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1. 发明授权

US08685962B2 Compositions, articles and methods comprising TSPO ligands for preventing or reducing tobacco-associated damage 有权
标题翻译：包含用于预防或减少烟草相关损伤的TSPO配体的组合物，制品和方法
公开(公告)号：US08685962B2
公开(公告)日：2014-04-01
申请号：US12452482
申请日：2008-07-02
申请人： Moshe Gavish , Rafael M. Nagler
发明人： Moshe Gavish , Rafael M. Nagler
IPC分类号： A01N43/62 , A61K31/55 , A01N25/00 , A61K9/72 , A61L9/02 , A61K51/00 , A61M36/14
CPC分类号： A61K31/472 , A61K31/498 , A61K31/502 , A61K31/517 , A61K31/5513
摘要： Articles of manufacturing (such as tobacco products), methods, devices and compositions for preventing or reducing tobacco-associated damage and/or disorders associated with oxidative stress in a subject, and which utilize a TSPO receptor ligand (such as diazepam), are disclosed.
摘要翻译：公开了用于预防或减少与受试者相关的烟草相关损伤和/或与氧化应激有关的障碍并且利用TSPO受体配体（例如地西泮））的制造用制品（例如烟草制品），方法，装置和组合物。

2. 发明申请

US20100179133A1 COMPOSITIONS, ARTICLES AND METHODS COMRISING TSPO LIGANDS FOR PREVENTING OR REDUCING TOBACCO-ASSOCIATED DAMAGE 有权
标题翻译：用于预防或减少烟草相关损害的TSPO配体的组合物，文章和方法
公开(公告)号：US20100179133A1
公开(公告)日：2010-07-15
申请号：US12452482
申请日：2008-07-02
申请人： Moshe Gavish , Rafael M. Nagler
发明人： Moshe Gavish , Rafael M. Nagler
IPC分类号： A61K31/55
CPC分类号： A61K31/472 , A61K31/498 , A61K31/502 , A61K31/517 , A61K31/5513
摘要： Articles of manufacturing (such as tobacco products), methods, devices and compositions for preventing or reducing tobacco-associated damage and/or disorders associated with oxidative stress in a subject, and which utilize a TSPO receptor ligand (such as diazepam), are disclosed.
摘要翻译：公开了用于预防或减少与受试者相关的烟草相关损伤和/或与氧化应激有关的障碍并且利用TSPO受体配体（例如地西泮））的制造用制品（例如烟草制品），方法，装置和组合物。

3. 发明申请

US20120012123A1 COMPOSITIONS, ARTICLES AND METHODS FOR PREVENTING OR REDUCING TOBACCO-ASSOCIATED DAMAGE 审中-公开
标题翻译：用于预防或减少烟草相关损害的组合物，文章和方法
公开(公告)号：US20120012123A1
公开(公告)日：2012-01-19
申请号：US13238115
申请日：2011-09-21
申请人： Moshe Gavish , Rafael M. Nagler
发明人： Moshe Gavish , Rafael M. Nagler
IPC分类号： A61K31/197 , A61K9/68 , A61P35/00 , A61P9/10 , A61P9/00 , A61P11/00 , A24B15/32 , A61K8/44
CPC分类号： A61K31/195 , A23G3/36 , A23G4/06 , A24B15/32 , A24D3/14
摘要： Articles of manufacturing, methods, devices and compositions for preventing or reducing tobacco-associated damage in a subject, and which utilize a metal ion chelating agent, a copper chelating agent, a penicillamine and/or a structural analog of penicillamine, with and without an additional antioxidant, are disclosed.
摘要翻译：使用金属离子螯合剂，铜螯合剂，青霉胺和/或青霉胺结构类似物的用于预防或减少烟草相关损害的制造方法，装置和组合物，具有和不具有额外的抗氧化剂。

4. 发明申请

US20100317040A1 METHODS AND KITS FOR DIAGNOSING CANCER 有权
标题翻译：用于诊断癌症的方法和工具
公开(公告)号：US20100317040A1
公开(公告)日：2010-12-16
申请号：US12816482
申请日：2010-06-16
申请人： Rafael M. Nagler , Moshe Gavish
发明人： Rafael M. Nagler , Moshe Gavish
IPC分类号： G01N33/53 , C12Q1/00 , C12Q1/34 , C12Q1/02
CPC分类号： G01N33/57407 , G01N33/57488
摘要： A method of diagnosing oral cancer or oral pharyngeal cancer in a subject in need thereof is provided. The method comprising determining a level or activity of at least one marker in a saliva sample of the subject, wherein a significant alteration in the level or the activity of the marker with respect to an unaffected saliva sample is indicative of the cancer, wherein the saliva marker is selected from the group consisting of Cyclin D1, phospho-Src, 8-oxoguanine DNA glycosylase (OGG1), Maspin, KI67 and translocator protein 18 kDa (TSPO).
摘要翻译：提供了在有需要的受试者中诊断口腔癌或口咽癌的方法。该方法包括确定受试者唾液样品中至少一种标记物的水平或活性，其中相对于未受影响的唾液样品的标记物的水平或活性的显着改变指示癌症，其中唾液标记物选自细胞周期蛋白D1，磷酸化Src，8-氧基鸟嘌呤DNA糖基化酶（OGG1），Maspin，KI67和易位蛋白18kDa（TSPO）。

5. 发明授权

US09075060B2 Methods for diagnosing oral or oral-pharyngeal cancer 有权
标题翻译：诊断口腔或口咽癌的方法
公开(公告)号：US09075060B2
公开(公告)日：2015-07-07
申请号：US12816482
申请日：2010-06-16
申请人： Rafael M. Nagler , Moshe Gavish
发明人： Rafael M. Nagler , Moshe Gavish
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N33/57488
摘要： A method of diagnosing oral cancer or oral pharyngeal cancer in a subject in need thereof is provided. The method comprising determining a level or activity of at least one marker in a saliva sample of the subject, wherein a significant alteration in the level or the activity of the marker with respect to an unaffected saliva sample is indicative of the cancer, wherein the saliva marker is selected from the group consisting of Cyclin D1, phospho-Src, 8-oxoguanine DNA glycosylase (OGG1), Maspin, KI67 and translocator protein 18 kDa (TSPO).
摘要翻译：提供了在有需要的受试者中诊断口腔癌或口咽癌的方法。该方法包括确定受试者唾液样品中至少一种标记物的水平或活性，其中相对于未受影响的唾液样品的标记物的水平或活性的显着改变指示癌症，其中唾液标记物选自细胞周期蛋白D1，磷酸化Src，8-氧基鸟嘌呤DNA糖基化酶（OGG1），Maspin，KI67和易位蛋白18kDa（TSPO）。

6. 发明申请

US20100166833A1 Compositions, articles and methods for preventing or reducing tobacco-associated damage 审中-公开
标题翻译：用于预防或减少烟草相关损害的组合物，物品和方法
公开(公告)号：US20100166833A1
公开(公告)日：2010-07-01
申请号：US12588825
申请日：2009-10-29
申请人： Moshe Gavish , Rafael M. Nagler
发明人： Moshe Gavish , Rafael M. Nagler
IPC分类号： A61K9/70 , A61K9/68 , A61K31/195
CPC分类号： A61K31/195 , A23G3/36 , A23G4/06 , A24B15/32 , A24D3/14
摘要： Articles of manufacturing, methods, devices and compositions for preventing or reducing tobacco-associated damage in a subject, and which utilize a metal ion chelating agent, a copper chelating agent, a penicillamine and/or a structural analog of penicillamine, with and without an additional antioxidant, are disclosed.
摘要翻译：使用金属离子螯合剂，铜螯合剂，青霉胺和/或青霉胺结构类似物的用于预防或减少烟草相关损害的制造方法，装置和组合物，具有和不具有额外的抗氧化剂。

7. 发明申请

US20100021928A1 METHODS AND KITS FOR DIAGNOSING CANCER 审中-公开
标题翻译：用于诊断癌症的方法和工具
公开(公告)号：US20100021928A1
公开(公告)日：2010-01-28
申请号：US12306548
申请日：2007-06-25
申请人： Rafael M. Nagler , Moshe Gavish
发明人： Rafael M. Nagler , Moshe Gavish
IPC分类号： G01N33/53 , C12Q1/28
CPC分类号： G01N33/57407 , G01N33/57488
摘要： Methods and kits for diagnosing cancer in a subject is disclosed. The method comprises determining a level and/or activity of at least one saliva secreted marker in a saliva sample of the subject wherein an alteration in said marker with respect to an unaffected saliva sample is indicative of the cancer, with the proviso that the saliva secreted marker is not circulatory carcinoembryonic antigen (CEA).
摘要翻译：公开了用于诊断受试者中的癌症的方法和试剂盒。该方法包括测定受试者唾液样品中至少一种唾液分泌标记物的水平和/或活性，其中所述标记物相对于未受影响的唾液样品的改变指示癌症，条件是分泌的唾液标记物不是循环癌胚抗原（CEA）。

8. 发明申请

US20100029658A1 HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF 有权
标题翻译：杂环衍生物，药物组合物及其使用方法
公开(公告)号：US20100029658A1
公开(公告)日：2010-02-04
申请号：US12438291
申请日：2006-08-22
申请人： Moshe Gavish , Jehuda Arieh Veenman , Alex Shterenberg , Ilan Marek
发明人： Moshe Gavish , Jehuda Arieh Veenman , Alex Shterenberg , Ilan Marek
IPC分类号： A61K31/498 , C07D237/30 , A61K31/502 , C07D239/72 , A61K31/517 , C07D241/36 , C07D217/02 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： C07D239/91 , C07D239/90
摘要： The present invention relates to novel quinoxaline, quinazoline and phthalazine derivatives as well as multimeric derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds for the treatment and prevention of brain damage resulting from brain injury, especially secondary brain damage due to traumatic brain injury (TBI). The compounds of the invention are also useful in treating and preventing neurodegenerative diseases.
摘要翻译：本发明涉及新颖的喹喔啉，喹唑啉和酞嗪衍生物以及多聚衍生物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物治疗和预防由脑损伤引起的脑损伤的方法，特别是二次由脑外伤引起的脑损伤（TBI）。本发明的化合物也可用于治疗和预防神经变性疾病。

9. 发明授权

US06310682B1 System and method for laser range finder 失效
标题翻译：激光测距仪的系统和方法
公开(公告)号：US06310682B1
公开(公告)日：2001-10-30
申请号：US09347976
申请日：1999-07-06
申请人： Moshe Gavish , Kuo-Tso Chen
发明人： Moshe Gavish , Kuo-Tso Chen
IPC分类号： G01C308
CPC分类号： G01S17/10 , G01S7/4865 , G01S7/497
摘要： The actual value of a parameter from a laser range finder to a target is determined by adjusting the measured parameter by a measurement error. The error adjustment is based on the relationship between the intensity of the detected pulse and the expected parameter error. The laser range finder has a laser diode for emitting a laser pulse to a target to produce a reflected pulse, and a detector for receiving the reflected pulse. A measurement circuit is coupled to the detector for determining a measured parameter based on the reflected pulse. An integrator is coupled to the detector for determining the pulse area, and therefore, the intensity of the reflected pulse. A processor is coupled to the measurement circuit and the integrator for adjusting the measured parameter based on the pulse area of the reflected pulse, to provide the actual value of the parameter.
摘要翻译：通过将测量参数调整为测量误差来确定从激光测距仪到目标的参数的实际值。误差调整基于检测到的脉冲强度与预期参数误差之间的关系。激光测距仪具有用于向目标发射激光脉冲以产生反射脉冲的激光二极管和用于接收反射脉冲的检测器。测量电路耦合到检测器，用于基于反射的脉冲确定测量的参数。积分器耦合到检测器以确定脉冲区域，并因此确定反射脉冲的强度。处理器耦合到测量电路和积分器，用于基于反射脉冲的脉冲面积来调整测量参数，以提供参数的实际值。

10. 发明授权

US5388048A Vehicle anti-collison device 失效
标题翻译：车辆反对设备
公开(公告)号：US5388048A
公开(公告)日：1995-02-07
申请号：US17742
申请日：1993-02-16
申请人： Amotz Yavnayi , Moshe Gavish , Pinchas Schechner , Israel Kantor
发明人： Amotz Yavnayi , Moshe Gavish , Pinchas Schechner , Israel Kantor
IPC分类号： G01S17/93 , G06F15/50
CPC分类号： G01S17/936
摘要： A vehicle anti-collision device comprising a laser rangefinder mounted inside a vehicle near to a windshield thereof. The distance of the vehicle from a leading vehicle is constantly calculated and sampled at predetermined time intervals, enabling the closing velocity of the vehicle with respect to the leading vehicle to be calculated. A digital speedometer is provided for determining the self-speed of the vehicle whereby the safety time between the two vehicles may be calculated. The safety time is displayed and an audible alarm is sounded in the event that the calculated safety time is less than a predetermined threshold. Preferably, the rangefinder is coupled to the vehicle's steering mechanism so as to be responsive to a turning radius of the vehicle in order that the rangefinder may distinguish between two vehicles travelling in the same lane and in different lanes, respectively. Likewise, provision is made for compensating for the elevation angle of the rangefinder beam for variations in load distribution within the vehicle.
摘要翻译：一种车辆防碰撞装置，包括安装在靠近其挡风玻璃的车辆内的激光测距仪。以预定的时间间隔不断地计算和采样车辆与前方车辆的距离，从而能够计算车辆相对于前方车辆的关闭速度。提供用于确定车辆的自身速度的数字车速表，由此可以计算两辆车辆之间的安全时间。在计算安全时间小于预定阈值的情况下，显示安全时间并发出声音报警。优选地，测距仪耦合到车辆的转向机构，以响应于车辆的转弯半径，以便测距仪可以分别在同一车道和不同车道中行驶的两辆车辆之间进行区分。同样地，为了补偿在车辆内的载荷分布的变化，用于补偿测距梁的仰角。

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