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1. 发明申请

US20070078319A1 Method and apparatus for enhancing the integrity of an implantable sensor device 有权
公开(公告)号：US20070078319A1
公开(公告)日：2007-04-05
申请号：US11606837
申请日：2006-11-30
申请人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
发明人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/686 , A61B2562/02 , G01N33/5438 , Y10T29/49002 , Y10T29/49007 , Y10T29/49128 , Y10T29/49155
摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

2. 发明申请

US20050049641A1 Method and apparatus for enhancing the integrity of an implantable sensor device 有权
标题翻译：用于增强可植入传感器装置完整性的方法和装置
公开(公告)号：US20050049641A1
公开(公告)日：2005-03-03
申请号：US10928863
申请日：2004-08-26
申请人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
发明人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
IPC分类号： A61B5/00 , A61N1/00 , C12Q1/68
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/686 , A61B2562/02 , G01N33/5438 , Y10T29/49002 , Y10T29/49007 , Y10T29/49128 , Y10T29/49155
摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
摘要翻译：一种用于增强可植入传感器的完整性的方法和装置。形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。涂层可沉积在传感器引线的表面上，提供加强和润滑。

3. 发明授权

US07162289B2 Method and apparatus for enhancing the integrity of an implantable sensor device 有权
标题翻译：用于增强可植入传感器装置完整性的方法和装置
公开(公告)号：US07162289B2
公开(公告)日：2007-01-09
申请号：US10335574
申请日：2002-12-31
申请人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
发明人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
IPC分类号： A61B5/00 , A61B5/05 , C12M1/00 , C12Q1/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/686 , A61B2562/02 , G01N33/5438 , Y10T29/49002 , Y10T29/49007 , Y10T29/49128 , Y10T29/49155
摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
摘要翻译：一种用于增强可植入传感器的完整性的方法和装置。形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。涂层可沉积在传感器引线的表面上，提供加强和润滑。

4. 发明授权

US07912525B2 Method and apparatus for enhancing the integrity of an implantable sensor device 有权
标题翻译：用于增强可植入传感器装置完整性的方法和装置
公开(公告)号：US07912525B2
公开(公告)日：2011-03-22
申请号：US11606837
申请日：2006-11-30
申请人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
发明人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/686 , A61B2562/02 , G01N33/5438 , Y10T29/49002 , Y10T29/49007 , Y10T29/49128 , Y10T29/49155
摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
摘要翻译：一种用于增强可植入传感器的完整性的方法和装置。形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。涂层可沉积在传感器引线的表面上，提供加强和润滑。

5. 发明授权

US07552522B2 Method of making a sensing apparatus 有权
标题翻译：制造感测装置的方法
公开(公告)号：US07552522B2
公开(公告)日：2009-06-30
申请号：US10928863
申请日：2004-08-26
申请人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
发明人： Rajiv Shah , Yanan Zhang , Rebecca Gottlieb , Bahar Reghabi , Michael Miller
IPC分类号： G01R3/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/686 , A61B2562/02 , G01N33/5438 , Y10T29/49002 , Y10T29/49007 , Y10T29/49128 , Y10T29/49155
摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
摘要翻译：一种用于增强可植入传感器的完整性的方法和装置。形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。涂层可沉积在传感器引线的表面上，提供加强和润滑。

6. 发明申请

US20070079836A1 Reusable Infusion Site and Method of Using the Same 审中-公开
标题翻译：可重复使用注射部位及其使用方法
公开(公告)号：US20070079836A1
公开(公告)日：2007-04-12
申请号：US11610269
申请日：2006-12-13
申请人： Bahar Reghabi , Rajiv Shah , Eunjoo Jin , Rebecca Gottlieb , Michael Miller , Nannette Van Antwerp , Bradley Enegren , William Van Antwerp , John Mastrototaro
发明人： Bahar Reghabi , Rajiv Shah , Eunjoo Jin , Rebecca Gottlieb , Michael Miller , Nannette Van Antwerp , Bradley Enegren , William Van Antwerp , John Mastrototaro
IPC分类号： A61B19/00
CPC分类号： A61B5/14532 , A61B5/076 , A61B5/14503 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61M39/0208
摘要： A reusable analyte sensor site for use with a replaceable analyte sensor for determining a level of an analyte includes a site housing and a resealable insertion site coupled to one end of the site housing. Preferably, the site housing is formed to have an interior cavity, and includes an outer membrane made of a material selected to promote vascularization and having a first pore size, and an inner membrane made of a material selected to be free of tissue ingress. Also, the site housing permits the analyte to pass through the site housing to the interior cavity to permit measurement by the replaceable analyte sensor. The resealable insertion site is provided for inserting the replaceable analyte sensor into the interior cavity of the site housing.
摘要翻译：与用于确定分析物水平的可更换分析物传感器一起使用的可重复使用的分析物传感器位点包括与站点外壳的一端连接的现场外壳和可重新密封的插入位置。优选地，所述部位壳体形成为具有内部空腔，并且包括由选择用于促进血管形成并具有第一孔径的材料制成的外膜和由选择为不具有组织进入的材料制成的内膜。此外，现场外壳允许分析物通过现场外壳进入内腔，以允许通过可更换的分析物传感器进行测量。可重新密封的插入位置用于将可更换的分析物传感器插入到现场外壳的内部空腔中。

7. 发明申请

US20050272989A1 Analyte sensors and methods for making and using them 审中-公开
标题翻译：分析物传感器和制造和使用它们的方法
公开(公告)号：US20050272989A1
公开(公告)日：2005-12-08
申请号：US10861837
申请日：2004-06-04
申请人： Rajiv Shah , Bahar Reghabi , Rebecca Gottlieb , Udo Hoss , John Mastrototaro
发明人： Rajiv Shah , Bahar Reghabi , Rebecca Gottlieb , Udo Hoss , John Mastrototaro
IPC分类号： A61B5/00 , C12Q1/00 , C12Q1/26 , G01N27/30 , G01N33/49 , A61B5/05 , G01N27/26 , G01N33/50
CPC分类号： C12Q1/006 , A61B5/14532 , A61B5/1486 , C12Q1/005 , C12Q1/26 , G01N33/4905
摘要： Embodiments of the invention provide analyte sensors having stabilized coating compositions and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having stabilized glucose oxidase coatings.
摘要翻译：本发明的实施方案提供了具有稳定的涂料组合物的分析物传感器和用于制造和使用这种传感器示例性实施方案包括具有稳定的葡萄糖氧化酶涂层的电化学葡萄糖传感器。

8. 发明授权

US08137927B2 Molded protein material in form of pellet for sensor 有权
标题翻译：用于传感器的颗粒形式的成型蛋白质材料
公开(公告)号：US08137927B2
公开(公告)日：2012-03-20
申请号：US11122172
申请日：2005-05-04
申请人： Rajiv Shah , Bahar Reghabi , Rudy Montalvo , Yanan Zhang
发明人： Rajiv Shah , Bahar Reghabi , Rudy Montalvo , Yanan Zhang
IPC分类号： C12Q1/26 , C12Q1/54 , C12N11/02 , C12M1/34
CPC分类号： C07K1/1077 , C12Q1/54 , Y10S435/817
摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
摘要翻译：一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。

9. 发明申请

US20090081753A1 METHOD FOR FORMULATING AND IMMOBILIZING A MATRIX PROTEIN AND A MATRIX PROTEIN FOR USE IN A SENSOR 有权
标题翻译：用于传感器的矩阵蛋白和矩阵蛋白的制备和固定方法
公开(公告)号：US20090081753A1
公开(公告)日：2009-03-26
申请号：US12179502
申请日：2008-07-24
申请人： Rajiv Shah , Bahar Reghabi , Rudolph A. Montalvo , Yanan Zhang
发明人： Rajiv Shah , Bahar Reghabi , Rudolph A. Montalvo , Yanan Zhang
IPC分类号： C12N11/02 , B28B1/14 , C12M1/34 , C07K14/00
CPC分类号： C07K1/1077 , C12Q1/54 , Y10S435/817
摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
摘要翻译：一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。

10. 发明授权

US07192766B2 Sensor containing molded solidified protein 有权
标题翻译：含有成型凝固蛋白的传感器
公开(公告)号：US07192766B2
公开(公告)日：2007-03-20
申请号：US10033723
申请日：2001-12-27
申请人： Rajiv Shah , Bahar Reghabi , Rudy Montalvo , Yanan Zhang
发明人： Rajiv Shah , Bahar Reghabi , Rudy Montalvo , Yanan Zhang
IPC分类号： C12M1/34 , C12Q1/54 , C12Q1/26 , C12N11/02
CPC分类号： C07K1/1077 , C12Q1/54 , Y10S435/817
摘要： A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
摘要翻译：一种用于配制和固定由该方法形成的蛋白质和蛋白质基质的方法。蛋白质基质制备方法产生物理和化学稳定的蛋白质基质，其具有低溶胀，非浸出，高活性和高机械强度性质。该方法包括将蛋白质混合物交联并硬化，并使用模具将蛋白质形成所需的形状和尺寸。

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