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1. 发明授权

US06205357B1 Methods and apparatus for detecting and treating medical conditions of the heart 有权
标题翻译：检测和治疗心脏病情的方法和装置
公开(公告)号：US06205357B1
公开(公告)日：2001-03-20
申请号：US09206022
申请日：1998-12-04
申请人： Raymond E. Ideker , Jay A. Warren , Bruce H. KenKnight
发明人： Raymond E. Ideker , Jay A. Warren , Bruce H. KenKnight
IPC分类号： A61N139
CPC分类号： A61N1/3622
摘要： An implantable system for detecting electrical activity from a patient's heart comprises a first sensing electrode configured for positioning through the coronary sinus ostium and within a vein on the left surface of the left ventricle of the heart for sensing electrical activity from the heart, and a detector operatively associated with the first sensing electrode for determining (e.g., diagnosing or prognosing) a medical condition of the heart with the sensed electrical activity. Typically the system further comprises a second sensing electrode configured for positioning in the right ventricle of the heart, where the detector is operatively associated with both the first sensing electrode and the second sensing electrode. The second sensing electrode may be positioned in other locations as well, such as also within a vein on the left surface of the left ventricle of the heart (although spaced apart from the first sensing electrode), in the right atrium, in the superior vena cava, etc. Finally, a third sensing electrode may also be included, with the third electrode positioned in any of the foregoing locations (again, spaced apart from the first and second electrodes), with the detector operatively associated with all of the first, second, and third sensing electrodes. Determination of a medical condition may be carried out by any suitable means, such as by detecting premature beats in the heart. The method is particularly useful for identifying the chamber of premature beat origin.
摘要翻译：用于从患者心脏检测电活动的可植入系统包括构造成用于定位穿过冠状窦口和心脏左心室左表面的静脉内的第一感测电极，用于感测来自心脏的电活动;以及检测器可操作地与第一感测电极相关联，用于利用感测到的电活动来确定（例如，诊断或预测）心脏的医学状况。通常，该系统还包括被配置用于定位在心脏的右心室中的第二感测电极，其中检测器与第一感测电极和第二感测电极两者可操作地相关联。第二感测电极也可以位于其他位置，例如也在心脏左心室左侧的静脉内（尽管与第一感测电极间隔开），在右心房中，在上腔静脉卡瓦等。最后，还可以包括第三感测电极，其中第三电极位于上述任何位置（再次与第一和第二电极间隔开），检测器与所有第一，第二和第三感测电极。可以通过任何合适的手段来进行医学状态的确定，例如通过检测心脏中的过早搏动。该方法对于识别过早搏动起源的室特别有用。

2. 发明授权

US06648881B2 Method for reducing arterial restenosis in the presence of an intravascular stent 失效
标题翻译：在血管内支架存在下减少动脉再狭窄的方法
公开(公告)号：US06648881B2
公开(公告)日：2003-11-18
申请号：US09940337
申请日：2001-08-27
申请人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
发明人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
IPC分类号： A61B1804
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
摘要翻译：第一电极位于植入的血管内支架附近的动脉内。第二电极相对于第一电极的位置定位在单独的位置。然后在第一和第二电极之间传递电能，以产生邻近植入的血管内支架的电场。当将血管内支架植入冠状动脉中时，电能的传递与在感测到的心脏信号中检测到的心脏周期协调，其中第一电极和第二电极之间的电能的传递发生在第一电极和第二电极的预定部分期间心动周期。

3. 发明授权

US06519488B2 Method and system for reducing arterial restenosis in the presence of an intravascular stent 失效
公开(公告)号：US06519488B2
公开(公告)日：2003-02-11
申请号：US09940336
申请日：2001-08-27
申请人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
发明人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
IPC分类号： A61B504
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.

4. 发明授权

US07769437B2 Method and apparatus for determining changes in heart failure status 有权
标题翻译：用于确定心力衰竭状态变化的方法和装置
公开(公告)号：US07769437B2
公开(公告)日：2010-08-03
申请号：US11299876
申请日：2005-12-12
申请人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Jay A. Warren
发明人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Jay A. Warren
IPC分类号： A61B5/04
CPC分类号： A61N1/3627 , A61N1/36585
摘要： A method for operating a cardiac rhythm management device in which a clinical state vector is computed as a combination of a plurality of parameters related to a patient's heart failure status and compared to a previously computed clinical state vector to determine a clinical trajectory indicative of changes in the patient's heart failure status. Such detected changes in status can be used both as a clinical tool to evaluate treatment and to automatically adjust the operation of the device.
摘要翻译：一种用于操作心律管理装置的方法，其中临床状态矢量被计算为与患者心力衰竭状态相关的多个参数的组合，并且与先前计算的临床状态向量进行比较，以确定指示变化的临床轨迹患者的心力衰竭状态。这种检测到的状态变化可以用作临床工具来评估治疗并自动调整装置的操作。

5. 发明授权

US06980851B2 Method and apparatus for determining changes in heart failure status 失效
标题翻译：用于确定心力衰竭状态变化的方法和装置
公开(公告)号：US06980851B2
公开(公告)日：2005-12-27
申请号：US10001223
申请日：2001-11-15
申请人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Jay A. Warren
发明人： Qingsheng Zhu , Julio C. Spinelli , Bruce H. KenKnight , Jay A. Warren
IPC分类号： A61N1/362 , A61N1/365 , A61B5/0402
CPC分类号： A61N1/3627 , A61N1/36585
摘要： A method for operating a cardiac rhythm management device in which a clinical state vector is computed as a combination of a plurality of parameters related to a patient's heart failure status and compared to a previously computed clinical state vector to determine a clinical trajectory indicative of changes in the patient's heart failure status. Such detected changes in status can be used both as a clinical tool to evaluate treatment and to automatically adjust the operation of the device.
摘要翻译：一种用于操作心律管理装置的方法，其中临床状态矢量被计算为与患者心力衰竭状态相关的多个参数的组合，并且与先前计算的临床状态向量进行比较，以确定指示变化的临床轨迹患者的心力衰竭状态。这种检测到的状态变化可以用作临床工具来评估治疗并自动调整装置的操作。

6. 发明授权

US06939345B2 Method for reducing restenosis in the presence of an intravascular stent 失效
标题翻译：在血管内支架存在下减少再狭窄的方法
公开(公告)号：US06939345B2
公开(公告)日：2005-09-06
申请号：US10397623
申请日：2003-03-26
申请人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
发明人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
IPC分类号： A61B18/14 , A61B18/04
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
摘要翻译：第一电极位于植入的血管内支架附近的动脉内。第二电极相对于第一电极的位置定位在单独的位置。然后在第一和第二电极之间传递电能，以产生邻近植入的血管内支架的电场。当将血管内支架植入冠状动脉中时，电能的传递与在感测到的心脏信号中检测到的心脏周期协调，其中第一电极和第二电极之间的电能的传递发生在第一电极和第二电极的预定部分期间心动周期。

7. 发明授权

US06317615B1 Method and system for reducing arterial restenosis in the presence of an intravascular stent 有权
标题翻译：在血管内支架存在下减少动脉再狭窄的方法和系统
公开(公告)号：US06317615B1
公开(公告)日：2001-11-13
申请号：US09294724
申请日：1999-04-19
申请人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
发明人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
IPC分类号： A61B504
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
摘要翻译：第一电极位于植入的血管内支架附近的动脉内。第二电极相对于第一电极的位置定位在单独的位置。然后在第一和第二电极之间传递电能，以产生邻近植入的血管内支架的电场。当将血管内支架植入冠状动脉中时，电能的传递与在感测到的心脏信号中检测到的心脏周期协调，其中第一电极和第二电极之间的电能的传递发生在第一电极和第二电极的预定部分期间心动周期。

8. 发明授权

US09149637B2 Adaptive confirmation of treatable arrhythmia in implantable cardiac stimulus devices 有权
标题翻译：可植入心脏刺激装置中可治疗心律失常的自适应确认
公开(公告)号：US09149637B2
公开(公告)日：2015-10-06
申请号：US12826241
申请日：2010-06-29
申请人： Jay A. Warren , Rick Sanghera , Venugopal Allavatam
发明人： Jay A. Warren , Rick Sanghera , Venugopal Allavatam
IPC分类号： A61N1/39 , A61N1/365 , A61N1/362 , A61B5/0464
CPC分类号： A61N1/3987 , A61B5/0464 , A61N1/3622 , A61N1/3925 , A61N1/3943 , A61N1/3956
摘要： Methods and devices for adjusting therapy delivery decisions in an implantable cardiac stimulus device by observing cardiac activity following an initial identification of a treatable condition. In some examples, cardiac activity that appears benign is quantified and a therapy confirmation threshold is adjusted according to how much apparently benign cardiac activity is seen after an initial identification of a treatable condition. In other examples, a new threshold is applied following the initial identification of treatable condition, removing historical data preceding the initial identification from subsequent therapy delivery decisions.
摘要翻译：用于通过在初始识别可治疗病症后观察心脏活动来调整可植入心脏刺激装置中的治疗递送决定的方法和装置。在一些实例中，显示良性的心脏活动被定量，并且根据在可治疗病症的初始鉴定之后看到多少明显良性的心脏活动来调整治疗确认阈值。在其他示例中，在可治疗条件的初始识别之后应用新阈值，从随后的治疗递送决定中移除初始识别之前的历史数据。

9. 发明授权

US08565878B2 Accurate cardiac event detection in an implantable cardiac stimulus device 有权
标题翻译：在可植入心脏刺激装置中精确的心脏事件检测
公开(公告)号：US08565878B2
公开(公告)日：2013-10-22
申请号：US12399901
申请日：2009-03-06
申请人： Venugopal Allavatam , Surekha Palreddy , Rick Sanghera , Jay A. Warren
发明人： Venugopal Allavatam , Surekha Palreddy , Rick Sanghera , Jay A. Warren
IPC分类号： A61N1/36
CPC分类号： A61N1/3987 , A61B5/0245 , A61B5/0452 , A61B5/04525 , A61B5/726 , A61N1/365 , A61N1/3704
摘要： Methods, systems, and devices for signal analysis in an implanted cardiac monitoring and treatment device such as an implantable cardioverter defibrillator. In some illustrative examples, detected events are analyzed to identify changes in detected event amplitudes. When detected event amplitudes are dissimilar from one another, a first set of detection parameters may be invoked, and, when detected event amplitudes are similar to one another, a second set of detection parameters may be invoked. Additional methods determine whether the calculated heart rate is “high” or “low,” and then may select a third set of detection parameters for use when the calculated heart rate is high.
摘要翻译：植入式心脏监测和治疗装置如植入式心律转复除颤器中的信号分析方法，系统和装置。在一些说明性示例中，分析检测到的事件以识别检测到的事件振幅的变化。当检测到的事件幅度彼此不同时，可以调用第一组检测参数，并且当检测到的事件幅度彼此相似时，可以调用第二组检测参数。另外的方法确定计算的心率是“高”还是“低”，然后可以选择第三组检测参数，以便在计算心率高时使用。

10. 发明授权

US08160697B2 Method for adapting charge initiation for an implantable cardioverter-defibrillator 有权
公开(公告)号：US08160697B2
公开(公告)日：2012-04-17
申请号：US11042911
申请日：2005-01-25
申请人： Jay A. Warren , Gust H. Bardy
发明人： Jay A. Warren , Gust H. Bardy
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3621 , A61N1/3943 , A61N1/3956
摘要： Adaptive methods for initiating charging of the high power capacitors of an implantable medical device for therapy delivery after the patient experiences a non-sustained arrhythmia. The adaptive methods adjust persistence criteria used to analyze an arrhythmia prior to initiating a charging sequence to deliver therapy.

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