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1. 发明申请

US20080185512A1 Method and apparatus for enhanced ion mobility based sample analysis using various analyzer configurations 审中-公开
标题翻译：使用各种分析仪配置增强离子迁移率样品分析的方法和设备
公开(公告)号：US20080185512A1
公开(公告)日：2008-08-07
申请号：US12080413
申请日：2008-04-01
申请人： Raanan A. Miller , Evgeny Krylov , Erkinjon G. Nazarov , Gary A. Eiceman , John A. Wright
发明人： Raanan A. Miller , Evgeny Krylov , Erkinjon G. Nazarov , Gary A. Eiceman , John A. Wright
IPC分类号： B01D59/44
CPC分类号： G01N27/624 , H01J49/004
摘要： A ion mobility-based analyzer system including a first ion mobility-based filter for passing selected ions through a time-varying field where the time-varying field being compensated by an adjustable compensation setting. The analyzer also includes a second ion mobility-based filter for receiving a first portion of ions from the first ion mobility-based filter. The second ion mobility-based filter includes a voltage gradient for separating ions of the first portion of ions where the ions have associated retention times based on their times of flight through the voltage gradient. The second ion mobility-based filter includes a detector for detecting the ions at their retention times. The analyzer system further includes a display that displays the detected ions in a plot relating the retention times of the ions in the second ion mobility-based filter with compensation settings of the first ion mobility-based filter.
摘要翻译：一种基于离子迁移率的分析仪系统，其包括第一离子迁移率滤波器，用于通过选择的离子通过时变场，其中时变场由可调节的补偿设置补偿。分析仪还包括第二离子迁移率过滤器，用于从第一基于离子迁移率的过滤器接收第一部分离子。基于第二离子迁移率的滤波器包括用于分离离子的第一部分的离子的电压梯度，其中离子具有相关联的保留时间，基于其通过电压梯度的飞行时间。第二基于离子迁移率的滤波器包括用于在其保留时间检测离子的检测器。分析仪系统还包括显示器，该显示器将图中的离子的保留时间与基于第一基于离子迁移率的滤波器的补偿设置相关联的第二离子迁移率滤波器中的离子的显示相关。

2. 发明授权

US07230238B2 Method and apparatus for control of mobility-based ion species identification 有权
标题翻译：用于控制基于迁移率的离子物种识别的方法和装置
公开(公告)号：US07230238B2
公开(公告)日：2007-06-12
申请号：US11011949
申请日：2004-12-13
申请人： Raanan A. Miller , Erkinjon G. Nazarov , Evgeny Krylov , Gary A. Eiceman
发明人： Raanan A. Miller , Erkinjon G. Nazarov , Evgeny Krylov , Gary A. Eiceman
IPC分类号： H01J49/00 , H01J49/40 , B01D59/44
CPC分类号： H01J49/0031 , G01N27/624 , G01N33/22
摘要： System for control of ion species behavior in a time-varying filter field of an ion mobility-based spectrometer to improve species identification, based on control of electrical and environmental aspects of sample analysis.
摘要翻译：在基于离子迁移率的光谱仪的时变滤波器场中控制离子物种行为的系统，以基于样品分析的电气和环境方面的控制来改善物种鉴定。

3. 发明授权

US07157700B2 System for collection of data and identification of unknown ion species in an electric field 有权
标题翻译：在电场中收集数据和识别未知离子物质的系统
公开(公告)号：US07157700B2
公开(公告)日：2007-01-02
申请号：US11190691
申请日：2005-07-26
申请人： Lawrence A. Kaufman , Raanan A. Miller , Erkinjon G. Nazarov , Gary A. Eiceman , Evgeny Krylov
发明人： Lawrence A. Kaufman , Raanan A. Miller , Erkinjon G. Nazarov , Gary A. Eiceman , Evgeny Krylov
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/42
摘要： An apparatus for identification of chemical species by measurement of mobility as a function of high electric field and for generating unique compound-dependent signatures based on ion mobility at a plurality of peak RF voltages for a given compensation. The resulting detection data is compared against a library of data in order to identify a detected chemical species.
摘要翻译：用于通过测量作为高电场的函数的迁移率和基于用于给定补偿的多个峰值RF电压的离子迁移率而产生独特的化合物相关特征的装置来识别化学物质。将所得到的检测数据与数据库进行比较，以便识别检测到的化学物质。

4. 发明授权

US07119328B2 System for DMS peak resolution 有权
标题翻译：用于DMS峰分辨率的系统
公开(公告)号：US07119328B2
公开(公告)日：2006-10-10
申请号：US10738967
申请日：2003-12-17
申请人： Lawrence A. Kaufman , Raanan A. Miller , Erkinjon G. Nazarov , Evgeny Krylov , Gary A. Eiceman
发明人： Lawrence A. Kaufman , Raanan A. Miller , Erkinjon G. Nazarov , Evgeny Krylov , Gary A. Eiceman
IPC分类号： B01D59/44 , H01J49/00 , H01J49/44
CPC分类号： G01N27/624
摘要： An apparatus for identification of chemical species by measurement of mobility as a function of high electric field and for generating unique compound-dependent signatures based on ion mobility at a plurality of peak RF voltages for a given compensation. The resulting detection data is compared against a library of data in order to identify a detected chemical species.
摘要翻译：用于通过测量作为高电场的函数的迁移率和基于用于给定补偿的多个峰值RF电压的离子迁移率而产生独特的化合物相关特征的装置来识别化学物质。将所得到的检测数据与数据库进行比较，以便识别检测到的化学物质。

5. 发明授权

US06690004B2 Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry 有权
标题翻译：用于电喷雾增强的高场不对称离子迁移谱的方法和装置
公开(公告)号：US06690004B2
公开(公告)日：2004-02-10
申请号：US10123030
申请日：2002-04-12
申请人： Raanan A. Miller , Erkinjon G. Nazarov , Gary A. Eiceman , Evgeny Krylov
发明人： Raanan A. Miller , Erkinjon G. Nazarov , Gary A. Eiceman , Evgeny Krylov
IPC分类号： B01D5944
CPC分类号： H01J49/165 , B01L3/502753 , G01N27/624 , G01N30/7206 , H01J49/0018
摘要： Method and apparatus for the analysis of compounds using electrospray in high field asymmetric ion mobility spectrometry.
摘要翻译：在高场不对称离子迁移谱中使用电喷雾分析化合物的方法和装置。

6. 发明授权

US07714284B2 Methods and apparatus for enhanced sample identification based on combined analytical techniques 有权
标题翻译：基于组合分析技术增强样品鉴定的方法和装置
公开(公告)号：US07714284B2
公开(公告)日：2010-05-11
申请号：US11035800
申请日：2005-01-13
申请人： Raanan A. Miller , Erkinjon G. Nazarov , Lawrence A. Kaufman , Evgeny Krylov , Gary A. Eiceman
发明人： Raanan A. Miller , Erkinjon G. Nazarov , Lawrence A. Kaufman , Evgeny Krylov , Gary A. Eiceman
IPC分类号： H01J39/34
CPC分类号： G01N27/624
摘要： The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample detection using multiple detection and analytical techniques in combination.
摘要翻译：本发明一般涉及基于离子迁移的系统，用于分析样品的方法和装置，更具体地涉及使用多个检测和分析技术组合的样品检测。

7. 发明申请

US20080156981A1 Method and apparatus for plasma generation 审中-公开
标题翻译：用于等离子体生成的方法和装置
公开(公告)号：US20080156981A1
公开(公告)日：2008-07-03
申请号：US11894803
申请日：2007-08-20
申请人： Raanan A. Miller , Erkinjon G. Nazarov , Evgeny Krylov , Gary A. Eiceman , John A. Wright , Stephen D. Kendig , C. James Morris , Douglas B. Cameron
发明人： Raanan A. Miller , Erkinjon G. Nazarov , Evgeny Krylov , Gary A. Eiceman , John A. Wright , Stephen D. Kendig , C. James Morris , Douglas B. Cameron
IPC分类号： B01D59/44
CPC分类号： G01N27/624 , H05H1/2406 , H05H2001/2456
摘要： An RF-driven plasma source, including a pair of spaced-apart plasma electrodes, wherein the electrodes act as plates of a capacitor, the gas electrically discharges and creates a plasma of both positive and negative ions, in a clean process that enables efficient sample analysis, with preferred isolated sample photo-ionization, reduced-power operation and also including signal detection with modulated drive electronics.
摘要翻译：一种RF驱动的等离子体源，包括一对间隔开的等离子体电极，其中电极用作电容器的平板，气体在清洁过程中进行放电并产生正离子和负离子的等离子体，从而能够实现有效的样品分析，采用优选的孤立样品光电离，降低功率运行，并且还包括带有调制驱动电子器件的信号检测。

8. 发明授权

US07365316B2 Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry 有权
标题翻译：色谱 - 高场非对称波形离子淌度光谱法的方法和装置
公开(公告)号：US07365316B2
公开(公告)日：2008-04-29
申请号：US11191309
申请日：2005-07-27
申请人： Raanan A. Miller , Erkinjon G. Nazarov , Gary A. Eiceman , Evgeny Krylov , Boris Tadjikov
发明人： Raanan A. Miller , Erkinjon G. Nazarov , Gary A. Eiceman , Evgeny Krylov , Boris Tadjikov
IPC分类号： B01D59/44 , H01J49/40
CPC分类号： G01N27/624 , G01N27/62 , G01N27/64 , G01N30/7206 , G01N2030/0095 , H01J49/0018 , H01J49/0022
摘要： Method and apparatus for chromatographic high field asymmetric waveform ion mobility spectrometry, including a gas chromatographic analyzer section intimately coupled with an ionization section, an ion filter section, and an ion detection section, in which the sample compounds are at least somewhat separated prior to ionization, and ion filtering proceeds in a planar chamber under influence of high field asymmetric periodic signals, with detection integrated into the flow path, for producing accurate, real-time, orthogonal data for identification of a broad range of chemical compounds.
摘要翻译：用于色谱高场非对称波形离子迁移谱的方法和装置，包括与电离部分紧密耦合的气相色谱分析器部分，离子过滤部分和离子检测部分，其中样品化合物在电离之前至少有些分离并且离子过滤在高场不对称周期信号的影响下在平面室中进行，其中检测集成到流路中，用于产生准确的实时正交数据，用于识别宽范围的化合物。

9. 发明授权

US07045776B2 System for collection of data and identification of unknown ion species in an electric field 有权
公开(公告)号：US07045776B2
公开(公告)日：2006-05-16
申请号：US10187464
申请日：2002-06-28
申请人： Lawrence A. Kaufman , Raanan A. Miller , Erkinjon G. Nazarov , Evgeny Krylov , Gary A. Eiceman
发明人： Lawrence A. Kaufman , Raanan A. Miller , Erkinjon G. Nazarov , Evgeny Krylov , Gary A. Eiceman
IPC分类号： B01D59/44 , H01J49/00 , H01J49/40
CPC分类号： G01N27/624
摘要： An apparatus for identification of chemical species by measurement of mobility as a function of high electric field and for generating unique compound-dependent signatures based on ion mobility at a plurality of peak RF voltages for a given compensation. The resulting detection data is compared against a library of data in order to identify a detected chemical species.

10. 发明授权

US07399958B2 Method and apparatus for enhanced ion mobility based sample analysis using various analyzer configurations 有权
标题翻译：使用各种分析仪配置增强离子迁移率样品分析的方法和设备
公开(公告)号：US07399958B2
公开(公告)日：2008-07-15
申请号：US11594505
申请日：2006-11-07
申请人： Raanan A. Miller , Evgeny Krylov , Erkinjon G. Nazarov , Gary A. Eiceman , John A. Wright
发明人： Raanan A. Miller , Evgeny Krylov , Erkinjon G. Nazarov , Gary A. Eiceman , John A. Wright
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： G01N27/624 , H01J49/004
摘要： A system for analyzing one or more ion species of a sample including a first ion mobility filter associated with a first flow path for passing first ions of the sample, a second ion mobility filter associated with a second flow path for passing second ions of the sample, a first outlet from the first flow path for passing a portion of the first ions from the first flow path to the second flow path, and a first outlet from the second flow path for removing neutral particles from the second flow path where the first outlet from the second flow path is upstream of the second ion mobility filter in relation to the ion flow in the second flow path.
摘要翻译：一种用于分析样品的一种或多种离子种类的系统，包括与用于通过样品的第一离子的第一流动路径相关联的第一离子迁移率过滤器，与第二流动路径相关联的第二离子迁移过滤器，用于使样品的第二离子来自第一流路的第一出口，用于将第一离子的一部分从第一流动路径传递到第二流动路径;以及来自第二流动路径的第一出口，用于从第二流动路径去除中性粒子，其中第一出口第二流路相对于第二流路中的离子流在第二离子迁移率过滤器的上游。

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