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1. 发明授权

US06608178B1 5-hydroxytryptophol (5-HTOL) derivatives, antibodies, immunoassays and detection of recent alcohol consumption 失效
标题翻译： 5-羟色胺（5-HTOL）衍生物，抗体，免疫测定和检测近期酒精消费
公开(公告)号：US06608178B1
公开(公告)日：2003-08-19
申请号：US09326647
申请日：1999-06-07
申请人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
发明人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
IPC分类号： C07K1644
CPC分类号： C07H17/02 , C07K16/44 , Y10T436/14 , Y10T436/145555 , Y10T436/17 , Y10T436/173845 , Y10T436/203332 , Y10T436/25
摘要： Antibody specific for a 5-HTOL compound. A glucuronide with 5-hydroxytryptophol (5-HTOL) characterized in that it comprises the structure of the &bgr;-glucuronide between the 5-hydroxy group of 5-HTOL and D-glucopyranosiduronic acid. An immunoassay and a diagnostic method utilizing the ummunoassay wherein a 5-hydroxytryptophol (5-HTOL) compound is determined by the use of an antibody specific for a 5-HTOL compound is used.
摘要翻译：针对5-HTOL化合物的抗体。具有5-羟基吡啶（5-HTOL）的葡糖苷酸的特征在于其包含5-羟基与5-羟基吡喃糖苷二糖酸的5-羟基之间的β-葡糖苷酸的结构。使用其中通过使用对5-HTOL化合物特异的抗体来测定5-羟色胺（5-HTOL）化合物的免疫测定和诊断方法。

2. 发明申请

US20060100420A1 5-hydroxytryptophol (5-HTOL) derivatives, antibodies, immunoassays and detection of recent alcohol consumption 审中-公开
标题翻译： 5-羟色胺（5-HTOL）衍生物，抗体，免疫测定和检测近期饮酒
公开(公告)号：US20060100420A1
公开(公告)日：2006-05-11
申请号：US10420931
申请日：2003-04-23
申请人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
发明人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
IPC分类号： C07K16/00
CPC分类号： C07H17/02 , C07K16/44 , Y10T436/14 , Y10T436/145555 , Y10T436/17 , Y10T436/173845 , Y10T436/203332 , Y10T436/25
摘要： Antibody specific for a 5-HTOL compound. A glucuronide with 5-hydroxytryptophol (5-HTOL) characterized in that it comprises the structure of the β-glucuronide between the 5-hydroxy group of 5-HTOL and D-glucopyranosiduronic acid. An immunoassay and a diagnostic method utilizing the immunoassay wherein a 5-hydroxytryptophol (5-HTOL) compound is determined by the use of an antibody specific for a 5-HTOL compound is used.
摘要翻译：针对5-HTOL化合物的抗体。具有5-羟基吡啶（5-HTOL）的葡糖苷酸的特征在于其包含5-羟基与5-羟基吡喃糖苷二糖酸的5-羟基之间的β-葡糖苷酸的结构。使用免疫测定法和诊断方法，其中使用5-羟色胺（5-HTOL）化合物通过使用对5-HTOL化合物特异的抗体来测定。

3. 发明申请

US20070276133A1 5-hydroxytryptophol (5-HTOL) derivatives, antibodies, immunoassays and detection of recent alcohol consumption 审中-公开
标题翻译： 5-羟色胺（5-HTOL）衍生物，抗体，免疫测定和检测近期饮酒
公开(公告)号：US20070276133A1
公开(公告)日：2007-11-29
申请号：US11648892
申请日：2007-01-03
申请人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
发明人： Ragnhild Brandt , Olof Beck , Anders Helander , Rose-Marie Jonsson , Eric Unger , Stefan Borg , Eva Akerblom
IPC分类号： C07H17/02
CPC分类号： C07H17/02 , C07K16/44 , Y10T436/14 , Y10T436/145555 , Y10T436/17 , Y10T436/173845 , Y10T436/203332 , Y10T436/25
摘要： Antibody specific for a 5-HTOL compound. A glucuronide with 5-hydroxytryptophol (5-HTOL) characterized in that it comprises the structure of the β-glucuronide between the 5-hydroxy group of 5-HTOL and D-glucopyranosiduronic acid. An immunoassay and a diagnostic method utilizing the immunoassay wherein a 5-hydroxytryptophol (5-HTOL) compound is determined by the use of an antibody specific for a 5-HTOL compound is used.
摘要翻译：针对5-HTOL化合物的抗体。具有5-羟基吡啶（5-HTOL）的葡糖苷酸的特征在于其包含5-羟基与5-羟基吡喃糖苷二糖酸的5-羟基之间的β-葡糖苷酸的结构。使用免疫测定法和诊断方法，其中使用5-羟色胺（5-HTOL）化合物通过使用对5-HTOL化合物特异的抗体来测定。

4. 发明授权

US5886051A Methods and compositions for the treatment of neurodegeneration 失效
标题翻译：用于治疗神经变性的方法和组合物
公开(公告)号：US5886051A
公开(公告)日：1999-03-23
申请号：US554370
申请日：1995-11-08
申请人： Raymond J. Bergeron, Jr. , Stefan Borg
发明人： Raymond J. Bergeron, Jr. , Stefan Borg
IPC分类号： A61K31/13 , A61K31/131 , A61K31/445
CPC分类号： A61K31/131 , A61K31/13
摘要： Methods and pharmaceutical compositions in unit dosage form for treating neurodegeneration in a human or non-human animal afflicted therewith wherein the active agent is a therapeutically effective amount of a polyamine having the formula: ##STR1## or a salt thereof with a pharmaceutically acceptable acid wherein: R.sub.1 and R.sub.6 may be the same or different and are hydrogen, alkyl, hydrocarbyl aryl, hydrocarbyl aryl alkyl, cycloalkyl, or any of the foregoing wherein the alkyl chain is interrupted by at least one etheric oxygen atom;N.sup.1, N.sup.2, N.sup.3 and N.sup.4 are nitrogen atoms capable of protonation at physiological pH's;a and b may be the same or different and are integers from 1 to 4;A, B and C may be the same or different and are bridging groups of variable length.
摘要翻译：用于治疗患有其的人或非人动物中的神经变性的单位剂型的方法和药物组合物，其中所述活性剂是治疗有效量的具有下式的多胺：其中：R 1和R 6可以是相同或不同的是氢，烷基，烃基芳基，烃基芳基烷基，环烷基或前述的任何一种，其中烷基链被至少一个醚氧原子间隔; N1，N2，N3和N4是能够在生理pH下质子化的氮原子; a和b可以相同或不同，为1至4的整数; A，B和C可以相同或不同，并且是可变长度的桥接基团。

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