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    • 1. 发明授权
    • Non-invasive blood glucose measurement system and method using
stimulated Raman spectroscopy
    • 非侵入性血液葡萄糖测量系统和使用刺激拉曼光谱的方法
    • US5243983A
    • 1993-09-14
    • US627631
    • 1990-12-14
    • Randall V. TarrPaul G. Steffes
    • Randall V. TarrPaul G. Steffes
    • A61B3/10A61B3/12A61B5/00A61B5/145A61B5/1455G01N21/65
    • A61B5/1455A61B5/14532
    • Stimulated Raman spectroscopy is used to non-invasively measure the concentration of an Raman active molecule, preferably D-glucose in the ocular aqueous humor of living being. The apparatus and method make use of two monochromatic laser beams, a pump laser beam and a probe laser beam. The output power of the pump laser beam is amplitude modulated, combined with the probe laser beam and directed into the ocular aqueous humor. The introduction of the laser beams into the ocular aqueous humor induces scattered Raman radiation, which causes a portion of the energy at the pump frequency to shift over to the probe frequency. The pump and probe laser beams are then detected as they exit the ocular aqueous humor. The probe laser beam is filtered, converted into an electrical signal and amplified. It is then compared to the modulation signal to generate an electrical signal representative of the concentration of D-glucose in the ocular aqueous humor.
    • 受激拉曼光谱法用于非侵入性地测量活体眼水族中的拉曼活性分子,优选D-葡萄糖的浓度。 该装置和方法利用两个单色激光束,一个泵激光束和一个探针激光束。 将泵激光束的输出功率进行幅度调制,并与探针激光束结合并引导到眼睛的房水中。 将激光束引入眼睛房水中会引起散射的拉曼辐射,这导致泵频率下的一部分能量转移到探针频率。 然后在泵和探针激光束离开眼睛房水时检测。 探头激光束被滤波,转换为电信号并放大。 然后将其与调制信号进行比较,以产生代表眼睛房水中D-葡萄糖浓度的电信号。