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1. 发明申请

US20090198223A1 SYSTEMS AND METHODS FOR CARDIAC ABLATION USING LASER INDUCED OPTICAL BREAKDOWN 审中-公开
标题翻译：使用激光诱导光学断裂进行心脏吸收的系统和方法
公开(公告)号：US20090198223A1
公开(公告)日：2009-08-06
申请号：US12297012
申请日：2007-04-02
申请人： Rachel Estelle Thilwind , Robbert Adrianus Maria van Hal , Rieko Verhagen , Paul Anton Josef Ackermans , Dirk Brokken , Jozef J.M. Janssen , Bart Gottenbos , Sieglinde Neerken , Francisco Morales Serrano
发明人： Rachel Estelle Thilwind , Robbert Adrianus Maria van Hal , Rieko Verhagen , Paul Anton Josef Ackermans , Dirk Brokken , Jozef J.M. Janssen , Bart Gottenbos , Sieglinde Neerken , Francisco Morales Serrano
IPC分类号： A61B18/24 , A61B5/04
CPC分类号： A61B18/24 , A61B2017/00243 , A61B2018/2266
摘要： Systems and methods for achieving sub-surface, highly spatially selective cardiac ablation by means of laser induced optical breakdown (LIOB) are disclosed. Damage to non-targeted heart and artery/vein tissue is to be minimized according to the present disclosure. A catheter enters the heart, e.g., via a vein, and catheter location is determined/confirmed. Laser pulses are guided through the optical path within the catheter and, at or near the catheter end, a focusing structure is provided that focuses the laser radiation through the non-targeted vein/heart tissue into the targeted tissue. In the focusing structure, laser induced LIOB occurs and related mechanical effects affect the targeted tissue.
摘要翻译：公开了通过激光诱导光学击穿（LIOB）实现子表面，高度空间选择性心脏消融的系统和方法。根据本公开，要使对非靶向心脏和动脉/静脉组织的损伤最小化。导管例如通过静脉进入心脏，并且确定/确认导管位置。激光脉冲被引导通过导管内的光路，并且在导管末端处或附近提供聚焦结构，其将激光辐射通过非靶向静脉/心脏组织聚焦到目标组织中。在聚焦结构中，激光诱导的LIOB发生并且相关的机械效应影响目标组织。

2. 发明授权

US08821482B2 Device and method for the treatment of skin, and use of the device 有权
标题翻译：用于治疗皮肤的装置和方法，以及使用该装置
公开(公告)号：US08821482B2
公开(公告)日：2014-09-02
申请号：US12305438
申请日：2007-06-21
申请人： Rieko Verhagen , Robbert Adrianus Maria Van Hal , Bart Gottenbos , Jozef Johannes Maria Janssen , Paul Anton Josef Ackermans , Francisco Morales Serrano , Sieglinde Neerken , Dirk Brokken , Guido Roosen
发明人： Rieko Verhagen , Robbert Adrianus Maria Van Hal , Bart Gottenbos , Jozef Johannes Maria Janssen , Paul Anton Josef Ackermans , Francisco Morales Serrano , Sieglinde Neerken , Dirk Brokken , Guido Roosen
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B5/1077 , A61B5/442 , A61B18/20 , A61B90/361 , A61B2017/00057 , A61B2017/00106 , A61B2017/00154 , A61B2018/00452 , A61B2018/0047 , A61B2018/00666 , A61B2018/00904 , A61B2018/20351
摘要： The invention provides a skin treatment device comprising a laser source (40) and focusing optics (50), such that a focal spot (18) is positioned in a dermis layer (24) of the skin to be treated. The laser beam (42) is powered and focused (16) such that a LIOB (laser induced optical breakdown) phenomenon is obtained, which affects the skin in order to stimulate re-growth of tissue. This in turn reduces wrinkles (30). The device may comprise wrinkle-determining means (52, 54, 56, 58). The focusing optics (50) may have a numerical aperture of at least 0.4. The invention also provides a corresponding method to treat skin, in particular to reduce wrinkles (30), by providing a focused laser beam (16) that causes LIOB in the dermis layer (24) of the skin. The advantage is that damage to overlaying epidermis layers may be avoided by the use of the very local LIOB phenomenon.
摘要翻译：本发明提供一种皮肤治疗装置，其包括激光源（40）和聚焦光学元件（50），使得焦点（18）位于待治疗皮肤的真皮层（24）中。激光束（42）被供电并聚焦（16），使得获得LIOB（激光诱导光学击穿）现象，其影响皮肤以刺激组织的再生长。这反过来又减少皱纹（30）。该装置可以包括皱纹确定装置（52,54,56,58）。聚焦光学元件（50）可以具有至少0.4的数值孔径。本发明还提供了一种相应的治疗皮肤的方法，特别是通过提供在皮肤真皮层（24）中引起LIOB的聚焦激光束（16）来减少皱纹（30）。优点是可以通过使用非常局部的LIOB现象来避免覆盖表皮层的损伤。

3. 发明申请

US20100063490A1 DEVICE AND METHOD FOR THE TREATMENT OF SKIN, AND USE OF THE DEVICE 有权
标题翻译：用于治疗皮肤的装置和方法以及装置的使用
公开(公告)号：US20100063490A1
公开(公告)日：2010-03-11
申请号：US12305438
申请日：2007-06-21
申请人： Rieko Verhagen , Robbert A.M. Van Hal , Bart Gottenbos , Jozef J.M. Janssen , Paul A.J. Ackermans , Francisco Morales Serrano , Sieglinde Nerken , Dirk Brokken , Guido Roosen
发明人： Rieko Verhagen , Robbert A.M. Van Hal , Bart Gottenbos , Jozef J.M. Janssen , Paul A.J. Ackermans , Francisco Morales Serrano , Sieglinde Nerken , Dirk Brokken , Guido Roosen
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B5/1077 , A61B5/442 , A61B18/20 , A61B90/361 , A61B2017/00057 , A61B2017/00106 , A61B2017/00154 , A61B2018/00452 , A61B2018/0047 , A61B2018/00666 , A61B2018/00904 , A61B2018/20351
摘要： The invention provides a skin treatment device comprising a laser source (40) and focusing optics (50), such that a focal spot (18) is positioned in a dermis layer (24) of the skin to be treated. The laser beam (42) is powered and focused (16) such that a LIOB (laser induced optical breakdown) phenomenon is obtained, which affects the skin in order to stimulate re-growth of tissue. This in turn reduces wrinkles (30). The device may comprise wrinkle-determining means (52, 54, 56, 58). The focusing optics (50) may have a numerical aperture of at least 0.4. The invention also provides a corresponding method to treat skin, in particular to reduce wrinkles (30), by providing a focused laser beam (16) that causes LIOB in the dermis layer (24) of the skin. The advantage is that damage to overlaying epidermis layers may be avoided by the use of the very local LIOB phenomenon.
摘要翻译：本发明提供一种皮肤治疗装置，其包括激光源（40）和聚焦光学元件（50），使得焦点（18）位于待治疗皮肤的真皮层（24）中。激光束（42）被供电并聚焦（16），使得获得LIOB（激光诱导光学击穿）现象，其影响皮肤以刺激组织的再生长。这反过来又减少皱纹（30）。该装置可以包括皱纹确定装置（52,54,56,58）。聚焦光学元件（50）可以具有至少0.4的数值孔径。本发明还提供了一种相应的治疗皮肤的方法，特别是通过提供在皮肤真皮层（24）中引起LIOB的聚焦激光束（16）来减少皱纹（30）。优点是可以通过使用非常局部的LIOB现象来避免覆盖表皮层的损伤。

4. 发明授权

US08684961B2 Insert for a breast pump 有权
标题翻译：插入吸奶器
公开(公告)号：US08684961B2
公开(公告)日：2014-04-01
申请号：US13377303
申请日：2010-06-09
申请人： Bart Gottenbos , Rachel Estelle Thilwind , Jozef Johannes Maria Janssen , Marjolein Irene Van Lieshout
发明人： Bart Gottenbos , Rachel Estelle Thilwind , Jozef Johannes Maria Janssen , Marjolein Irene Van Lieshout
IPC分类号： A61M1/06
CPC分类号： A61M1/066
摘要： An insert for a breast-receiving funnel of a breast pump includes an elongate inflatable bladder which defines a pressure chamber. The elongate inflatable bladder is configured to fit in a teat receiving space of the breast receiving funnel so that the bladder extends from an inner end of the funnel towards an outer end of the funnel. The bladder lies between a user's teat and the funnel when a breast is inserted in the funnel, such that the elongate inflatable bladder is configured to deform towards a user's teat located in the teat receiving space in a predetermined manner when a pressure difference is applied between the teat receiving space and the pressure chamber such that a peristaltic action is applied to the user's teat, to aid the expression of milk therefrom.
摘要翻译：用于吸乳器的乳房接收漏斗的插入件包括限定压力室的细长的可充气囊。细长的可充气囊被构造成装配在乳房容纳漏斗的奶嘴接收空间中，使得囊从漏斗的内端朝向漏斗的外端延伸。当乳房插入漏斗中时，膀胱位于使用者的乳头和漏斗之间，使得细长的可充气气囊被配置成在预定方式上朝向位于乳头接收空间中的使用者乳头变形时，乳头接收空间和压力室，使得蠕动作用施加于使用者的乳头，以帮助从其中表达牛奶。

5. 发明申请

US20120035536A1 BREAST PUMP INSERT 审中-公开
标题翻译：乳房插管
公开(公告)号：US20120035536A1
公开(公告)日：2012-02-09
申请号：US13257050
申请日：2010-03-31
申请人： Bart Gottenbos , Rachel Estelle Thilwind , Jozef Johannes Maria Janssen , Marjolein Irene Van Lieshout
发明人： Bart Gottenbos , Rachel Estelle Thilwind , Jozef Johannes Maria Janssen , Marjolein Irene Van Lieshout
IPC分类号： A61M1/06
CPC分类号： A61M1/066
摘要： A breast pump insert to receive the breast of a user of a breast pump is disclosed. The insert is formed from inner and outer materials, wherein the outer material exhibits greater hardness than the inner material.
摘要翻译：公开了一种用于接收吸奶器使用者的乳房的吸奶器插入件。插入件由内部和外部材料形成，其中外部材料表现出比内部材料更大的硬度。

6. 发明申请

US20120083731A1 Insert for a breast pump 有权
标题翻译：插入吸奶器
公开(公告)号：US20120083731A1
公开(公告)日：2012-04-05
申请号：US13377303
申请日：2010-06-09
申请人： Bart Gottenbos , Rachel Estelle Thilwind , Jozef Johannes Maria Janssen , Marjolein Irene Van Lieshout
发明人： Bart Gottenbos , Rachel Estelle Thilwind , Jozef Johannes Maria Janssen , Marjolein Irene Van Lieshout
IPC分类号： A61M1/06
CPC分类号： A61M1/066
摘要： An insert for a breast-receiving funnel (10) of a breast pump comprising an elongate inflatable bladder (23) which defines a pressure chamber (26), the elongate inflatable bladder (23) being adapted to fit in a teat receiving space (11) of said breast receiving funnel (10) so that the bladder extends from an inner end of said funnel towards an outer end of said funnel, and lie between a user's teat and the funnel when a breast is inserted in the funnel, such that the elongate inflatable bladder is configured to deform towards a user's teat located in the teat receiving space in a predetermined manner when a pressure difference is applied between the teat receiving space and the pressure chamber such that a peristaltic action is applied to said user's teat, to aid the expression of milk therefrom.
摘要翻译：一种用于乳房接收漏斗（10）的插入物，其包括限定压力室（26）的细长的可充气气囊（23），所述细长的可充气囊（23）适于装配在奶嘴接收空间（11 ），使得所述囊从所述漏斗的内端朝向所述漏斗的外端延伸，并且当乳房插入漏斗中时，位于使用者的乳头和漏斗之间，使得细长的可充气囊被构造成当在奶头接收空间和压力室之间施加压力差时以预定的方式朝着位于奶头接收空间内的使用者的奶头变形，使得蠕动动作施加到所述使用者的乳头，以帮助牛奶的表达。

7. 发明申请

US20090305187A1 LIQUID INTERDENTAL CLEANER 有权
标题翻译：液体内部清洁剂
公开(公告)号：US20090305187A1
公开(公告)日：2009-12-10
申请号：US12374505
申请日：2007-07-06
申请人： Jozef Johannes Maria Janssen , Bart Gottenbos , Luciana Opran , Petrus Henricus De Leeuw , Dirk Brokken , Arjan Leo Van Der Sande
发明人： Jozef Johannes Maria Janssen , Bart Gottenbos , Luciana Opran , Petrus Henricus De Leeuw , Dirk Brokken , Arjan Leo Van Der Sande
IPC分类号： A61C17/02
CPC分类号： A61C17/0217 , A61C17/0202 , A61C17/028
摘要： The interdental cleaner includes a source of liquid (22) and a control system (42) including a manual pump (26), for moving a selected amount of liquid, suitable for a single use, into a liquid pathway and there to a mixing chamber (53). A source of pressurized gas (30), such as a CO2 cartridge, is used to preload a selected amount of gas into a gas chamber (52). The control system includes a spring-loaded button (18), which upon operation results in the manual pump (26) being operated, forcing the selected amount of liquid into the mixing chamber, and then upon release, permits the pressurized gas in the gas chamber to enter the mixing chamber, breaking up the liquid therein into droplets and a liquid stream, and propelling the resulting liquid out of a nozzle portion (14) of the cleaner into the interproximal area of the teeth.
摘要翻译：齿间清洁器包括液体源（22）和包括手动泵（26）的控制系统（42），用于将选定量的适于一次使用的液体移动到液体通道中，并且到达混合室（53）。使用诸如CO 2筒的加压气体源（30）将选定量的气体预加载到气室（52）中。控制系统包括弹簧加载按钮（18），其在操作时导致手动泵（26）被操作，迫使选定量的液体进入混合室，然后在释放时允许气体中的加压气体室进入混合室，将其中的液体分解为液滴和液体流，并将所得液体从吸尘器的喷嘴部分（14）推出到齿的邻近区域中。

8. 发明授权

US08668493B2 Liquid interdental cleaner 有权
标题翻译：液体齿间清洁剂
公开(公告)号：US08668493B2
公开(公告)日：2014-03-11
申请号：US12374505
申请日：2007-07-06
申请人： Jozef Johannes Maria Janssen , Bart Gottenbos , Luciana Opran , Petrus Henricus Le Leeuw , Dirk Brokken , Arjan Leo Van Der Sande
发明人： Jozef Johannes Maria Janssen , Bart Gottenbos , Luciana Opran , Petrus Henricus Le Leeuw , Dirk Brokken , Arjan Leo Van Der Sande
IPC分类号： A61C3/02
CPC分类号： A61C17/0217 , A61C17/0202 , A61C17/028
摘要： The interdental cleaner includes a source of liquid (22) and a control system (42) including a manual pump (26), for moving a selected amount of liquid, suitable for a single use, into a liquid pathway and there to a mixing chamber (53). A source of pressurized gas (30), such as a CO2 cartridge, is used to preload a selected amount of gas into a gas chamber (52). The control system includes a spring-loaded button (18), which upon operation results in the manual pump (26) being operated, forcing the selected amount of liquid into the mixing chamber, and then upon release, permits the pressurized gas in the gas chamber to enter the mixing chamber, breaking up the liquid therein into droplets and a liquid stream, and propelling the resulting liquid out of a nozzle portion (14) of the cleaner into the interproximal area of the teeth.
摘要翻译：齿间清洁器包括液体源（22）和包括手动泵（26）的控制系统（42），用于将选定量的适于一次使用的液体移动到液体通道中，并且到达混合室（53）。使用诸如CO 2筒的加压气体源（30）将选定量的气体预加载到气室（52）中。控制系统包括弹簧加载按钮（18），其在操作时导致手动泵（26）被操作，迫使选定量的液体进入混合室，然后在释放时允许气体中的加压气体室进入混合室，将其中的液体分解为液滴和液体流，并将所得液体从吸尘器的喷嘴部分（14）推出到齿的邻近区域中。

9. 发明申请

US20100269281A1 ANTIMICROBIAL FILLED CAPSULES IN AN ULTRASOUND FIELD FOR TREATMENT OF DENTAL BIOFILM 失效
标题翻译：用于治疗牙齿生物膜的超声波填充胶囊中的抗微生物填充胶囊
公开(公告)号：US20100269281A1
公开(公告)日：2010-10-28
申请号：US12808254
申请日：2008-12-09
申请人： Bart Gottenbos , Marcel Rene Bohmer , Jozef Johannes Marie Janssen
发明人： Bart Gottenbos , Marcel Rene Bohmer , Jozef Johannes Marie Janssen
IPC分类号： A46B9/04
CPC分类号： A61C17/20 , A46B15/0002 , A46B15/0028 , A46B2200/1066 , A61C17/0202 , A61C17/22 , A61C17/227 , A61K8/11 , A61K2800/82 , A61Q11/00
摘要： An appliance and corresponding method for delivering antimicrobial agents to the vicinity of dental biofilm and for killing bacteria therein includes a system (18, 20, 24) for delivering polymeric capsules containing gas bubbles and an antimicrobial agent. A source of ultrasonic energy (18) is provided for moving the capsules toward the biofilm, the ultrasonic energy having sufficient intensity for thereafter bursting the capsules, in the vicinity of the biofilm, releasing the gas bubbles and the agent. The gas bubbles vibrate within the ultrasound field, disrupting the biofilm, so that the released agent can act effectively against the bacteria in the disrupted biofilm.
摘要翻译：用于将抗微生物剂递送到牙齿生物膜附近并用于杀死细菌的器具和相应方法包括用于递送含有气泡的聚合物胶囊和抗微生物剂的系统（18,20,24）。提供超声波能量源（18），用于将胶囊朝向生物膜移动，超声能量具有足够的强度，此后使生物膜附近的胶囊爆裂，释放出气泡和药剂。气泡在超声波场内振动，破坏了生物膜，使得释放的试剂能够有效地对抗破坏的生物膜中的细菌。

10. 发明授权

US08454360B2 Liquid droplet interproximal cleaning apparatus with gas stream protection 失效
标题翻译：具有气流保护的液滴邻接清洗装置
公开(公告)号：US08454360B2
公开(公告)日：2013-06-04
申请号：US13126497
申请日：2009-10-30
申请人： Jozef Johannes Maria Janssen , Bart Gottenbos
发明人： Jozef Johannes Maria Janssen , Bart Gottenbos
IPC分类号： A61C3/02
CPC分类号： A61C17/0217 , A61C17/0202
摘要： The interproximal cleaning apparatus includes a gas reservoir (12) containing a compressed gas, such as CO2, in both liquid and gaseous states. A siphon tube (20) extends down into the liquid region of the gas reservoir when the apparatus is in an upright position. The siphon tube connects the reservoir to a metering valve (18) which has a metered volume to accommodate an amount of liquid compressed gas which is sufficient for good liquid droplet cleaning when it decompresses and forms a gaseous stream, without damage to the dental regions of the user. If the apparatus is severely tilted or turned upside down, gaseous CO2 or a combination of gaseous and liquid CO2 will enter the siphon tube and then the metering valve. The size of the metering valve will limit the volume of the gaseous CO2 to a safe amount, both when liquid CO2 or gaseous CO2 are applied to the metering valve.
摘要翻译：邻间清洁装置包括在液态和气态两者中含有诸如CO 2的压缩气体的气体储存器（12）。当设备处于直立位置时，虹吸管（20）向下延伸到气体储存器的液体区域中。虹吸管将储存器连接到计量阀（18），计量阀（18）具有计量体积以容纳一定量的液体压缩气体，当液体压缩气体减压并形成气流时，该液体压缩气体足够用于良好的液滴清洁，而不损害牙齿区域用户。如果设备严重倾斜或倒过来，气态CO2或气态和液态二氧化碳的组合将进入虹吸管，然后进入计量阀。当液体CO2或气态二氧化碳被施加到计量阀时，计量阀的尺寸将限制气态二氧化碳的体积达到安全的量。

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