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1. 发明申请

US20080269879A1 Implantable Prosthetic Vascular Valve 审中-公开
标题翻译：植入式假体血管瓣膜
公开(公告)号：US20080269879A1
公开(公告)日：2008-10-30
申请号：US11996791
申请日：2006-07-26
申请人： Rahul Dilip Sathe , David N. Ku
发明人： Rahul Dilip Sathe , David N. Ku
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2475
摘要： The present disclosure generally relates to implantable, prosthetic vascular valves, methods of making the valves, and methods of using the valves, in particular, in the human venous system.
摘要翻译：本公开总体上涉及可植入的假体血管瓣膜，制造瓣膜的方法，以及特别是在人静脉系统中使用瓣膜的方法。

2. 发明授权

US07910124B2 Load bearing biocompatible device 有权
标题翻译：承重生物兼容设备
公开(公告)号：US07910124B2
公开(公告)日：2011-03-22
申请号：US11053409
申请日：2005-02-07
申请人： Barbara D. Boyan , Robert E. Guldberg , Stephen J. Kennedy , David N. Ku , Zvi Schwartz
发明人： Barbara D. Boyan , Robert E. Guldberg , Stephen J. Kennedy , David N. Ku , Zvi Schwartz
IPC分类号： A61F2/32
CPC分类号： A61L27/56 , A61F2/3094 , A61F2/442 , A61F2002/30011 , A61F2002/30014 , A61F2002/30784 , A61F2250/0018 , A61F2250/0023 , A61L27/52 , A61L2430/38
摘要： Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
摘要翻译：提供可植入生物材料，特别是具有多孔表面的水凝胶基质，以及用于增强生物材料与活组织的相容性以及引起生物材料与活组织之间的物理附着的方法。还提供了适用于硬组织修复，替换或增加中的承载表面的植入物及其使用方法。本发明的一个实施例涉及一种可植入的椎间盘假体。

3. 发明授权

US08821409B2 Lung aerosol collection device 有权
标题翻译：肺气溶胶收集装置
公开(公告)号：US08821409B2
公开(公告)日：2014-09-02
申请号：US13141908
申请日：2009-12-21
申请人： David N. Ku , Larry J. Anderson , Prem A. Midha , Harris L. Bergman , Tamera Scholz
发明人： David N. Ku , Larry J. Anderson , Prem A. Midha , Harris L. Bergman , Tamera Scholz
IPC分类号： A61B5/08 , B65D81/00 , A61B10/00 , G01N33/497 , A61B5/097
CPC分类号： A61B5/097 , A61B5/082 , A61B2010/0087 , G01N33/497
摘要： A device for collecting material from lung aerosols. The device functions by collecting aerosols from the lower airway separated from material in the by collecting air from the upper airway in a chamber that when full causes the remaining exhaled aerosols from the lungs to be captured by a filter. The filter collects sample of material from the separated lung aerosols.
摘要翻译：用于从肺气溶胶收集材料的装置。该装置通过从下部气道中收集气溶胶而起作用，其通过在室中从上呼吸道收集空气而收集气体，当其完全导致剩余的来自肺部的呼出气溶胶被过滤器捕获时。过滤器从分离的肺气溶胶中收集材料样品。

4. 发明申请

US20110172771A1 HYDROGEL IMPLANT WITH SUPERFICIAL PORES 有权
公开(公告)号：US20110172771A1
公开(公告)日：2011-07-14
申请号：US13052826
申请日：2011-03-21
申请人： Barbara D. Boyan , Robert E. Guldberg , Stephen J. Kennedy , David N. Ku , Zvi Schwartz
发明人： Barbara D. Boyan , Robert E. Guldberg , Stephen J. Kennedy , David N. Ku , Zvi Schwartz
IPC分类号： A61F2/44 , A61F2/28
CPC分类号： A61L27/56 , A61F2/3094 , A61F2/442 , A61F2002/30011 , A61F2002/30014 , A61F2002/30784 , A61F2250/0018 , A61F2250/0023 , A61L27/52 , A61L2430/38
摘要： Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
摘要翻译：提供可植入生物材料，特别是具有多孔表面的水凝胶基质，以及用于增强生物材料与活组织的相容性以及引起生物材料与活组织之间的物理附着的方法。还提供了适用于硬组织修复，替换或增加中的承载表面的植入物及其使用方法。本发明的一个实施例涉及一种可植入的椎间盘假体。

5. 发明授权

US06231605B1 Poly(vinyl alcohol) hydrogel 有权
标题翻译：聚（乙烯醇）水凝胶
公开(公告)号：US06231605B1
公开(公告)日：2001-05-15
申请号：US09271032
申请日：1999-03-17
申请人： David N. Ku
发明人： David N. Ku
IPC分类号： A61F202
CPC分类号： A61K9/0024 , A61F2/30756 , A61K9/06 , A61K47/32 , A61L27/16 , A61L27/38 , A61L27/3804 , A61L27/52 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/254 , A61L2300/256 , A61L2300/414 , A61L2300/42 , A61L2300/426 , A61L2300/432 , A61L2300/64 , C08J3/075 , C08J2329/04 , Y10S623/901 , C08L29/04
摘要： The present invention relate to a poly(vinyl alcohol) hydrogel construct having a wide range of mechanical strengths for use as a human tissue replacement. The hydrogel construct may include a tissue scaffolding, a low bearing surface within a joint, or any other structure which is suitable for supporting the growth of tissue.
摘要翻译：本发明涉及用作人体组织置换的具有广泛机械强度的聚（乙烯醇）水凝胶结构。水凝胶构造可以包括组织脚手架，关节内的低轴承表面或适合于支持组织生长的任何其它结构。

6. 发明授权

US5521502A Flow differentiation scheme for magnetic resonance angiography 失效
标题翻译：磁共振血管造影的流动分化方案
公开(公告)号：US5521502A
公开(公告)日：1996-05-28
申请号：US232377
申请日：1994-04-25
申请人： John M. Siegel, Jr. , David N. Ku
发明人： John M. Siegel, Jr. , David N. Ku
IPC分类号： G01F1/704 , G01R33/561 , G01R33/563 , G01R33/48
CPC分类号： G01F1/704 , G01R33/563 , G01R33/5615
摘要： A flow differentiation scheme is disclosed for magnetic resonance imaging (MRI) of fluid flow in regions of turbulent flow. The flow differentiation scheme comprises the steps of (1) obtaining a first magnetic resonance (MR) image of the region, (2) obtaining a second MR image of the same region with an imaging parameter or imaging sequence altered, and (3) logically differentiating the first and second images with respect to flow to create a difference image. The process may be enhanced by superimposing one of the original images, upon an image that has been flow differentiated. As a result, a substantial amount of the static signal is suppressed producing superior angiograms of diseased and undiseased blood vessels. Additionally, the scheme can be used to image any fluid flow in any body or thing.
摘要翻译：公开了用于湍流区域中流体流动的磁共振成像（MRI）的流动分化方案。流动微分方案包括以下步骤：（1）获得该区域的第一磁共振（MR）图像，（2）用成像参数或成像序列改变获得相同区域的第二MR图像，以及（3）逻辑上相对于流动来区分第一和第二图像以产生差异图像。可以通过将原始图像中的一个重叠在已经被流分辨的图像上来增强该过程。结果，大量的静电信号被抑制，从而产生患病和未发病的血管的优异血管造影。此外，该方案可用于对任何身体或物体中的任何流体流进行成像。

7. 发明申请

US20120010712A1 MOLDS USED TO PRODUCE PVA HYDROGEL IMPLANTS AND RELATED IMPLANTS 审中-公开
标题翻译：用于生产PVA HYDROGEL植入物和相关植入物的MOLDS
公开(公告)号：US20120010712A1
公开(公告)日：2012-01-12
申请号：US13237039
申请日：2011-09-20
申请人： Guilhem Denoziere , David N. Ku
发明人： Guilhem Denoziere , David N. Ku
IPC分类号： A61F2/44 , B29C45/14 , B29C41/20
CPC分类号： A61F2/30965 , A61F2/30771 , A61F2/3094 , A61F2002/30014 , A61F2002/30069 , A61F2002/30075 , A61F2002/30133 , A61F2002/30556 , A61F2002/30576 , A61F2002/30884 , A61F2002/30909 , A61F2002/3092 , A61F2002/30957 , A61F2002/4495 , A61F2210/0061 , A61F2230/0015 , A61F2250/0009 , A61F2250/0018 , A61F2310/00365 , A61L27/16 , A61L27/52 , C08L29/04
摘要： Methods of fabricating elastomeric implants employ a mold with PVA crystals and irrigant added to the mold independent of each other. Related molds are also described.
摘要翻译：制造弹性体植入物的方法使用具有PVA晶体的模具和冲洗剂，彼此独立地添加到模具中。还描述了相关模具。

8. 发明授权

US5981826A Poly(vinyl alcohol) cryogel 失效
标题翻译：聚（乙烯醇）冷冻凝胶
公开(公告)号：US5981826A
公开(公告)日：1999-11-09
申请号：US932029
申请日：1997-09-17
申请人： David N. Ku , Linda G. Braddon , David M. Wootton
发明人： David N. Ku , Linda G. Braddon , David M. Wootton
IPC分类号： A61L27/00 , A61F2/02 , A61F2/30 , A61K9/00 , A61K9/06 , A61K9/10 , A61K31/765 , A61K47/32 , A61L27/16 , A61L27/38 , A61L27/52 , A61L27/54 , C08L29/04 , C12N5/06 , A61F13/00
CPC分类号： A61K9/0024 , A61K47/32 , A61K9/06 , A61L27/16 , A61L27/38 , A61L27/3804 , A61L27/52 , A61L27/54 , C08J3/075 , A61F2/30756 , A61L2300/236 , A61L2300/252 , A61L2300/254 , A61L2300/256 , A61L2300/414 , A61L2300/42 , A61L2300/426 , A61L2300/432 , A61L2300/64 , C08J2329/04 , Y10S623/901
摘要： The present invention includes a poly(vinyl alcohol) hydrogel construct having a wide range of mechanical strengths for use as a human tissue replacement. A process in connection with the present invention eliminates any step involved with dehydration of the hydrogel prior to implantation thereof. The hydrogel construct may include a tissue scaffolding, a load bearing surface within a joint, or any other structure which is suitable for supporting the growth of tissue.
摘要翻译：本发明包括用作人体组织置换的具有广泛机械强度的聚（乙烯醇）水凝胶构造。与本发明有关的方法消除了在植入之前水凝胶脱水所涉及的任何步骤。水凝胶构造可以包括组织支架，关节内的承载表面或适合于支持组织生长的任何其它结构。

9. 发明授权

US5756044A Apparatus and method for treating articles in solution with effervescent tablets 失效
标题翻译：用泡腾片处理溶液中的制品的装置和方法
公开(公告)号：US5756044A
公开(公告)日：1998-05-26
申请号：US629715
申请日：1996-04-09
申请人： Mary Mowrey-McKee , Rafael Victor Andino , David N. Ku , Paul J. Mulhauser , David R. Schiff
发明人： Mary Mowrey-McKee , Rafael Victor Andino , David N. Ku , Paul J. Mulhauser , David R. Schiff
IPC分类号： A61L2/16 , A45C11/00 , A61L12/08 , A61L2/00
CPC分类号： A61L12/08 , A45C11/005
摘要： An article treatment system which provides improved solution mixing and concentration uniformity. The treatment system includes a container, a closure and a channel for guiding fluid flow. The treatment system is especially advantageous for use with effervescent tablets and for use in treating contact lenses. Cleaning and disinfecting of articles is improved by use of a tubular channel which guides upwardly gas and other components released from an effervescent tablet which is located at the bottom of the treatment container. The upward central flow through the channel induces a downward flow between the container walls, the exterior walls of the channel, and the article-retaining means and towards the bottom of the container.
摘要翻译：一种提供改进的溶液混合和浓度均匀性的制品处理系统。处理系统包括容器，封闭件和用于引导流体流动的通道。治疗系统特别适用于泡腾片剂和用于治疗隐形眼镜。通过使用引导向上的气体和从位于处理容器底部的泡腾片剂释放的其它组分的管状通道来改善制品的清洁和消毒。通过通道的向上的中心流在容器壁，通道的外壁和物品保持装置之间并朝向容器的底部引起向下的流动。

10. 发明授权

US5438992A Flow-induced artifact elimination in magnetic resonance images 失效
标题翻译：磁共振图像中的流感神经消除
公开(公告)号：US5438992A
公开(公告)日：1995-08-08
申请号：US146393
申请日：1993-11-01
申请人： John M. Siegel, Jr. , David N. Ku , John N. Oshinski , Roderic I. Pettigrew
发明人： John M. Siegel, Jr. , David N. Ku , John N. Oshinski , Roderic I. Pettigrew
IPC分类号： G01R33/56 , G01R33/563 , A61B5/055
CPC分类号： G01R33/563 , G01R33/56
摘要： Magnetic resonance imaging of a blood vessel exhibits flow artifacts, or signal loss, around a constriction (26) due to turbulent fluid flow. Signal loss in a region (27) prior to the constricted region (26) is primarily caused by convective acceleration, and this signal loss is substantially eliminated by performing an acceleration compensation process. Signal loss in a region (32) situated after the constriction (26) is primarily caused by velocity fluctuations, and this signal loss is cured by an imaging process which does not rely on the phase of the electromagnetic excitation signal(s) for spatial localization. Examples of imaging processes for minimizing signal loss due to turbulence include a projection reconstruction process (34) and a two dimensional slice selection process (56). Further, the two dimensional slice selection process (56) may be used for generating instantaneous velocities of fluid flowing through a fluid channel. Also, if a number of instantaneous velocities are produced over a time period, then fluctuation velocities can be determined via time-resolved averaging.
摘要翻译：血管的磁共振成像由于湍流流动而在收缩（26）周围显示出流动假象或信号损失。在收缩区域（26）之前的区域（27）中的信号损失主要由对流加速度引起，并且通过执行加速度补偿处理基本上消除了该信号损失。位于收缩（26）之后的区域（32）中的信号损失主要是由速度波动引起的，并且该信号损失通过不依赖于用于空间定位的电磁激励信号的相位的成像过程来固化。用于使由湍流引起的信号损失最小化的成像处理的示例包括投影重建处理（34）和二维切片选择处理（56）。此外，二维切片选择过程（56）可用于产生流过流体通道的流体的瞬时速度。此外，如果在一段时间内产生多个瞬时速度，则可以通过时间分辨平均来确定波动速度。

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