专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07622464B2 Morpholinyl-urea derivatives for use in the treatment of inflammatory diseases 有权
标题翻译：用于治疗炎性疾病的吗啉基 - 脲衍生物
公开(公告)号：US07622464B2
公开(公告)日：2009-11-24
申请号：US10509162
申请日：2003-03-27
申请人： Rachael Ann Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Martin Alistair Hayes , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Gail Mills , Graeme Michael Robertson , Stephen Swanson , Andrew John Walker , Mark Wilkinson
发明人： Rachael Ann Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Martin Alistair Hayes , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Gail Mills , Graeme Michael Robertson , Stephen Swanson , Andrew John Walker , Mark Wilkinson
IPC分类号： A61K31/535 , C07D413/14 , C07D413/12
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents —(CRnaRnb)n—; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 0 to 5; R2 represents unsubstituted or substituted aryl or unsubstituted or substituted heteroaryl; R3 and R4 each independently represent hydrogen or C1-6-alkyl; R7 represents hydrogen or C1-6alkyl; R8 represents hydrogen or C1-6alkyl; and salts and solvates thereof; are CCR3 antagonists and are thus indicated to be useful in therapy.
摘要翻译：式（I）化合物：其中：R 1表示取代或未取代的杂芳基; Y表示 - （CRnaRnb）n-; Rna和Rnb各自独立地为氢或C 1-6烷基; n为0〜5的整数， R2表示未取代或取代的芳基或未取代或取代的杂芳基; R3和R4各自独立地表示氢或C1-6烷基; R 7表示氢或C 1-6烷基; R8代表氢或C1-6烷基; 其盐和溶剂合物; 是CCR3拮抗剂，因此被认为可用于治疗。

2. 发明授权

US07157457B2 Compounds useful in the treatment of inflammatory diseases 有权
标题翻译：可用于治疗炎性疾病的化合物
公开(公告)号：US07157457B2
公开(公告)日：2007-01-02
申请号：US10381871
申请日：2001-09-28
申请人： Rachael Anne Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Graeme Michael Robertson , Stephen Swanson
发明人： Rachael Anne Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Graeme Michael Robertson , Stephen Swanson
IPC分类号： A61K31/5375 , C07D265/30
CPC分类号： C07D265/30 , C07D267/10 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译：根据本发明，提供了式（I）的新化合物，其中R 1，R 2，R 3，R 3， 4，R 5，R 6，X，a，b和Z如说明书中所定义，制备方法，含有它们的制剂及其制备方法用于治疗炎症性疾病。

3. 发明授权

US07101882B2 Morpholin-acetamide derivatives for the treatment of inflammatory diseases 有权
标题翻译：吗啉 - 乙酰胺衍生物用于治疗炎性疾病
公开(公告)号：US07101882B2
公开(公告)日：2006-09-05
申请号：US10381767
申请日：2001-09-28
申请人： Rachael Anne Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Graeme Michael Robertson , Stephen Swanson
发明人： Rachael Anne Ancliff , Caroline Mary Cook , Colin David Eldred , Paul Martin Gore , Lee Andrew Harrison , Simon Teanby Hodgson , Duncan Bruce Judd , Suzanne Elaine Keeling , Xiao Qing Lewell , Graeme Michael Robertson , Stephen Swanson
IPC分类号： A61K31/535 , C07D265/30 , A61P29/00
CPC分类号： C07D265/30 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel morpholin-acetamide compounds of formula (I) useful for the treatment of inflammatory diseases. Compounds of formula (I) wherein R1, R2, R3, R4, R5, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译：本发明涉及可用于治疗炎性疾病的式（I）的新型吗啉 - 乙酰胺化合物。式（I）的化合物，其中R 1，R 2，R 3，R 4，R 4， > 5，X，a，b和Z如说明书中所定义，制备方法，含有它们的制剂及其在治疗炎性疾病中的用途。

4. 发明申请

US20100075953A1 SUBSTITUTED PIPERAZINES, (1,4) DIAZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS 审中-公开
标题翻译：替代哌嗪，（1,4）双嘧达嗪和2,5-DIAZABICYCLO（2.2.1）作为组胺H1和/或H3拮抗剂或组胺H3逆转拮抗剂的HEPTANES
公开(公告)号：US20100075953A1
公开(公告)日：2010-03-25
申请号：US12562285
申请日：2009-09-18
申请人： Rachael Ancliff , Colin David Eldred , Ashley Paul Hancock , Thomas Daniel Heightman , Heather Hobbs , Simon Teanby Hodgson , David Matthew Wilson
发明人： Rachael Ancliff , Colin David Eldred , Ashley Paul Hancock , Thomas Daniel Heightman , Heather Hobbs , Simon Teanby Hodgson , David Matthew Wilson
IPC分类号： A61K31/496 , A61K31/55 , A61K31/551 , A61K31/541 , A61K31/538 , C07D403/12 , C07D405/14 , C07D417/12 , C07D401/12 , C07D401/14 , A61P11/00
CPC分类号： C07D213/81 , C07D209/42 , C07D211/46 , C07D213/50 , C07D213/64 , C07D215/40 , C07D215/46 , C07D215/50 , C07D239/28 , C07D243/08 , C07D265/36 , C07D277/62 , C07D285/06 , C07D295/088 , C07D295/185 , C07D295/192 , C07D295/215 , C07D295/26 , C07D307/79 , C07D307/85 , C07D311/84 , C07D317/68 , C07D333/38 , C07D405/06 , C07D487/08 , C07D491/04
摘要： The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease.
摘要翻译：本发明涉及具有药理活性的新颖的哌嗪和吖庚因衍生物，其制备方法，含有它们的组合物及其在治疗包括阿尔茨海默病的神经变性疾病中的用途。

5. 发明授权

US5998388A Adenosine derivatives 失效
标题翻译：腺苷衍生物
公开(公告)号：US5998388A
公开(公告)日：1999-12-07
申请号：US180442
申请日：1998-11-06
申请人： Frank Ellis , Stephen Swanson , Richard Peter Charles , Brian Cox , Andrew Michael Kenneth Pennell , Colin David Eldred
发明人： Frank Ellis , Stephen Swanson , Richard Peter Charles , Brian Cox , Andrew Michael Kenneth Pennell , Colin David Eldred
IPC分类号： C07H19/167 , A61K31/7076 , A61P9/00 , A61P25/00 , C07H15/04 , C07H19/16 , A61K31/70
CPC分类号： C07H15/04 , C07H19/16
摘要： This invention relates to novel adenosine derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine. Thus the invention provides compounds of formula (I) which are agonists at the adenosine A1 receptor. ##STR1## wherein R.sup.1 represents phenyl optionally substituted by one or more substituents selected from halogen, C.sub.1-3 alkyl, trifluoromethyl, nitro, cyano, --CO.sub.2 R.sup.a.sub.1 --CONR.sup.a R.sup.b, --COR.sup.a, --SOR.sup.c, --SO.sub.2 R.sup.c, --SO.sub.3 H, --SO.sub.2 NR.sup.a R.sup.b, --OR.sup.a, --NHSO.sub.2 R.sup.c, --NHCOR.sup.a and --NR.sup.a R.sup.b,R.sup.2 represents a C.sub.1-6 alkyl or C.sub.3-6 alkenyl group; R.sup.3 represents C.sub.1-3 alkyl;R.sup.a and R.sup.b may each independently represent hydrogen or C.sub.1-3 alkyl or, when --NR.sup.a R.sup.b is directly attached to said phenyl, R.sup.a and R.sup.b together with the nitrogen atom may form a -5 or -6 or membered heterocyclic ring optionally containing a second heteroatom selected from oxygen or nitrogen, which second nitrogen heteroatom may optionally be further substituted by hydrogen or C.sub.1-3 alkyl;R.sup.c represents C.sub.1-3 alkyl;and salts and solvates thereof, in particular physiologically acceptable salts and solvates thereof.
摘要翻译： PCT No.PCT / EP97 / 02403 Sec。 371日期：1998年11月6日 102（e）日期1998年11月6日PCT提交1997年5月13日PCT公布。 WO97 / 43300 PCT出版物日期1997年11月20日本发明涉及新型腺苷衍生物，其制备方法，含有它们的药物组合物及其在医药中的用途。因此，本发明提供了作为腺苷A1受体的激动剂的式（I）化合物。其中R 1表示任选被一个或多个选自卤素，C 1-3烷基，三氟甲基，硝基，氰基，-CO 2 R 1a -CONR a R b，-COR a，-SOR c，-SO 2 Rc，-SO 3 H，-SO 2 NR a R b，-OR a，-NHSO 2 R c ，-NHCOR a和-NR a R b，R 2表示C 1-6烷基或C 3-6烯基; R 3表示C 1-3烷基; R a和R b可各自独立地表示氢或C 1-3烷基，或当-NR a R b直接与所述苯基连接时，R a和R b与氮原子一起可以形成任选地含有选自第二杂原子的-5或-6元杂环来自氧或氮，该第二氮杂原子可以任选地被氢或C 1-3烷基进一步取代; Rc表示C1-3烷基; 及其盐和溶剂合物，特别是其生理上可接受的盐和溶剂化物。

6. 发明申请

US20110039889A1 COMPOUNDS 失效
标题翻译：化合物
公开(公告)号：US20110039889A1
公开(公告)日：2011-02-17
申请号：US12989700
申请日：2009-04-29
申请人： Colin David Eldred , Jag Paul Heer , Thomas Daniel Heightman , John Skidmore , Hailong Wang
发明人： Colin David Eldred , Jag Paul Heer , Thomas Daniel Heightman , John Skidmore , Hailong Wang
IPC分类号： A61K31/4709 , C07D413/10 , C07D413/14 , A61P19/02
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译：本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种病症中的用途。

7. 发明申请

US20090074675A1 INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS 有权
标题翻译： INDAZOLES作为GLUCOCORTICOID受体配体
公开(公告)号：US20090074675A1
公开(公告)日：2009-03-19
申请号：US11910935
申请日：2006-04-12
申请人： Colin David Eldred , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Philip Alan Skone
发明人： Colin David Eldred , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Philip Alan Skone
IPC分类号： A61K9/12 , C07D401/04 , A61K31/4439
CPC分类号： C07D405/14 , C07D231/56 , C07D401/04 , C07D405/12
摘要： A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents —C(R3)— or nitrogen; when X represents —C(R3)—, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents —C(R3)— and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents —C(R3)— and R2 represents hydroxy, methoxy, —CO2CH3 or —CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; or a physiologically functional derivative thereof.
摘要翻译：式（I）的化合物：其中A1表示2,3-二氢-1-苯并呋喃-7-基，5-氟-2-甲氧基 - 苯基或5-氟-2-羟基 - 苯基; X表示-C（R 3） - 或氮; 当X表示-C（R3） - 时，R2表示氢，R1表示氟，R3表示氢或氟，当X表示-C（R3） - 且R2和R1各自表示氢时，R3表示氢，羟基，甲氧基或氟当X表示-C（R 3） - 且R 2表示羟基，甲氧基，-CO 2 CH 3或-CO 2 CH 2 CH 3时，R 1和R 3各自表示氢，当X表示氮时，R 1和R 2各自表示氢; Y表示H或甲基; 或其生理功能衍生物。

8. 发明授权

US06492348B1 Adenosine derivatives 有权
标题翻译：腺苷衍生物
公开(公告)号：US06492348B1
公开(公告)日：2002-12-10
申请号：US09736018
申请日：2001-03-06
申请人： David Edmund Bays , Richard Peter Charles Cousins , Hazel Joan Dyke , Colin David Eldred , Brian David Judkins , Martin Pass , Andrew Michael Kenneth Pennell
发明人： David Edmund Bays , Richard Peter Charles Cousins , Hazel Joan Dyke , Colin David Eldred , Brian David Judkins , Martin Pass , Andrew Michael Kenneth Pennell
IPC分类号： A61K3170
CPC分类号： C07D473/00 , C07H19/16
摘要： A compound of formula (I) which is an agonist at the adenosine Al receptor, wherein Y, Z, and W represent heteroatoms, and salts and solvates thereof, in particular, physiologically acceptable solvates and salts thereof for use in therapy.
摘要翻译：作为腺苷A1受体的激动剂的式（I）化合物，其中Y，Z和W表示杂原子，以及其盐和溶剂化物，特别是用于治疗的生理学上可接受的溶剂合物及其盐。

9. 发明授权

US08093281B2 Indazoles as glucocorticoid receptor ligands 有权
标题翻译：吲哚类作为糖皮质激素受体配体
公开(公告)号：US08093281B2
公开(公告)日：2012-01-10
申请号：US11910935
申请日：2006-04-12
申请人： Colin David Eldred , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Philip Alan Skone
发明人： Colin David Eldred , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Philip Alan Skone
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D405/14 , C07D231/56 , C07D401/04 , C07D405/12
摘要： A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents —C(R3)— or nitrogen; when X represents —C(R3)—, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents —C(R3)— and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents —C(R3)— and R2 represents hydroxy, methoxy, —CO2CH3 or —CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; or a physiologically functional derivative thereof.
摘要翻译：式（I）的化合物：其中A1表示2,3-二氢-1-苯并呋喃-7-基，5-氟-2-甲氧基 - 苯基或5-氟-2-羟基 - 苯基; X表示-C（R 3） - 或氮; 当X表示-C（R3） - 时，R2表示氢，R1表示氟，R3表示氢或氟，当X表示-C（R3） - 且R2和R1各自表示氢时，R3表示氢，羟基，甲氧基或氟当X表示-C（R 3） - 且R 2表示羟基，甲氧基，-CO 2 CH 3或-CO 2 CH 2 CH 3时，R 1和R 3各自表示氢，当X表示氮时，R 1和R 2各自表示氢; Y表示H或甲基; 或其生理功能衍生物。

10. 发明申请

US20090270444A1 1,7-Naphthyridines 审中-公开
标题翻译： 1,7-萘啶
公开(公告)号：US20090270444A1
公开(公告)日：2009-10-29
申请号：US11718892
申请日：2005-11-17
申请人： Colin David Eldred , John Edward Robinson , Alison Judith Steel
发明人： Colin David Eldred , John Edward Robinson , Alison Judith Steel
IPC分类号： A61K31/4375 , C07D471/04 , A61P37/08
CPC分类号： C07D471/04
摘要： There are provided according to the invention novel compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein: R1 is phenyl which may be unsubstituted or substituted by one or two substituents selected from fluorine, chlorine, C1-2alkoxy-, —CN; phenyl fused to a 5-membered saturated ring containing one oxygen atom; pyridinyl which may be unsubstituted or substituted by one or two substituents selected from fluorine or chlorine; or C-linked pyrazolyl which may be unsubstituted or substituted by the substituent C1-2alkyl; R2 is C1-4alkyl; R3 is C1-2alkyl; and n is 0, 1 or 2.
摘要翻译：根据本发明，提供新的式（I）化合物及其药学上可接受的盐和溶剂化物，其中：R1是可以是未取代的或被一个或两个选自氟，氯，C 1-2烷氧基 - ， - CN; 与含有一个氧原子的5元饱和环稠合的苯基; 吡啶基，其可以是未取代的或被一个或两个选自氟或氯的取代基取代; 或C连接的吡唑基，其可以是未取代的或被取代基C 1-2烷基取代; R2是C1-4烷基; R3是C1-2烷基; n为0,1或2。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式