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1. 发明申请

US20130209985A1 SAMPLE COLLECTION DEVICES WITH BLOOD STABILIZING AGENTS 审中-公开
标题翻译：血液收集装置与血液稳定剂
公开(公告)号：US20130209985A1
公开(公告)日：2013-08-15
申请号：US13757080
申请日：2013-02-01
申请人： Randal A. Hoke , Justyna M. Dudaronek , Keith A. Moskowitz , Frank Sinquett
发明人： Randal A. Hoke , Justyna M. Dudaronek , Keith A. Moskowitz , Frank Sinquett
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A61B5/15003 , A61B5/150274 , A61B5/150351 , A61B5/150389 , A61B5/150473 , A61B5/150755 , A61B5/154 , B01L3/5021 , B01L2200/16 , B01L2300/044 , G01N33/491
摘要： Disclosed are devices for collecting and stabilizing blood or plasma and which contain an anti-coagulant, an antiplatelet agent, and a solubilization agent, and which may optionally include at least one other blood stabilization agent. Methods of making and using the devices in clinical medicine are also provided.
摘要翻译：公开了用于收集和稳定血液或血浆并且含有抗凝血剂，抗血小板剂和增溶剂的装置，并且其可任选地包括至少一种其他血液稳定剂。还提供了在临床医学中制造和使用器械的方法。

2. 发明授权

US06235464B1 Immunoassay on a preblocked solid surface 失效
标题翻译：在预先固定的表面进行免疫测定
公开(公告)号：US06235464B1
公开(公告)日：2001-05-22
申请号：US08326304
申请日：1994-10-20
申请人： Glenn L. Henderson , Randal A. Hoke , Anne C. Hopkins , Daniel A. McLaurin
发明人： Glenn L. Henderson , Randal A. Hoke , Anne C. Hopkins , Daniel A. McLaurin
IPC分类号： C12Q170
CPC分类号： G01N33/581 , G01N33/54393 , G01N33/56983 , Y10S435/975
摘要： A method for immunoassay of a viral antigen is performed on a membrane precoated with an inert protein. Nonimmunological capture of antigen takes place by absorption onto the coated membrane. Captured antigen binds to a tracer which includes a label conjugated to a specific antibody, the inert protein concomitantly inhibiting nonspecific binding of tracer. The label may be an enzyme which converts a substrate to a detectable product or converts a blocked inhibitor to an inhibitor whereby a second enzyme is inhibited from converting a substrate to a product. The invention includes a kit of materials for performing an assay in accordance with the method of the invention.
摘要翻译：在预先涂有惰性蛋白质的膜上进行病毒抗原的免疫测定方法。抗原的非免疫捕获通过吸收到涂覆的膜上进行。捕获的抗原结合示踪剂，其包括与特异性抗体缀合的标记物，惰性蛋白质伴随地抑制示踪剂的非特异性结合。标记可以是将底物转化为可检测产物或将封闭的抑制剂转化为抑制剂的酶，由此抑制第二种酶将底物转化成产物。本发明包括用于根据本发明的方法进行测定的一组材料。

3. 发明授权

US5093231A Substrate composition for alkaline phosphatase and method for assay using same 失效
标题翻译：用于碱性磷酸酶的底物组合物及其使用方法
公开(公告)号：US5093231A
公开(公告)日：1992-03-03
申请号：US639847
申请日：1991-01-11
申请人： Randal A. Hoke
发明人： Randal A. Hoke
IPC分类号： C12Q1/42 , G01N33/569 , G01N33/58
CPC分类号： G01N33/56983 , C12Q1/42 , G01N33/581 , Y10S435/975
摘要： A composition contains levamisole and a substrate for alkaline phosphatase in a high pH buffer including 2-amino-2-methyl-1-propanol. The composition may be included in a kit of materials useful in performing an immunoassay in which intestinal alkaline phosphatase is the label. The invention includes a method for detection of a viral antigen by an immunoassay including intestinal alkaline phosphatase as the label and the composition of the invention to provide stabilized levamisole to inhibit nonintestinal alkaline phosphatase.
摘要翻译：一种组合物在包含2-氨基-2-甲基-1-丙醇的高pH缓冲液中含有左旋咪唑和碱性磷酸酶底物。组合物可以包括在用于进行肠碱性磷酸酶是标记物的免疫测定中的材料试剂盒中。本发明包括通过包括肠碱性磷酸酶作为标记的免疫测定法检测病毒抗原的方法，本发明的组合物提供稳定的左旋咪唑以抑制非肠碱性磷酸酶。

4. 发明授权

US5583217A Fluorogenic and chromogenic .beta.-lactamase substrates 失效
公开(公告)号：US5583217A
公开(公告)日：1996-12-10
申请号：US417569
申请日：1995-04-06
申请人： J. Michael Quante , Randal A. Hoke , Patrick D. Mize , Daniel L. Woodard , O. Elmo Millner, deceased
发明人： J. Michael Quante , Randal A. Hoke , Patrick D. Mize , Daniel L. Woodard , O. Elmo Millner, deceased
IPC分类号： C07D501/00 , C07D501/04 , C07D501/24 , C07D501/34 , C07D501/36 , C12Q1/34 , C07D501/20 , C07D501/26
CPC分类号： C07D501/00 , C12Q1/34 , C12Q2334/00 , G01N2333/986 , G01N2415/00 , Y10S435/81
摘要： Chromogenic and fluorogenic substrates for .beta.-lactamase, methods for synthesis thereof and methods for detecting .beta.-lactamase in a sample are provided. The substrates are substantially colorless or substantially nonfluorescent .beta.-lactam compounds which include an electronegative leaving group. The leaving group comprises a carbamate, carbonate, thiocarbamate or thiocarbonate linkage and a fluorescent moiety or a moiety capable of producing a visually detectable colored product. Upon cleavage of the lactam ring by .beta.-lactamase, the leaving group is liberated and fluorescence or a colored product is produced.

5. 发明授权

US5380880A Fluorescent pH indicators 失效
标题翻译：荧光pH指标
公开(公告)号：US5380880A
公开(公告)日：1995-01-10
申请号：US163099
申请日：1993-12-06
申请人： J. Bruce Pitner , Randal A. Hoke
发明人： J. Bruce Pitner , Randal A. Hoke
IPC分类号： C09B11/28 , C07D311/82 , C09B11/24 , C09K11/06 , G01N21/80 , G01N31/22 , C07D311/88
CPC分类号： C09B11/24 , C07D311/82 , G01N31/221
摘要： Fluorescent pH indicator compounds which exhibit an increase in fluorescence intensity with decreasing pH. The indicators are derivatives of rhodamine and sulforhodamine type dyes and are particularly useful for measuring pH in acidic environments such as carbon dioxide production by microorganisms and pH of certain acidic intracellular compartments.
摘要翻译：荧光pH指示剂化合物，随着pH值的降低，荧光强度呈现增加的趋势。指示剂是罗丹明和磺酰罗丹明型染料的衍生物，并且特别可用于在酸性环境中测量pH，例如微生物产生的二氧化碳和某些酸性细胞内区室的pH。

6. 发明授权

US5302731A Fluorescent pH indicators 失效
标题翻译：荧光pH指标
公开(公告)号：US5302731A
公开(公告)日：1994-04-12
申请号：US912426
申请日：1992-07-13
申请人： J. Bruce Pitner , Randal A. Hoke
发明人： J. Bruce Pitner , Randal A. Hoke
IPC分类号： C09B11/28 , C07D311/82 , C09B11/24 , C09K11/06 , G01N21/80 , G01N31/22 , C07D311/90
CPC分类号： C09B11/24 , C07D311/82 , G01N31/221
摘要： Fluorescent pH indicator compounds which exhibit an increase in fluorescence intensity with decreasing pH. The indicators are derivatives of rhodamine and sulforhodamine type dyes and are particularly useful for measuring pH in acidic environments such as carbon dioxide production by microorganisms and pH of certain acidic intracellular compartments.
摘要翻译：荧光pH指示剂化合物，随着pH值的降低，荧光强度呈现增加的趋势。指示剂是罗丹明和磺酰罗丹明型染料的衍生物，并且特别可用于在酸性环境中测量pH，例如微生物产生的二氧化碳和某些酸性细胞内区室的pH。

7. 发明授权

US5817044A User activated iontophoertic device 失效
标题翻译：用户激活离子电位器
公开(公告)号：US5817044A
公开(公告)日：1998-10-06
申请号：US282100
申请日：1994-07-28
申请人： Hans Christer Arvid Evers , Bernt Fredrick Julius Broberg , John D. DeNuzzio , Randal A. Hoke
发明人： Hans Christer Arvid Evers , Bernt Fredrick Julius Broberg , John D. DeNuzzio , Randal A. Hoke
IPC分类号： A61M37/00 , A61N1/30
CPC分类号： A61N1/0448
摘要： A user activated iontophoretic device of the present invention includes an electrode assembly, an electrode reservoir and at least one drug reservoir. The device is divided or otherwise separated into at least two portions, with one portion containing the electrode reservoir and the other containing the drug reservoir, which may include a medication in a dry form. In one embodiment, the two portions are each contained in separate compartments of a pouch. In another embodiment, the portions are contained in a single compartment and divided by a barrier. A method of activating the device includes causing the two portions to come into electrical conducting contact with one another to at least partially hydrate one of the reservoirs. This can be accomplished, for example, by either folding the device to bring the two portions into contact with one another or simply by removing the barrier dividing the two portions. In the alternative, the device may include two separate portions which can be brought together to activate the device. In this way, the device is suitable for use to deliver a high dose efficiency, while providing a commercially suitable shelf-life.
摘要翻译：本发明的用户激活的离子电渗疗法装置包括电极组件，电极储存器和至少一个药物贮存器。该装置被分割或以其他方式分离成至少两部分，其中一部分包含电极储存器，另一部分包含药物储存器，其可包括干燥形式的药物。在一个实施例中，两个部分各自包含在袋的独立隔室中。在另一个实施例中，这些部分被包含在单个隔室中并且被屏障隔开。激活装置的方法包括使两部分彼此进行导电接触以至少部分地水合其中一个储存器。这可以通过例如折叠装置来使两个部分彼此接触或简单地通过去除划分两个部分的屏障来实现。在替代方案中，该装置可以包括两个分开的部分，这些部分可以组合在一起以启动装置。以这种方式，该装置适合用于提供高剂量效率，同时提供商业上合适的保质期。

8. 发明授权

US5514561A Fluorogenic and chromogenic .beta.-lactamase substrates 失效
标题翻译：荧光和显色β-内酰胺酶底物
公开(公告)号：US5514561A
公开(公告)日：1996-05-07
申请号：US227809
申请日：1994-04-14
申请人： J. Michael Quante , Randal A. Hoke , Patrick D. Mize , Daniel L. Woodard , O. Elmo Millner, deceased
发明人： J. Michael Quante , Randal A. Hoke , Patrick D. Mize , Daniel L. Woodard , O. Elmo Millner, deceased
IPC分类号： C07D501/00 , C07D501/04 , C07D501/24 , C07D501/34 , C07D501/36 , C12Q1/34
CPC分类号： C07D501/00 , C12Q1/34 , C12Q2334/00 , G01N2333/986 , G01N2415/00 , Y10S435/81
摘要： Chromogenic and fluorogenic substrates for .beta.-lactamase, methods for synthesis thereof and methods for detecting .beta.-lactamase in a sample are provided. The substrates are substantially colorless or substantially nonfluorescent .beta.-lactam compounds which include an electronegative leaving group. The leaving group comprises a carbamate, carbonate, thiocarbamate or thiocarbonate linkage and a fluorescent moiety or a moiety capable of producing a visually detectable colored product. Upon cleavage of the lactam ring by .beta.-lactamase, the leaving group is liberated and fluorescence or a colored product is produced.
摘要翻译：提供β-内酰胺酶的显色和荧光底物，其合成方法和样品中β-内酰胺酶的检测方法。底物基本上是无色或基本上非荧光的β-内酰胺化合物，其包括电负离子基团。离去基团包括氨基甲酸酯，碳酸酯，硫代氨基甲酸酯或硫代碳酸酯键和荧光部分或能够产生视觉可检测的有色产物的部分。当β-内酰胺酶裂解内酰胺环时，释放出离去基团并产生荧光或有色产物。

9. 发明授权

US5494679A Molecules for iontophoretic delivery 失效
标题翻译：用于离子电渗传递的分子
公开(公告)号：US5494679A
公开(公告)日：1996-02-27
申请号：US174589
申请日：1993-12-28
申请人： Burton H. Sage, Jr. , Randal A. Hoke
发明人： Burton H. Sage, Jr. , Randal A. Hoke
IPC分类号： A61K38/00 , A61K9/00 , A61K9/70 , A61K38/04 , A61K47/48 , A61N1/30 , C07K1/113 , C07K7/23 , A61F13/00
CPC分类号： A61K47/48238 , A61K9/0009
摘要： The invention discloses peptides and proteins for iontophoretic delivery. Specifically disclosed are methods for iontophoretic delivery of assemblages of amino acids which comprises modifying said assemblages of amino acids to an isoelectric point less than about 4.0 or greater than about 7.3 with an electrostatic charge of plus or minus 1 and patches with assemblages of amino acids with isoelectric points less than about 4.0 or greater than about 7.3 with an electrostatic charge of plus or minus 1.
摘要翻译：本发明公开了用于离子电渗传递的肽和蛋白质。具体公开的是用于离子电渗疗法递送氨基酸组合的方法，其包括将所述氨基酸组合改变为小于约4.0或大于约7.3的等电点，静电荷为正或负1，并且具有氨基酸组合的贴片与等电点小于约4.0或大于约7.3，静电荷为正或负1。

10. 发明授权

US5393514A Fluorescent pH indicators 失效
公开(公告)号：US5393514A
公开(公告)日：1995-02-28
申请号：US162554
申请日：1993-12-06
申请人： J. Bruce Pitner , Randal A. Hoke
发明人： J. Bruce Pitner , Randal A. Hoke
IPC分类号： C09B11/28 , C07D311/82 , C09B11/24 , C09K11/06 , G01N21/80 , G01N31/22 , A61K49/00 , A61K31/35
CPC分类号： C09B11/24 , C07D311/82 , G01N31/221
摘要： Fluorescent pH indicator compounds which exhibit an increase in fluorescence intensity with decreasing pH. The indicators are derivatives of rhodamine and sulforhodamine type dyes and are particularly useful for measuring pH in acidic environments such as carbon dioxide production by microorganisms and pH of certain acidic intracellular compartments.

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