专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09629922B2 Nanoparticle-based tumor-targeted drug delivery 有权
公开(公告)号：US09629922B2
公开(公告)日：2017-04-25
申请号：US13820413
申请日：2011-09-02
申请人： Ralph A. Reisfeld , Rong Xiang , Yunping Luo , Debbie Liao , Ze Liu , Tingmei Chen , Si Chen , Dan Lu
发明人： Ralph A. Reisfeld , Rong Xiang , Yunping Luo , Debbie Liao , Ze Liu , Tingmei Chen , Si Chen , Dan Lu
IPC分类号： A61K47/48 , B82Y5/00 , A61K9/127
CPC分类号： A61K31/58 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/4164 , A61K31/704 , A61K47/28 , A61K47/6911 , A61K47/6913 , B82Y5/00
摘要： The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.

2. 发明授权

US09616137B2 Nanoparticle-based tumor-targeted drug delivery 有权
公开(公告)号：US09616137B2
公开(公告)日：2017-04-11
申请号：US13224399
申请日：2011-09-02
申请人： Ralph A. Reisfeld , Rong Xiang , Yunping Luo , Debbie Liao , Ze Liu , Tingmei Chen , Si Chen , Dan Lu
发明人： Ralph A. Reisfeld , Rong Xiang , Yunping Luo , Debbie Liao , Ze Liu , Tingmei Chen , Si Chen , Dan Lu
IPC分类号： A61K47/48 , B82Y5/00 , A61K9/127
CPC分类号： A61K31/58 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/4164 , A61K31/704 , A61K47/28 , A61K47/6911 , A61K47/6913 , B82Y5/00
摘要： The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety.

3. 发明申请

US20130330399A1 NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY 有权
标题翻译：基于纳米颗粒的肿瘤靶向药物递送
公开(公告)号：US20130330399A1
公开(公告)日：2013-12-12
申请号：US13820413
申请日：2011-09-02
申请人： Ralph A. Reisfeld , Rong Xiang , Yunping Luo , Debbie Liao , Ze Liu , Tingmei Chen , Si Chen , Dan Lu
发明人： Ralph A. Reisfeld , Rong Xiang , Yunping Luo , Debbie Liao , Ze Liu , Tingmei Chen , Si Chen , Dan Lu
IPC分类号： A61K47/48 , A61K9/127
CPC分类号： A61K31/58 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/4164 , A61K31/704 , A61K47/28 , A61K47/6911 , A61K47/6913 , B82Y5/00
摘要： The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.
摘要翻译：本发明提供了包含脂质体纳米颗粒的水分散体的含水肿瘤靶向脂质体纳米颗粒组合物。纳米颗粒优选包封抗癌化学治疗剂，其可以加入到预形成的脂质体组合物中，或者可以在形成脂质体期间掺入脂质体中。脂质体纳米颗粒包含与分散在水性载体中的纳米颗粒脂质体形式的一种或多种其它胶束或形成囊泡的脂质材料混合的豆粕靶向脂质。优选的肿瘤靶向脂质体纳米颗粒组合物包含（a）脂肪组织靶向脂质组分，（b）两性离子脂质组分; （c）氨基取代的脂质成分; （d）中性脂质组分; 和（e）聚乙二醇缀合的脂质组分。所述脂肪组分包含疏水性脂质部分，其与共轭结合部分共价连接。

4. 发明申请

US20120058177A1 NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY 有权
标题翻译：基于纳米颗粒的肿瘤靶向药物递送
公开(公告)号：US20120058177A1
公开(公告)日：2012-03-08
申请号：US13224399
申请日：2011-09-02
申请人： Ralph A. Reisfeld , Rong Xiang , Yunping Luo , Debbie Liao , Ze Liu , Tingmei Chen , Si Chen , Dan Lu
发明人： Ralph A. Reisfeld , Rong Xiang , Yunping Luo , Debbie Liao , Ze Liu , Tingmei Chen , Si Chen , Dan Lu
IPC分类号： A61K9/127 , A61P35/00 , A61K31/704 , B82Y5/00
CPC分类号： A61K31/58 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/4164 , A61K31/704 , A61K47/28 , A61K47/6911 , A61K47/6913 , B82Y5/00
摘要： The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety.
摘要翻译：本发明提供了包含脂质体纳米颗粒的水分散体的含水肿瘤靶向脂质体纳米颗粒组合物。纳米颗粒优选包封抗癌化学治疗剂，其可以加入到预形成的脂质体组合物中，或者可以在形成脂质体期间掺入脂质体中。脂质体纳米颗粒包含与分散在水性载体中的纳米颗粒脂质体形式的一种或多种其它胶束或形成囊泡的脂质材料混合的豆粕靶向脂质。优选的肿瘤靶向脂质体纳米颗粒组合物包含（a）脂肪组织靶向脂质组分，（b）两性离子脂质组分; （c）氨基取代的脂质成分; （d）中性脂质组分; 和（e）聚乙二醇缀合的脂质组分。所述脂肪组分包含疏水性脂质部分，其与共轭结合部分共价连接。

5. 发明申请

US20100112408A1 CHEMICAL COMPOSITIONS, METHODS OF MAKING THE CHEMICAL COMPOSITIONS, AND STRUCTURES MADE FROM THE CHEMICAL COMPOSITIONS 有权
标题翻译：化学成分，制备化学成分的方法和化学成分的结构
公开(公告)号：US20100112408A1
公开(公告)日：2010-05-06
申请号：US12609179
申请日：2009-10-30
申请人： Lei Yang , Zhe Cheng , Ze Liu , Meilin Liu
发明人： Lei Yang , Zhe Cheng , Ze Liu , Meilin Liu
IPC分类号： H01M8/10 , H01B1/02
CPC分类号： H01B1/12 , C01G25/006 , C01G53/006 , C01P2002/34 , C01P2002/52 , C01P2002/72 , C01P2002/82 , C01P2002/85 , C01P2002/88 , C01P2006/40 , C04B35/50 , C04B35/6262 , C04B2235/3201 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3229 , C04B2235/3244 , H01M4/9008 , H01M4/9033 , H01M8/1246 , H01M2008/1293 , Y02E60/522 , Y02E60/525 , Y02P70/56
摘要： Embodiments of the present disclosure include chemical compositions, structures, anodes, cathodes, electrolytes for solid oxide fuel cells, solid oxide fuel cells, fuel cells, fuel cell membranes, separation membranes, catalytic membranes, sensors, coatings for electrolytes, electrodes, membranes, and catalysts, and the like, are disclosed.
摘要翻译：本公开的实施方案包括用于固体氧化物燃料电池的化学组成，结构，阳极，阴极，电解质，固体氧化物燃料电池，燃料电池，燃料电池膜，分离膜，催化膜，传感器，电解质涂层，电极，膜，和催化剂等。

6. 发明授权

US08932781B2 Chemical compositions, methods of making the chemical compositions, and structures made from the chemical compositions 有权
标题翻译：化学成分，化学成分的制造方法以及由化学成分制成的结构
公开(公告)号：US08932781B2
公开(公告)日：2015-01-13
申请号：US12609179
申请日：2009-10-30
申请人： Lei Yang , Zhe Cheng , Ze Liu , Meilin Liu
发明人： Lei Yang , Zhe Cheng , Ze Liu , Meilin Liu
IPC分类号： H01M8/10 , H01B1/02 , C04B35/50 , H01M4/90 , C04B35/626 , C01G53/00 , H01B1/12 , C01G25/00 , H01M8/12
CPC分类号： H01B1/12 , C01G25/006 , C01G53/006 , C01P2002/34 , C01P2002/52 , C01P2002/72 , C01P2002/82 , C01P2002/85 , C01P2002/88 , C01P2006/40 , C04B35/50 , C04B35/6262 , C04B2235/3201 , C04B2235/3215 , C04B2235/3224 , C04B2235/3225 , C04B2235/3229 , C04B2235/3244 , H01M4/9008 , H01M4/9033 , H01M8/1246 , H01M2008/1293 , Y02E60/522 , Y02E60/525 , Y02P70/56
摘要： Embodiments of the present disclosure include chemical compositions, structures, anodes, cathodes, electrolytes for solid oxide fuel cells, solid oxide fuel cells, fuel cells, fuel cell membranes, separation membranes, catalytic membranes, sensors, coatings for electrolytes, electrodes, membranes, and catalysts, and the like, are disclosed.
摘要翻译：本公开的实施方案包括用于固体氧化物燃料电池的化学组成，结构，阳极，阴极，电解质，固体氧化物燃料电池，燃料电池，燃料电池膜，分离膜，催化膜，传感器，电解质涂层，电极，膜，和催化剂等。

7. 发明授权

US08802316B1 Solid oxide fuel cells having porous cathodes infiltrated with oxygen-reducing catalysts 有权
标题翻译：具有多孔阴极的固体氧化物燃料电池被氧还原催化剂渗透
公开(公告)号：US08802316B1
公开(公告)日：2014-08-12
申请号：US12837757
申请日：2010-07-16
申请人： Meilin Liu , Ze Liu , Mingfei Liu , Lifang Nie , David Spencer Mebane , Lane Curtis Wilson , Wayne Surdoval
发明人： Meilin Liu , Ze Liu , Mingfei Liu , Lifang Nie , David Spencer Mebane , Lane Curtis Wilson , Wayne Surdoval
IPC分类号： H01M2/12
CPC分类号： H01M4/9025 , H01M4/8657 , H01M4/8807 , H01M4/8846 , H01M4/8889 , H01M4/9033 , H01M8/1213 , H01M2004/8689 , H01M2008/1293 , H01M2300/0094
摘要： Solid-oxide fuel cells include an electrolyte and an anode electrically coupled to a first surface of the electrolyte. A cathode is provided, which is electrically coupled to a second surface of the electrolyte. The cathode includes a porous backbone having a porosity in a range from about 20% to about 70%. The porous backbone contains a mixed ionic-electronic conductor (MIEC) of a first material infiltrated with an oxygen-reducing catalyst of a second material different from the first material.
摘要翻译：固体氧化物燃料电池包括与电解质的第一表面电耦合的电解质和阳极。提供阴极，其电耦合到电解质的第二表面。阴极包括孔隙率在约20％至约70％范围内的多孔骨架。多孔骨架包含第一材料的混合离子电子导体（MIEC），该第一材料浸入与不同于第一材料的第二材料的氧还原催化剂。

8. 发明授权

US09079387B2 Method for preparing color microcapsule membrane and display comprising same 有权
标题翻译：彩色微胶囊膜的制备方法及其制备方法
公开(公告)号：US09079387B2
公开(公告)日：2015-07-14
申请号：US13700977
申请日：2012-09-13
申请人： Ze Liu
发明人： Ze Liu
IPC分类号： B32B37/02 , B32B37/14 , B32B38/04 , G02F1/17 , G02F1/167 , B32B37/24 , B32B37/04 , B32B38/00
CPC分类号： B32B37/24 , B32B37/02 , B32B37/04 , B32B37/14 , B32B37/142 , B32B37/144 , B32B38/0004 , B32B2305/54 , G02F1/167 , G02F1/17 , Y10T156/1052 , Y10T156/1062 , Y10T156/12
摘要： Embodiments of the invention disclose a method for preparing a color microcapsule electrophoresis display membrane by preparing individually various monochromatic microcapsule membranes, then binding each monochromatic microcapsule membrane together using a binding agent by stacking the membranes in sequence, so as to form multiple membrane layer units, and cutting the stacked multiple membrane layer units in a longitudinal direction perpendicular to a surface, thereby preparing the color microcapsule electrophoresis display membrane. The color microcapsule electrophoresis display membranes prepared by the method have high light reflectivity, high color contrast and precise color positioning. The invention further discloses a method for preparing a color microcapsule electrophoresis display comprising the color microcapsule electrophoresis display membrane.
摘要翻译：本发明的实施方式公开了通过制备单独的各种单色微胶囊膜，然后使用粘合剂将每个单色微胶囊膜依次层叠以形成多个膜层单元，从而制备彩色微胶囊电泳显示膜的方法，并且在与表面垂直的纵向上切割层叠的多个膜层单元，从而制备彩色微胶囊电泳显示膜。通过该方法制备的彩色微胶囊电泳显示膜具有高反射率，高色彩对比度和精确的色彩定位。本发明还公开了一种制备彩色微胶囊电泳显示膜的彩色微胶囊电泳显示器的方法。

9. 发明申请

US20130206316A1 METHOD FOR PREPARING COLOR MICROCAPSULE MEMBRANE AND DISPLAY COMPRISING SAME 有权
标题翻译：制备彩色微孔膜的方法和包含其的显示方法
公开(公告)号：US20130206316A1
公开(公告)日：2013-08-15
申请号：US13700977
申请日：2012-09-13
申请人： Ze Liu
发明人： Ze Liu
IPC分类号： B32B37/24
CPC分类号： B32B37/24 , B32B37/02 , B32B37/04 , B32B37/14 , B32B37/142 , B32B37/144 , B32B38/0004 , B32B2305/54 , G02F1/167 , G02F1/17 , Y10T156/1052 , Y10T156/1062 , Y10T156/12
摘要： Embodiments of the invention disclose a method for preparing a color microcapsule electrophoresis display membrane by preparing individually various monochromatic microcapsule membranes, then binding each monochromatic microcapsule membrane together using a binding agent by stacking the membranes in sequence, so as to form multiple membrane layer units, and cutting the stacked multiple membrane layer units in a longitudinal direction perpendicular to a surface, thereby preparing the color microcapsule electrophoresis display membrane. The color microcapsule electrophoresis display membranes prepared by the method have high light reflectivity, high color contrast and precise color positioning. The invention further discloses a method for preparing a color microcapsule electrophoresis display comprising the color microcapsule electrophoresis display membrane.
摘要翻译：本发明的实施方式公开了通过制备单独的各种单色微胶囊膜，然后使用粘合剂将每个单色微胶囊膜依次层叠以形成多个膜层单元，从而制备彩色微胶囊电泳显示膜的方法，并且在与表面垂直的纵向上切割层叠的多个膜层单元，从而制备彩色微胶囊电泳显示膜。通过该方法制备的彩色微胶囊电泳显示膜具有高反射率，高色彩对比度和精确的色彩定位。本发明还公开了一种制备彩色微胶囊电泳显示膜的彩色微胶囊电泳显示器的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式