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1. 发明申请

US20060111337A1 Substituted biaryl quinolin-4-ylamine analogues 有权
标题翻译：取代的联芳基喹啉-4-基胺类似物
公开(公告)号：US20060111337A1
公开(公告)日：2006-05-25
申请号：US11250135
申请日：2005-10-12
申请人： Rajagopal Bakthavatchalam , Timothy Caldwell , Bertrand Chenard , Kevin Hodgetts , Scott Capitosti
发明人： Rajagopal Bakthavatchalam , Timothy Caldwell , Bertrand Chenard , Kevin Hodgetts , Scott Capitosti
IPC分类号： A61K31/506 , A61K31/5377 , A61K31/501 , A61K31/498 , A61K31/497 , A61K31/496 , A61K31/4745 , C07D471/02 , C07D487/02
CPC分类号： C07D471/04 , C07D401/04 , C07D401/12 , C07D401/14
摘要： Substituted biaryl quinolin-4-ylamine analogues of Formula I are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供式I的取代的联芳基喹啉-4-基胺类似物。这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

2. 发明申请

US20050070547A1 Substituted quinolin-4-ylamine analogues 失效
标题翻译：取代的喹啉-4-基胺类似物
公开(公告)号：US20050070547A1
公开(公告)日：2005-03-31
申请号：US10891832
申请日：2004-07-14
申请人： Rajagopal Bakthavatchalam , Timothy Caldwell , Bertrand Chenard , Stephane De Lombaert , Kevin Hodgetts
发明人： Rajagopal Bakthavatchalam , Timothy Caldwell , Bertrand Chenard , Stephane De Lombaert , Kevin Hodgetts
IPC分类号： A61K31/4745 , A61K31/498 , C07D401/04 , C07D471/02 , C07D471/04 , C07D491/14
CPC分类号： C07D401/04 , C07D215/44 , C07D471/04 , C07D491/14
摘要： Substituted quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders-are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供取代的喹啉-4-基胺类似物。这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。提供了用于治疗这种疾病的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

3. 发明申请

US20060194805A1 Capsaicin receptor agonists 审中-公开
标题翻译：辣椒素受体激动剂
公开(公告)号：US20060194805A1
公开(公告)日：2006-08-31
申请号：US11412526
申请日：2006-04-26
申请人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , Timothy Caldwell , Daniel Cortright , Kevin Hodgetts , John Peterson , Xiaozhang Zheng
发明人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , Timothy Caldwell , Daniel Cortright , Kevin Hodgetts , John Peterson , Xiaozhang Zheng
IPC分类号： A61K31/525 , A61K31/517 , A61K31/519 , A61K31/498 , C07D475/10 , C07D487/02
CPC分类号： C04B35/632 , C07D215/44 , C07D239/94 , C07D401/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D475/06
摘要： Capsaicin receptor agonists are provided. Such compounds are ligands that may be used to modulate VR1 activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to capsaicin receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供辣椒素受体激动剂。这样的化合物是可用于在体内或体外调节VR1活性的配体，并且特别可用于治疗对人，驯养的伴侣动物和家畜中的辣椒素受体激活有反应的病症。还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

4. 发明申请

US20080015183A1 SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES 审中-公开
标题翻译：取代的喹唑啉-4-亚胺类似物
公开(公告)号：US20080015183A1
公开(公告)日：2008-01-17
申请号：US11864987
申请日：2007-09-29
申请人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , Timothy Caldwell , Stephane De Lombaert , Kevin Hodgetts , Xiaozhang Zheng , James Krause , Uri Herzberg , Taeyoung Yoon
发明人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , Timothy Caldwell , Stephane De Lombaert , Kevin Hodgetts , Xiaozhang Zheng , James Krause , Uri Herzberg , Taeyoung Yoon
IPC分类号： A61K31/517 , A61K31/47 , A61K31/519 , A61K31/541 , A61P11/14 , A61P17/02 , C07D215/58 , C07D237/30 , C07D279/12 , C07D471/04 , C07D417/12 , C07D413/14 , C07D413/10 , C07D401/14 , C07D401/10 , C07D239/84 , C07D223/04 , A61P25/04 , A61P11/16 , A61K31/55 , A61K31/5377 , A61K31/502
CPC分类号： C07D401/04 , C07D215/42 , C07D215/44 , C07D237/34 , C07D239/94 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D471/04
摘要： Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供了取代的喹唑啉-4-基胺类似物。这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

5. 发明申请

US20060089354A1 Carboxylic acid, phosphate or phosphonate substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators 失效
标题翻译：羧酸，磷酸酯或膦酸酯取代的喹唑啉-4-基胺类似物作为辣椒素受体调节剂
公开(公告)号：US20060089354A1
公开(公告)日：2006-04-27
申请号：US10539031
申请日：2003-12-12
申请人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , Timothy Caldwell , Stephane DeLombaert , Kevin Hodgetts , Xiaozhang Zheng
发明人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , Timothy Caldwell , Stephane DeLombaert , Kevin Hodgetts , Xiaozhang Zheng
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/4745 , A61K31/4709 , C07D487/02 , C07D413/02 , C07D401/02 , C07D471/02
CPC分类号： C07D417/14 , C07D239/94 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D491/10 , C07F9/65128 , C07F9/65583 , C07F9/6561
摘要： Acid-substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供了酸取代的喹唑啉-4-基胺类似物。这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

6. 发明申请

US20060173003A1 Substituted quinazolin-4-ylamine analogues 有权
公开(公告)号：US20060173003A1
公开(公告)日：2006-08-03
申请号：US11345926
申请日：2006-02-01
申请人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , Timothy Caldwell , Stephane De Lombaert , Kevin Hodgetts , Xiaozhang Zheng , James Krause , Uri Herzberg
发明人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , Timothy Caldwell , Stephane De Lombaert , Kevin Hodgetts , Xiaozhang Zheng , James Krause , Uri Herzberg
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/517 , C07D413/02 , C07D487/02 , C07D403/02
CPC分类号： C07D401/04 , C07D215/42 , C07D215/44 , C07D237/34 , C07D239/94 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D471/04
摘要： Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

7. 发明申请

US20080085901A1 Heteroaryl Substituted Quinolin-4-Ylamine Analogues 审中-公开
标题翻译：杂芳基取代喹啉-4-胺类似物
公开(公告)号：US20080085901A1
公开(公告)日：2008-04-10
申请号：US11795269
申请日：2006-01-13
申请人： Timothy Caldwell , Bertrand Chenard , Kevin Hodgetts
发明人： Timothy Caldwell , Bertrand Chenard , Kevin Hodgetts
IPC分类号： A61K31/497 , A61K31/47 , A61P25/00 , C07D401/00 , C07D471/02 , C07D471/00 , C07D215/38 , A61K31/495
CPC分类号： C07D471/04 , C07D417/14
摘要： Heteroaryl substituted quinolin-4-ylamine analogues of Formula I are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供式I的杂芳基取代的喹啉-4-基胺类似物。这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

8. 发明申请

US20060229298A1 Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues 失效
公开(公告)号：US20060229298A1
公开(公告)日：2006-10-12
申请号：US11436099
申请日：2006-05-17
申请人： Alan Hutchison , Linda Gustavson , John Peterson , Dario Dollar , Timothy Caldwell , Taeyoung Yoon , Wallace Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl Steenstra , Helen Yin , Robert DeSimone , Xiao-shu He
发明人： Alan Hutchison , Linda Gustavson , John Peterson , Dario Dollar , Timothy Caldwell , Taeyoung Yoon , Wallace Pringle , Rajagopal Bakthavatchalam , Yiping Shen , Cheryl Steenstra , Helen Yin , Robert DeSimone , Xiao-shu He
IPC分类号： A61K31/496 , A61K31/551 , A61K31/495 , C07D403/02
CPC分类号： C07D513/04 , C07D209/86 , C07D211/52 , C07D213/64 , C07D213/74 , C07D215/12 , C07D215/20 , C07D243/08 , C07D295/096 , C07D295/108 , C07D311/18 , C07D317/58 , C07D401/12 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

9. 发明申请

US20100227527A1 Robotic Marionettes on Magnetically-Supported and Highly Mobile Puppeteer Platforms 有权
标题翻译：关于磁支持和高度移动的Puppeteer平台的机器人木偶
公开(公告)号：US20100227527A1
公开(公告)日：2010-09-09
申请号：US12397990
申请日：2009-03-04
申请人： Lanny S. Smoot , Timothy Caldwell , Gary W. Schnuckle
发明人： Lanny S. Smoot , Timothy Caldwell , Gary W. Schnuckle
IPC分类号： A63J19/00
CPC分类号： A63F7/0088 , A63F9/34 , A63F2003/00662 , A63J19/00
摘要： An apparatus for suspending and positioning marionettes. The apparatus includes a thin, planar support membrane such as a plastic sheet. A tender vehicle is positioned on the upper side of the support membrane. A motor or other drive mechanism selectively positions the tender vehicle relative to the support membrane. The apparatus includes a puppeteer vehicle from which a marionette is suspended. The puppeteer vehicle is positioned proximate to the lower side of the support membrane opposite the tender vehicle. To support the puppeteer vehicle, one or both of the vehicles includes one or more rotatable magnetic elements such that the attractive forces support the weight of the puppeteer vehicle and the marionette. Typically, the puppeteer vehicle is a passive follower, and the drive mechanism of the tender vehicle includes motors to move the magnetic elements and position the tender and following puppeteer vehicle with its marionette to provide a show.
摘要翻译：用于悬挂和定位牵线木偶的装置。该装置包括薄的平面支撑膜，例如塑料片。招标车位于支撑膜的上侧。马达或其他驱动机构选择性地将招标车辆相对于支撑膜定位。该装置包括木偶车辆，牵引木马从该木偶车辆悬挂。木偶车辆定位在支撑膜的与招标车辆相对的下侧附近。为了支持木偶车辆，一个或两个车辆包括一个或多个可旋转的磁性元件，使得吸引力支撑木偶车辆和牵线木偶的重量。通常，木偶车辆是被动跟随器，招标车辆的驱动机构包括用于移动磁性元件的马达，并且使用其牵线木偶定位招标和跟随木偶车辆以提供展示。

10. 发明申请

US20070203133A1 Substituted 5,12-diaza-benzoanthracene analogues 审中-公开
标题翻译：取代的5,12-二氮杂 - 苯并蒽类似物
公开(公告)号：US20070203133A1
公开(公告)日：2007-08-30
申请号：US10592297
申请日：2005-03-11
申请人： Timothy Caldwell
发明人： Timothy Caldwell
IPC分类号： A61K31/5383 , A61K31/5377 , A61K31/496 , A61K31/498 , A61K31/4745 , C07D491/22 , C07D471/22
CPC分类号： C07D498/14 , C07D471/12 , C07D471/14 , C07D491/22 , C07D498/04
摘要： Substituted 5,12-diaza-benzoanthracene analogues are provided, of the Formula (I) wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译：提供了取代的5,12-二氮杂 - 苯并蒽类似物，其中变量如本文所述。这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

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