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1. 发明申请

US20060240464A1 Novel 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552, and 65577 molecules and uses therefor 失效
标题翻译：新颖的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577分子及其用途
公开(公告)号：US20060240464A1
公开(公告)日：2006-10-26
申请号：US11429599
申请日：2006-05-05
申请人： Rachel Meyers , Joseph Carroll , William Cook , Rosana Kapeller-Libermann , Nadine Weich , Rajasekhar Bandaru
发明人： Rachel Meyers , Joseph Carroll , William Cook , Rosana Kapeller-Libermann , Nadine Weich , Rajasekhar Bandaru
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： A61K38/16 , A01K2217/05 , A61K38/4813 , A61K39/00 , A61K2039/53 , C07K14/47 , C07K2319/00 , C12N9/0008 , C12N9/12 , C12N9/16 , C12N9/20 , C12N9/6416 , C12N9/6424 , C12N9/6491 , C12N9/93 , C12Q1/25 , C12Q1/37 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Y603/02019 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/573 , G01N33/68 , G01N2500/10 , Y10T436/143333 , A61K2300/00
摘要： The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。还提供了利用本发明组合物的诊断和治疗方法。

2. 发明申请

US20070065848A1 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor 有权
标题翻译： 26199,33530,3949,47148,50226,58764,612113,32144,32235,23565,13305,14911,86216,25206和8843分子及其用途
公开(公告)号：US20070065848A1
公开(公告)日：2007-03-22
申请号：US11493347
申请日：2006-07-26
申请人： Rachel Meyers , Kyle MacBeth , Rory Curtis , Laura Rudolph-Owen , Nadine Weich , Peter Olandt , Fong-Ying Tsai , Rosana Kapeller-Libermann , Joseph Carroll
发明人： Rachel Meyers , Kyle MacBeth , Rory Curtis , Laura Rudolph-Owen , Nadine Weich , Peter Olandt , Fong-Ying Tsai , Rosana Kapeller-Libermann , Joseph Carroll
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12N9/001 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N9/0006 , C12N9/10 , C12N9/1048 , C12N9/1096 , C12N9/12 , C12N9/1205 , C12N9/16 , C12N9/48 , C12N9/80 , C12N2799/021 , C12Q1/32 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N2500/10 , Y10T436/143333
摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。还提供了利用本发明组合物的诊断和治疗方法。

3. 发明申请

US20070099274A1 Novel human protein kinase, phosphatase, and protease family members and uses thereof 失效
标题翻译：新型人蛋白激酶，磷酸酶和蛋白酶家族成员及其用途
公开(公告)号：US20070099274A1
公开(公告)日：2007-05-03
申请号：US11636948
申请日：2006-12-11
申请人： Rachel Meyers , Peter Olandt , Rosana Kapeller-Libermann , Rory Curtis , Mark Williamson , Nadine Weich
发明人： Rachel Meyers , Peter Olandt , Rosana Kapeller-Libermann , Rory Curtis , Mark Williamson , Nadine Weich
IPC分类号： C12P21/06 , C12N9/12 , C12N9/16 , C12N9/64 , C07H21/04
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40 , C12N9/12 , C12N9/16 , C12N9/48 , C12N9/6424 , C12N9/6427 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。还提供了利用本发明组合物的诊断方法。

4. 发明申请

US20060003413A1 Novel human protein kinase, phosphatase, and protease family members and uses thereof 有权
公开(公告)号：US20060003413A1
公开(公告)日：2006-01-05
申请号：US11151601
申请日：2005-06-13
申请人： Rachel Meyers , Peter Olandt , Rosana Kapeller-Libermann , Rory Curtis , Mark Williamson , Nadine Weich
发明人： Rachel Meyers , Peter Olandt , Rosana Kapeller-Libermann , Rory Curtis , Mark Williamson , Nadine Weich
IPC分类号： C07H21/04 , C12P21/06 , C12N9/12 , C12N9/16 , C12N9/64
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40 , C12N9/12 , C12N9/16 , C12N9/48 , C12N9/6424 , C12N9/6427 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

5. 发明授权

US07070947B2 Human protein kinase, phosphatase, and protease family members and uses thereof 失效
标题翻译：人蛋白激酶，磷酸酶和蛋白酶家族成员及其用途
公开(公告)号：US07070947B2
公开(公告)日：2006-07-04
申请号：US10170789
申请日：2002-06-13
申请人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
发明人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
IPC分类号： C12N1/20 , C12N15/00 , C12N5/00 , C12N9/14 , C12Q1/34
CPC分类号： C12N9/12 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K16/40 , C07K2319/00 , C12N9/1205 , C12N9/14 , C12N9/16 , C12N9/6424 , C12N9/6427 , C12N9/6437 , C12Q1/34 , C12Q1/44 , C12Y207/01001 , C12Y301/02015 , C12Y304/21004 , C12Y304/21021 , G01N33/5011 , G01N33/502 , G01N33/5041 , G01N33/6893 , G01N2500/00
摘要： The invention provides isolated nucleic acids molecules, designated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, hexokinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, 14760, 53070, 15985, 50365, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族的分离的核酸分子，命名为2504,15977,14760,53070,15985,5042,56583,21953，m32404,14089和23436核酸分子成员，己糖激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。本发明还提供了反义核酸分子，含有2504,15977,14760,53070,15985,5042,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，和非人类转基因动物，其中引入或破坏了2504,15977,14760,53070,15985,550365,26583,21953，m32404,14089或23436基因。本发明还进一步提供分离的2504,15977,14760,53070,15985,5038,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗2504,15977,14760,53070,15985,50365， 26583,21953，m32404,14089或23436抗体。还提供了利用本发明组合物的诊断方法。

6. 发明授权

US07282360B2 Human protein kinase, phosphatase, and protease family members and uses thereof 失效
标题翻译：新型人类蛋白激酶，磷酸酶和蛋白酶家族成员及其用途
公开(公告)号：US07282360B2
公开(公告)日：2007-10-16
申请号：US11636948
申请日：2006-12-11
申请人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
发明人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
IPC分类号： C12N9/20 , C12N15/00 , C12N1/20 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40 , C12N9/12 , C12N9/16 , C12N9/48 , C12N9/6424 , C12N9/6427 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人类蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。还提供了利用本发明组合物的诊断方法。

7. 发明申请

US20090324608A1 Novel human protein kinase, phosphatase, and protease family members and uses thereof 审中-公开
标题翻译：新型人蛋白激酶，磷酸酶和蛋白酶家族成员及其用途
公开(公告)号：US20090324608A1
公开(公告)日：2009-12-31
申请号：US11899343
申请日：2007-09-05
申请人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
发明人： Rachel E. Meyers , Peter J. Olandt , Rosana Kapeller-Libermann , Rory A. J. Curtis , Mark Williamson , Nadine Weich
IPC分类号： C12N15/52 , C12N15/85 , C12N5/10 , C12N9/12 , C12N9/48 , C12N9/76 , C07K16/40 , C12P21/02 , C12N9/99 , A61K38/02 , A61K39/395 , C12Q1/68
摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。还提供了利用本发明组合物的诊断方法。

8. 发明申请

US20080051322A1 14400, 2838, 14618, 15334, 14274, 32164, 39404, 38911, 26904, 31237, 18057, 16405, 32705, 23224, 27423, 32700, 32712 and 12216, novel seven-transmembrane proteins/G-protein coupled receptors 审中-公开
标题翻译： 14400,2838,14618,15334,14274,32164,39404,38911,26904,313237,18057,16405,32705,23224,27423,32700,32712和12216，新型七跨膜蛋白/ G蛋白偶联受体
公开(公告)号：US20080051322A1
公开(公告)日：2008-02-28
申请号：US11810360
申请日：2007-06-05
申请人： Maria Glucksmann , Nadine Weich , John Hunter , David White , Kyle MacBeth , Mark Williamson , Rachel Meyers , Miyoung Chun
发明人： Maria Glucksmann , Nadine Weich , John Hunter , David White , Kyle MacBeth , Mark Williamson , Rachel Meyers , Miyoung Chun
IPC分类号： A61K38/16 , A61K38/00 , A61P43/00 , C07H21/04 , C07K16/00 , C12N5/00 , C12P21/04 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/566 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K14/723 , C07K2319/00 , C12N9/16 , G01N2333/726
摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.
摘要翻译：本发明涉及属于G蛋白偶联受体的超家族的新鉴定的受体。本发明还涉及编码受体的多核苷酸。本发明还涉及使用受体多肽和多核苷酸作为在受体介导的病症中进行诊断和治疗的靶标的方法。本发明还涉及使用受体多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于受体多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生受体多肽和多核苷酸的方法。

9. 发明授权

US07695712B2 Recovery of tissue function following administration of B cells to injured tissue 有权
标题翻译：将B细胞给予损伤组织后恢复组织功能
公开(公告)号：US07695712B2
公开(公告)日：2010-04-13
申请号：US11406508
申请日：2006-04-18
申请人： Mark C. Poznansky , Traci T. Goodchild , Mark T. Ungs , Nicholas A. F. Chronos , Nadine Weich
发明人： Mark C. Poznansky , Traci T. Goodchild , Mark T. Ungs , Nicholas A. F. Chronos , Nadine Weich
IPC分类号： C12N5/0781 , A01N65/00
CPC分类号： A61K35/17 , A61K2035/124 , C12N5/0635
摘要： The present invention relates generally to systems and methods of enhancing recovery of function of injured tissue through administration of a composition comprising a relatively pure populations of B lymphocyte cells in a pharmaceutically acceptable carrier to the injured tissue. Kits are provided to aid in purification of B cells from heterogeneous mixtures of cells and administration of B cells to injured tissue.
摘要翻译：本发明一般涉及通过将包含药学上可接受的载体中相对纯的B淋巴细胞群体的组合物施用于受损组织来增强受损组织的功能恢复的系统和方法。提供试剂盒以帮助从异种细胞混合物中纯化B细胞，并将B细胞给予损伤组织。

10. 发明申请

US20070031882A1 Methods and compositions for treating AIDS and HIV-related disorders using 1414, 1481,1553, 34021, 1720, 1683, 1552, 1682, 1675, 12825, 9952, 5816, 10002, 1611, 1371, 14324, 126, 270, 312, 167, 326, 18926, 6747, 1793, 1784 or 2045 molecules 审中-公开
标题翻译：使用1414,1481,1553,3402,1720,1683,1552,1682,1675,122825,9952,5816,10002,1611,1371,14324,126,270,312,39， 167,326,18926,6747,1793,1784或2045分子
公开(公告)号：US20070031882A1
公开(公告)日：2007-02-08
申请号：US11545891
申请日：2006-10-11
申请人： Douglas Powell , Nadine Weich
发明人： Douglas Powell , Nadine Weich
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： C12Q1/703
摘要： The present invention relates to methods for the diagnosis and treatment of AIDS or an HIV-related disorder or disorders. Specifically, the present invention identifies the differential expression of 1414, 1481, 1553, 34021, 1720, 1683, 1552, 1682, 1675, 12825, 9952, 5816, 10002, 1611, 1371, 14324, 126, 270, 312, 167, 326, 18926, 6747, 1793, 1784 and 2045 genes in tissues relating to AIDS or an HIV-related disorder, relative to their expression in normal, or non-AIDS or HIV-related disease states, and/or in response to manipulations relevant to AIDS or an HIV-related disorder. The present invention describes methods for the diagnostic evaluation and prognosis of various HIV-related disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating AIDS or an HIV-related disorder or disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of AIDS or an HIV-related disorder.
摘要翻译：本发明涉及用于诊断和治疗AIDS或HIV相关疾病或病症的方法。具体地说，本发明鉴定1414,1481,1553,34021,1720,1683,1552,1682,1675,122825,9952,516,10002,1611,1371,14324,126,270,312，相对于其在正常或非艾滋病或HIV相关疾病状态中的表达，和/或响应于相关操作相关的与艾滋病或HIV相关疾病有关的组织中的326,389,267,47,47和1784和2045个基因艾滋病或艾滋病毒相关疾病。本发明描述了用于各种HIV相关疾病的诊断评价和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。本发明还提供了鉴定能够调节艾滋病或HIV相关疾病或病症的化合物的方法。本发明还提供了用于鉴定和治疗性使用化合物作为AIDS或HIV相关病症治疗的方法。

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