专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070179089A1 Structure of SOCS and uses thereof 有权
标题翻译： SOCS的结构及其用途
公开(公告)号：US20070179089A1
公开(公告)日：2007-08-02
申请号：US11598212
申请日：2006-11-09
申请人： Raymond Norton , Jeffrey Babon , Sandra Nicholson , Nicos Nicola , Edward McManus , Manuel Baca , Shenggen Yao
发明人： Raymond Norton , Jeffrey Babon , Sandra Nicholson , Nicos Nicola , Edward McManus , Manuel Baca , Shenggen Yao
IPC分类号： A61K48/00 , C07K14/705 , A61K38/17 , C07H21/04 , C12P21/06
CPC分类号： C07K14/4703 , A61K38/17
摘要： The present invention relates to the identification of a PEST motif in Suppressor of Cytokine Signalling (SOCS) proteins, the deletion/inactivation of which has been found to increase the stability of the protein whilst maintaining at least one biological activity of the protein. Such SOCS proteins with deleted/inactivated PEST motifs can be used in gene and protein therapy procedures to provide a more stable SOCS protein when compared to the native protein. The present invention also relates to the characterization of the structure of SOCS proteins, and methods of using this structural information to identify compounds which modulate the activity of SOCS.
摘要翻译：本发明涉及鉴定细胞因子信号传导抑制因子（SOCS）蛋白质的抑制因子的PEST基序，已经发现其缺失/失活增加了蛋白质的稳定性，同时保持蛋白质的至少一种生物学活性。具有缺失/失活的PEST基序的这种SOCS蛋白质可用于基因和蛋白质治疗程序，以便与天然蛋白质相比提供更稳定的SOCS蛋白质。本发明还涉及SOCS蛋白质结构的表征，以及使用该结构信息鉴定调节SOCS活性的化合物的方法。

2. 发明申请

US20080057517A1 Methods of regulating cytokine signalling 审中-公开
标题翻译：调节细胞因子信号传导的方法
公开(公告)号：US20080057517A1
公开(公告)日：2008-03-06
申请号：US11818589
申请日：2007-06-15
申请人： Sandra Nicholson , Manuel Baca , Nicos Nicola , Douglas Hilton , Jian Zhang , Louis Fabri , Andrew Nash
发明人： Sandra Nicholson , Manuel Baca , Nicos Nicola , Douglas Hilton , Jian Zhang , Louis Fabri , Andrew Nash
IPC分类号： G01N33/53
CPC分类号： G01N33/6863
摘要： The present invention relates generally to a method for regulating cytokine signalling and agents useful for same. The method of the present invention is predicated in part on the identification of the molecular target of suppressor of cytokine signalling (SOCS) interaction in controlling cytokine signalling. The identification of the molecular target permits the development of assays to screen for a range of agonists and antagonists useful in modulating cytokine function. The present invention further provides, therefore, screening assays and more particularly high through-put screening assays for agonists and antagonists of SOCS-receptor interaction. Such agonists and antagonists are useful in the manufacture of medicaments for controlling cytokine signalling. Control of cytokine signalling is important for the treatment of a range of conditions including cancer, inflammatory conditions, immunological disorders and any other conditions involving aberrations of signal transduction.
摘要翻译：本发明一般涉及用于调节细胞因子信号传导的方法和可用于其的试剂。本发明的方法部分地基于在控制细胞因子信号传导中识别细胞因子信号传导抑制剂（SOCS）相互作用的分子靶标。分子靶标的鉴定允许开发测定以筛选可用于调节细胞因子功能的一系列激动剂和拮抗剂。因此，本发明进一步提供用于SOCS-受体相互作用的激动剂和拮抗剂的筛选测定和更特别的高通量筛选测定。这样的激动剂和拮抗剂可用于制备用于控制细胞因子信号传导的药物。细胞因子信号传导的控制对于治疗一系列病症（包括癌症，炎性病症，免疫学障碍和涉及信号转导异常的任何其他病症）是重要的。

3. 发明申请

US20060242718A1 SOCS-box containing peptides 审中-公开
标题翻译：含有SOCS盒的肽
公开(公告)号：US20060242718A1
公开(公告)日：2006-10-26
申请号：US11400964
申请日：2006-04-10
申请人： Tracy Willson , Richard Simpson , Alison Farley , Sandra Nicholson , Jian Zhang , Manuel Baca , Nicos Nicola , Douglas Hilton , Warren Alexander , Donald Metcalf
发明人： Tracy Willson , Richard Simpson , Alison Farley , Sandra Nicholson , Jian Zhang , Manuel Baca , Nicos Nicola , Douglas Hilton , Warren Alexander , Donald Metcalf
IPC分类号： A01K67/00 , A61K38/22
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： The present invention relates generally to amino acid sequences obtainable from SOCS proteins and which are capable of interacting with intracellular molecules. The present invention further relates to nucleic acid molecules encoding said amino acid sequences. The amino acid sequences and the nucleic acid molecules encoding same of the present invention are useful in modulating degradation of proteinaceous molecules such as but not limited to SOCS proteins and proteinaceous molecules associate therewith. The present invention provides a mechanism for modulating cytokine or cytokine-like molecule signaling by modulating the degradation of activated signal transduction molecules or their negative regulators, i.e. the SOCS proteins.
摘要翻译：本发明一般涉及可从SOCS蛋白获得并且能够与细胞内分子相互作用的氨基酸序列。本发明还涉及编码所述氨基酸序列的核酸分子。编码本发明的氨基酸序列和核酸分子可用于调节蛋白质分子的降解，例如但不限于与其缔合的SOCS蛋白和蛋白质分子。本发明提供了通过调节活化的信号转导分子或其负调节物（即SOCS蛋白）的降解来调节细胞因子或细胞因子样分子信号传导的机制。

4. 发明授权

US07517959B2 SOCS3 proteins 有权
标题翻译： SOCS3蛋白
公开(公告)号：US07517959B2
公开(公告)日：2009-04-14
申请号：US11598212
申请日：2006-11-09
申请人： Raymond Stanley Norton , Jeffrey James Babon , Sandra Elaine Nicholson , Nicos Anthony Nicola , Edward James McManus , Manuel Baca , Shenggen Yao
发明人： Raymond Stanley Norton , Jeffrey James Babon , Sandra Elaine Nicholson , Nicos Anthony Nicola , Edward James McManus , Manuel Baca , Shenggen Yao
IPC分类号： C07K14/46 , A61K38/17
CPC分类号： C07K14/4703 , A61K38/17
摘要： The present invention relates to the identification of a PEST motif in Suppressor of Cytokine Signalling (SOCS) proteins, the deletion/inactivation of which has been found to increase the stability of the protein whilst maintaining at least one biological activity of the protein. Such SOCS proteins with deleted/inactivated PEST motifs can be used in gene and protein therapy procedures to provide a more stable SOCS protein when compared to the native protein. The present invention also relates to the characterization of the structure of SOCS proteins, and methods of using this structural information to identify compounds which modulate the activity of SOCS.
摘要翻译：本发明涉及鉴定细胞因子信号传导抑制因子（SOCS）蛋白质的抑制因子的PEST基序，已经发现其缺失/失活增加了蛋白质的稳定性，同时保持蛋白质的至少一种生物学活性。具有缺失/失活的PEST基序的这种SOCS蛋白质可用于基因和蛋白质治疗程序，以便与天然蛋白质相比提供更稳定的SOCS蛋白质。本发明还涉及SOCS蛋白质结构的表征，以及使用该结构信息鉴定调节SOCS活性的化合物的方法。

5. 发明申请

US20050058645A1 Monoclonal antibody against Interleukin-13 receptor alpha 1 (IL-13Ralpha1) 有权
标题翻译：白细胞介素-13受体α1单克隆抗体（IL-13Rα1）
公开(公告)号：US20050058645A1
公开(公告)日：2005-03-17
申请号：US10850270
申请日：2004-05-20
申请人： Felicity Dunlop , Manuel Baca , Andrew Nash , Louis Fabri , Douglas Hilton , Nicos Nicola
发明人： Felicity Dunlop , Manuel Baca , Andrew Nash , Louis Fabri , Douglas Hilton , Nicos Nicola
IPC分类号： C07K16/28 , C12N5/20 , A61K39/395 , C07K16/24
CPC分类号： C07K16/2866 , C07K2317/24 , C07K2317/55 , C07K2319/00
摘要： The present invention relates generally to antibodies that bind to the Interleukin-13 receptor α1 chain (IL-13Rα1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13Rα1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13Rα1/ligand interaction is also provided.
摘要翻译：本发明一般涉及结合白细胞介素-13受体α1链（IL-13Rα1）并通过IL-13和/或IL-4拮抗IL-13受体介导的信号传导的抗体。更具体地说，本发明为哺乳动物，特别是IL-13Rα1提供人源化或人抗体。这些抗体在治疗或预防IL-13和/或IL-4介导的疾病或病症中具有应用。本发明进一步考虑通过施用受试者抗体调节IL-13和/或IL-4介导的疾病或病症的方法。本发明还提供了可用于鉴定通过IL-13受体复合物调节IL-13和/或IL-4信号传导的抗体或其它试剂的测定系统。因此，还提供了筛选IL-13Rα1/配体相互作用的调节剂的方法。

6. 发明申请

US20130079280A1 FIBRONECTIN TYPE III DOMAIN-BASED MULTIMERIC SCAFFOLDS 审中-公开
标题翻译：基于FIBRONECTIN III型的多基因多态性
公开(公告)号：US20130079280A1
公开(公告)日：2013-03-28
申请号：US13640057
申请日：2011-04-12
申请人： Manuel Baca , Thomas Thisted , Jeffrey Swers
发明人： Manuel Baca , Thomas Thisted , Jeffrey Swers
IPC分类号： C07K19/00
CPC分类号： C07K19/00 , A61K2039/505 , C07K14/001 , C07K14/78 , C07K16/1027 , C07K16/2878 , C07K16/468 , C07K2317/73 , C07K2317/90 , C07K2318/20 , C07K2319/00 , C07K2319/30 , C07K2319/33 , C07K2319/70 , C07K2319/74
摘要： The present invention provides fibronectin type III (Fn3)-based multimeric scaffolds that specifically bind to one or more specific target antigen. The invention further provides bispecific Fn3-derived binding molecules that bind to two or more target antigens simultaneously, fusions, conjugates, and methods to increase the stability of Fn3-based binding molecules. Furthermore, the present invention is related to a prophylactic, therapeutic or diagnostic agent, which contains Fn3-based multimeric scaffolds.
摘要翻译：本发明提供了特异性结合一种或多种特异性靶抗原的基于纤连蛋白III（Fn3）的多聚体支架。本发明还提供了同时结合两种或多种靶抗原的双特异性Fn3衍生结合分子，融合物，缀合物和增加Fn3基结合分子稳定性的方法。此外，本发明涉及含有Fn3的多聚体支架的预防，治疗或诊断试剂。

7. 发明申请

US20100285035A1 High Affinity Antibody Antagonists of Interleukin-13 Receptor Alpha 1 有权
标题翻译：白细胞介素-13受体α高亲和抗体拮抗剂1
公开(公告)号：US20100285035A1
公开(公告)日：2010-11-11
申请号：US12774966
申请日：2010-05-06
申请人： Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
发明人： Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , A61P35/00 , A61P1/00 , A61P17/06 , A61P11/06 , A61P37/08 , A61P29/00 , A61P17/00 , C12N15/60 , C12N5/10
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/43 , C12P21/005
摘要： High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.
摘要翻译：公开了人白细胞介素-13受体α1的高亲和力抗体拮抗剂。抗体分子在抑制IL-13Rα1介导的活性中是有效的，因此，在治疗与hIL-13Rα1活性相关的病症中使用所需的拮抗剂。本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。还公开了使用抗体分子抑制或拮抗IL-13Rα1介导的活性的方法。

8. 发明授权

US07683213B2 Oxidation of propane to give acrylic acid using catalysts in a mixture of crystalline phases 失效
标题翻译：使用催化剂在结晶相的混合物中氧化丙烷以产生丙烯酸
公开(公告)号：US07683213B2
公开(公告)日：2010-03-23
申请号：US10558023
申请日：2004-05-25
申请人： Jean-Luc Dubois , Manuel Baca , Jean-Marc Millet
发明人： Jean-Luc Dubois , Manuel Baca , Jean-Marc Millet
IPC分类号： C07C51/16
CPC分类号： B01J23/28 , B01J23/002 , B01J23/18 , B01J23/20 , B01J27/0576 , B01J35/0006 , B01J2523/00 , C07C51/215 , C07C57/04 , B01J2523/55 , B01J2523/56 , B01J2523/64 , B01J2523/68 , B01J2523/53
摘要： The invention relates to a method for the production of acrylic acid from propane, in which a gas mixture comprising propane, water vapour and, optionally, an inert gas and/or molecular oxygen is passed over a catalyst, comprising a crystalline catalyst phase of formula (I) or (I′) TeaMolVbNbcOx (I) Sba Mol VbOy (I′), associated with a crystalline catalyst phase for activating the propane.
摘要翻译：本发明涉及一种从丙烷生产丙烯酸的方法，其中将包含丙烷，水蒸汽和任选的惰性气体和/或分子氧的气体混合物通过催化剂，该催化剂包含式（I）或（I'）TeaMolVbNbcOx（I）Sba Mol VbOy（I'），与用于活化丙烷的结晶催化剂相关。

9. 发明申请

US20080166343A1 High affinity antibody antagonists of interleukin-13 receptor alpha 1 有权
标题翻译：白细胞介素-13受体α1的高亲和力抗体拮抗剂
公开(公告)号：US20080166343A1
公开(公告)日：2008-07-10
申请号：US11875017
申请日：2007-10-19
申请人： Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
发明人： Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06 , A61P43/00
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/43 , C12P21/005
摘要： High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.
摘要翻译：公开了人白细胞介素-13受体α1的高亲和力抗体拮抗剂。抗体分子在抑制IL-13Rα1介导的活性中是有效的，因此，在治疗与hIL-13Rα1活性相关的病症中使用所需的拮抗剂。本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。还公开了使用抗体分子抑制或拮抗IL-13Rα1介导的活性的方法。

10. 发明授权

US06884879B1 Anti-VEGF antibodies 失效
标题翻译：抗VEGF抗体
公开(公告)号：US06884879B1
公开(公告)日：2005-04-26
申请号：US08908469
申请日：1997-08-06
申请人： Manuel Baca , James A. Wells
发明人： Manuel Baca , James A. Wells
IPC分类号： C12N15/02 , A61K38/00 , C07K16/18 , C07K16/22 , C12P21/08 , C07H21/04
CPC分类号： C07K16/22 , A61K38/00 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/73
摘要： Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
摘要翻译：公开了人源化和变异的抗VEGF抗体及其各种用途。抗VEGF抗体对VEGF具有很强的结合亲和力; 体外抑制VEGF诱导的内皮细胞增殖; 并在体内抑制肿瘤生长。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式