专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US10059659B2 Enantiomerically pure binaphthol derivatives and method for preparing the same 有权
公开(公告)号：US10059659B2
公开(公告)日：2018-08-28
申请号：US13994328
申请日：2011-12-13
申请人： Rae Kyu Chang , Yun Soo Ahn , Heejung Jung , Hyerim Ga , Juwan Maeng , Young-Kook Koh , Young Hee Lee , Kwang Jae Lee , Joonseo Kim , Hyunil Lee , Heungsik Yoon
发明人： Rae Kyu Chang , Yun Soo Ahn , Heejung Jung , Hyerim Ga , Juwan Maeng , Young-Kook Koh , Young Hee Lee , Kwang Jae Lee , Joonseo Kim , Hyunil Lee , Heungsik Yoon
IPC分类号： C07C273/18 , C07B57/00 , C07C275/32
CPC分类号： C07C273/1854 , C07B57/00 , C07C275/32
摘要： The present invention relates to compounds 1, 1a (S-enantiomer) and 1b (R-enantiomer) of the following formula 1, and a method for preparing the same. [formula 1] The novel compound of the formula 1 is used as an important intermediate for preparing compounds 6, 6a (S-enantiomer) and 6b (R-enantiomer) of the following formula 6, which are 2,2′-binaphthol-3-aldehyde derivatives. Also, the present invention provides a method for preparing the compound of formula 1 with a very safe method at low cost. [formula 6]

2. 发明申请

US20140012038A1 ENANTIOMERICALLY PURE BINAPHTHOL DERIVATIVES AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：全自动双酚A衍生物及其制备方法
公开(公告)号：US20140012038A1
公开(公告)日：2014-01-09
申请号：US13994328
申请日：2011-12-13
申请人： Rae Kyu Chang , Yun Soo Ahn , Heejung Jung , Hyerim Ga , Juwan Maeng , Young-Kook Koh , Young Hee Lee , Kwang Jae Lee , Joonseo Kim , Hyunil Lee
发明人： Rae Kyu Chang , Yun Soo Ahn , Heejung Jung , Hyerim Ga , Juwan Maeng , Young-Kook Koh , Young Hee Lee , Kwang Jae Lee , Joonseo Kim , Hyunil Lee
IPC分类号： C07C275/32 , C07C273/18
CPC分类号： C07C273/1854 , C07B57/00 , C07C275/32
摘要： The present invention relates to compounds 1, 1a (S-enantiomer) and 1b (R-enantiomer) of the following formula 1, and a method for preparing the same. [formula 1] The novel compound of the formula 1 is used as an important intermediate for preparing compounds 6, 6a (S-enantiomer) and 6b (R-enantiomer) of the following formula 6, which are 2,2′-binaphthol-3-aldehyde derivatives. Also, the present invention provides a method for preparing the compound of formula 1 with a very safe method at low cost. [formula 6]
摘要翻译：本发明涉及下式1的化合物1,1a（S-对映体）和1b（R-对映异构体）及其制备方法。 [式1]式1的新化合物用作制备下式6的化合物6,6a（S-对映异构体）和6b（R-对映异构体）的重要中间体，它是2,2'-联萘酚 - 3-醛衍生物。此外，本发明提供了一种以低成本非常安全的方法制备式1化合物的方法。 [公式6]

3. 发明授权

US09725391B2 Synthetic method of enantiomerically pure 2,2′-dihydroxy-1,1′-binaphthyl-3-carboxylic acid 有权
公开(公告)号：US09725391B2
公开(公告)日：2017-08-08
申请号：US13990020
申请日：2011-11-24
申请人： Hyunil Lee , Heungsik Yoon , Young Hee Lee , Heejung Jung , Young-Kook Koh
发明人： Hyunil Lee , Heungsik Yoon , Young Hee Lee , Heejung Jung , Young-Kook Koh
IPC分类号： C07C63/36 , C07C51/02 , C07B57/00 , C07C51/41 , C07C51/43
CPC分类号： C07C51/02 , C07B57/00 , C07B2200/07 , C07C51/412 , C07C51/43 , C07C65/11
摘要： The present invention relates to a method for preparing enantiomerically pure compounds 1a and 1b of the following formula 1 from racemic compound 1 of the following formula 1. [formula 1] The compounds 1a and 1b of the above formula 1 respectively are important intermediates for a process for preparing the respective compounds 2a and 2b of the following formula 2, which are 2,2′-binaphthol-3-aldehyde derivatives. The following compounds 2a and 2b are useful for preparing enantiomerically pure amino acids. The present invention provides a method for preparing the above compounds 1a and 1b very conveniently and economically, and suitably for mass production. [formula 2]

4. 发明申请

US20140142336A1 SYNTHETIC METHOD OF ENANTIOMERICALLY PURE 2,2'-DIHYDROXY-1,1'-BINAPHTHYL-3-CARBOXYLIC ACID 有权
标题翻译： 2,2'-DIHYDROXY-1,1'-联苯三羧酸的合成方法
公开(公告)号：US20140142336A1
公开(公告)日：2014-05-22
申请号：US13990020
申请日：2011-11-24
申请人： Hyunil Lee , Heungsik Yoon , Young Hee Lee , Heejung Jung , Young-Kook Koh
发明人： Hyunil Lee , Heungsik Yoon , Young Hee Lee , Heejung Jung , Young-Kook Koh
IPC分类号： C07C51/02
CPC分类号： C07C51/02 , C07B57/00 , C07B2200/07 , C07C51/412 , C07C51/43 , C07C65/11
摘要： The present invention relates to a method for preparing enantiomerically pure compounds 1a and 1b of the following formula 1 from racemic compound 1 of the following formula 1. [formula 1] The compounds 1a and 1b of the above formula 1 respectively are important intermediates for a process for preparing the respective compounds 2a and 2b of the following formula 2, which are 2,2′-binaphthol-3-aldehyde derivatives. The following compounds 2a and 2b are useful for preparing enantiomerically pure amino acids. The present invention provides a method for preparing the above compounds 1a and 1b very conveniently and economically, and suitably for mass production. [formula 2]
摘要翻译：本发明涉及由下式1的外消旋化合物1制备下式1的对映异构体纯的化合物1a和1b的方法。[式1]上式1的化合物1a和1b分别是制备2,2'-联萘酚-3-醛衍生物的下式2的各化合物2a和2b的方法。以下化合物2a和2b可用于制备对映体纯氨基酸。本发明提供了一种非常方便，经济地制备上述化合物1a和1b的方法，适用于批量生产。 [公式2]

5. 发明申请

US20110278610A1 PACKAGE STRUCTURE AND PACKAGE PROCESS OF LIGHT EMITTING DIODE 有权
标题翻译：发光二极管的封装结构和封装工艺
公开(公告)号：US20110278610A1
公开(公告)日：2011-11-17
申请号：US12777525
申请日：2010-05-11
申请人： Hyunsoo Jeong , Seongoo Lee , Ryungshik Park , Hyunil Lee
发明人： Hyunsoo Jeong , Seongoo Lee , Ryungshik Park , Hyunil Lee
IPC分类号： H01L33/52 , H01L33/62 , H01L33/44
CPC分类号： H01L33/508 , H01L33/54 , H01L2224/48091 , H01L2224/73265 , H01L2224/8592 , H01L2924/181 , H01L2933/0066 , H01L2924/00014 , H01L2924/00012
摘要： A light emitting diode (LED) package structure comprising a carrier, an LED chip, a first encapsulant, at least one bonding wire, a plurality of phosphor particles and a second encapsulant is provided. The LED chip is disposed on the carrier. The LED chip has at least one electrode. The first encapsulant is disposed on the carrier and covering the LED chip. The first encapsulant is provided with at least one preformed opening exposing at least a portion of the at least one electrode. The at least one bonding wire is electrically connected between the at least one electrode and the carrier via the at least one preformed opening. The phosphor particles are distributed within the first encapsulant. The second encapsulant is disposed on the carrier and encapsulates the LED chip, the first encapsulant and the at least one bonding wire.
摘要翻译：提供了包括载体，LED芯片，第一密封剂，至少一个接合线，多个荧光体颗粒和第二密封剂的发光二极管（LED）封装结构。 LED芯片设置在载体上。 LED芯片具有至少一个电极。第一密封剂设置在载体上并覆盖LED芯片。第一密封剂设置有暴露至少一个电极的至少一部分的至少一个预制开口。所述至少一个接合线经由所述至少一个预制开口电连接在所述至少一个电极和所述载体之间。磷光体颗粒分布在第一密封剂内。第二密封剂设置在载体上并封装LED芯片，第一密封剂和至少一个接合线。

6. 发明申请

US20110278609A1 PACKAGE STRUCTURE AND PACKAGE PROCESS OF LIGHT EMITTING DIODE 有权
标题翻译：发光二极管的封装结构和封装工艺
公开(公告)号：US20110278609A1
公开(公告)日：2011-11-17
申请号：US12777510
申请日：2010-05-11
申请人： Hyunsoo Jeong , Seongoo Lee , Ryungshik Park , Hyunil Lee
发明人： Hyunsoo Jeong , Seongoo Lee , Ryungshik Park , Hyunil Lee
IPC分类号： H01L33/44 , H01L33/48 , H01L33/52 , H01L33/62
CPC分类号： H01L33/60 , H01L33/501 , H01L33/502 , H01L33/54 , H01L2224/48091 , H01L2224/8592 , H01L2933/0091 , H01L2924/00014
摘要： A light emitted diode (LED) package structure and an LED package process are provided. The LED package structure comprises a carrier, a spacer, at least one LED chip, a junction coating, a plurality of phosphor particles, and an encapsulant. The spacer is disposed on the carrier and provided with a reflective layer covering a top surface of the spacer. The LED chip is disposed on the reflective layer and electrically connected to the carrier. The junction coating is disposed over the spacer and covers the LED chip. The phosphor particles are distributed within the junction coating. The encapsulant is disposed on the carrier and encapsulates the LED chip, the spacer and the junction coating. Uniform light output and high illuminating efficiency can be obtained by the phosphor particles uniformly distributed in the junction coating. The junction coating is formed by package level dispensing process to reduce the fabrication cost.
摘要翻译：提供发光二极管（LED）封装结构和LED封装工艺。 LED封装结构包括载体，间隔物，至少一个LED芯片，接合涂层，多个荧光体颗粒和密封剂。间隔件设置在载体上并且设置有覆盖间隔件顶表面的反射层。 LED芯片设置在反射层上并与载体电连接。接合涂层设置在间隔物上并覆盖LED芯片。荧光体颗粒分布在接合涂层内。密封剂设置在载体上并封装LED芯片，间隔物和接合涂层。均匀分布在接合涂层中的荧光体颗粒可以获得均匀的光输出和高照明效率。连接涂层由封装级分配工艺形成，以降低制造成本。

7. 发明授权

US07371859B2 PNA monomer and precursor 有权
标题翻译： PNA单体和前体
公开(公告)号：US07371859B2
公开(公告)日：2008-05-13
申请号：US11182935
申请日：2005-07-15
申请人： Sung Kee Kim , Hyunil Lee , Jong Chan Lim , Hoon Choi , Jae Hoon Jeon , Sang Youl Ahn , Sung Hee Lee , Won Jun Yoon
发明人： Sung Kee Kim , Hyunil Lee , Jong Chan Lim , Hoon Choi , Jae Hoon Jeon , Sang Youl Ahn , Sung Hee Lee , Won Jun Yoon
IPC分类号： C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D239/54 , C07D241/18
CPC分类号： C07D417/04 , C07B2200/11 , C07D277/80 , C07D417/12 , C07D417/14 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R′; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.
摘要翻译：本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为氮或C-R' ; J为硫或氧; R'，R 1，R 2，R 3，R 4独立地为H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基，苯基或卤代苯基，R 5为H或保护或未保护的天然或非天然α- 氨基酸; 并且B是天然或非天然核碱基，其中当所述核碱基具有环外氨基功能时，所述功能受到在硫醇存在下对酸不稳定但对弱至中碱稳定的保护基保护。

8. 发明授权

US07211668B2 PNA monomer and precursor 有权
标题翻译： PNA单体和前体
公开(公告)号：US07211668B2
公开(公告)日：2007-05-01
申请号：US10819769
申请日：2004-04-06
申请人： Sung Kee Kim , Hyunil Lee , Jong Chan Lim , Sung Hee Lee
发明人： Sung Kee Kim , Hyunil Lee , Jong Chan Lim , Sung Hee Lee
IPC分类号： C07D473/34 , C07D473/30 , C07D473/18 , C07D239/47 , C07D239/54
CPC分类号： C07D271/113 , C07D263/46 , C07D413/12 , C07D417/12 , Y02P20/55
摘要： This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is sulfur or oxygen; J is nitrogen or C—R′; R1, R′ is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy or a functional group having one of following general formulae: wherein A1, A2, A3, A4, A5, is independently selected from H, halogen such as F, Cl, Br or I, CF3, alkyl, preferably C1–C4 alkyl, nitro, nitrile, alkoxy, preferably C1–C4 alkoxy, halogenated (such as F, Cl, Br and I) alkyl, preferably halogenated C1–C4 alkyl, halogenated (such as F, Cl, Br and I) alkoxy, preferably halogenated C1–C4 alkoxy, phenyl, and halogenated (such as F, Cl, Br and I phenyl; R2 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.
摘要翻译：本申请涉及用于制备PNA（肽核酸）寡聚体的通式（I）的单体，并提供合成预定义的序列PNA寡聚体和随机序列PNA寡聚体的方法：其中E为硫或氧; J为氮或C-R'; R1，R'独立地为H，卤素，烷基，硝基，腈，烷氧基，卤代烷基，卤代烷氧基或具有以下通式之一的官能团：其中A 1， A 3，A 4，A 5 H独立地选自H，卤素如F，Cl，Br或 I，CF 3，烷基，优选C 1 -C 4烷基，硝基，腈，烷氧基，优选C 1〜卤代（如F，Cl，Br和I）烷基，优选卤代C 1 -C 4烷基，C 1 -C 4烷基，，卤代（如F，Cl，Br和I）烷氧基，优选卤代C 1 -C 4烷氧基，苯基和卤代（如F，Cl，Br 和I苯基; R2是H或天然或非天然α-氨基酸的保护或未保护的侧链; B是天然或非天然核碱基，其中当所述核碱基具有外来氨基功能时，所述功能受保护基团不稳定酸，但稳定在硫醇存在下为弱至中等碱。

9. 发明授权

US08450770B2 Light emitting package structure 有权
标题翻译：发光封装结构
公开(公告)号：US08450770B2
公开(公告)日：2013-05-28
申请号：US12777525
申请日：2010-05-11
申请人： Hyunsoo Jeong , Seongoo Lee , Ryungshik Park , Hyunil Lee
发明人： Hyunsoo Jeong , Seongoo Lee , Ryungshik Park , Hyunil Lee
IPC分类号： H01L27/15 , H01L29/267 , H01L31/12 , H01L33/00 , H01L21/00
CPC分类号： H01L33/508 , H01L33/54 , H01L2224/48091 , H01L2224/73265 , H01L2224/8592 , H01L2924/181 , H01L2933/0066 , H01L2924/00014 , H01L2924/00012
摘要： A light emitting diode (LED) package structure comprising a carrier, an LED chip, a first encapsulant, at least one bonding wire, a plurality of phosphor particles and a second encapsulant is provided. The LED chip is disposed on the carrier. The LED chip has at least one electrode. The first encapsulant is disposed on the carrier and covering the LED chip. The first encapsulant is provided with at least one preformed opening exposing at least a portion of the at least one electrode. The at least one bonding wire is electrically connected between the at least one electrode and the carrier via the at least one preformed opening. The phosphor particles are distributed within the first encapsulant. The second encapsulant is disposed on the carrier and encapsulates the LED chip, the first encapsulant and the at least one bonding wire.
摘要翻译：提供了包括载体，LED芯片，第一密封剂，至少一个接合线，多个荧光体颗粒和第二密封剂的发光二极管（LED）封装结构。 LED芯片设置在载体上。 LED芯片具有至少一个电极。第一密封剂设置在载体上并覆盖LED芯片。第一密封剂设置有暴露至少一个电极的至少一部分的至少一个预制开口。所述至少一个接合线经由所述至少一个预制开口电连接在所述至少一个电极和所述载体之间。磷光体颗粒分布在第一密封剂内。第二密封剂设置在载体上并封装LED芯片，第一密封剂和至少一个接合线。

10. 发明申请

US20110014715A1 Synthesis of Peptide Nucleic Acids Conjugated with Amino Acids and Their Application 有权
标题翻译：氨基酸共轭肽核酸的合成及其应用
公开(公告)号：US20110014715A1
公开(公告)日：2011-01-20
申请号：US12810453
申请日：2009-01-08
申请人： Hyunil Lee , Jung Hyun Min
发明人： Hyunil Lee , Jung Hyun Min
IPC分类号： G01N33/48 , C07K9/00 , C07C271/06 , C08G64/00
CPC分类号： C07H7/00 , C07K14/003 , Y10T436/143333
摘要： This invention relates to a peptide nucleic acid (PNA) oligomer which is conjugated with one or more linear-type amino acid containing a plurality of alkyleneglycols and to a synthesis method thereof. In addition, this invention related to a linear amino acid spacer in a device for detection for detecting a target gene using the PNA oligomers which is fixed on a surface of a functionalized solid support. The linear amino acid spacer contains a plurality of alkyleneglycols and maintains enough space between the solid support and PNA oligomer in the device in order to prevent the interference of the interaction between the PNA oligomer and a target gene. Furthermore, this invention relates to a PNA array, a PNA chip and a gene diagnosis kit whereof sensitivity and specificity are improved by being manufactured with the PNA conjugated with the amino acid spacer.
摘要翻译：本发明涉及与含有多个亚烷基二醇的一种或多种线型氨基酸缀合的肽核酸（PNA）寡聚体及其合成方法。此外，本发明涉及使用固定在官能化固体支持物表面上的PNA低聚物检测靶基因的检测装置中的线性氨基酸间隔物。线性氨基酸间隔物包含多个亚烷基二醇并且在该装置中的固体支持物和PNA低聚物之间保持足够的空间，以便防止PNA低聚物与靶基因之间的相互作用的干扰。此外，本发明涉及一种PNA阵列，PNA芯片和基因诊断试剂盒，其通过用氨基酸间隔基缀合的PNA制备灵敏度和特异性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式