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1. 发明申请

US20130023576A1 Pyrazole Compounds as CRTH2 Antagonists 有权
标题翻译：吡唑化合物作为CRTH2拮抗剂
公开(公告)号：US20130023576A1
公开(公告)日：2013-01-24
申请号：US13353621
申请日：2012-01-19
申请人： Ralf Anderskewitz , Domnic Martyres , Thorsten Oost , Wolfgang Rist , Peter Seither
发明人： Ralf Anderskewitz , Domnic Martyres , Thorsten Oost , Wolfgang Rist , Peter Seither
IPC分类号： A61K31/4155 , C07D405/12 , C07D409/12 , A61P29/00 , A61P31/00 , A61P27/14 , A61P11/00 , A61P1/00 , A61P19/02 , A61P37/08 , A61P11/06 , C07D403/12 , A61P37/02
CPC分类号： C07D403/12 , C07D405/12 , C07D409/12
摘要： Pyrazole compounds of formula (Ia) or (Ib) and pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Y1, Y2, Y3, Y4, Y5, Z, R1, R2, n and R3 have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical formulations containing the compounds and to pharmaceutical formulations containing the compounds in combination with one or more active substances.
摘要翻译：式（Ia）或（Ib）的吡唑化合物及其药学上可接受的盐，其中Ra，Rb，Rc，Rd，Y1，Y2，Y3，Y4，Y5，Z，R1，R2，n和R3具有以下含义之一如说明书和权利要求书中所指出的，它们作为药物的用途，含有该化合物的药物制剂和含有与一种或多种活性物质组合的化合物的药物制剂。

2. 发明授权

US08759386B2 Pyrazole compounds as CRTH2 antagonists 有权
标题翻译：吡唑化合物作为CRTH2拮抗剂
公开(公告)号：US08759386B2
公开(公告)日：2014-06-24
申请号：US13353621
申请日：2012-01-19
申请人： Ralf Anderskewitz , Domnic Martyres , Thorsten Oost , Wolfgang Rist , Peter Seither
发明人： Ralf Anderskewitz , Domnic Martyres , Thorsten Oost , Wolfgang Rist , Peter Seither
IPC分类号： A61K31/4155 , C07D231/10 , C07D403/12 , C07D405/12 , C07D409/12
CPC分类号： C07D403/12 , C07D405/12 , C07D409/12
摘要： Pyrazole compounds of formula (Ia) or (Ib) and pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Y1, Y2, Y3, Y4, Y5, Z, R1, R2, n and R3 have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical formulations containing the compounds and to pharmaceutical formulations containing the compounds in combination with one or more active substances.
摘要翻译：式（Ia）或（Ib）的吡唑化合物及其药学上可接受的盐，其中Ra，Rb，Rc，Rd，Y1，Y2，Y3，Y4，Y5，Z，R1，R2，n和R3具有以下含义之一如说明书和权利要求书中所指出的，它们作为药物的用途，含有该化合物的药物制剂和含有与一种或多种活性物质组合的化合物的药物制剂。

3. 发明授权

US09206164B2 Pyrazole compounds as CRTH2 antagonists 有权
标题翻译：吡唑化合物作为CRTH2拮抗剂
公开(公告)号：US09206164B2
公开(公告)日：2015-12-08
申请号：US14006170
申请日：2012-03-15
申请人： Domnic Martyres , Ralf Anderskewitz , Christoph Hoenke , Jan Kriegl , Thorsten Oost , Wolfgang Rist , Peter Seither
发明人： Domnic Martyres , Ralf Anderskewitz , Christoph Hoenke , Jan Kriegl , Thorsten Oost , Wolfgang Rist , Peter Seither
IPC分类号： A61K31/335 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D403/10 , C07D471/04 , C07D487/04 , A61K31/4155 , A61K31/4184 , A61K31/437 , A61K31/52 , A61K45/06 , C07D473/00
CPC分类号： C07D403/10 , A61K31/335 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4184 , A61K31/421 , A61K31/437 , A61K31/52 , A61K45/06 , C07D471/04 , C07D473/00 , C07D487/04
摘要： The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2 antagonistic activity, wherein L, Y1, Y2, Y3, Y4, Y5, Z, R1, R2, R3 and n have one of the meanings as indicated in the specification and claims, to their use as medicaments, to pharmaceutical compositions containing said compounds and to pharmaceutical compositions containing said compounds in combination with one or more active substances.
摘要翻译：本发明涉及具有CRTH2拮抗活性的式（I）的吡唑化合物及其药学上可接受的盐，其中L，Y1，Y2，Y3，Y4，Y5，Z，R1，R2，R3和n具有以下含义之一：在说明书和权利要求书中指出其作为药物的用途，含有所述化合物的药物组合物和含有所述化合物与一种或多种活性物质组合的药物组合物。

4. 发明授权

US08791272B2 Pyrazole compounds as CRTH2 antagonists 有权
标题翻译：吡唑化合物作为CRTH2拮抗剂
公开(公告)号：US08791272B2
公开(公告)日：2014-07-29
申请号：US13012244
申请日：2011-01-24
申请人： Thorsten Oost , Ralf Anderskewitz , Dieter Wolfgang Hamprecht , Christoph Hoenke , Domnic Martyres , Wolfgang Rist , Peter Seither
发明人： Thorsten Oost , Ralf Anderskewitz , Dieter Wolfgang Hamprecht , Christoph Hoenke , Domnic Martyres , Wolfgang Rist , Peter Seither
IPC分类号： C07D231/12 , A61K31/415 , C07D405/12 , C07D401/06
CPC分类号： C07D231/12 , C07D401/06 , C07D405/12
摘要： The present invention relates to pyrazole compounds of formula (I) and pharmaceutically acceptable salts thereof having CRTH2-activity, wherein W, L1, L2, X, L3, Y, R1 and R2 are as defined in the specification and claims, to their use as medicaments and to pharmaceutical formulations, containing said compounds or containing a combination of said compounds with one or more active substances.
摘要翻译：本发明涉及具有CRTH2-活性的式（I）的吡唑化合物及其药学上可接受的盐，其中W，L1，L2，X，L3，Y，R1和R2如说明书和权利要求中所定义，作为药物和药物制剂，含有所述化合物或含有所述化合物与一种或多种活性物质的组合。

5. 发明授权

US4745959A Drive mechanism for movable cloth awnings 失效
标题翻译：活动布篷的驱动机构
公开(公告)号：US4745959A
公开(公告)日：1988-05-24
申请号：US942279
申请日：1986-12-16
申请人： Wolfgang Rist
发明人： Wolfgang Rist
IPC分类号： E04F10/02 , E04F10/06 , E06B9/17 , E06B9/72
CPC分类号： E04F10/06 , E06B9/17 , E06B9/72 , E04F10/0607
摘要： The drive mechanism is used for movable cloth awnings employed as protective sunscreens and is mounted on a tubular roll-up shaft (1). In coaxial alignment with the roll-up shaft (1) is a drive shaft (2), and the two are mechanically coupled together. At each end there is a draw-cord plate (pulley) (7) in which the draw cord (9) is wound. Furthermore, at each side there is a guide track (11) with a configuration symmetrically matched to that of an open channel (14) on each side for a roller carriage (15), as well as a closed guide chamber (16) in which the draw cord (9) is forcibly retained. End support plates (3) engages medially with the profile of the guide track (11) and is provided with a mounting (4) which serves as a motor bearing, while the draw-cord plate (7) is rotatably mounted over the mounting (4) and the motor head (5).
摘要翻译：驱动机构用于作为保护性防晒剂的可动布遮阳篷，并安装在管状卷起轴（1）上。与卷起轴（1）同轴对准的是驱动轴（2），并且两者机械地联接在一起。在每一端有一个牵引绳（滑轮）（7），其中牵引绳（9）被卷绕。此外，在每一侧都有一个导轨（11），其具有与用于滚子滑架（15）的每一侧上的开放通道（14）对称的构造以及封闭的导向室（16），其中牵引绳（9）被强制地保持。端部支撑板（3）与导轨（11）的轮廓中间接合，并且设置有用作电动机轴承的安装件（4），而拉绳板（7）可旋转地安装在安装件上 4）和马达头（5）。

6. 发明申请

US20130172323A1 PYRIDAZINONES AS GPR119 AGONISTS 有权
标题翻译： PYRIDAZINONES作为GPR119激动剂
公开(公告)号：US20130172323A1
公开(公告)日：2013-07-04
申请号：US13696094
申请日：2011-05-06
申请人： Matthias Grauert , Remko Bakker , Steffen Breitfelder , Frank Buettner , Peter Eickelmann , Thomas Fox , Marc Grundl , Thorsten Lehmann-Lintz , Wolfgang Rist
发明人： Matthias Grauert , Remko Bakker , Steffen Breitfelder , Frank Buettner , Peter Eickelmann , Thomas Fox , Marc Grundl , Thorsten Lehmann-Lintz , Wolfgang Rist
IPC分类号： C07D413/10 , C07D498/04 , C07D417/14 , C07D413/14 , C07D453/02
CPC分类号： C07D413/10 , C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D498/04
摘要： The present invention relates to pyridazinone derivatives of general formula I, wherein the groups A, G and R1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译：本发明涉及通式I的哒嗪酮衍生物，其中基团A，G和R 1如本申请中所定义，其互变异构体，其立体异构体，其混合物及其盐具有有价值的药理学性质，特异性结合GPR119受体并调节其活性。

7. 发明授权

US08772323B2 Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists 有权
标题翻译：苯并恶唑和四氢苯并恶唑取代的哒嗪酮作为GPR119激动剂
公开(公告)号：US08772323B2
公开(公告)日：2014-07-08
申请号：US13696094
申请日：2011-05-06
申请人： Matthias Grauert , Remko Bakker , Steffen Breitfelder , Frank Buettner , Peter Eickelmann , Thomas Fox , Marc Grundl , Thorsten Lehmann-Lintz , Wolfgang Rist
发明人： Matthias Grauert , Remko Bakker , Steffen Breitfelder , Frank Buettner , Peter Eickelmann , Thomas Fox , Marc Grundl , Thorsten Lehmann-Lintz , Wolfgang Rist
IPC分类号： A61K31/423 , C07D263/54
CPC分类号： C07D413/10 , C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D498/04
摘要： The present invention relates to pyridazinone derivatives of general formula I, wherein the groups A, G and R1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译：本发明涉及通式I的哒嗪酮衍生物，其中基团A，G和R 1如本申请中所定义，其互变异构体，其立体异构体，其混合物及其盐具有有价值的药理学性质，特异性结合GPR119受体并调节其活性。

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