专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5686410A Polypeptide derivatives 失效
标题翻译：多肽衍生物
公开(公告)号：US5686410A
公开(公告)日：1997-11-11
申请号：US276280
申请日：1994-07-18
申请人： Rainer Albert , Wilfried Bauer , Janos Pless
发明人： Rainer Albert , Wilfried Bauer , Janos Pless
IPC分类号： A61K47/48 , A61K51/08 , A61K38/18 , C07K14/485
CPC分类号： A61K47/48276 , A61K47/48238 , A61K51/088 , A61K2121/00 , A61K2123/00
摘要： A biologically active peptide selected from growth factors, peptide hormones, interferons and cytokines and analogues and derivatives thereof, and bearing at least one chelating group linked to an amino group of said peptide, the chelating group being capable of complexing a detectable element and such amino group having no significant binding affinity to target receptors, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of target tissues or for therapy.
摘要翻译：选自生长因子，肽激素，干扰素和细胞因子及其类似物和衍生物的生物活性肽，并且具有与所述肽的氨基连接的至少一个螯合基团，所述螯合基团能够络合可检测元件，并且所述氨基与靶受体没有显着结合亲和力的基团与可检测元件复合并且可用作药物，例如，用于靶组织的体内成像或用于治疗的放射性药物。

2. 发明授权

US5656721A Peptide derivatives 失效
标题翻译：肽衍生物
公开(公告)号：US5656721A
公开(公告)日：1997-08-12
申请号：US272704
申请日：1994-07-07
申请人： Rainer Albert , Wilfried Bauer , Francois Cardinaux , Monika Mergler , Janos Pless , Walter Prikoszovich
发明人： Rainer Albert , Wilfried Bauer , Francois Cardinaux , Monika Mergler , Janos Pless , Walter Prikoszovich
IPC分类号： A61K31/70 , A61K38/00 , A61K38/04 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/43 , A61K38/55 , A61P1/00 , A61P1/04 , A61P3/08 , A61P5/00 , A61P9/00 , C07K1/00 , C07K1/02 , C07K1/107 , C07K1/113 , C07K1/12 , C07K7/06 , C07K7/16 , C07K9/00 , C07K14/00 , C07K14/52 , C07K14/575 , C07K14/585 , C07K14/60 , C07K14/62 , C07K14/655 , C07K17/08 , A61K38/31
CPC分类号： C07K9/00 , C07K1/1077 , Y02P20/55
摘要： The present invention provides a sugar derivative of a biologically active peptide, which derivative has a prolonged duration of action when compared to the non-sugar modified peptide, and contains at least on one of the amino acid units a sugar residue which is attached to an amino group thereof by a coupling other than a direct N-glycosidic bond, and additionally, when it is a condensation product of a carboxyl group containing sugar and a peptide with less than 8 amino acid units, by a coupling other than a direct amide bond.
摘要翻译：本发明提供了一种生物活性肽的糖衍生物，该衍生物与非糖修饰肽相比具有延长的作用时间，并且在至少一个氨基酸单元上含有连接到通过除直接N-糖苷键以外的偶联的氨基，此外，当它是含羧基的糖和小于8个氨基酸单元的肽的缩合产物时，通过除直接酰胺键之外的偶联。

3. 发明授权

US5541159A Calcitonin derivatives 失效
标题翻译：降钙素衍生物
公开(公告)号：US5541159A
公开(公告)日：1996-07-30
申请号：US346118
申请日：1994-11-29
申请人： Rainer Albert , Wilfried Bauer , Fran.cedilla.ois Cardinaux , Janos Pless
发明人： Rainer Albert , Wilfried Bauer , Fran.cedilla.ois Cardinaux , Janos Pless
IPC分类号： A61K38/23 , A61K38/00 , A61K38/04 , A61P1/00 , A61P3/00 , A61P43/00 , C07K1/02 , C07K1/06 , C07K1/113 , C07K7/23 , C07K9/00 , C07K14/575 , C07K14/585 , A61K8/23
CPC分类号： C07K9/005 , C07K14/585 , C07K7/23 , C07K9/001 , A61K38/00
摘要： Peptide derivatives selected from (i) a calcitonin peptide and a LHRH antagonist peptide modified by at least one sugar residue and/or at least one short polyhydroxy compound or derivative, and (ii) a calcitonin peptide modified by at least one formyl and/or at least C.sub.3-5 alkyl attached to an amino group other than a N-terminal amino group, and (iii) a calcitonin peptide modified by a combination of said substituents, with the provisos thati) when the calcitonin peptide comprises at least one sugar residue a), this sugar residue is attached by a coupling other than a direct N-glycosidic bond to an .omega.-amino group of an .omega.-amino substituted side chain in the 24 position, andii) when the LHRH antagonist comprises at least one sugar residue a), this sugar residue is an Amadori sugar residue attached by a coupling other than a direct N-glycosidic bond to an .omega.-amino group of an .omega.-amino substituted side chain in the 8 positionin free form or in salt or complex form, have pharmacological activity.
摘要翻译：选自（i）由至少一种糖残基和/或至少一种短多羟基化合物或衍生物修饰的降钙素肽和LHRH拮抗剂肽的肽衍生物，和（ii）通过至少一种甲酰基和/或至少C3-5烷基连接到除了N-末端氨基以外的氨基，和（iii）通过所述取代基的组合修饰的降钙素肽，条件是i）当降钙素肽包含至少一个糖残基 a），该糖残基通过除了直接N-糖苷键之外的偶联与在24位的ω-氨基取代侧链的ω-氨基连接，和ii）当LHRH拮抗剂包含至少一种糖残基a），该糖残基是通过除直接N-糖苷键之外的偶联与游离形式的8位的ω-氨基取代侧链的ω-氨基或盐或复合物连接的阿马多糖残基形式，有p 有害活动。

4. 发明授权

US5776894A Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors 失效
标题翻译：螯合生长抑素肽及其复合物，含有它们的药物组合物及其在治疗肿瘤中的用途
公开(公告)号：US5776894A
公开(公告)日：1998-07-07
申请号：US479052
申请日：1995-06-06
申请人： Rainer Albert , Eric P. Krenning , Steven W. J. Lamberts , Janos Pless
发明人： Rainer Albert , Eric P. Krenning , Steven W. J. Lamberts , Janos Pless
IPC分类号： A61K38/00 , A61K51/08 , C07K14/655 , A61K38/04 , A61K38/31 , C07K7/08
CPC分类号： A61K51/088 , A61K51/0478 , A61K51/0482 , A61K51/083 , C07K14/6555 , A61K2121/00 , A61K2123/00 , A61K38/00
摘要： Somatostatin peptides bearing at least one chelating group for a detectable element, said chelating group being linked to an amino group of said peptide, and said amino group having no significant binding affinity for somatostatin receptors, in free or salt form, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of somatostatin receptor positive tumors or for therapy.
摘要翻译：具有至少一个可检测元素螯合基团的生长抑素肽，所述螯合基团与所述肽的氨基连接，并且与游离或盐形式的生长抑素受体无显着结合亲和力的所述氨基与可检测的组合物复合元素，并且可用作药物，例如用于体内成像生长抑素受体阳性肿瘤或用于治疗的放射性药物。

5. 发明授权

US5753627A Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis 失效
标题翻译：使用某些复合生长抑素肽进行生长抑素受体阳性肿瘤和转移的体内成像
公开(公告)号：US5753627A
公开(公告)日：1998-05-19
申请号：US470099
申请日：1995-06-06
申请人： Rainer Albert , Eric P. Krenning , Steven W. J. Lamberts , Janos Pless
发明人： Rainer Albert , Eric P. Krenning , Steven W. J. Lamberts , Janos Pless
IPC分类号： A61K38/00 , C07K14/655 , C07K7/08 , C07K7/50
CPC分类号： C07K14/6555 , A61K38/00
摘要： Somatostatin peptides bearing at least one chelating group for a detectable element, said chelating group being linked to an amino group of said peptide, and said amino group having no significant binding affinity for somatostatin receptors, in free or salt form, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of somatostatin receptor positive tumors or for therapy.
摘要翻译：具有至少一个可检测元素螯合基团的生长抑素肽，所述螯合基团与所述肽的氨基连接，并且与游离或盐形式的生长抑素受体无显着结合亲和力的所述氨基与可检测的组合物复合元素，并且可用作药物，例如用于体内成像生长抑素受体阳性肿瘤或用于治疗的放射性药物。

6. 发明授权

US07939625B2 Somatostatin analogues 有权
标题翻译：生长抑素类似物
公开(公告)号：US07939625B2
公开(公告)日：2011-05-10
申请号：US12265135
申请日：2008-11-05
申请人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
摘要翻译：本发明提供任选以保护形式的环[{4-（NH 2 -C 2 H 4 -NH-CO-O-）Pro} -Phg-DTrp-Lys-Tyr（4-苄基）-Phe]或其药学上可接受的盐或其复合物，其具有有趣的药物性质。

7. 发明申请

US20080318838A1 PEPTIDES 审中-公开
公开(公告)号：US20080318838A1
公开(公告)日：2008-12-25
申请号：US12169134
申请日：2008-07-08
申请人： Wilfried Bauer , Robin Breckenridge , Francois Cardinaux , Frank Gombert , Hermann Gram , Paul Ramage , Helmut Schneider , Rudolf Waelchli , Rainer Albert , Ian Lewis
发明人： Wilfried Bauer , Robin Breckenridge , Francois Cardinaux , Frank Gombert , Hermann Gram , Paul Ramage , Helmut Schneider , Rudolf Waelchli , Rainer Albert , Ian Lewis
IPC分类号： A61K38/00 , C07K7/00 , C12P21/04 , C12N15/11 , A61P19/00 , C12N15/00 , C12N1/20
CPC分类号： C07K14/005 , A61K38/00 , C07K14/635 , C07K2319/00 , C07K2319/50 , C07K2319/75 , C12N2795/10222
摘要： PTH compounds having PTH-like activity and comprising at least one modification, said modification being either 1. at least one radical selected from a L- or D-α-amino acid, C2-6alcoxycarbonyl and optionally substituted C1-8alkyl, C2-8alkenyl, C2-8alkynyl, aralkyl, aralkenyl or C3-6cycloalkyl-C1-4alkyl and attached to the terminal amino group of the PTH compound, and/or at least one radical selected from C2-6alcoxycarbonyl and optionally substituted C1-8alkyl, C2-8alkenyl, C2-8alkynyl, aralkyl, aralkenyl or C3-6cycloalkyl-C1-4alkyl and attached to one or more side chain amino groups of the PTH compound, or 2. at least one α-amino acid unit in the positions 1 to 38 of a naturally occurring PTH sequence being replaced by a natural or unnatural amino acid unit optionally in protected form, whereby the α-amino acid units present in positions 1 and 2 at the amino terminus of the PTH sequence may be replaced by a pseudo-peptide, or a combination of such modifications, in free form or in salt form, have pharmacological activity, e.g. for preventing or treating all bone conditions which are associated with increased calcium depletion or resorption or in which calcium fixation in the bone is desirable.
摘要翻译：具有PTH样活性并且包含至少一个修饰的PTH化合物，所述修饰是1.至少一个选自L-或D-α-氨基酸，C2-6羰基和任选取代的C 1-8烷基的基团，C 2-8烯基，C 2-8炔基，芳烷基，芳烯基或C 3-6环烷基-C 1-4烷基，并且连接到PTH化合物的末端氨基，和/或至少一个选自C 2-6烷氧基羰基和任选取代的C 1-8烷基基团，C 2-8烯基，C 2-8炔基，芳烷基，芳烯基或C 3-6环烷基-C 1-4烷基，并且连接到PTH化合物的一个或多个侧链氨基，或2个至少一个α-氨基酸单元的位置1至38 天然存在的PTH序列被任选以保护形式的天然或非天然氨基酸单元替代，由此存在于PTH序列的氨基末端的位置1和2中的α-氨基酸单元可被假肽替代，或这些修改的组合，免费的 m或盐形式，具有药理活性，例如。用于预防或治疗与增加的钙耗竭或吸收相关的所有骨骼状况或其中期望骨中的钙固定。

8. 发明申请

US20110166320A1 SOMATOSTATIN ANALOGUES 审中-公开
公开(公告)号：US20110166320A1
公开(公告)日：2011-07-07
申请号：US13048935
申请日：2011-03-16
申请人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.

9. 发明申请

US20110172157A1 SOMATOSTATIN ANALOGUES 有权
公开(公告)号：US20110172157A1
公开(公告)日：2011-07-14
申请号：US13048932
申请日：2011-03-16
申请人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： A61K38/12 , A61P35/00 , A61P1/02 , A61P19/00
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
摘要翻译：本发明提供任选以保护形式的环[{4-（NH 2 -C 2 H 4 -NH-CO-O-）Pro} -Phg-DTrp-Lys-Tyr（4-苄基）-Phe]或其药学上可接受的盐或其复合物，其具有有趣的药物性质。

10. 发明授权

US07473761B2 Somatostatin analogues 有权
标题翻译：生长抑素类似物
公开(公告)号：US07473761B2
公开(公告)日：2009-01-06
申请号：US10343288
申请日：2001-07-30
申请人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
发明人： Rainer Albert , Wilfried Bauer , David Bodmer , Christian Bruns , Ivo Felner , Heribert Hellstern , Ian Lewis , Mark Meisenbach , Gisbert Weckbecker , Bernhard Wietfeld
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , A61K38/00 , C07K14/655 , Y02P20/55
摘要： The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical properties.
摘要翻译：本发明提供任选以保护形式的环[{4-（NH 2 -C 2 H 4 -NH-CO-O-）Pro} -Phg-DTrp-Lys-Tyr（4-苄基）-Phe]或其药学上可接受的盐或其复合物，其具有有趣的药物性质。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式