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1. 发明授权

US5293261A Device for low electric-field induced switching of Langmuir-Blodgett ferroelecric liquid crystal polymer films 失效
标题翻译： Langmuir-Blodgett铁电液晶聚合物薄膜的低电场感应切换装置
公开(公告)号：US5293261A
公开(公告)日：1994-03-08
申请号：US999619
申请日：1992-12-31
申请人： Ranganathan Shashidhar , Jawad Naciri , Sebastian Pfeiffer , Thomas L. Fare
发明人： Ranganathan Shashidhar , Jawad Naciri , Sebastian Pfeiffer , Thomas L. Fare
IPC分类号： G02F1/1333 , G02F1/141 , G02F1/13 , G02F1/1343
CPC分类号： G02F1/133365 , G02F1/141
摘要： Devices in which a Langmuir-Blodgett film of a liquid crystal polymer is disposed between electrodes on the surface of a substrate exhibit fast ferroelectric switching in response to an electric field generated by the electrodes, and Langmuir-Blodgett films of a liquid crystal polymer exhibit pyroelectric properties even at thicknesses below 10-15 .mu.m.
摘要翻译：其中液晶聚合物的Langmuir-Blodgett膜设置在基板表面上的电极之间的装置响应于由电极产生的电场而显示出快速的铁电切换，液晶聚合物的Langmuir-Blodgett膜显示热释电甚至在低于10-15（我）米的厚度下的性能。

2. 发明授权

US5461322A Autonulling DC bridge for real-time sensor transduction and voltage measurements 失效
标题翻译：用于实时传感器转换和电压测量的自动调节直流电桥
公开(公告)号：US5461322A
公开(公告)日：1995-10-24
申请号：US102835
申请日：1993-08-06
申请人： Paul P. Bey, Jr. , Thomas L. Fare , David J. Yonce
发明人： Paul P. Bey, Jr. , Thomas L. Fare , David J. Yonce
IPC分类号： G01N27/02 , G01R17/06 , G01R17/02
CPC分类号： G01N27/02 , G01R17/06
摘要： A feedback operated DC bridge circuit for monitoring the voltage variations in a voltage divider circuit using a voltage controlled resistance component to reach a null balance across the bridge. Amplification is provided at higher accuracy near the null point when the voltage difference across the bridge is zero. The feedback bridge circuit includes an integrator which directly drives the controlling component to the value of the resistance in an unknown branch to force the null condition. The voltage controlled component (configured as a discrete metal oxide semiconductor device or bipolar junction transistor) and the balancing scheme are suitable for microfabrication and provides noise-rejection enhancement. The interconnected integral feedback of the autonulling DC bridge enables both a neural network for pre-processing sensor input in a spatial domain as well as general analog computation that mimics a first order differential equation in the form of the system state equation.
摘要翻译：一个反馈操作的直流电桥电路，用于使用电压控制的电阻分量来监测分压器电路中的电压变化，以达到跨桥的零平衡。当桥上的电压差为零时，在零点附近以更高的精度提供放大。反馈桥接电路包括一个积分器，它将控制分量直接驱动到未知分支中的电阻值，以迫使空值。电压控制部件（配置为离散金属氧化物半导体器件或双极结型晶体管）和平衡方案适用于微细加工，并提供噪声抑制。自动直流电桥的互连整体反馈使神经网络能够预处理空间域中的传感器输入以及以系统状态方程式的形式模拟一阶微分方程的一般模拟计算。

3. 发明授权

US5510628A Deep ultraviolet photolithographically defined ultra-thin films for selective cell adhesion and outgrowth and method of manufacturing the same and devices containing the same 失效
标题翻译：用于选择性细胞粘附和生长的深紫外光刻光刻的超薄膜及其制造方法以及含有该超薄膜的装置
公开(公告)号：US5510628A
公开(公告)日：1996-04-23
申请号：US206147
申请日：1994-03-07
申请人： Jacque H. Georger, Jr. , David A. Stenger , Thomas L. Fare
发明人： Jacque H. Georger, Jr. , David A. Stenger , Thomas L. Fare
IPC分类号： B05D1/18 , C09D4/00 , C12N5/00 , C23C18/16 , C40B60/14 , G03F7/004 , G03F7/16 , G06N3/00 , G06N99/00 , H01L21/288 , H05K3/06 , H05K3/18 , H01L27/12 , B05D5/12
CPC分类号： G03F7/165 , B05D1/185 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C09D4/00 , C12N5/0068 , C23C18/1608 , C23C18/1612 , C23C18/1893 , G03F7/004 , G06N3/002 , G06N99/007 , H01L21/288 , H01L21/2885 , H01L51/0595 , H05K3/185 , B01J2219/00432 , B01J2219/00603 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B82Y5/00 , C12N2535/10 , C40B60/14 , Y10T428/12056 , Y10T428/265
摘要： Patterned surfaces for the selective adhesion and outgrowth of cells are useful in cell culture devices, prosthetic implants, and cell-based microsensors. Such surfaces may be prepared by a deep ultraviolet photolithographic technique.
摘要翻译：用于细胞的选择性粘附和生长的图案化表面可用于细胞培养装置，假体植入物和基于细胞的微传感器。这样的表面可以通过深紫外光刻技术制备。

4. 发明授权

US5264798A Autonulling AC bridge using differential and integration feedback 失效
标题翻译：使用差分和积分反馈自动调节交流电桥
公开(公告)号：US5264798A
公开(公告)日：1993-11-23
申请号：US783904
申请日：1991-10-29
申请人： Paul P. Bey, Jr. , Thomas L. Fare
发明人： Paul P. Bey, Jr. , Thomas L. Fare
IPC分类号： G01N27/02 , G01R17/06
CPC分类号： G01R17/06 , G01N27/028
摘要： A self-contained autonulling bridge circuit based on phase-sensitive deteon of an impedance to be measured is described. The system utilizes a feedback structure to control a variable impedance in order to establish the null of the bridge. The system utilizes a voltage-variable impedance having both resistance and capacitance and provides the phase sensitive relationship in the control means in order to provide highly accurate measurement of an unknown test impedance. The ability to measure small changes in impedance provides particularly useful application to the area of biological sensor impedance measurement or electrochemical impedance measurement using silicon-based devices.
摘要翻译：描述了一种基于待测量阻抗的相敏检测的独立自适应桥接电路。该系统利用反馈结构来控制可变阻抗，以建立桥的零点。该系统利用具有电阻和电容两者的电压可变阻抗，并在控制装置中提供相位敏感关系，以便提供未知测试阻抗的高精度测量。测量阻抗变化小的能力为使用硅基器件的生物传感器阻抗测量或电化学阻抗测量领域提供了特别有用的应用。

5. 发明授权

US5225374A Method of fabricating a receptor-based sensor 失效
标题翻译：制造基于受体的传感器的方法
公开(公告)号：US5225374A
公开(公告)日：1993-07-06
申请号：US820123
申请日：1992-01-14
申请人： Thomas L. Fare , Frances S. Ligler
发明人： Thomas L. Fare , Frances S. Ligler
IPC分类号： G01N27/49 , G01N33/543
CPC分类号： G01N33/5438 , G01N27/3277 , B01J2219/00734
摘要： This invention relates to a semiconductor substrate having a porous surfacend to the amperometric receptor-based sensors formed with the substrate. More specifically, this invention pertains to the substrate in the form of a bipolar junction transistor having a porous hydrophilic surface directly on its base wherein the surface forms a support for an amperometric sensor. The invention also pertains to the methods of making and using the substrate and sensor.
摘要翻译：本发明涉及一种具有多孔表面的半导体衬底和与衬底形成的基于电流接收器的传感器。更具体地说，本发明涉及一种双极结型晶体管形式的衬底，其基底上具有多孔亲水表面，其中表面形成电流传感器的支撑。本发明还涉及制造和使用基底和传感器的方法。

6. 发明授权

US08979770B2 Extraction and diagnostic fluid devices, systems and methods of use 有权
标题翻译：提取和诊断流体装置，系统和使用方法
公开(公告)号：US08979770B2
公开(公告)日：2015-03-17
申请号：US12280504
申请日：2007-02-15
申请人： Thomas L. Fare , Deborah A. Kessler , Kristopher A. Kilian
发明人： Thomas L. Fare , Deborah A. Kessler , Kristopher A. Kilian
IPC分类号： B65D81/00 , A61B5/00 , A01N1/02 , C12N15/10
CPC分类号： C12N15/1017
摘要： The present invention provides devices, systems and methods for RNA isolation from biological samples containing white blood cells, such as whole blood. The devices have a device body that includes a first chamber having a first membrane that selectively binds white blood cells, a second chamber having a second membrane that reversibly binds RNA and a plurality of ports that are removably attached to a reagent pack and waste receptacle via a valving system controlled by a control unit.
摘要翻译：本发明提供了用于从含有白血球（例如全血）的生物样品中分离RNA的装置，系统和方法。所述装置具有装置主体，其包括具有选择性地结合白细胞的第一膜的第一腔室，具有可逆地结合RNA的第二膜的第二腔室和可移除地连接到试剂盒和废物容器的多个端口，由控制单元控制的阀门系统。

7. 发明申请

US20110111976A1 MICRORNA BIOMARKERS OF TISSUE INJURY 审中-公开
标题翻译：组织损伤的MICRORNA生物标志物
公开(公告)号：US20110111976A1
公开(公告)日：2011-05-12
申请号：US12989246
申请日：2009-04-24
申请人： Thomas L. Fare , Philip W. Garrett-Engele , Warren E. Glaab , Jason M. Johnson , Omar F. Laterza , Lee Lim , Steve W. Ludmerer , David B. Olsen , Joseph F. Sina , Frank D. Sistare
发明人： Thomas L. Fare , Philip W. Garrett-Engele , Warren E. Glaab , Jason M. Johnson , Omar F. Laterza , Lee Lim , Steve W. Ludmerer , David B. Olsen , Joseph F. Sina , Frank D. Sistare
IPC分类号： C40B30/04 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , Y10T436/143333
摘要： One aspect of the invention generally relates to use of tissue enriched miRNAs as biomarker to estimate tissue damage in a fluid sample. In a second aspect, methods are provided for monitoring a subject who is exposed or might have been exposed to an agent that has a risk of causing tissue injury. In a third aspect, methods are provided for identifying an agent as having a risk of causing tissue injury to a vertebrate subject. In a fourth aspect, kits are provided for practicing the methods of above-listed aspects. The contents of this ABSTRACT are not intended to in anyway limit the scope of the inventions claimed herein.
摘要翻译：本发明的一个方面通常涉及使用组织富集的miRNA作为生物标志物来估计流体样品中的组织损伤。在第二方面，提供了用于监测暴露于或可能暴露于具有引起组织损伤风险的药剂的受试者的方法。在第三方面，提供了用于鉴定具有对脊椎动物受试者造成组织损伤风险的试剂的方法。在第四方面，提供了用于实践上述方面的方法的试剂盒。本摘要的内容并不旨在限制本文所要求保护的发明的范围。

8. 发明申请

US20090280470A1 EXTRACTION AND DIAGNOSTIC FLUID DEVICES, SYSTEMS AND METHODS OF USE 有权
标题翻译：提取和诊断流体装置，系统和使用方法
公开(公告)号：US20090280470A1
公开(公告)日：2009-11-12
申请号：US12280504
申请日：2007-02-15
申请人： Thomas L. Fare , Deborah A. Kessler , Kristopher A. Killian
发明人： Thomas L. Fare , Deborah A. Kessler , Kristopher A. Killian
IPC分类号： A01N1/02 , C12M1/00
CPC分类号： C12N15/1017
摘要： The present invention provides devices, systems and methods for RNA isolation from biological samples containing white blood cells, such as whole blood. The devices have a device body that includes a first chamber having a first membrane that selectively binds white blood cells, a second chamber having a second membrane that reversibly binds RNA and a plurality of ports that are removably attached to a reagent pack and waste receptacle via a valving system controlled by a control unit.
摘要翻译：本发明提供了用于从含有白血球（例如全血）的生物样品中分离RNA的装置，系统和方法。所述装置具有装置主体，其包括具有选择性地结合白细胞的第一膜的第一腔室，具有可逆地结合RNA的第二膜的第二腔室和可移除地连接到试剂盒和废物容器的多个端口，由控制单元控制的阀门系统。

9. 发明授权

US5324591A Deep ultraviolet photolithographically defined ultra-thin films for selective cell adhesion and outgrowth and method of manufacturing the same and devices containing the same 失效
标题翻译：用于选择性细胞粘附和生长的深紫外光刻光刻的超薄膜及其制造方法以及含有该超薄膜的装置
公开(公告)号：US5324591A
公开(公告)日：1994-06-28
申请号：US598194
申请日：1990-10-16
申请人： Jacque H. Georger, Jr. , David A. Stenger , Thomas L. Fare
发明人： Jacque H. Georger, Jr. , David A. Stenger , Thomas L. Fare
IPC分类号： B05D1/18 , C09D4/00 , C12N5/00 , C23C18/16 , C40B60/14 , G03F7/004 , G03F7/16 , G06N3/00 , G06N99/00 , H01L21/288 , H05K3/06 , H05K3/18 , B22F7/00 , G03C5/00
CPC分类号： G03F7/165 , B05D1/185 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C09D4/00 , C12N5/0068 , C23C18/1608 , C23C18/1612 , C23C18/1893 , G03F7/004 , G06N3/002 , G06N99/007 , H01L21/288 , H01L21/2885 , H01L51/0595 , H05K3/185 , B01J2219/00432 , B01J2219/00603 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B82Y5/00 , C12N2535/10 , C40B60/14 , Y10T428/12056 , Y10T428/265
摘要： Patterned surfaces for the selective adhesion and outgrowth of cells are useful in cell culture devices, prosthetic implants, and cell-based microsensors. Such surfaces may be prepared by a deep ultraviolet photolithographic technique.
摘要翻译：用于细胞的选择性粘附和生长的图案化表面可用于细胞培养装置，假体植入物和基于细胞的微传感器。这样的表面可以通过深紫外光刻技术制备。

10. 发明授权

US5111221A Receptor-based sensor 失效
标题翻译：基于受体的传感器
公开(公告)号：US5111221A
公开(公告)日：1992-05-05
申请号：US544442
申请日：1990-06-27
申请人： Thomas L. Fare , Frances S. Ligler
发明人： Thomas L. Fare , Frances S. Ligler
IPC分类号： G01N27/49 , G01N33/543
CPC分类号： G01N33/5438 , G01N27/3277 , B01J2219/00734 , Y10S438/96
摘要： This invention relates to a semiconductor substrate having a porous surfacend to the amperometric receptor-based sensors formed with the substrate. More specifically, this invention pertains to the substrate in the form of a bipolar junction transistor having a porous hydrophilic surface directly on its base wherein the surface forms a support for an amperometric sensor. The invention also pertains to the methods of making and using the substrate and sensor.
摘要翻译：本发明涉及一种具有多孔表面的半导体衬底和与衬底形成的基于电流接收器的传感器。更具体地说，本发明涉及一种双极结型晶体管形式的衬底，其基底上具有多孔亲水表面，其中表面形成电流传感器的支撑。本发明还涉及制造和使用基底和传感器的方法。

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