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1. 发明申请

US20070281040A1 COMBINATION THERAPY OF HEDGEHOG INHIBITORS, RADIATION AND CHEMOTHERAPEUTIC AGENTS 审中-公开
标题翻译： HEDGEHOG抑制剂，辐射和化学治疗剂的联合治疗
公开(公告)号：US20070281040A1
公开(公告)日：2007-12-06
申请号：US11576310
申请日：2005-09-30
申请人： Ralph Weichselbaum , Zahra Shafaee , Wei Du
发明人： Ralph Weichselbaum , Zahra Shafaee , Wei Du
IPC分类号： A61K31/4355 , A61K31/337 , A61K31/56 , A61K31/70 , A61K33/24 , A61N5/10 , A61P35/00
CPC分类号： A61K31/56 , A61K31/337 , A61K31/4355 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic combinations and methods of inhibiting the proliferation of cancerous cells, the abnormal growth of cells, and tumor cell growth using the combination of a hedgehog inhibitor with chemotherapy and/or radiation therapy. The present invention also relates to methods of enhancing the antiproliferative effect of chemotherapy and/or radiation therapy in a mammalian cancer patient undergoing either chemotherapy or radiation or a combination of radiation and chemotherapy by co-administering a therapeutically amount of a hedgehog inhibitor, concurrently or sequentially, with the chemotherapy and/or radiation therapy.
摘要翻译：本发明涉及使用刺猬蛋白抑制剂与化疗和/或放射治疗的组合来抑制癌细胞增殖，细胞异常生长和肿瘤细胞生长的治疗组合和方法。本发明还涉及通过共同施用治疗量的刺猬蛋白抑制剂同时或同时施用化学疗法和/或放射治疗在化疗或放射的哺乳动物癌症患者或辐射和化学疗法的组合中增强抗增殖作用的方法依次进行化疗和/或放射治疗。

2. 发明申请

US20100221228A1 y134.5 Deficient HSV and the MAPK Pathway 审中-公开
标题翻译： y134.5缺血性HSV和MAPK通路
公开(公告)号：US20100221228A1
公开(公告)日：2010-09-02
申请号：US12161763
申请日：2007-01-24
申请人： Kerrington D. Smith , James J. Mezhir , Ralph Weichselbaum , Bernard Roizman
发明人： Kerrington D. Smith , James J. Mezhir , Ralph Weichselbaum , Bernard Roizman
IPC分类号： A61K35/76 , A61P35/00 , C12N7/00
CPC分类号： C12N9/1205 , A61K35/763 , A61K38/00 , C07K2319/43 , C12N15/86 , C12N2710/16632 , C12N2710/16643 , A61K2300/00
摘要： The invention provides materials and methods for the identification of cells exhibiting a cell proliferative disorder that are amenable to treatment with a herpes simplex virus that does not express an approximately wild-type level of ICP34.5. Also provided are methods of treating cell proliferative diseases, disorders or conditions, such as cancers, rheumatoid arthritis and macular degeneration, using these HSVs. Further provided are methods for preventing such cell proliferative disorders by administering the HSVs as well as methods for ameliorating a symptom associated with a cell proliferative disorder by administering such HSVs.
摘要翻译：本发明提供用于鉴定表现出细胞增殖性病症的细胞的材料和方法，其适于用不表达近似野生型水平的ICP34.5的单纯疱疹病毒处理。还提供了使用这些HSV来治疗细胞增殖性疾病，病症或病症如癌症，类风湿性关节炎和黄斑变性的方法。还提供了通过施用HSV来预防这种细胞增殖性疾病的方法以及通过施用这种HSV来改善与细胞增殖性病症相关的症状的方法。

3. 发明申请

US20060113482A1 Image-guided medical intervention apparatus and method 有权
标题翻译：图像引导医疗介入装置及方法
公开(公告)号：US20060113482A1
公开(公告)日：2006-06-01
申请号：US10998509
申请日：2004-11-29
申请人： Charles Pelizzari , Chin-Tu Chen , Ralph Weichselbaum , Samuel Hellman
发明人： Charles Pelizzari , Chin-Tu Chen , Ralph Weichselbaum , Samuel Hellman
IPC分类号： G01T1/24
CPC分类号： G01T1/1641 , A61N5/1049 , A61N5/1065 , A61N2005/1052 , A61N2005/1061 , G01T1/166
摘要： In some embodiments, an image-guided radiotherapy apparatus and method is provided in which a radiotherapy radiation source and a gamma ray photon imaging device are positioned with respect to a patient area so that a patient can be treated by a beam emitted from the radiotherapy apparatus and can have images taken by the gamma ray photon imaging device. Radiotherapy treatment and imaging can be performed substantially simultaneously and/or can be performed without moving the patient in some embodiments. The gamma ray photon imaging device can be coupled and movable with respect to any part of a building structure, can be located on a portable frame movable to and from the radiotherapy radiation source and patient, or can take other forms. In some embodiments, the gamma ray photon imaging device can be used for imaging in connection with other types of medical interventions.
摘要翻译：在一些实施例中，提供了一种图像引导放射治疗装置和方法，其中放射治疗辐射源和伽马射线光子成像装置相对于患者区域定位，使得可以通过从放射治疗装置发射的束来对患者进行治疗并且可以具有由伽马射线光子成像装置拍摄的图像。在一些实施例中，放射治疗和成像可以基本上同时进行和/或执行而不移动患者。伽马射线光子成像装置可以相对于建筑结构的任何部分联接和移动，可以位于可移动到放射治疗辐射源和患者的便携式框架上，或者可以采取其他形式。在一些实施例中，伽马射线光子成像装置可用于与其他类型的医疗干预相结合的成像。

4. 发明申请

US20050147591A1 Methods and compositions for viral enhancement of cell killing 审中-公开
标题翻译：病毒增强细胞杀伤的方法和组合物
公开(公告)号：US20050147591A1
公开(公告)日：2005-07-07
申请号：US10946365
申请日：2004-09-21
申请人： Dennis Hallahan , Ralph Weichselbaum , Donald Kufe , Gregory Sibley , Bernard Roizman
发明人： Dennis Hallahan , Ralph Weichselbaum , Donald Kufe , Gregory Sibley , Bernard Roizman
IPC分类号： A61K51/00 , A61K31/00 , A61K31/40 , A61K31/70 , A61K35/761 , A61K35/763 , A61K45/00 , A61K48/00 , A61N5/10 , A61P35/00 , C12Q1/70 , C12N15/869
CPC分类号： A61K48/00 , A61K35/761 , A61K35/763 , A61K38/191 , A61K45/06 , A61N2005/1098 , C12N2710/10032 , C12N2710/10332 , A61K2300/00
摘要： The present invention is directed to novel methods of enhancing the effectiveness of DNA damaging agents by exposing cells to viruses prior to or during exposure to the damaging agent. In certain embodiments of the invention, the DNA damaging agent is ionizing radiation, the virus is an adenovirus, and the increase in cell killing is synergistic when compared to radiation alone.
摘要翻译：本发明涉及通过在暴露于损伤剂之前或期间将细胞暴露于病毒来增强DNA损伤剂的有效性的新方法。在本发明的某些实施方案中，DNA损伤剂是电离辐射，病毒是腺病毒，与单独的辐射相比，细胞杀伤的增加是协同的。

5. 发明申请

US20090011439A1 Prognosis and Therapy Predictive Markers and Methods of Use 有权
标题翻译：预后和治疗预测标记和使用方法
公开(公告)号：US20090011439A1
公开(公告)日：2009-01-08
申请号：US12087964
申请日：2007-01-19
申请人： Ralph Weichselbaum , Bernard Roizman , Andy Minn , Nikolai Khodarev , Edwardine Labay
发明人： Ralph Weichselbaum , Bernard Roizman , Andy Minn , Nikolai Khodarev , Edwardine Labay
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , G01N33/57407 , G01N33/57484 , G01N2800/52
摘要： Disclosed is a set of genes differentially expressed in chemotherapy and radiation resistant tumors useful in predicting response to therapy and assessing risk of local-regional failure, survival and metastasis in cancer patients. Also disclosed are methods for characterizing tumors according to gene expression and kits for use in the methods of the invention.
摘要翻译：公开了一组在化学疗法和耐辐射肿瘤中差异表达的基因，可用于预测治疗反应和评估癌症患者局部局部衰竭，存活和转移的风险。还公开了根据基因表达表征肿瘤的方法和用于本发明方法的试剂盒。

6. 发明申请

US20060199210A1 Methods and kits for monitoring Barrett's metaplasia 失效
公开(公告)号：US20060199210A1
公开(公告)日：2006-09-07
申请号：US11367602
申请日：2006-03-02
申请人： Ralph Weichselbaum , Nikolai Khodarev , Eric Kimchi , Mitchell Posner
发明人： Ralph Weichselbaum , Nikolai Khodarev , Eric Kimchi , Mitchell Posner
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Disclosed are methods and kits for assessing risk of progression of Barrett's esophagus to adenocarcinoma.

7. 发明申请

US20060058258A1 Gene transcription and ionizing radiation: methods and compositions 审中-公开
公开(公告)号：US20060058258A1
公开(公告)日：2006-03-16
申请号：US11257553
申请日：2005-10-25
申请人： Ralph Weichselbaum , Dennis Hallahan , Vikas Sukhatme , Donald Kufe
发明人： Ralph Weichselbaum , Dennis Hallahan , Vikas Sukhatme , Donald Kufe
IPC分类号： A61K48/00 , C07H21/04
CPC分类号： A61K41/0023 , A61K38/00 , A61K48/00 , C07K14/52 , C07K14/525 , C07K14/82 , C07K2319/00 , C07K2319/61 , C07K2319/71 , C07K2319/81 , C12N15/63 , C12N15/635 , C12N15/67 , C12N15/85 , C12N2830/001 , C12N2830/002 , C12N2830/008 , C12N2830/85 , G03G15/2025 , G03G2215/2083
摘要： The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region can comprise a single encoding sequence for a polypeptide or two or more encoding sequences encoding DNA binding, activation or repression domains of a transcription factor. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.

8. 发明授权

US6025365A Chelerythrine and radiation combined tumor therapy 失效
标题翻译：白藜芦醇和辐射联合肿瘤治疗
公开(公告)号：US6025365A
公开(公告)日：2000-02-15
申请号：US826814
申请日：1997-03-25
申请人： Ralph Weichselbaum , Steven Chmura , Jose Quintans , Donald W. Kufe
发明人： Ralph Weichselbaum , Steven Chmura , Jose Quintans , Donald W. Kufe
IPC分类号： A61K31/4741 , A61K41/00 , A61P35/00 , A61P43/00 , A61N43/42 , A61N5/00
CPC分类号： A61K31/4741 , A61K41/00
摘要： Combination of low doses of irradiation and chelerythrine results in increased apoptosis in tumor cells. The doses of either irradiation or chelerythrine alone are such that increased apoptosis or decreased tumor growth or proliferation would not be expected.
摘要翻译：组合低剂量的照射和白藜芦醇导致肿瘤细胞凋亡增加。单独使用照射剂或螯合菊酯的剂量使得不能预期增加的凋亡或降低的肿瘤生长或增殖。

9. 发明授权

US07892740B2 Prognosis and therapy predictive markers and methods of use 有权
标题翻译：预后和治疗预测标记及使用方法
公开(公告)号：US07892740B2
公开(公告)日：2011-02-22
申请号：US12087964
申请日：2007-01-19
申请人： Ralph Weichselbaum , Bernard Roizman , Andy Minn , Nikolai Khodarev , Edwardine Labay
发明人： Ralph Weichselbaum , Bernard Roizman , Andy Minn , Nikolai Khodarev , Edwardine Labay
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , G01N33/57407 , G01N33/57484 , G01N2800/52
摘要： Disclosed is a set of genes differentially expressed in chemotherapy and radiation resistant tumors useful in predicting response to therapy and assessing risk of local-regional failure, survival and metastasis in cancer patients. Also disclosed are methods for characterizing tumors according to gene expression and kits for use in the methods of the invention.
摘要翻译：公开了一组在化学疗法和耐辐射肿瘤中差异表达的基因，可用于预测治疗反应和评估癌症患者局部局部衰竭，存活和转移的风险。还公开了根据基因表达表征肿瘤的方法和用于本发明方法的试剂盒。

10. 发明申请

US20080014175A1 Methods and Compositions for Viral Enhancement of Cell Killing 审中-公开
标题翻译：病毒增强细胞杀伤的方法和组合
公开(公告)号：US20080014175A1
公开(公告)日：2008-01-17
申请号：US11863173
申请日：2007-09-27
申请人： Dennis Hallahan , Ralph Weichselbaum , Donald Kufe , Gregory Sibley , Bernard Roizman
发明人： Dennis Hallahan , Ralph Weichselbaum , Donald Kufe , Gregory Sibley , Bernard Roizman
IPC分类号： A61K48/00 , A61N5/00 , A61K31/407
CPC分类号： A61K48/00 , A61K35/761 , A61K35/763 , A61K38/191 , A61K45/06 , A61N2005/1098 , C12N2710/10032 , C12N2710/10332 , A61K2300/00
摘要： The present invention is directed to novel methods of enhancing the effectiveness of DNA damaging agents by exposing cells to viruses prior to or during exposure to the damaging agent. In certain embodiments of the invention, the DNA damaging agent is ionizing radiation, the virus is an adenovirus, and the increase in cell killing is synergistic when compared to radiation alone.
摘要翻译：本发明涉及通过在暴露于损伤剂之前或期间将细胞暴露于病毒来增强DNA损伤剂的有效性的新方法。在本发明的某些实施方案中，DNA损伤剂是电离辐射，病毒是腺病毒，与单独的辐射相比，细胞杀伤的增加是协同的。

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