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1. 发明授权

US3833596A Carbazole derivatives 失效
标题翻译：卡博唑衍生物
公开(公告)号：US3833596A
公开(公告)日：1974-09-03
申请号：US31714972
申请日：1972-12-21
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT W , FLEMING R
IPC分类号： C07D209/86 , C07D29/28
CPC分类号： C07D209/86 , Y10S514/883
摘要： NOVEL 3,6-BIS-BASIC ALKANES OF CARBAZOLE, THEIR PREPARATION AND USE FOR THE PREVENTION AND INHIBITION OF VIRAL INFECTIONS ARE DISCLOSED.

2. 发明授权

US3808206A Bis-basic ketones of phenoxathiins and antiviral compositions thereof 失效
标题翻译：苯并噻唑类的双酚S基础组合物及其抗病毒组合物
公开(公告)号：US3808206A
公开(公告)日：1974-04-30
申请号：US15812271
申请日：1971-06-29
申请人： RICHARDSON MERRELL INC
发明人： FLEMING R , DE WITT SILL A
IPC分类号： A61K31/535 , C07D327/08 , A61K27/00 , C07D89/16
CPC分类号： A61K31/535 , C07D327/08
摘要： WHEREIN X IS OXYGEN OR NR4, IS HYDROGEN OR LOWER ALKYL OF FROM 1 TO 4 CARBON ATOMS; OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THESE COMPOUNDS CAN BE PREPARED BY SEVERAL DIFFERENT METHODS. ANTIVIRAL COMPOSITIONS AND METHODS OF INHIBITING OR INACTIVATING VIRUSES BY ADMINISTERING TO HOSTS AN ANTIVIRALLY EFFECTIVE QUANTITY OF AN ACTIVE INGREDIENT ARE DISCLOSED HEREIN.

BIS(Y-A-CO-)PHENOXATHIIN

WHEREIN A IS A STRAIGHT OR BRANCHED ALKYLENE CHAIN HAVING FROM 1 TO 6 CARBON ATOMS; AND EACH Y IS SELECTED FROM (A) THE GROUP

-N(-R1)-R2

WHEREIN R1 AND R2 ARE INDIVIDUALLY SELECTED FROM HYDROGEN, LOWER ALKYL HAVING FROM 1 TO 6 CARBON ATOMS, CYCLOALKYL HAVING FROM 3 TO 6 CARBON ATOMS, ALKENYL OF FROM 3 TO 6 CARBON ATOMS AND HAVING THE VINYL UNSATURATION IN OTHER THAN THE I-POSITION OF THE ALKENYL GROUP; OR (B) THE GROUP

-N
WHEREIN N IS A WHOLE INTEGER OF FROM 4 TO 6 AND R3 IS SELECTED FROM HYDROGEN OR LOWER ALKYL OF FROM 1 TO 4 CARBON ATOMS AND CAN BE LINKED TO ANY ONE OF THE CARBON ATOMS OF THE HETEROCYCLIC GROUP; OR (C) THE GROUP
-N BIS-BASIC KETONES OF PHENOXATHIINS HAVE ANTIVIRAL ACTIVITY WHEN ADMINISTERED ORALLY AND PARENTERALLY. THE COMPOUNDS ARE REPRESENTED BY THE FOLLOWING FORMULA:

3. 发明授权

US3856789A Bis-basic ketones of thioxanthene 失效
标题翻译： BIS基础的三氯乙烯酮
公开(公告)号：US3856789A
公开(公告)日：1974-12-24
申请号：US13705571
申请日：1971-04-23
申请人： RICHARDSON MERRELL INC
发明人： FLEMING R , SILL A
IPC分类号： C07D335/12 , A61K27/00 , C07D87/34
CPC分类号： C07D335/12
摘要： The novel bis-basic ketones of thioxanthene have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: WHEREIN A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group WHEREIN R1 and R2 are individually hydrogen, allyl or lower alkyl having from 1 to about 4 carbon atoms; or B. the group WHEREIN N IS A WHOLE INTEGER OF 4 OR 5, AND R3 is hydrogen or lower alkyl having from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group WHEREIN X is oxygen or NR4, and R4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF SAID BASE. These new compounds can be prepared by several different methods which are described.
摘要翻译：当口服和肠胃外给药时，噻吨酮的新型双碱性酮具有抗病毒活性。这些化合物由下式表示：

4. 发明授权

US3718685A Fluorenol bis-basic esters 失效
标题翻译：佛罗里达基本食物
公开(公告)号：US3718685A
公开(公告)日：1973-02-27
申请号：US3718685D
申请日：1971-05-14
申请人： RICHARDSON MERRELL INC
发明人： SILL A , FLEMING R
IPC分类号： C07C63/49 , C07C69/76
CPC分类号： C07C63/49 , C07C2603/18
摘要： Novel fluorene and fluorenol bis-basic ester compounds, their method of preparation and use as antiviral agents. The compounds are of the formula

WHEREIN: A. each of R1 and R2 is hydrogen, (lower) alkyl, cycloalkyl of three to six ring carbon atoms, alkenyl of three to six carbon atoms or each set of R1 and R2 taken together with the nitrogen to which they are attached is pyrrolidino, piperidino, N(lower)alkylpiperazino or morpholino; B. each A is alkylene of two to about eight carbon atoms and separates its adjacent oxygen and nitrogen atoms by an alkylene chain of at least two carbon atoms; and C. X is H or OH; or a pharmaceutically acceptable acid addition salt thereof.
摘要翻译：新型芴和芴醇双碱酯化合物，其制备方法和用作抗病毒剂。该化合物具有下列化学式：WHEREIN：

5. 发明授权

US3847953A Anthraquinone derivatives 失效
标题翻译：蒽醌衍生物
公开(公告)号：US3847953A
公开(公告)日：1974-11-12
申请号：US31723972
申请日：1972-12-21
申请人： RICHARDSON MERRELL INC
发明人： SILL A , FLEMING R
IPC分类号： C07D211/14 , A61K31/235 , A61K31/40 , A61K31/445 , A61K31/535 , C07C20060101 , C07C67/00 , C07C69/76 , C07C213/00 , C07C219/14 , C07D295/14 , C07C93/20
CPC分类号： C07C225/24
摘要： 1. A BIS-BASIC ESTER OF ANTHRAQUINONE HAVING THE GENERAL FORMULA:

BIS((-R1-R-)>N-(CH2)N-OOC-)-ANTHRAQUINONE

WHEREIN N IS AN INTEGER OF FROM 2 TO 6; R AND R1 ARE EACH SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL HAVING FROM 1 TO 6 CARBON ATOMS, CYCLOALKYL HAVING FROM 3 TO 6 CARBON ATOMS, ALKENYL HAVING FROM 3 TO 6 CARBON ATOMS IN WHICH THE SATURATION IS IN A POSITION OTHER THAN IN THE 1-POSITION OF THE ALKENYL GROUP, AND WHEN R AND R1 ARE TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED REPRESENT THE PYRROLIDINYL, PIPERIDINO OR MORPHOLINO RADICALS; AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF.

6. 发明授权

US3720680A Bis-basic ethers and thioethers of dibenzothiophene 失效
标题翻译：二苯并噻吩的双酚A基和二苯醚
公开(公告)号：US3720680A
公开(公告)日：1973-03-13
申请号：US3720680D
申请日：1972-04-28
申请人： RICHARDSON MERRELL INC
发明人： ALBRECHT W , FLEMING R , HORGAN S
IPC分类号： C07D333/76 , C07D63/24
CPC分类号： C07D333/76
摘要： WHEREIN N IS A WHOLE INTEGER OF FROM 0 TO 2, N IS 1 OR 2, AND R2 IS HYDROGEN, (LOWER)ALKYL HAVING FROM 1 TO 6 CARBON ATOMS, OR ALKENYL OF FROM 3 TO 6 CARBON ATOMS AND HAVING THE VINYL UNSATURATION IN OTHER THAN THE 1-POSITION OF THE ALKENYL GROUP. THIS INVENTION ALSO INCLUDES PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF THE BASES REPRESENTED BY FORMULA 1. THESE NEW COMPOUNDS MAY BE PREPARED BY SEVERAL DIFFERENT METHODS WHICH ARE DESCRIBED.

THE GROUP -(CH2)N-CH
WHEREIN EACH A IS A STRAIGHT OR BRANCHED ALKYLENE CHAIN HAVING FROM 2 TO 8 CARBON ATOMS AND WHICH SEPARATES THE AMINO NITROGEN AND Y BY AT LEAST 2 CARBON ATOMS; R AND R1 ARE INDIVIDUALLY HYDROGEN, (LOWER)ALKYL HAVING FROM 1 TO 6 CARBON ATOMS, CYCLOALKY HAVING FROM 3 TO 6 CARBON ATOMS, ALKENYL HAVING FROM 3 TO 6 CARBON ATOMS AND HAVING THE VINYL UNSATURATION IN OTHER THAN THE 1-POSITION OF THE ALKENYL GROUP; OR EACH SET OF R AND R1 TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED IS A SATURATED MONOCYCLIC HETEROCYCLIC GROUP SUCH AS PYRROLIDNO, PIPERIDINO, MORPHOLINO, OR N-(LOWER) ALKYLPIPERAZINO; OR

THE GROUP -A-N(-R)-R1

WHEREIN EACH Y IS OXYGEN OR DIVALENT SULFUR; AND EACH X IS

(X-Y-)2-DIBENZOTHIOPHENE

THE NOVEL BIS-BASIC ESTERS AND THIOETHERS OF DIBENZOTHIOPHENE OF THE PRESENT INVENTION HAVE ANTIVIRAL PROPERTIES. THESE COMPOUNDS ARE REPRESENTED BY THE FORMULA

7. 发明授权

US3829578A Antiviral compositions containing bis-basic ethers and thioethers of xanthene and xanthen-9-ones and methods of treating viruses therewith 失效
标题翻译：含有BIS基础物质和XENTHENE和XANTHEN-9-ONES的硫醇的抗病毒组合物及其治疗病毒的方法
公开(公告)号：US3829578A
公开(公告)日：1974-08-13
申请号：US30325572
申请日：1972-11-02
申请人： RICHARDSON MERRELL INC
发明人： FLEMING R , CARR A
IPC分类号： A23K1/16 , A61K27/00
CPC分类号： A23K20/121
摘要： Antiviral compositions and methods of inhibiting or inactivating viruses by administering to hosts an antivirally effective quantity of an active ingredient are disclosed herein. The active ingredients are those compounds having the formula

WHEREIN Z is oxygen or H2; each Y is oxygen or divalent sulfur; each A is a straight or branched alkylene chain of from two to four carbon atoms and which separates the amino nitrogen and Y by at least two carbon atoms; each R and R1 are individually selected from hydrogen, lower alkyl of from 1 to 4 carbon atoms, alkenyl of from three to six carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or each set of R and R1 taken together with the nitrogen atom to which they are attached is a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino or N-(lower)alkylpiperazino; or pharmaceutically acceptable acid addition salts of said compounds.

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