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1. 发明授权

US08197462B1 Method and system for mitigating effects of biomechanical forces on cell, particle and drug based therapies 有权
标题翻译：减轻生物力学对细胞，颗粒和药物治疗效果的方法和系统
公开(公告)号：US08197462B1
公开(公告)日：2012-06-12
申请号：US12454396
申请日：2009-05-18
申请人： Raymond P. Vito , Michael L. Wach , Jack C. Griffis, III , W. Robert Taylor
发明人： Raymond P. Vito , Michael L. Wach , Jack C. Griffis, III , W. Robert Taylor
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2034/102 , G06F19/00
摘要： A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.
摘要翻译：医生可以指定涉及递送治疗剂的过程的某些参数，同时留下其他参数。治疗剂可以对与递送相关的生物力学力（或其他影响）敏感。该过程可以涉及再生医学，例如使用导管将祖细胞或干细胞递送到患病心脏，由此在导管中的肆无忌惮的运输可能损害功效。开放参数可以影响药剂的疗效，从而影响治疗效果。基于计算机的系统可以应用诸如数据库之类的存储信息来缩小开放参数的可能值。从缩小的可能性，优化程序可以确定开放参数的合适或优化的值。确定的值可以管理治疗剂引起的生物力学力，从而促进功效和愈合。优化的参数可以指导实践者在程序中。

2. 发明授权

US08535291B1 Guided delivery of cell, particle, and drug based therapies 有权
标题翻译：引导细胞，颗粒和药物治疗的传递
公开(公告)号：US08535291B1
公开(公告)日：2013-09-17
申请号：US13466041
申请日：2012-05-07
申请人： Raymond P. Vito , Jack C. Griffis, III , W. Robert Taylor , Michael L. Wach
发明人： Raymond P. Vito , Jack C. Griffis, III , W. Robert Taylor , Michael L. Wach
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2034/102 , G06F19/00
摘要： A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.
摘要翻译：医生可以指定涉及递送治疗剂的过程的某些参数，同时留下其他参数。治疗剂可以对与递送相关的生物力学力（或其他影响）敏感。该过程可以涉及再生医学，例如使用导管将祖细胞或干细胞递送到患病心脏，由此在导管中的肆无忌惮的运输可能损害功效。开放参数可以影响药剂的疗效，从而影响治疗效果。基于计算机的系统可以应用诸如数据库之类的存储信息来缩小开放参数的可能值。从缩小的可能性，优化程序可以确定开放参数的合适或优化的值。确定的值可以管理治疗剂引起的生物力学力，从而促进功效和愈合。优化的参数可以指导实践者在程序中。

3. 发明授权

US08152755B1 System and method for delivering a therapeutic agent with finesse 有权
标题翻译：用于递送治疗剂的系统和方法
公开(公告)号：US08152755B1
公开(公告)日：2012-04-10
申请号：US12731019
申请日：2010-03-24
申请人： Michael L. Wach , W. Robert Taylor , Jack C. Griffis, III , Raymond P. Vito
发明人： Michael L. Wach , W. Robert Taylor , Jack C. Griffis, III , Raymond P. Vito
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： A61M25/00 , A61M5/178 , A61M25/0026 , A61M25/007 , A61M2206/20
摘要： A catheter for delivering a therapeutic agent to a target site of a human or animal subject can include a substantially flexible and biocompatible catheter body having a proximal end and a distal end. An eductor can be located at the distal end of the catheter body, and a first lumen within the catheter body for housing the therapeutic agent can be in fluid communication with the eductor. A second lumen, also in fluid communication with the first lumen, can extend from the proximal end of the catheter body towards the eductor and can have an output port at the distal end of the catheter body. The eductor can be operable to induce the therapeutic agent to flow from the first lumen out of the output port in response to fluid flowing through the second lumen.
摘要翻译：用于将治疗剂递送到人或动物受试者的靶位点的导管可以包括具有近端和远端的基本上柔性且生物相容的导管主体。喷射器可以位于导管主体的远端，并且用于容纳治疗剂的导管主体内的第一腔可以与喷射器流体连通。也与第一腔流体连通的第二腔可以从导管主体的近端延伸到喷射器，并且可以在导管主体的远端具有输出端口。喷射器可操作以响应于流体流过第二腔而致使治疗剂从第一腔流出输出端口。

4. 发明授权

US08147479B1 Monitoring stress on a therapeutic agent during patient delivery 有权
标题翻译：在患者分娩期间监测治疗剂的压力
公开(公告)号：US08147479B1
公开(公告)日：2012-04-03
申请号：US12460097
申请日：2009-07-14
申请人： Michael L. Wach , W. Robert Taylor , Raymond P. Vito , Jack C. Griffis, III
发明人： Michael L. Wach , W. Robert Taylor , Raymond P. Vito , Jack C. Griffis, III
IPC分类号： A61M31/00
CPC分类号： A61M5/16831 , A61M5/48 , A61M5/484 , A61M25/01 , G01F1/34 , G01F1/58 , G01F1/66 , G01F1/661 , G01F1/663 , G01F1/7086 , G01F15/001
摘要： A physician, nurse, or other healthcare practitioner can deliver a therapeutic agent to a patient in a manner that maintains effectiveness of the therapeutic agent, via monitoring and controlling shear, stress, or other potentially detrimental effect. A gauge, meter, or other monitoring device can provide an indication of shear (or other effect) that the therapeutic agent is experiencing during delivery. The monitoring device can provide information relevant to delivering the therapeutic agent in a manner that maintains effectiveness, thereby guiding the practitioner during delivery. For example, the monitoring device can display an estimate of shear based on sensing flow rate or pressure. The therapeutic agent can comprise one or more therapeutic cells, such as progenitor cells or stem cells, or some other healing substance delivered via a cardiac catheter to the patient's cardiovascular tissue, for example.
摘要翻译：医师，护士或其他保健医生可以通过监测和控制剪切力，压力或其它潜在的不利影响，以维持治疗剂的有效性的方式向患者递送治疗剂。仪表，仪表或其他监测装置可提供治疗剂在输送过程中经历的剪切（或其他影响）的指示。监测装置可以以保持有效性的方式提供与递送治疗剂相关的信息，从而在分娩期间指导医师。例如，监测装置可以基于感测流量或压力显示剪切的估计。例如，治疗剂可以包含一种或多种治疗细胞，例如祖细胞或干细胞，或通过心脏导管递送至患者的心血管组织的一些其它愈合物质。

5. 发明申请

US20140005595A1 DELIVERY DEVICES AND METHODS FOR DELIVERING THERAPEUTIC AGENTS 审中-公开
标题翻译：递送装置和递送治疗剂的方法
公开(公告)号：US20140005595A1
公开(公告)日：2014-01-02
申请号：US14004738
申请日：2012-03-19
申请人： W. Robert Taylor , Raymond P. Vito , Michael L. Wach , Jack Griffis
发明人： W. Robert Taylor , Raymond P. Vito , Michael L. Wach , Jack Griffis
IPC分类号： A61M31/00
CPC分类号： A61M31/007 , A61K9/5036 , A61M37/0069
摘要： Devices and methods for delivering therapeutic agents use a movable sheath member to deliver a therapeutic agent with little or no shear stress. The delivery device may include an outer body being configured to move away from a distal end of the delivery device. The movable sheath member may have a first section and a second section opposing the first section, the second section being configured to hold the therapeutic agent. The movable sheath may be configured to deliver the therapeutic agent by increasing the first section by moving the outer body away from the distal end.
摘要翻译：用于递送治疗剂的装置和方法使用可移动护套构件递送具有很小或没有剪切应力的治疗剂。输送装置可以包括外体，其被配置为远离输送装置的远端移动。可移动护套构件可以具有与第一部分相对的第一部分和第二部分，第二部分构造成保持治疗剂。可移动护套可经配置以通过使外体远离远端移动来增加第一部分来递送治疗剂。

6. 发明申请

US20150050348A1 BIOMECHANICAL FORCE MITIGATION IN THE DELIVERY OF STEM CELL THERAPIES 审中-公开
标题翻译：干细胞治疗的生物力学减少
公开(公告)号：US20150050348A1
公开(公告)日：2015-02-19
申请号：US13969317
申请日：2013-08-16
申请人： Raymond P. Vito , Jack C. Griffis , W. Robert Taylor , Michael L. Wach
发明人： Raymond P. Vito , Jack C. Griffis , W. Robert Taylor , Michael L. Wach
IPC分类号： A61K35/12 , A61K9/00
CPC分类号： A61K35/12 , C12N2527/00
摘要： A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.
摘要翻译：医生可以指定涉及递送治疗剂的过程的某些参数，同时留下其他参数。治疗剂可以对与递送相关的生物力学力（或其他影响）敏感。该过程可以涉及再生医学，例如使用导管将祖细胞或干细胞递送到患病心脏，由此在导管中的肆无忌惮的运输可能损害功效。开放参数可以影响药剂的疗效，从而影响治疗效果。基于计算机的系统可以应用诸如数据库之类的存储信息来缩小开放参数的可能值。从缩小的可能性，优化程序可以确定开放参数的合适或优化的值。确定的值可以管理治疗剂引起的生物力学力，从而促进功效和愈合。优化的参数可以指导实践者在程序中。

7. 发明授权

US07018402B2 Intravascular device and method for axially stretching blood vessels 失效
公开(公告)号：US07018402B2
公开(公告)日：2006-03-28
申请号：US10093715
申请日：2002-03-07
申请人： Raymond P. Vito , Jack C. Griffis, III
发明人： Raymond P. Vito , Jack C. Griffis, III
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/885
摘要： Intravascular devices and methods are provided for forming a vascular graft by axially distending a blood vessel to induce growth. These devices advantageously can be implanted via a catheter, thereby eliminating the need for a more invasive implantation procedure when the stretching is to be done in vivo. Preferably, the device for axially distending a blood vessel to induce growth of the vessel includes an intravascular stretching mechanism attachable directly to an interior lumen portion of the blood vessel, and a means for operating the stretching mechanism to cause the vessel to distend axially. The stretching mechanism can include a pair of wires or stents that engage the blood vessel wall. Components of the stretching mechanism can include a shape memory material.

8. 发明授权

US07300455B2 Intravascular device for axially stretching blood vessels 有权
标题翻译：用于轴向拉伸血管的血管内装置
公开(公告)号：US07300455B2
公开(公告)日：2007-11-27
申请号：US11371663
申请日：2006-03-09
申请人： Raymond P. Vito , Jack C. Griffis, III
发明人： Raymond P. Vito , Jack C. Griffis, III
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/885
摘要： Intravascular devices are provided for forming a vascular graft by axially distending a blood vessel to induce growth. These devices advantageously can be implanted via a catheter, thereby eliminating the need for a more invasive implantation procedure when the stretching is to be done in vivo. The implantable medical device for distending a blood vessel to induce axial growth of the blood vessel includes an intravascular stretching mechanism securable to an interior luminal surface of a blood vessel in vivo, and a means for operating the intravascular stretching mechanism in vivo to cause the vessel to stretch and grow axially. The stretching mechanism can include a pair of wires or stents that engage the blood vessel wall, and components of the stretching mechanism may include a shape memory material.
摘要翻译：提供血管内装置用于通过轴向膨胀血管以诱导生长形成血管移植物。这些装置有利地可以通过导管植入，从而当拉伸在体内进行时不需要更具侵入性的植入程序。用于使血管膨胀以引起血管轴向生长的可植入医疗装置包括可固定于体内血管内腔内表面的血管内拉伸机构，以及用于在体内操作血管内拉伸机构以引起血管的装置拉伸和轴向生长。拉伸机构可以包括与血管壁接合的一对线或支架，并且拉伸机构的部件可以包括形状记忆材料。

9. 发明授权

US06641576B1 Devices for creating vascular grafts by vessel distension using rotatable elements 有权
标题翻译：用于通过使用可旋转元件的血管扩张产生血管移植物的装置
公开(公告)号：US06641576B1
公开(公告)日：2003-11-04
申请号：US09994500
申请日：2001-11-27
申请人： Raymond P. Vito , Jack C. Griffis, III
发明人： Raymond P. Vito , Jack C. Griffis, III
IPC分类号： A61B1700
CPC分类号： A61F2/06 , A61F2/062 , Y10S623/903
摘要： Devices and methods are provided for forming a vascular graft by axially distending a blood vessel to induce growth. The device preferably comprises a stretching mechanism which includes (i) a stabilization rod, (ii) a pair of rotatable elements, wherein each rotatable element is rotatably attached to the elongated body and has a channel substantially perpendicular to the axis of rotation, and (iii) a means for rotating each rotatable element to axially distend a blood vessel positioned in the channels of the rotatable elements. The elements can be rotated intermittently, cyclically, or continuously, over a period to distend or elongate the donor vessel. Preferably, the device is implanted, for example using endoscopic techniques, for use in vivo, although the device also can be used in vitro.
摘要翻译：提供了通过轴向膨胀血管以诱导生长来形成血管移植物的装置和方法。该装置优选地包括拉伸机构，其包括（i）稳定杆，（ii）一对可旋转元件，其中每个可旋转元件可旋转地附接到细长主体并且具有基本上垂直于旋转轴线的通道，和 iii）用于使每个可旋转元件旋转以使位于可旋转元件的通道中的血管轴向膨胀的装置。元件可以在一段时间内间歇地，循环地或连续地旋转以膨胀或延长供体容器。优选地，该装置例如使用内窥镜技术植入体内使用，尽管该装置也可以在体外使用。

10. 发明授权

US06991628B2 Device and method for creating a vascular graft in vitro 失效
标题翻译：用于在体外产生血管移植物的装置和方法
公开(公告)号：US06991628B2
公开(公告)日：2006-01-31
申请号：US10652775
申请日：2003-08-29
申请人： Raymond P. Vito , Jack C. Griffis, III
发明人： Raymond P. Vito , Jack C. Griffis, III
IPC分类号： A61B17/00
CPC分类号： A61F2/06 , A61F2/062 , Y10S623/903
摘要： Methods and apparatus are provided for forming a vascular graft in vitro by axially distending a blood vessel to induce growth. The apparatus comprises a chamber containing a tissue culture medium, an inlet cannula, an outlet cannula, and a means for moving the inlet cannula, the outlet cannula, or both, to axially stretch a donor blood vessel secured between the inlet cannula and the outlet cannula in a submerged position in the tissue culture medium, wherein the inlet cannula, the outlet cannula, and the donor blood vessel are secured together to form a conduit through which the tissue culture medium can flow.
摘要翻译：提供了通过轴向膨胀血管以诱导生长的体外形成血管移植物的方法和装置。该装置包括包含组织培养基的腔室，入口插管，出口插管和用于移动入口套管，出口插管或两者的装置，以轴向拉伸固定在入口套管和出口之间的供体血管插管在组织培养基中的浸没位置，其中入口插管，出口插管和供体血管固定在一起以形成组织培养基可以通过该导管通过的导管。

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