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1. 发明申请

US20080064700A1 Aryl triazines as LPAAT-beta inhibitors and uses thereof 失效
标题翻译：芳基三嗪作为LPAAT-β抑制剂及其用途
公开(公告)号：US20080064700A1
公开(公告)日：2008-03-13
申请号：US11890746
申请日：2007-08-06
申请人： Rama Bhatt , Baoqing Gong , Feng Hong , Scott Jenkins , J. Klein , Anil Kumar , John Tulinsky
发明人： Rama Bhatt , Baoqing Gong , Feng Hong , Scott Jenkins , J. Klein , Anil Kumar , John Tulinsky
IPC分类号： A61K31/53 , A61P35/00 , C07D251/42 , C07D251/48 , C07D403/10 , C07D407/02 , C12N5/00
CPC分类号： C07D403/12 , C07D251/16 , C07D251/18 , C07D251/22 , C07D405/12
摘要： The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells.
摘要翻译：本发明涉及芳基三嗪及其用途，包括抑制溶血磷脂酸酰基转移酶β（LPAAT-β）活性和/或细胞例如肿瘤细胞的增殖。

2. 发明申请

US20050049262A1 Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same 审中-公开
标题翻译：用于抑制白细胞介素-12信号的治疗化合物及其使用方法
公开(公告)号：US20050049262A1
公开(公告)日：2005-03-03
申请号：US10918709
申请日：2004-08-16
申请人： J. Klein , Stephen Klaus , Anil Kumar , Baoqing Gong
发明人： J. Klein , Stephen Klaus , Anil Kumar , Baoqing Gong
IPC分类号： A61K31/00 , C07D239/54 , C07D473/04 , C07D473/06 , C07D473/10 , C07D487/04 , C07D495/04 , C07D513/04 , A61K31/519 , A61K31/522
CPC分类号： C07D239/54 , A61K31/00 , C07D473/04 , C07D473/06 , C07D473/10 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by lnterleukin-12 (“IL-12”) intracellular signaling, such as, for example, Th1 cell-mediated disorders. The therapeutic compounds, pharmaceutically acceptable derivatives (e.g., resolved enantiomers, diastereomers, tautomers, salts and solvates thereof) or prodrugs thereof, have the following general formula: Each X, Y and Z are independently selected from a member of the group consisting of C(R3), N, N(R3) and S. Each R1, R2 and R3 is substituted or unsubstituted and is independently selected from a member of the group consisting of hydrogen, halo, oxo, C(1-20)alkyl, C(1-20)hydroxyalkyl, C(1-20)thioalkyl, C(1-20)alkylamino, C(1-20)alkylaminoalkyl, C(1-20)aminoalkyl, C(1-20)aminoalkoxyalkenyl, C(1-20)aminoalkoxyalkynyl, C(1-20)diaminoalkyl, C(1-20)triaminoalkyl, C(1-20)tetraaminoalkyl, C(5-15)aminotrialkoxyamino, C(1-20)alkylamido, C(1-20)alkylamidoalkyl, C(1-20)amidoalkyl, C(1-20)acetamidoalkyl, C(1-20)alkenyl, C(1-20)alkynyl, C(3-8)alkoxyl, C(1-11)alkoxyalkyl, and C(1-20)dialkoxyalkyl.
摘要翻译：发现具有与五元环结构稠合的六元环结构的新型杂环化合物可用于治疗和预防与白细胞介素-12（“IL-12”）受细胞内信号传导的疾病相关的症状或表现，例如，例如，Th1细胞介导的疾病。治疗化合物，药学上可接受的衍生物（例如分解的对映异构体，非对映异构体，互变异构体，其盐和溶剂合物）或其前药具有以下通式：每个X，Y和Z独立地选自C （R 3），N，N（R 3）和S.每个R 1，R 2和R 3是取代或未取代的，并且独立地选自氢，卤素，氧代，C（1-20）烷基，C （1-20）羟基烷基，C（1-20）硫代烷基，C（1-20）烷基氨基，C（1-20）烷基氨基烷基，C（1-20）氨基烷基，C（1-20）氨基烷氧羰基，C（1 （1-20）氨基烷基，C（1-20）四氨基烷基，C（5-15）氨基三烷氧基氨基，C（1-20）烷基酰氨基，C（1-20）烷基氨基烷基，C（1-20））烷基酰氨基烷基，C（1-20）酰氨基烷基，C（1-20）乙酰氨基烷基，C（1-20）烯基，C（1-20）炔基，C（3-8）烷氧基，C（1-11）烷氧基烷基，和C（1-20）二烷氧基烷基。

3. 发明申请

US20050032748A1 Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same 审中-公开
标题翻译：用于抑制白细胞介素-12信号的治疗化合物及其使用方法
公开(公告)号：US20050032748A1
公开(公告)日：2005-02-10
申请号：US10909321
申请日：2004-08-03
申请人： J. Klein , Stephen Klaus , Anil Kumar , Baoqing Gong
发明人： J. Klein , Stephen Klaus , Anil Kumar , Baoqing Gong
IPC分类号： A61K31/00 , C07D473/04 , C07D473/06 , C07D487/04 , C07D495/04 , C07D513/04 , A61K31/675 , A61K31/519 , A61K31/522
CPC分类号： C07D473/04 , A61K31/00 , C07D473/06 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by Interleukin-12 (“IL-12”) intracellular signaling, such as, for example, Th1 cell-mediated disorders. The therapeutic compounds, pharmaceutically acceptable derivatives (e.g., resolved enantiomers, diastereomers, tautomers, salts and solvates thereof) or prodrugs thereof, have the following general formula: Each X, Y and Z are independently selected from a member of the group consisting of C(R3), N,N(R3) and S. Each R1, R2 and R3 is substituted or unsubstituted and is independently selected from a member of the group consisting of hydrogen, halo, oxo, C(1-20)alkyl, C(1-20)hydroxyalkyl, C(1-20)thioalkyl, C(1-20)alkylamino, C(1-20)alkylaminoalkyl, C(1-20)aminoalkyl, C(1-20)aminoalkoxyalkenyl, C(1-20)aminoalkoxyalkynyl, C(1-20)diaminoalkyl, C(1-20)triaminoalkyl, C(1-20)tetraminoalkyl, C(5-15)aminotrialkoxyamino, C(1-20)alkylamido, C(1-20)alkylamidoalkyl, C(1-20)amidoalkyl, C(1-20)acetamidoalkyl, C(1-20)alkenyl, C(1-20)alkynyl, C(3-8)alkoxyl, C(1-11)alkoxyalkyl, and C(1-20)dialkoxyalkyl.
摘要翻译：发现具有与五元环结构稠合的六元环结构的新型杂环化合物可用于治疗和预防与受白细胞介素-12（“IL-12”）影响的紊乱相关的症状或表现，，例如，Th1细胞介导的疾病。治疗化合物，药学上可接受的衍生物（例如分解的对映异构体，非对映异构体，互变异构体，其盐和溶剂合物）或其前药具有以下通式：每个X，Y和Z独立地选自C （R 3），N，N（R 3）和S.每个R 1，R 2和R 3是取代或未取代的，并且独立地选自氢，卤素，氧代，C（1-20）烷基，C （1-20）羟基烷基，C（1-20）硫代烷基，C（1-20）烷基氨基，C（1-20）烷基氨基烷基，C（1-20）氨基烷基，C（1-20）氨基烷氧羰基，C（1 -20）氨基烷基，C（1-20）三氨基烷基，C（1-20）四氨基烷基，C（5-15）氨基三烷氧基氨基，C（1-20）烷基酰氨基，C（1-20））烷基酰氨基烷基，C（1-20）酰氨基烷基，C（1-20）乙酰氨基烷基，C（1-20）烯基，C（1-20）炔基，C（3-8）烷氧基，C（1-11）烷氧基烷基，和C（1-20）二烷氧基烷基。

4. 发明申请

US20060211713A1 Compounds having selective hydrolytic potentials 审中-公开
标题翻译：具有选择性水解电位的化合物
公开(公告)号：US20060211713A1
公开(公告)日：2006-09-21
申请号：US11370164
申请日：2006-03-08
申请人： David Porubek , Anil Kumar , Charles Bredl , J. Klein
发明人： David Porubek , Anil Kumar , Charles Bredl , J. Klein
IPC分类号： A61K31/522 , A61K31/52 , C07D473/02 , C07D473/04
CPC分类号： C07D473/04 , C07D473/10
摘要： Disclosed are compounds having selective hydrolytic potential. The disclosed compounds are useful as compounds having selective stability and are capable of undergoing programmed hydrolysis in biologic systems.
摘要翻译：公开了具有选择性水解电位的化合物。所公开的化合物可用作具有选择性稳定性且能够在生物系统中进行程序水解的化合物。

5. 发明授权

US09206155B2 Chiral 1-(4-methylphenylmethyl)-5-OXO-{N-[3-T-butoxycarbonyl-aminomethyl)]-piperidin-1-yl-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion 有权
标题翻译：手性1-（4-甲基苯基甲基）-5-氧代-N- {N- [3-叔丁氧基羰基 - 氨基甲基）] - 哌啶-1-基 - 吡咯烷-2-甲酰胺作为胶原诱导的血小板活化和粘附抑制剂
公开(公告)号：US09206155B2
公开(公告)日：2015-12-08
申请号：US13995336
申请日：2012-01-12
申请人： Dinesh Kumar Dikshit , Madhu Dikshit , Tanveer Irshad Siddiqui , Anil Kumar , Rabi Sankar Bhatta , Girish Kumar Jain , Manoj Kumar Barthwal , Ankita Misra , Vivek Khanna , Prem Prakash , Manish Jain , Vishal Singh , Varsha Gupta , Anil Kumar Dwivedi
发明人： Dinesh Kumar Dikshit , Madhu Dikshit , Tanveer Irshad Siddiqui , Anil Kumar , Rabi Sankar Bhatta , Girish Kumar Jain , Manoj Kumar Barthwal , Ankita Misra , Vivek Khanna , Prem Prakash , Manish Jain , Vishal Singh , Varsha Gupta , Anil Kumar Dwivedi
IPC分类号： C07D401/06 , C07B53/00
CPC分类号： A61K31/454 , C07B53/00 , C07D401/06
摘要： Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-1-(4-methyl-phenylmethyl)-5-oxo-(3S)—{N-[(3-t-butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)—{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p methylphenylmethyl)lpyroglutamate in good chiral purity.
摘要翻译：手性1-（4-甲基苯基甲基）-5-氧代 - {N - [（3-叔丁氧基羰基 - 氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-甲酰胺作为胶原诱导的血小板活化和粘附抑制剂本发明提供手性（2S）-1-（4-甲基 - 苯基甲基）-5-氧代 - （3S） - {N - [（3-叔丁氧基羰基氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-酮（2S）-1-（4-甲基苯基甲基）-5-氧代 - （3R） - {N - [（3-叔丁氧基羰基氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-酮分别为式6和7的甲酰胺。本发明还涉及这些部分作为通过胶原受体介导的胶原诱导的血小板粘附和聚集的抑制剂的用途。本发明提供了一种制备式6和7的手性羧酰胺的方法，该方法在N-烷基化过程中有利于避免在α-羧酸中心的任何外消旋化。在低温下使用试剂LiHMDS以提供良好的手性纯度的N-（p甲基苯基甲基）l吡咯烷酸甲酯。

6. 发明申请

US20130338193A1 CHIRAL 1-(4-METHYLPHENYLMETHYL)-5-OXO--PYRROLIDINE-2-CARBOXAMIDES AS INHIBITORS OF COLLAGEN INDUCED PLATELET ACTIVATION AND ADHESION 有权
标题翻译： CHIRAL 1-（4-甲基苯基甲基）-5-氧代 - 吡咯烷-2-羧酸酰胺作为胶原诱导的板激活和粘附的抑制剂
公开(公告)号：US20130338193A1
公开(公告)日：2013-12-19
申请号：US13995336
申请日：2012-01-12
申请人： Dinesh Kumar Dikshit , Madhu Dikshit , Tanveer Irshad Siddiqui , Anil Kumar , Rabi Sankar Bhata , Girish Kumar Jain , Manoj Kumar Barthwal , Ankita Misra , Vivek Khanna , Prem Prakash , Manish Jain , Vishal Singh , Varsha Gupta , Anil Kumar Dwivedi
发明人： Dinesh Kumar Dikshit , Madhu Dikshit , Tanveer Irshad Siddiqui , Anil Kumar , Rabi Sankar Bhata , Girish Kumar Jain , Manoj Kumar Barthwal , Ankita Misra , Vivek Khanna , Prem Prakash , Manish Jain , Vishal Singh , Varsha Gupta , Anil Kumar Dwivedi
IPC分类号： C07D401/06
CPC分类号： A61K31/454 , C07B53/00 , C07D401/06
摘要： Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-1-(4-methyl-phenylmethyl)-5-oxo-(3S)-{N-[(3-t butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)-{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p methylphenylmethyl)lpyroglutamate in good chiral purity.
摘要翻译：手性1-（4-甲基苯基甲基）-5-氧代 - {N - [（3-叔丁氧基羰基 - 氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-甲酰胺作为胶原诱导的血小板活化和粘附抑制剂本发明提供手性（2S）-1-（4-甲基 - 苯基甲基）-5-氧代 - （3S） - {N - [（3-叔丁氧基羰基氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-酮（2S）-1-（4-甲基苯基甲基）-5-氧代 - （3R） - {N - [（3-叔丁氧基羰基氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-甲酰胺分别为式6和7。本发明还涉及这些部分作为通过胶原受体介导的胶原诱导的血小板粘附和聚集的抑制剂的用途。本发明提供了一种制备式6和7的手性羧酰胺的方法，该方法在N-烷基化过程中有利于避免在α-羧酸中心的任何外消旋化。在低温下使用试剂LiHMDS以提供良好的手性纯度的N-（p甲基苯基甲基）l吡咯烷酸甲酯。

7. 发明授权

US09475901B2 Photoalignment materials having improved adhesion 有权
标题翻译：具有改善粘附性的光对准材料
公开(公告)号：US09475901B2
公开(公告)日：2016-10-25
申请号：US12959467
申请日：2010-12-03
申请人： Gobinda Saha , Anil Kumar
发明人： Gobinda Saha , Anil Kumar
IPC分类号： C09K19/00 , C08F220/30 , C08F220/62 , C09K19/56 , G02B1/04 , C08F220/36
CPC分类号： C08F222/20 , C08F220/30 , C08F220/62 , C08F2220/301 , C08F2220/303 , C08F2220/305 , C08F2220/365 , C09K19/56 , G02B1/04 , G02F1/1337 , G02F1/133788 , Y10T428/1005 , Y10T428/1014 , Y10T428/31931 , C08L33/10 , C08L101/12 , C08F220/34 , C08F2220/343 , C08F230/08 , C08F2220/281
摘要： The present disclosure provides for new photoalignment (co)polymer materials which demonstrate improved adhesion to a substrate. The (co)polymeric structure includes at least one photochemically active chromophore and at least one adhesion promoter group. Articles of manufacture, optical elements, ophthalmic elements and liquid crystal cells which include at least one photoalignment layer made from the photoalignment (co)polymer materials and methods for formation are also disclosed.
摘要翻译：本公开提供了新的光取向（共）聚合物材料，其表现出对基材的改善的粘附性。（共）聚合物结构包括至少一种光化学活性发色团和至少一个粘合促进剂基团。还公开了包括由光取向（共）聚合物材料和形成方法制成的至少一个光取向层的制造物，光学元件，眼用元件和液晶单元。

8. 发明授权

US09425859B2 Interference mitigation for broadband over power line 有权
标题翻译：电力线宽带干扰减轻
公开(公告)号：US09425859B2
公开(公告)日：2016-08-23
申请号：US12911625
申请日：2010-10-25
申请人： Timothy M. Mitchell , Anil Kumar , Roger C. Vondoenhoff , Matthias Beck
发明人： Timothy M. Mitchell , Anil Kumar , Roger C. Vondoenhoff , Matthias Beck
IPC分类号： H04L5/16 , H04B3/54
CPC分类号： H04B3/546 , H04B2203/5445
摘要： Systems and methods to exchange data between a vehicle and a remote computer system, are disclosed. In one embodiment, a system to exchange data between a vehicle and a remote computer system comprises at least one power line adapted to couple to the vehicle, a local area network, a modem coupled to the local area network and the at least one power line, and a power line interference server comprising logic to allocate communication channels within a specified frequency range on the power line. Other embodiments may be described.
摘要翻译：公开了在车辆和远程计算机系统之间交换数据的系统和方法。在一个实施例中，在车辆和远程计算机系统之间交换数据的系统包括适于耦合到车辆的至少一个电力线，局域网，耦合到局域网的调制解调器和至少一个电力线以及电力线干扰服务器，其包括用于在电力线上的指定频率范围内分配通信信道的逻辑。可以描述其他实施例。

9. 发明申请

US20150002688A1 AUTOMATED CAMERA ADJUSTMENT 审中-公开
标题翻译：自动相机调整
公开(公告)号：US20150002688A1
公开(公告)日：2015-01-01
申请号：US13928262
申请日：2013-06-26
申请人： James A. Baldwin , Richard S. Bell , Anil Kumar
发明人： James A. Baldwin , Richard S. Bell , Anil Kumar
IPC分类号： H04N5/232
CPC分类号： H04N5/23203 , H04N5/23296 , H04N5/77
摘要： In embodiments, apparatuses, methods and storage media are described that are associated with controlling production of images on a camera. In embodiments, a device with a camera, such as a content consumption device, may determine a current orientation of the camera and may adjust production of images from the camera to account for the orientation. The device may determine the orientation based on physical data, such as data from an accelerometer, compass, and/or gyroscope. the device may also determine the orientation from image data. The device may adjust production of images by either before capture, such as by physically adjusting the orientation of the camera, or after capture, such as by panning, tilting, and/or zooming captured images. Other embodiments may be described and claimed.
摘要翻译：在实施例中，描述与控制相机上的图像的生成相关联的装置，方法和存储介质。在实施例中，具有诸如内容消费设备的照相机的设备可以确定照相机的当前方向，并且可以调整来自相机的图像的生成以解决方向。设备可以基于诸如来自加速度计，罗盘和/或陀螺仪的数据的物理数据来确定取向。该装置还可以确定来自图像数据的取向。该装置可以在拍摄之前通过例如通过物理地调整相机的方向，或者在拍摄之后，例如通过平移，倾斜和/或缩放拍摄的图像来调整图像的产生。可以描述和要求保护其他实施例。

10. 发明授权

US08920928B2 Photochromic compounds and compositions 有权
标题翻译：光致变色化合物和组合物
公开(公告)号：US08920928B2
公开(公告)日：2014-12-30
申请号：US13325285
申请日：2011-12-14
申请人： Meng He , Darrin R. Dabideen , Sujit Mondal , Xiao-Man Dai , Ruisong Xu , Wenjing Xiao , Massimiliano Tomasulo , Huayun Yu , Anu Chopra , Anil Kumar
发明人： Meng He , Darrin R. Dabideen , Sujit Mondal , Xiao-Man Dai , Ruisong Xu , Wenjing Xiao , Massimiliano Tomasulo , Huayun Yu , Anu Chopra , Anil Kumar
IPC分类号： G02B1/04 , G02C7/02 , G02C7/10 , G02C7/14 , C07D311/92 , C07D311/94
CPC分类号： C07D311/94 , C07D311/92 , G02B1/04 , G02C7/02 , G02C7/102 , G02C7/14 , Y10T428/31504 , Y10T428/31551 , Y10T428/31663 , Y10T428/31935
摘要： Described herein are compounds generally comprising an indeno[2′,3′:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles.
摘要翻译：本文描述的是通常包含茚并[2'，3'：3,4]萘酚[1,2-b]吡喃结构的化合物。这些化合物可用于其光致变色性质，并可用于某些光致变色组合物中。这样的组合物还可以包含其它光致变色组合物和/或材料。另外，这样的化合物和/或组合物可适用于制备某些光致变色制品。

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