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1. 发明申请

US20050107386A1 Methods of treating diseases and disorders by targeting multiple kinases 审中-公开
标题翻译：通过靶向多种激酶治疗疾病和病症的方法
公开(公告)号：US20050107386A1
公开(公告)日：2005-05-19
申请号：US10994093
申请日：2004-11-19
申请人： Rama Krishna Narla , Steven Sakata
发明人： Rama Krishna Narla , Steven Sakata
IPC分类号： A61K20060101 , A61K31/4196 , A61K31/4709 , A61K31/519 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14
CPC分类号： A61K31/4196 , A61K31/4709 , A61K31/519 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14
摘要： The present invention is directed to the use of single agents, which are compounds that target two or more kinases simultaneously, thus substantially avoiding resistance to therapy. The invention provides methods for the use for, administration to, and treatment of individuals having a variety of diseases or conditions associated with the activity of two or more kinases, comprising administration of one or more single agents, either alone or in combination with other therapies for the same disease or condition.
摘要翻译：本发明涉及使用单一药剂，其是同时靶向两种或多种激酶的化合物，因此基本上避免了对治疗的抵抗力。本发明提供了用于，施用和治疗具有与两种或更多种激酶的活性相关的多种疾病或病症的个体的方法，包括单独施用或与其它疗法组合施用一种或多种单一试剂相同的疾病或病症。

2. 发明授权

US06552027B2 Quinazolines for treating brain tumor 失效
公开(公告)号：US06552027B2
公开(公告)日：2003-04-22
申请号：US09903294
申请日：2001-07-11
申请人： Fatih M. Uckun , Rama Krishna Narla , Xing-Ping Liu
发明人： Fatih M. Uckun , Rama Krishna Narla , Xing-Ping Liu
IPC分类号： A61K31517
CPC分类号： C07D239/94 , C07D239/88
摘要： Novel substituted quinozaline compounds and conjugates useful to inhibit the growth of brain tumor cells and to inhibit adhesion and migration of brain tumor cells. The compounds of the invention include 4-(3′-bromo-4′-hydroxy phenyl)-amino-6,7-dimethoxyquinazoline and this compound covalently bound to EGF.

3. 发明授权

US07038049B2 Haloanilino quinazolines and therapeutic use thereof 失效
标题翻译：卤代苯胺喹唑啉及其治疗用途
公开(公告)号：US07038049B2
公开(公告)日：2006-05-02
申请号：US10852076
申请日：2004-05-24
申请人： Fatih M. Uckun , Xing-Ping Liu , Rama Krishna Narla
发明人： Fatih M. Uckun , Xing-Ping Liu , Rama Krishna Narla
IPC分类号： C07D239/94 , A61K31/517 , A61P35/00 , A61P35/02
CPC分类号： C07D239/94
摘要： The present disclosure includes compounds, for example a compound according to formula I or a pharmaceutically acceptable salt thereof. The compounds of the present disclosure are useful in methods of treating cancerous conditions.
摘要翻译：本公开内容包括化合物，例如根据式I的化合物或其药学上可接受的盐。本公开的化合物可用于治疗癌症的方法。

4. 发明授权

US06878388B1 Vanadium compounds for treating proliferative cell disorders 失效
标题翻译：用于治疗增殖性细胞病症的钒化合物
公开(公告)号：US06878388B1
公开(公告)日：2005-04-12
申请号：US09713379
申请日：2000-11-15
申请人： Fatih M Uckun , Rama Krishna Narla
发明人： Fatih M Uckun , Rama Krishna Narla
IPC分类号： A61K31/28 , A61K31/55 , A61K33/24 , A61K31/555 , A61P17/06 , A61P35/00
CPC分类号： A61K33/24 , A61K31/28 , A61K31/55 , Y10S514/822 , Y10S514/824 , Y10S514/863 , Y10S514/883
摘要： Vanadium compounds useful to prevent and/or inhibit adhesion, migration, and invasion of proliferative cells into surrounding tissue.
摘要翻译：用于预防和/或抑制增殖细胞粘附，迁移和侵入周围组织的钒化合物。

5. 发明授权

US06258820B1 Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines 失效
标题翻译： 6,7-二烷氧基-4-苯基氨基 - 喹唑啉的合成和抗肿瘤活性
公开(公告)号：US06258820B1
公开(公告)日：2001-07-10
申请号：US09357404
申请日：1999-07-20
申请人： Faith M. Uckun , Xing-Ping Liu , Rama Krishna Narla
发明人： Faith M. Uckun , Xing-Ping Liu , Rama Krishna Narla
IPC分类号： A61K35517
CPC分类号： C07D239/94
摘要： Compounds of the formula: wherein: Ra is iodo, (C1-C4)hydroxyalkyl, benzyloxy, OCF3, SCF3, SO3H, SO2F, SO2NR2R3 where R2 is hydrogen or (C1-C4)alkyl and R3 is hydrogen, (C1-C4)alkyl, or phenyl, NR2R4 where R2 is hydrogen or (C1-C4)alkyl and R4 is phenyl; or a group of the formula wherein R5 and R6 are each independently, hydrogen, (C1-C4)alkyl, or (C1-C4) perfluoroalkyl, and R7 is hydrogen, halo, hydroxy, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)hydroxyalkyl, or N(R2)2, where R2 is hydrogen or (C1-C4)alkyl; n is an integer of 1-4; Rb is each, independently, hydrogen, halo, hydroxy, mercapto, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)thioalkyl, (C1-C4)hydroxyalkyl, nitro, cyano, methylenedioxy, ethylenedioxy, COCH3, CF3, OCF3, SCF3, COOH, SO3H, SO2F, phenyl, or phenyl substituted by a group selected from halo, hydroxy, mercapto, (C1-C4)alkyl, (C1-C4) alkoxy, (C1-C4)thioalkyl, (C1-C4)hydroxyalkyl, amino, nitro, cyano, CF3, COOH, SO3H, SO2NR2R3, SO2F where R2 is H or (C1-C4)alkyl and R3 is H, (C1-C4)alkyl, phenyl, or phenyl substituted by a group as defined above; benzyloxy or benzyloxy substituted on the phenyl portion by a group defined above; NR2R3 where R2 is H or (C1-C4)alkyl and R3 is H, (C1-C4)alkyl, phenyl, or phenyl substituted by a group as defined above; and R1 is (C1-C4)alkyl or a pharmaceutically acceptable salt thereof; and methods for the treatment of cancer and for the treatment of allergic reactions.
摘要翻译：下式的化合物：其中：R a为碘，（C 1 -C 4）羟基烷基，苄氧基，OCF 3，SCF 3，SO 3 H，SO 2 F，SO 2 NR 2 R 3，其中R 2为氢或（C 1 -C 4）烷基且R 3为氢，（C 1 -C 4）烷基或苯基，NR2R4，其中R2是氢或（C1-C4）烷基，R4是苯基; 或者一组式R 5和R 6各自独立地为氢，（C 1 -C 4）烷基或（C 1 -C 4）全氟烷基，R 7为氢，卤素，羟基，（C 1 -C 4）烷基，）烷氧基，（C1-C4）羟基烷基或N（R2）2，其中R2是氢或（C1-C4）烷基; n是1-4的整数; Rb各自独立地是氢，卤素，羟基，巯基，（C 1 -C 4）烷基，（C 1 -C 4）烷氧基，（C 1 -C 4）硫代烷基，（C 1 -C 4）羟烷基，硝基，氰基，亚甲二氧基，亚乙二氧基，COCH 3，CF 3，OCF 3，SCF 3，COOH，SO 3 H， SO2F，苯基或被选自卤素，羟基，巯基，（C1-C4）烷基，（C1-C4）烷氧基，（C1-C4）硫代烷基，（C1-C4）羟基烷基，氨基，硝基，氰基，CF 3，COOH，SO 3 H，SO 2 NR 2 R 3，SO 2 F，其中R 2是H或（C 1 -C 4）烷基，R 3是H，（C 1 -C 4）烷基，苯基或被如上定义的基团取代的苯基; 在苯基部分被苄基氧基或苄氧基取代上述定义; NR2R3，其中R2是H或（C1-C4）烷基，R3是H，（C1-C4）烷基，苯基或被如上定义的基取代的苯基; 并且R 1是（C 1 -C 4）烷基或其药学上可接受的盐; 以及用于治疗癌症和治疗过敏反应的方法。

6. 发明授权

US06638939B2 6,7-dimethoxyquinazolines and therapeutic use thereof 失效
标题翻译： 6,7-二甲氧基喹唑啉及其治疗用途
公开(公告)号：US06638939B2
公开(公告)日：2003-10-28
申请号：US09923903
申请日：2001-08-07
申请人： Fatih M. Uckun , Xing-Ping Liu , Rama Krishna Narla
发明人： Fatih M. Uckun , Xing-Ping Liu , Rama Krishna Narla
IPC分类号： C07D23994
CPC分类号： C07D239/94
摘要： Quinazoline compounds and methods for the treatment of cancer and for the treatment of allergic reactions.
摘要翻译：喹唑啉化合物和治疗癌症和治疗过敏反应的方法。

7. 发明授权

US06316454B1 6,7-Dimethoxy-4-anilinoquinazolines 失效
标题翻译： 6,7-二甲氧基-4-苯胺基喹唑啉
公开(公告)号：US06316454B1
公开(公告)日：2001-11-13
申请号：US09361088
申请日：1999-07-26
申请人： Fatih M. Uckun , Rama Krishna Narla , Xing-Ping Liu
发明人： Fatih M. Uckun , Rama Krishna Narla , Xing-Ping Liu
IPC分类号： C07D23994
CPC分类号： C07D239/94 , C07D239/88
摘要： 6,7-Dimethoxy-4-anilinoquinaozolines of the formula: or pharmaceutically acceptable acid addition salts thereof are disclosed. These novel compounds are useful for inducing apoptosis and preventing metastases of brain tumor cells.
摘要翻译：公开了下式的6,7-二甲氧基-4-苯胺基喹唑啉或其药学上可接受的酸加成盐。这些新型化合物可用于诱导凋亡和预防脑肿瘤细胞的转移。

8. 发明授权

US06358962B2 6,7-Dimethoxyquinazolines and therapeutic use thereof 失效
标题翻译： 6,7-二甲氧基喹唑啉及其治疗用途
公开(公告)号：US06358962B2
公开(公告)日：2002-03-19
申请号：US09779809
申请日：2001-02-08
申请人： Fatih M. Uckun , Xing-Ping Liu , Rama Krishna Narla
发明人： Fatih M. Uckun , Xing-Ping Liu , Rama Krishna Narla
IPC分类号： C07D23994
CPC分类号： C07D239/94
摘要： Quinazoline compounds and methods for the treatment of cancer and for the treatment of allergic reactions.
摘要翻译：喹唑啉化合物和治疗癌症和治疗过敏反应的方法。

9. 发明授权

US06251882B1 Alkyl ketones as potent anti-cancer agents 失效
标题翻译：烷基酮作为有效的抗癌剂
公开(公告)号：US06251882B1
公开(公告)日：2001-06-26
申请号：US09352647
申请日：1999-06-29
申请人： Fatih M. Uckun , Rama Krishna Narla , David Alan Perry
发明人： Fatih M. Uckun , Rama Krishna Narla , David Alan Perry
IPC分类号： A61K3116
CPC分类号： C07C323/25 , C07C233/31 , C07C245/14 , C07C271/18 , C07C271/22 , C07C323/22 , C07C323/48 , C07C323/52 , C07C323/58 , C07C323/59 , C07C323/60 , C07C2603/18
摘要： Novel alkyl ketone compounds having potent cytotoxic activity are described as anti-tumor agents and are particularly effective against leukemia and breast tumor cells.
摘要翻译：具有强力细胞毒活性的新型烷基酮化合物被描述为抗肿瘤剂，对白血病和乳腺肿瘤细胞特别有效。

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