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1. 发明申请

US20080176760A1 PEPTIDE TEMPLATES FOR NANOPARTICLE SYNTHESIS OBTAINED THROUGH PCR-DRIVEN PHAGE DISPLAY METHOD 审中-公开
标题翻译：通过PCR-DRIVEN PHAGE显示方法获得的纳米级合成肽肽模板
公开(公告)号：US20080176760A1
公开(公告)日：2008-07-24
申请号：US12056857
申请日：2008-03-27
申请人： Rajesh R. Naik , Morley O. Stone , Daniel C. Carter
发明人： Rajesh R. Naik , Morley O. Stone , Daniel C. Carter
IPC分类号： C40B30/04 , C07K16/00 , C07H21/04
CPC分类号： C12N15/1037 , B82Y30/00 , C07K7/08
摘要： A method is provided for identifying and isolating peptides capable of binding of inorganic materials such as silica, silver, germanium, cobalt, iron, or oxides thereof, or other materials on a nanometric scale such as carbon nanotubes, using a combinatorial phage display peptide library and a polymerase-chain reaction (PCR) step to obtain specific amino acids sequences. In the method of the invention, a combinatorial phage display library is used to isolate and select the desired binding peptides by a series of steps of target binding of phage with the nanometric material of interest, elution and purification of the bound phages, and amplification using PCR to determine the sequences of phages producing the desired binding peptides. The binding peptides of the invention are particularly advantageous in that they may be used as templates to guide the development of useful structures on a nanometric scale.
摘要翻译：提供了一种方法，用于使用组合噬菌体展示肽文库鉴定和分离能够结合无机材料如二氧化硅，银，锗，钴，铁或其氧化物或纳米级别的其它材料的肽，例如碳纳米管和聚合酶链式反应（PCR）步骤，以获得特定的氨基酸序列。在本发明的方法中，组合噬菌体展示文库用于通过目标结合噬菌体与感兴趣的纳米材料，洗脱和纯化结合的噬菌体的一系列步骤来分离和选择所需的结合肽，并使用 PCR以确定产生所需结合肽的噬菌体的序列。本发明的结合肽是特别有利的，因为它们可以用作模板以指导在纳米尺度上开发有用的结构。

2. 发明授权

US07193037B2 Method and apparatus for use of thermally switching proteins in sensing and detecting devices 失效
标题翻译：用于在感测和检测装置中热切换蛋白质的方法和装置
公开(公告)号：US07193037B2
公开(公告)日：2007-03-20
申请号：US10313010
申请日：2002-12-06
申请人： Lawrence L. Brott , Rajesh R. Naik , Morley O. Stone , Daniel C. Carter
发明人： Lawrence L. Brott , Rajesh R. Naik , Morley O. Stone , Daniel C. Carter
IPC分类号： A61K38/00
CPC分类号： H01L51/428 , B82Y10/00 , G01J5/20 , G01N21/3563 , G01N25/72 , H01L27/305 , H01L27/307 , H01L51/0093 , H01L51/4206 , H01L51/4253 , Y02E10/549
摘要： An apparatus and method for detecting infrared radiation is provided which comprises a temperature-sensing helical coiled-coil protein such as TlpA, CC1, collagen or myosin, incorporated into an electrically conductive film or gel deposited onto an electrically conductive medium such as an electrode, means for recording changes in conductivity or resistance of the conductive film or gel caused by the presence of infrared radiation and the effect of the infrared radiation on the thermal-sensing protein, and means to analyze the changes in conductivity or resistance in the conductive film caused by the infrared radiation so as to determine if infrared radiation is present. By virtue of the present invention, a “biomimetic” infrared sensor is provided which can integrate a recombinantly produced thermally sensitive protein in a conductive polymer matrix, such as a film or gel, so as to provide for the first time a low-cost, lightweight, conformable, and even possibly disposable, infrared detecting device having high sensitivity and excellent dynamic range.
摘要翻译：提供了一种用于检测红外辐射的装置和方法，其包括温度感测螺旋卷曲螺旋蛋白如TlpA，CC1，胶原或肌球蛋白，结合到导电膜或凝胶中沉积到诸如电极的导电介质上，用于记录由红外辐射的存在引起的导电膜或凝胶的电导率或电阻的变化以及红外辐射对热感测蛋白的影响的手段，以及分析导电膜中导电性或电阻变化的手段通过红外辐射来确定是否存在红外辐射。凭借本发明，提供了一种“仿生”红外传感器，其可以将重组产生的热敏蛋白整合到导电聚合物基质如膜或凝胶中，以便首次提供低成本，重量轻，一致，甚至一次性的红外线检测装置具有高灵敏度和优异的动态范围。

3. 发明授权

US08445641B2 Nanocomposites of repeat sequence proteins and phyllosilicate clays and their preparation 有权
公开(公告)号：US08445641B2
公开(公告)日：2013-05-21
申请号：US11990665
申请日：2006-08-22
申请人： Lawrence F. Drummy , Joseph C. McAuliffe , Rajesh R. Naik , Richard A. Vaia
发明人： Lawrence F. Drummy , Joseph C. McAuliffe , Rajesh R. Naik , Richard A. Vaia
IPC分类号： C07K4/12
CPC分类号： A61L27/446 , A61L17/10 , A61L2400/12 , C07K14/43586 , C07K17/14 , C08L89/00
摘要： Nanocomposites of repeat sequence protein polymers and phyllosilicates demonstrated improved material properties, for example, improved elasticity, and are useful as suture, tissue scaffolding, and biodegradable composite materials.

4. 发明授权

US07905943B1 Synthesis of hybrid inorganic nanoparticle structures using peptides 有权
标题翻译：使用肽合成杂化无机纳米颗粒结构
公开(公告)号：US07905943B1
公开(公告)日：2011-03-15
申请号：US12008537
申请日：2008-01-08
申请人： Joseph M. Slocik , Rajesh R. Naik
发明人： Joseph M. Slocik , Rajesh R. Naik
IPC分类号： B22F9/24
CPC分类号： B22F9/24 , B22F1/0018 , B22F1/025 , B22F2001/0037 , B82Y30/00 , Y10S977/705
摘要： Bimetallic hybrid nanostructures exhibit enhanced properties beyond a single composition nanoparticle, but present technical challenges for synthesis that includes the ability to process two or more materials while offering control over structural arrangement. Unlike conventional synthetic strategies, biological systems are excellent manufacturers of complex inorganic materials which possess maximal functionality, quality, and structures. Using a bio-mediated approach, Applicants have developed a synthetic method for the controlled synthesis of bimetallic nanostructures using multifunctional peptides.
摘要翻译：双金属杂合纳米结构表现出超越单一组成纳米颗粒的增强性能，但目前的综合技术挑战包括处理两种或更多种材料同时提供结构布置控制的能力。不同于传统的合成策略，生物系统是具有最大功能，质量和结构的复杂无机材料的优秀制造商。使用生物介导的方法，申请人已经开发了使用多功能肽来控制合成双金属纳米结构的合成方法。

5. 发明授权

US08273319B1 Enrichment of specific chirality single wall carbon nanotubes with genomic DNA 有权
标题翻译：用基因组DNA富集特异性手性单壁碳纳米管
公开(公告)号：US08273319B1
公开(公告)日：2012-09-25
申请号：US12843182
申请日：2010-07-26
申请人： Sang N. Kim , Rajesh R. Naik , James G. Grote , Barry L. Farmer
发明人： Sang N. Kim , Rajesh R. Naik , James G. Grote , Barry L. Farmer
IPC分类号： D01F9/12
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/172 , C01B32/174 , C01B2202/02
摘要： An improved method for enriched chirality of single wall carbon nanotubes is described. Genomic DNA, particularly salmon DNA (SaDNA) is shown to sort out single wall carbon nanotubes of specific chirality by a process of solubilization (dissolving in solution) and separation (such as centrifuging), without requiring more complex processes such as anion exchange chromatography. A possible reason for enhanced chirality separation using DNA may be attributed to its lowered GC (guanine-cytosine) content.
摘要翻译：描述了改进的单壁碳纳米管富集手性的方法。基因组DNA，特别是鲑鱼DNA（SaDNA）显示出通过溶解（溶解）和分离（如离心）的过程，整理出具有特定手性的单壁碳纳米管，而不需要更复杂的过程如阴离子交换色谱法。使用DNA增强手性分离的一个可能原因可归因于其降低的GC（鸟嘌呤 - 胞嘧啶）含量。

6. 发明授权

US08137597B1 One-part, pressure activated chemiluminescent material 有权
标题翻译：一部分，压力活化化学发光材料
公开(公告)号：US08137597B1
公开(公告)日：2012-03-20
申请号：US12787418
申请日：2010-05-26
申请人： Lawrence L. Brott , Brian E. O'Toole , Christopher A. Vaiana , Rajesh R. Naik
发明人： Lawrence L. Brott , Brian E. O'Toole , Christopher A. Vaiana , Rajesh R. Naik
IPC分类号： C09K3/00
CPC分类号： F21K2/06
摘要： A one-part, pressure activated chemiluminescent material is disclosed. The free-flowing powder is made by coating microcapsules, filled with a solvent and dye, with a powdered oxalate and a solid source for hydrogen peroxide. The reaction begins when the capsules are crushed, releasing the solvent, which dissolves the oxalate and the source for hydrogen peroxide. The resulting reaction transfers energy to the dye, which produces light.
摘要翻译：公开了一部分压力活化化学发光材料。自由流动的粉末通过用填充有溶剂和染料的微胶囊与草酸粉末和用于过氧化氢的固体源一起来制备。当胶囊被粉碎时，反应开始，释放溶剂，溶解草酸盐和过氧化氢源。所得到的反应将能量转移到染料上，产生光。

7. 发明申请

US20090312455A1 Nanocomposites of repeat sequence proteins and phyllosilicate clays and their preparation 有权
标题翻译：重复序列蛋白和页硅酸盐粘土的纳米复合物及其制备
公开(公告)号：US20090312455A1
公开(公告)日：2009-12-17
申请号：US11990665
申请日：2006-08-22
申请人： Lawrence F. Drummy , Joseph C. McAuliffe , Rajesh R. Naik , Richard A. Vaia
发明人： Lawrence F. Drummy , Joseph C. McAuliffe , Rajesh R. Naik , Richard A. Vaia
IPC分类号： C08K3/34 , C08L89/00
CPC分类号： A61L27/446 , A61L17/10 , A61L2400/12 , C07K14/43586 , C07K17/14 , C08L89/00
摘要： Nanocomposites of repeat sequence protein polymers and phyllosilicates demonstrated improved material properties, for example, improved elasticity, and are useful as suture, tissue scaffolding, and biodegradable composite materials.
摘要翻译：重复序列蛋白聚合物和页硅酸盐的纳米复合材料表现出改善的材料性质，例如改善的弹性，并且可用作缝合线，组织支架和可生物降解的复合材料。

8. 发明授权

US08716029B1 Carbon nanotube sensors employing synthetic multifunctional peptides for surface functionalization 有权
标题翻译：使用合成多功能肽进行表面官能化的碳纳米管传感器
公开(公告)号：US08716029B1
公开(公告)日：2014-05-06
申请号：US13235561
申请日：2011-09-19
申请人： Steve S. Kim , Zhifeng Kuang , Rajesh R. Naik , Barry L. Farmer
发明人： Steve S. Kim , Zhifeng Kuang , Rajesh R. Naik , Barry L. Farmer
IPC分类号： C12M1/00
CPC分类号： G01N33/5306
摘要： A biosensor that utilizes carbon nanotubes functionalized with a protein sequence. One domain of the multifunctional peptide sequence noncovalently binds to the surface of single-walled carbon nanotubes (SWNTs), while a second domain of the sequence recognizes and binds to a target molecule. The sequence of the peptide may be tailored to allow it to recognize and bind to specific target molecules, such as chemicals, biological materials, and explosives. The binding of the target molecule to the peptide may alter a material property of the SWNTs.
摘要翻译：利用蛋白质序列功能化的碳纳米管的生物传感器。多功能肽序列的一个结构域非共价结合单壁碳纳米管（SWNT）的表面，而序列的第二结构域识别并结合靶分子。肽的序列可以被定制以允许其识别并结合特定的靶分子，例如化学物质，生物材料和爆炸物。靶分子与肽的结合可能改变SWNT的材料性质。

9. 发明授权

US07976727B1 Chromium-doped zinc-nitro-antimony-gallium-tellurium infrared phosphors 有权
标题翻译：铬掺杂的锌 - 硝基锑镓碲红外荧光粉
公开(公告)号：US07976727B1
公开(公告)日：2011-07-12
申请号：US12862869
申请日：2010-08-25
申请人： Rajesh R. Naik , Lawrence L. Brott , George D. Jia
发明人： Rajesh R. Naik , Lawrence L. Brott , George D. Jia
IPC分类号： C09K11/70 , C09K11/77
CPC分类号： C09K11/883 , C09K11/623 , C09K11/7756
摘要： This patent covers infrared phosphorescent materials which exhibit extended persistence lifetimes and are composed of mixtures of the elements zinc, antimony, gallium, tellurium, oxygen and nitrogen, and are doped with varying amounts of chromium, neodymium, dysprosium, yttrium or thulium. A typical formula is given by Zn(1-n %-m %-l %)SbxGa2-xTezO4+2z-yNy: n % Cr3+, m % P, l % Q, where Zn is zinc, Sb is antimony, Ga is gallium, Te is tellurium, O is oxygen, N is nitrogen. Additionally, x (0 to 2) y (0 to 0.5) and z (0 to 1) are the molar concentration in the composition. Cr3+ is the doped chromium ion, P is a codopant and Q is a second codopant and n, m, l are the concentration respectively (m,m,l are from 0.1 to 10). An example is the material ZnSbGaTeO5.95N0.05:3% Cr3+, 1% Nd3+, which has an emission peak at 760 nm and a persistent time of over 20 hours (measured with Fluorolog-3 spectrometer with a PMT detector).
摘要翻译：该专利涉及具有延长的持续寿命并且由元素锌，锑，镓，碲，氧和氮的混合物组成的红外磷光材料，并且掺杂有不同量的铬，钕，镝，钇或。。典型的配方由Zn（1-n％-m％-1％）SbxGa2-xTezO4 + 2z-yNy：n％Cr3 +，m％P，1％Q给出，其中Zn是锌，Sb是锑，Ga是镓，Te是碲，O是氧，N是氮。另外，x（0至2）y（0至0.5）和z（0至1）是组合物中的摩尔浓度。 Cr3 +是掺杂的铬离子，P是共掺杂物，Q是第二共轭体，n，m，l分别是浓度（m，m，l是从0.1到10）。一个例子是材料ZnSbGaTeO5.95N0.05：3％Cr3 +，1％Nd3 +，其在760nm处具有发射峰，并且持续时间超过20小时（用具有PMT检测器的Fluorolog-3光谱仪测量）。

10. 发明授权

US07314735B2 Identification and characterization of reflectin proteins from squid reflective tissues 有权
标题翻译：来自鱿鱼反射组织的反射蛋白的鉴定和表征
公开(公告)号：US07314735B2
公开(公告)日：2008-01-01
申请号：US11070723
申请日：2005-03-01
申请人： Wendy J. Goodson , Margaret McFall-Ngai , Jennifer Kimbell , Joseph Horwitz , Ryan Kramer , Rajesh R. Naik
发明人： Wendy J. Goodson , Margaret McFall-Ngai , Jennifer Kimbell , Joseph Horwitz , Ryan Kramer , Rajesh R. Naik
IPC分类号： C12P21/06 , C07K14/00 , G01N33/53
CPC分类号： C07K14/43504
摘要： A family of reflectin proteins is identified herein that is deposited in flat, structural platelets in reflective tissues of the squid Euprymna scolopes. These proteins are encoded by at least six genes in three subfamilies and have no reported homologues outside of squids. Reflectins possess 5 repeating domains, that are remarkably conserved among members of the family. The proteins have a highly unusual composition with four relatively rare residues (tyrosine, methionine, arginine, and tryptophan) comprising ˜57% of a reflectin, and several common residues (alanine, isoleucine, leucine, and lysine) occurring in none of the family members. These protein-based reflectors in squids provide a striking example of nanofabrication in animal systems.
摘要翻译：本文鉴定了一系列反射蛋白，其沉积在鱿鱼Euprymna sc in的反射组织中的平坦结构血小板中。这些蛋白质由三个亚家族中的至少六个基因编码，并且在鱿鱼之外没有报道的同系物。 Reflectins拥有5个重复的领域，在家庭成员中是非常保守的。这些蛋白质具有非常不寻常的组成，其中包含约57％的反射蛋白的四种相对罕见的残基（酪氨酸，甲硫氨酸，精氨酸和色氨酸），以及几种常见的残基（丙氨酸，异亮氨酸，亮氨酸和赖氨酸）都不存在于家族中会员鱿鱼中的这些基于蛋白质的反射器提供了动物系统中纳米制造的突出例子。

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