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1. 发明申请

US20090068181A1 BISPECIFIC ANTIBODIES 审中-公开
标题翻译：双重抗体
公开(公告)号：US20090068181A1
公开(公告)日：2009-03-12
申请号：US12207285
申请日：2008-09-09
申请人： Randall J. LEE , James Larrick , Lawrence G. Lum
发明人： Randall J. LEE , James Larrick , Lawrence G. Lum
IPC分类号： A61K39/395 , A61K39/44 , C07K16/28 , C12N5/06
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/289 , C07K2317/31
摘要： The present invention provides compositions and methods for targeting stem cells to injured cardiac tissue.
摘要翻译：本发明提供了将干细胞靶向损伤的心脏组织的组合物和方法。

2. 发明申请

US20120076786A1 BISPECIFIC ANTIBODIES 审中-公开
标题翻译：双重抗体
公开(公告)号：US20120076786A1
公开(公告)日：2012-03-29
申请号：US13306888
申请日：2011-11-29
申请人： Randall J. Lee , James Larrick , Lawrence G. Lum
发明人： Randall J. Lee , James Larrick , Lawrence G. Lum
IPC分类号： A61K39/395 , C12N5/07 , A61P9/00 , C07K16/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/289 , C07K2317/31
摘要： The present invention provides compositions and methods for targeting stem cells to injured cardiac tissue.
摘要翻译：本发明提供了将干细胞靶向损伤的心脏组织的组合物和方法。

3. 发明申请

US20070014827A1 Gamma-tocopherol therapy for restenosis prevention 失效
标题翻译：伽马生育酚治疗预防再狭窄
公开(公告)号：US20070014827A1
公开(公告)日：2007-01-18
申请号：US10595453
申请日：2004-10-21
申请人： James Larrick , James Peacock
发明人： James Larrick , James Peacock
IPC分类号： A61F2/00
CPC分类号： A61K48/005 , A61K31/355 , A61K45/06 , A61L31/16 , A61L2300/258 , A61L2300/416 , A61L2300/428
摘要： A stent is provided in combination with delivery of a tocopherol agent, and in particular a des-methyl tocopherol agent, and further beneficially a gamma-tocopherol agent, so as to reduce restenosis along the vessel or other lumenal wall where the stent is implanted. In particular applications, the stent is an endolumenal stent, and more specific beneficial applications is an endovascular stent, and the gamma-tocopherol elutes from a coating or carrier coupled with the stent. Certain combinations are provided with the des-methyl-tocopherol or phytyl substituted chromanol, e.g. gamma-tocopherol, combined with an additional agent such as an anti-restenosis agent, e.g. sirolimus, tacrolimus, everolimus, or paclitaxel, in order to provide synergistic benefit to tissues along the stented or recanalized regions. Other forms of tocopherol or tocotrienol, or other phytyl substituted chromanols, and other compounds such as palm oil, are also contemplated, for use to treat restenosis.
摘要翻译：提供支架与生育酚试剂，特别是脱甲基生育酚试剂的输送结合，进一步有益地提供γ-生育酚试剂，以便沿植入支架的血管或其它内腔壁减少再狭窄。在具体应用中，支架是腔内支架，更具体的有益应用是血管内支架，并且γ-生育酚从与支架耦合的涂层或载体洗脱。提供了去甲基 - 生育酚或植酰取代的色原烷醇的某些组合，例如。 γ-生育酚与另外的药物如抗再狭窄剂组合，如抗再狭窄剂。西罗莫司，他克莫司，依维莫司或紫杉醇，以便为沿着支架或再通的区域的组织提供协同的益处。还考虑了其它形式的生育酚或生育三烯酚或其它植烷基取代的色原醇，以及其它化合物如棕榈油，用于治疗再狭窄。

4. 发明申请

US20050124701A1 Method of targeting a therapeutic agent 审中-公开
标题翻译：靶向治疗剂的方法
公开(公告)号：US20050124701A1
公开(公告)日：2005-06-09
申请号：US10868044
申请日：2004-06-14
申请人： Gregory Went , Jan Wasley , Stuart Lipton , James Larrick , Laurence Meyerson
发明人： Gregory Went , Jan Wasley , Stuart Lipton , James Larrick , Laurence Meyerson
IPC分类号： A61K31/13 , A61K31/40 , C07D20060101
CPC分类号： A61K31/40 , A61K47/51
摘要： Disclosed are conjugates in which an aminoadamantane derivative, such as amantadine, memantine, or rimantadine is linked to a therapeutic agent. The conjugate can then be used to target the therapeutic agent to an injured neuron.
摘要翻译：公开了其中氨基金刚烷衍生物如金刚烷胺，美金刚或金刚烷胺与治疗剂连接的缀合物。然后可以将缀合物用于将治疗剂靶向损伤的神经元。

5. 发明申请

US20120076806A1 Chloramphenicol Acetyl Transferase (CAT)-Defective Somatostatin Fusion Protein And Uses Thereof 有权
标题翻译：氯霉素乙酰转移酶（CAT） - 有益生长抑素融合蛋白及其用途
公开(公告)号：US20120076806A1
公开(公告)日：2012-03-29
申请号：US13069592
申请日：2011-03-23
申请人： Andrew R. Mendelsohn , Keith N. Haffer , James Larrick
发明人： Andrew R. Mendelsohn , Keith N. Haffer , James Larrick
IPC分类号： A61K39/00 , A61P37/04 , C07K19/00
CPC分类号： C07K14/655 , A23K50/60 , A61K38/31 , A61K39/0005 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K2319/00 , C12N9/1033 , C12Y203/01028
摘要： Chimeric somatostatin-based polypeptides, polynucleotides used to encode the polypeptides, the methods for isolating and producing the polypeptides and the uses thereof are provided. In addition, low cost adjuvants for enhanced immunogenic response are provided. Vaccinations that include both chimeric somatostatin-based polypeptides and novel adjuvants are included, useful in facilitating farm animal productivity.
摘要翻译：提供基于生物抑素的嵌段多肽，用于编码多肽的多核苷酸，分离和产生多肽的方法及其用途。此外，提供了用于增强免疫原性应答的低成本佐剂。包括嵌合生长抑素基多肽和新型佐剂两者的疫苗接种，可用于促进农场动物生产力。

6. 发明授权

US07943143B2 Chloramphenicol acetyl transferase (CAT)-defective somatostatin fusion protein and uses thereof 有权
标题翻译：氯霉素乙酰转移酶（CAT） - 有效生长抑素融合蛋白及其用途
公开(公告)号：US07943143B2
公开(公告)日：2011-05-17
申请号：US12703631
申请日：2010-02-10
申请人： Andrew R. Mendelsohn , Keith N. Haffer , James Larrick
发明人： Andrew R. Mendelsohn , Keith N. Haffer , James Larrick
IPC分类号： A61K39/00
CPC分类号： C07K14/655 , A23K50/60 , A61K38/31 , A61K39/0005 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K2319/00 , C12N9/1033 , C12Y203/01028
摘要： Chimeric somatostatin-based polypeptides, polynucleotides used to encode the polypeptides, the methods for isolating and producing the polypeptides and the uses thereof are provided. In addition, low cost adjuvants for enhanced immunogenic response are provided. Vaccinations that include both chimeric somatostatin-based polypeptides and novel adjuvants are included, useful in facilitating farm animal productivity.
摘要翻译：提供基于生物抑素的嵌段多肽，用于编码多肽的多核苷酸，分离和产生多肽的方法及其用途。此外，提供了用于增强免疫原性应答的低成本佐剂。包括嵌合生长抑素基多肽和新型佐剂两者的疫苗接种，可用于促进农场动物生产力。

7. 发明申请

US20090324629A1 CHLORAMPHENICOL ACETYL TRANSFERASE (CAT)-DEFECTIVE SOMATOSTATIN FUSION PROTEIN AND USES THEREOF 有权
标题翻译：氯胺酮乙酰转移酶（CAT） - 灭活蛋白融合蛋白及其用途
公开(公告)号：US20090324629A1
公开(公告)日：2009-12-31
申请号：US12198579
申请日：2008-08-26
申请人： Andrew R. Mendelsohn , Keith N. Haffer , James Larrick
发明人： Andrew R. Mendelsohn , Keith N. Haffer , James Larrick
IPC分类号： A61K39/00 , C12N9/10
CPC分类号： C07K14/655 , A23K50/60 , A61K38/31 , A61K39/0005 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K2319/00 , C12N9/1033 , C12Y203/01028
摘要： Chimeric somatostatin-based polypeptides, polynucleotides used to encode the polypeptides, the methods for isolating and producing the polypeptides and the uses thereof are provided. In addition, low cost adjuvants for enhanced immunogenic response are provided. Vaccinations that include both chimeric somatostatin-based polypeptides and novel adjuvants are included, useful in facilitating farm animal productivity.
摘要翻译：提供基于生物抑素的嵌段多肽，用于编码多肽的多核苷酸，分离和产生多肽的方法及其用途。此外，提供了用于增强免疫原性应答的低成本佐剂。包括嵌合生长抑素基多肽和新型佐剂两者的疫苗接种，可用于促进农场动物生产力。

8. 发明申请

US20070118934A1 Chimeric toxin receptor proteins and chimeric toxin receptor proteins for treatment and prevention of anthrax 审中-公开
标题翻译：嵌合毒素受体蛋白和嵌合毒素受体蛋白用于治疗和预防炭疽
公开(公告)号：US20070118934A1
公开(公告)日：2007-05-24
申请号：US11498488
申请日：2006-08-02
申请人： Lloyd Yu , Keith Wycoff , James Larrick
发明人： Lloyd Yu , Keith Wycoff , James Larrick
IPC分类号： A01H1/00 , A61K39/395 , C07K16/44 , C12N5/04 , C12N15/82
CPC分类号： C07K14/705 , C07K16/1278 , C07K2319/30 , C07K2319/32 , C12N15/8257 , C12N15/8258
摘要： Chimeric toxin receptor proteins having a toxin receptor associated with an immunoglobulin complex having least a portion of an immunoglobulin heavy chain and at least a portion of an immunoglobulin light chain are described. Such chimeric toxin receptor proteins have improved stability as compared to chimeric toxin receptor proteins lacking the light chain. Anthrax and botulinum chimeric toxin receptor proteins with increased stability are also described.
摘要翻译：描述了具有与具有至少一部分免疫球蛋白重链和免疫球蛋白轻链的至少一部分的免疫球蛋白复合体相关联的毒素受体的嵌合毒素受体蛋白。与不存在轻链的嵌合毒素受体蛋白相比，这种嵌合毒素受体蛋白具有改善的稳定性。还描述了具有增加的稳定性的炭疽和肉毒杆菌嵌合毒素受体蛋白质。

9. 发明申请

US20060018897A1 Bispecific antibodies 审中-公开
标题翻译：双特异性抗体
公开(公告)号：US20060018897A1
公开(公告)日：2006-01-26
申请号：US11170716
申请日：2005-06-28
申请人： Randall Lee , James Larrick , Lawrence Lum
发明人： Randall Lee , James Larrick , Lawrence Lum
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/289 , C07K2317/31
摘要： The present invention provides compositions and methods for targeting stem cells to injured cardiac tissue.
摘要翻译：本发明提供了将干细胞靶向损伤的心脏组织的组合物和方法。

10. 发明申请

US20110195080A1 Compositions and Methods for Enhanced Somatostatin Immunogenicity in the Treatment of Growth Hormone and Insulin-Like Growth Factor One Deficiency 有权
标题翻译：增强生长抑素免疫原性在生长激素和胰岛素样生长因子治疗中的组合物和方法一种缺乏
公开(公告)号：US20110195080A1
公开(公告)日：2011-08-11
申请号：US12523952
申请日：2009-06-24
申请人： Keith N. Haffer , James Larrick , Andrew R. Mendelsohn
发明人： Keith N. Haffer , James Larrick , Andrew R. Mendelsohn
IPC分类号： A61K39/00 , A61K47/26 , A61P3/04 , A61P9/00 , A61P5/02 , A61P37/04
CPC分类号： A61K39/0008 , A61K39/0005 , A61K39/39 , A61K2039/55555 , A61K2039/55566 , C07K14/655 , C07K2319/00 , C07K2319/31 , C12N9/1033
摘要： Compositions and methods are provided for treatment growth hormone and/or insulin-like growth factor 1 deficiency in a patient in need of such treatment. Compositions and methods include novel vaccines that provide immunogenicity for somatostatin and result in the increased release of endogenously produced growth hormone and/or insulin-like growth factor 1.
摘要翻译：提供了在需要这种治疗的患者中治疗生长激素和/或胰岛素样生长因子1缺陷的组合物和方法。组合物和方法包括为生长抑素提供免疫原性并导致内源性产生的生长激素和/或胰岛素样生长因子1的增加释放的新型疫苗。

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