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1. 发明授权

US09220812B2 Surface interactions to improve retention of medical devices 有权
标题翻译：表面相互作用，以改善医疗器械的保留
公开(公告)号：US09220812B2
公开(公告)日：2015-12-29
申请号：US11742441
申请日：2007-04-30
申请人： Randolf Von Oepen , John Toner
发明人： Randolf Von Oepen , John Toner
IPC分类号： A61F2/00 , A61L29/08 , A61F2/958 , A61L29/14 , A61L31/10 , A61L31/14
CPC分类号： A61F2/958 , A61F2002/9583 , A61L29/085 , A61L29/14 , A61L31/08 , A61L31/10 , A61L31/14
摘要： A method for improving the retention between the surfaces of medical devices. The method includes coating a surface of one medical device such as a stent with a coating that includes a functional group and coating a surface of another medical device such as a balloon with a coating that includes an identical or different functional group. The method further includes interacting the coated surfaces to produce a plurality of bonds between the surfaces, thereby improving retention.
摘要翻译：一种用于改善医疗装置表面之间的保持性的方法。该方法包括用包括官能团的涂层涂覆诸如支架的一个医疗装置的表面，并用包括相同或不同官能团的涂层涂覆其它医疗装置例如气囊的表面。该方法还包括相互作用涂覆的表面以在表面之间产生多个键，从而改善保留。

2. 发明申请

US20070264305A1 SURFACE INTERACTIONS TO IMPROVE RETENTION OF MEDICAL DEVICES 有权
标题翻译：表面相互作用改善医疗器械的保留
公开(公告)号：US20070264305A1
公开(公告)日：2007-11-15
申请号：US11742441
申请日：2007-04-30
申请人： Randolf Von Oepen , John Toner
发明人： Randolf Von Oepen , John Toner
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2002/9583 , A61L29/085 , A61L29/14 , A61L31/08 , A61L31/10 , A61L31/14
摘要： A method for improving the retention between the surfaces of medical devices. The method includes coating a surface of one medical device such as a stent with a coating that includes a functional group and coating a surface of another medical device such as a balloon with a coating that includes an identical or different functional group. The method further includes interacting the coated surfaces to produce a plurality of bonds between the surfaces, thereby improving retention.
摘要翻译：一种用于改善医疗装置表面之间的保持性的方法。该方法包括用包括官能团的涂层涂覆诸如支架的一个医疗装置的表面，并用包括相同或不同官能团的涂层涂覆其它医疗装置例如气囊的表面。该方法还包括相互作用涂覆的表面以在表面之间产生多个键，从而改善保留。

3. 发明申请

US20070224240A1 Methods of administering rapamycin analogs with anti-inflammatories using medical devices 失效
标题翻译：使用医疗器械用抗炎药管理雷帕霉素类似物的方法
公开(公告)号：US20070224240A1
公开(公告)日：2007-09-27
申请号：US11548827
申请日：2006-10-12
申请人： John Toner , Sandra Burke , Keith Cromack , Matthew Mack
发明人： John Toner , Sandra Burke , Keith Cromack , Matthew Mack
IPC分类号： A61F2/00
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0067 , A61L2300/416 , A61L2300/45
摘要： A medical device comprising a supporting structure capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may include one or more therapeutic agents or substances, with the carrier including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.
摘要翻译：一种医疗装置，其包括能够包含或支撑药学上可接受的载体或赋形剂的支持结构，所述载体或赋形剂可以包含一种或多种治疗剂或物质，所述载体在其表面上包括涂层，并且所述包衣包含治疗物质，例如药物。适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。适用于本发明的药物包括但不限于：该药物可与另一药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

4. 发明申请

US20070088255A1 METHOD OF TREATING VASCULAR DISEASE AT A BIFURCATED VESSEL USING A COATED BALLOON 审中-公开
标题翻译：使用涂层气囊治疗血管病变血管疾病的方法
公开(公告)号：US20070088255A1
公开(公告)日：2007-04-19
申请号：US11539944
申请日：2006-10-10
申请人： John Toner , Sandra Burke , Keith Cromack , Randolf Oepen
发明人： John Toner , Sandra Burke , Keith Cromack , Randolf Oepen
IPC分类号： A61M29/00
CPC分类号： A61L31/10 , A61F2/856 , A61F2/86 , A61F2/91 , A61F2/954 , A61F2/958 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00
摘要： Disclosed is a method for delivery of at least one therapeutic agent from an angioplasty balloon for treating vascular disease at a bifurcated vessel. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to a method of loading multiple beneficial agents onto the balloon surfaces
摘要翻译：公开了一种用于从血管成形术球囊递送至少一种治疗剂以在分叉血管处理血管疾病的方法。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及一种将多种有益剂装载到球囊表面上的方法

5. 发明授权

US09888103B2 Device stand with integral cradle port 有权
公开(公告)号：US09888103B2
公开(公告)日：2018-02-06
申请号：US15227606
申请日：2016-08-03
申请人： John Toner
发明人： John Toner
IPC分类号： H04M1/04 , G06F1/16 , H04M1/02 , H04M1/725
CPC分类号： H04M1/04 , G06F1/1632 , H04M1/0254 , H04M1/0258 , H04M1/72527 , H04M2250/18
摘要： A stand for supporting a device such as a cellphone or tablet computer includes a body section for physically connecting to the device. The body section has one or more legs. The legs have at least two positions; a first position flush with the body section and a second position extended for supporting the device at an angle with respect to a surface on which the device and stand rest. A power input for connecting to a source of power is provided on the body. A device connector is electrically coupled to the power input and electrically connected to the device, thereby providing electrical power to the device. A docking port is formed in the body section. The docking port accepts and holds a peripheral device and has a docking port connector for providing power to the peripheral device.

6. 发明申请

US20170163779A1 Device Stand with Integral Cradle Port 有权
公开(公告)号：US20170163779A1
公开(公告)日：2017-06-08
申请号：US15227606
申请日：2016-08-03
申请人： John Toner
发明人： John Toner
IPC分类号： H04M1/04 , H04M1/02 , G06F1/16
CPC分类号： H04M1/04 , G06F1/1632 , H04M1/0254 , H04M1/0258 , H04M1/72527 , H04M2250/18
摘要： A stand for supporting a device such as a cellphone or tablet computer includes a body section for physically connecting to the device. The body section has one or more legs. The legs have at least two positions; a first position flush with the body section and a second position extended for supporting the device at an angle with respect to a surface on which the device and stand rest. A power input for connecting to a source of power is provided on the body. A device connector is electrically coupled to the power input and electrically connected to the device, thereby providing electrical power to the device. A docking port is formed in the body section. The docking port accepts and holds a peripheral device and has a docking port connector for providing power to the peripheral device.

7. 发明授权

US08221495B2 Integration of therapeutic agent into a bioerodible medical device 有权
标题翻译：将治疗剂整合到生物腐蚀性医疗器械中
公开(公告)号：US08221495B2
公开(公告)日：2012-07-17
申请号：US11563283
申请日：2006-11-27
申请人： Sanjay Shrivastava , John Toner , Sandra Burke , Keith Cromack , Peter Tarcha , Donald Verlee
发明人： Sanjay Shrivastava , John Toner , Sandra Burke , Keith Cromack , Peter Tarcha , Donald Verlee
IPC分类号： A61F2/82
CPC分类号： B22F3/15 , B22F2998/00 , C04B35/111 , C04B35/486 , C04B35/645 , C04B35/6455 , C04B38/00 , C04B2103/0072 , C04B2103/0074 , C04B2111/00836 , C04B38/0051 , B22F3/1109
摘要： A medical device which is at least partially bio-erodible and which exhibits controlled elution of therapeutic agent.
摘要翻译：至少部分生物可侵蚀并且显示受控制的治疗剂洗脱的医疗装置。

8. 发明申请

US20070191943A1 Integration Of Therapeutic Agent Into A Bioerodible Medical Device 有权
标题翻译：将治疗剂整合到生物可蚀刻医疗器械中
公开(公告)号：US20070191943A1
公开(公告)日：2007-08-16
申请号：US11563283
申请日：2006-11-27
申请人： Sanjay Shrivastava , John Toner , Sandra Burke , Keith Cromack , Peter Tarcha , Donald Verlee
发明人： Sanjay Shrivastava , John Toner , Sandra Burke , Keith Cromack , Peter Tarcha , Donald Verlee
IPC分类号： A61F2/02
CPC分类号： B22F3/15 , B22F2998/00 , C04B35/111 , C04B35/486 , C04B35/645 , C04B35/6455 , C04B38/00 , C04B2103/0072 , C04B2103/0074 , C04B2111/00836 , C04B38/0051 , B22F3/1109
摘要： A medical device which is at least partially bio-erodible and which exhibits controlled elution of therapeutic agent.
摘要翻译：至少部分生物可侵蚀并且显示受控制的治疗剂洗脱的医疗装置。

9. 发明申请

US20070027523A1 Method of treating vascular disease at a bifurcated vessel using coated balloon 审中-公开
标题翻译：使用涂覆气球在分叉血管处理血管疾病的方法
公开(公告)号：US20070027523A1
公开(公告)日：2007-02-01
申请号：US11483030
申请日：2006-07-07
申请人： John Toner , Sandra Burke , Keith Cromack , Randolf Oepen
发明人： John Toner , Sandra Burke , Keith Cromack , Randolf Oepen
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/856 , A61F2/86 , A61F2/91 , A61F2/954 , A61F2/958 , A61F2250/0067 , A61F2310/0097 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00
摘要： Disclosed is a method for delivery of at least one therapeutic agent from an angioplasty balloon for treating vascular disease at a bifurcated vessel. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to a method of loading multiple beneficial agents onto the balloon surfaces
摘要翻译：公开了一种用于从血管成形术球囊递送至少一种治疗剂以在分叉血管处理血管疾病的方法。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及一种将多种有益剂装载到球囊表面上的方法

10. 发明申请

US20050265923A1 Embolus therapy using insoluble microparticles or vesicles containing contrast agents 审中-公开
标题翻译：使用含有造影剂的不溶性微粒或囊泡进行栓塞治疗
公开(公告)号：US20050265923A1
公开(公告)日：2005-12-01
申请号：US11165259
申请日：2005-06-23
申请人： John Toner , Gerald Wolf , Daryl Simmons , Gregory McIntire , Edward Bacon , Kathleen Illio
发明人： John Toner , Gerald Wolf , Daryl Simmons , Gregory McIntire , Edward Bacon , Kathleen Illio
IPC分类号： A61K9/48 , A61K31/7004 , A61K33/42 , A61K38/00 , A61K38/21 , A61K38/22 , A61K41/00 , A61K45/00 , A61K48/00 , A61K49/00 , A61K49/04 , A61K51/00 , A61P9/00
CPC分类号： A61K41/0038 , A61K49/048
摘要： The invention provides a method of embolus therapy comprising administering into the vasculature of a perfused zone of tissue in a human or non-human animal subject a composition comprising particles of a size or formulation selected to generate emboli at a target site within said subject, characterised in that as said particles are used solid water-insoluble particles of a non-radioactive diagnostically effective compound or vesicles encapsulating a non-radioactive diagnostically effective compound or a solution thereof, and in that embolus location is detected by a diagnostic imaging technique.
摘要翻译：本发明提供了一种栓塞治疗方法，包括向人类或非人类动物灌注组织灌注区域的脉管系统施用包含选定为在所述受试者内的靶位点产生栓塞的大小或制剂的颗粒的组合物，其特征在于因为所述颗粒使用非放射性诊断有效化合物的固体水不溶性颗粒或包封非放射性诊断有效化合物或其溶液的囊泡，并且通过诊断成像技术检测该栓塞位置。

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