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    • 3. 发明授权
    • Medicament-loaded transdermal reservoir and method for its formation
    • 药物载体透皮储库及其形成方法
    • US06496727B1
    • 2002-12-17
    • US09584453
    • 2000-05-31
    • Michael I. BernhardRalph EwallCurtis KarlPreston KeuschGary KupperblattDaniel O'Grady
    • Michael I. BernhardRalph EwallCurtis KarlPreston KeuschGary KupperblattDaniel O'Grady
    • A61N130
    • A61N1/30
    • A transdermal reservoir and method for loading a material into a reservoir includes providing a bibulous reservoir blocking a backing with an interior surface having a patient contact surface with a shape disposed on the interior surface of the backing. A closure is sized and shaped to engage the backing for forming a releasable seal to isolate the bibulous reservoir from the ambient environment. The closure has an inside surface with a section of an absorbent material disposed thereon. When the closure is disposed on the backing, the absorbent material is positioned in intimate physical contact with the reservoir. The method includes applying an aliquot of a material to the absorbent material,. placing the closure on the backing so that the absorbent material is in intimate physical contact with the contact surface of the bibulous reservoir and the closure forms the releasable seal with the backing. The reservoir is allowed to stand for a sufficient time to allow the aliquot to be absorbed into the bibulous material thereby loading the reservoir.
    • 用于将材料装载到储存器中的透皮储存器和方法包括提供阻塞背衬的吸水储存器,其具有带有设置在背衬的内表面上的形状的患者接触表面的内表面。 封闭件的尺寸和形状被设计成与背衬接合以形成可释放的密封,以将吸水容器与环境环境隔离。 封闭件具有内表面,其上设置有一部分吸收材料。 当封闭件设置在背衬上时,吸收材料定位成与贮存器紧密地物理接触。 该方法包括将一种材料的等分试样施加到吸收材料上。 将封闭物放置在背衬上,使得吸收材料与吸水容器的接触表面紧密地物理接触并且封闭物与背衬形成可释放的密封。 允许储存器放置足够的时间以允许将等分试样吸收到吸水材料中,从而装载储存器。