent mass of randomly oriented fibers having an interconnected network of pores.
摘要翻译：一种角膜假体，其包括具有光学透明中心部分和能够支撑一层上皮细胞的前表面的光学元件，所述光学元件由水含量为50％至90％且抗拉强度大于20的光学材料制成 kg / cm 2，以及固定到所述元件的周边的多孔外裙，所述裙部足够多孔以允许细胞向内生长和组织附着。还公开了制造，接种和使用其上具有上皮层的角膜植入物的方法，以及具有互连的孔网络的随机取向纤维的相干团块的多孔植入材料。

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