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1. 发明授权

US07045116B2 Treatment of osteomyelitis with radiopharmaceuticals 失效
公开(公告)号：US07045116B2
公开(公告)日：2006-05-16
申请号：US10317738
申请日：2002-12-11
申请人： Dana W. Simon , Alan D. Strickland , Jaime Simon , Daniel J. Macey , R. Keith Frank , Kenneth McMillan
发明人： Dana W. Simon , Alan D. Strickland , Jaime Simon , Daniel J. Macey , R. Keith Frank , Kenneth McMillan
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/0478 , A61K51/0489
摘要： This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharmaceuticals to the site of osteomyelitis.

2. 发明申请

US20090252675A1 Radionuclide Therapy for Urinary Bladder Cancer 审中-公开
标题翻译：放射性核素治疗膀胱癌
公开(公告)号：US20090252675A1
公开(公告)日：2009-10-08
申请号：US12225464
申请日：2007-03-23
申请人： R. Keith Frank , Daniel J. Macey , Jaime Simon , Alan D. Strickland
发明人： R. Keith Frank , Daniel J. Macey , Jaime Simon , Alan D. Strickland
IPC分类号： A61K51/04 , A61P39/04 , A61P35/00
CPC分类号： A61K51/0482 , A61K9/0019 , A61K51/0402 , A61K51/0478 , A61K51/048
摘要： The compounds used in this method for the treatment of bladder cancer comprise a radioisotope particle emitter, such as alpha- or beta-emitters or low energy gamma-emitters, associated with a chelating agent (for metallic radioisotopes) or other compound (by covalent bond for iodine or other non-metals) selected such that these permit delivery of the radionuclide by an I.V. injection that is then cleared into the bladder by the kidneys. Furthermore, it is expected that these radioisotopes are formulated with customary pharmaceutically-acceptable salts, adjuvants, binders, desiccants, diluents, and excipients.
摘要翻译：用于治疗膀胱癌的该方法中使用的化合物包括与螯合剂（用于金属放射性同位素）或其它化合物（通过共价键）相关联的放射性同位素颗粒发射体，例如α-发射体或β-发射体或低能γ-发射体用于碘或其他非金属），使得这些允许放射性核素通过IV递送注射，然后被肾脏清除进膀胱。此外，预期这些放射性同位素与常规的药学上可接受的盐，佐剂，粘合剂，干燥剂，稀释剂和赋形剂配制。

3. 发明授权

US06861044B2 Radioiodinated sulfonated phenols and process therefore 失效
标题翻译：因此，放射性碘化磺化酚和过程
公开(公告)号：US06861044B2
公开(公告)日：2005-03-01
申请号：US10022885
申请日：2001-12-18
申请人： Jaime Simon , R. Keith Frank , Alan D. Strickland
发明人： Jaime Simon , R. Keith Frank , Alan D. Strickland
IPC分类号： A61K47/10 , A61K47/12 , A61K47/16 , A61K47/20 , A61K47/42 , A61K51/00 , A61K51/04 , A61P35/00
CPC分类号： A61K51/04 , A61K51/0406
摘要： The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2 and R3 are independently hydrogen, C1-C4 alkyl, or a carboxyl group, and I* is 123I, 131I or 125I, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.
摘要翻译：本发明涉及式（Ⅰ）的放射性碘化酚类化合物的用途：m和n分别独立地为0,1,2或3，X为在生理pH值为负或带正电的基团，R 1，R 1，R 2 R 2和R 3独立地是氢，C 1 -C 4烷基或羧基，I *是123 I，131 I或125 I及其药学上可接受的盐。该化合物在可植入导管中的近距离放射治疗的动物体内被配制和使用。此外，由于这些化合物的肾脏清除速度快，因此可用于研究肾功能。还公开了制备这些化合物的方法。

4. 发明授权

US06506364B1 Radioiodinated sulfonated phenols for the study of renal function 失效
标题翻译：放射碘化磺化酚用于研究肾功能
公开(公告)号：US06506364B1
公开(公告)日：2003-01-14
申请号：US09672541
申请日：2000-09-28
申请人： Jaime Simon , Alan D. Strickland , R. Keith Frank
发明人： Jaime Simon , Alan D. Strickland , R. Keith Frank
IPC分类号： A61K5100
CPC分类号： A61K51/04 , A61K51/0406
摘要： The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2 and R3 are independently hydrogen, C1-C4 alkyl, or a carboxyl group, and I* is 123I, 131I or 125I, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.
摘要翻译：本发明涉及糠醛的放射性碘化酚类化合物的用途：m和n独立地为0,1,2或3，X为在生理pH下为负或带正电的基团，R，R 1，R 2和R 3为独立地是氢，C 1 -C 4烷基或羧基，I *为123 I，131 I或125 I及其药学上可接受的盐。该化合物在可植入导管中的近距离放射治疗的动物体内被配制和使用。此外，由于这些化合物的肾脏清除速度快，因此可用于研究肾功能。还公开了制备这些化合物的方法。

5. 发明授权

US06506363B1 Radioiodinated sulfonated phenols and process therefore 失效
标题翻译：因此，放射性碘化磺化酚和过程
公开(公告)号：US06506363B1
公开(公告)日：2003-01-14
申请号：US09671982
申请日：2000-09-28
申请人： Jaime Simon , R. Keith Frank , Alan D. Strickland
发明人： Jaime Simon , R. Keith Frank , Alan D. Strickland
IPC分类号： A61K5100
CPC分类号： A61K51/04 , A61K51/0406
摘要： The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2 and R3 are independently hydrogen, C1-C4 alkyl, or a carboxyl group, and I* is 123I, 131I or 125I, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.
摘要翻译：本发明涉及糠醛的放射性碘化酚类化合物的用途：m和n独立地为0,1,2或3，X为在生理pH下为负或带正电的基团，R，R 1，R 2和R 3为独立地是氢，C 1 -C 4烷基或羧基，I *为123 I，131 I或125 I及其药学上可接受的盐。该化合物在可植入导管中的近距离放射治疗的动物体内被配制和使用。此外，由于这些化合物的肾脏清除速度快，因此可用于研究肾功能。还公开了制备这些化合物的方法。

6. 发明申请

US20090258088A1 USE OF MATERIALS AND EXTERNAL STIMULI FOR SYNOVECTOMY 审中-公开
标题翻译：材料的使用和外部刺激的概要
公开(公告)号：US20090258088A1
公开(公告)日：2009-10-15
申请号：US12311949
申请日：2007-10-24
申请人： R. Keith Frank , Kenneth McMillan , Jaime Simon , Alan D. Strickland
发明人： R. Keith Frank , Kenneth McMillan , Jaime Simon , Alan D. Strickland
IPC分类号： A61K33/26 , A61K9/14 , A61K33/24
CPC分类号： A61K51/1244 , A61K41/0052 , A61K47/6849
摘要： This invention has as one of its aspects a method to provide a safe an effective treatment for synovectomy. The method involves the administration a material to the affected joint, allowing the material to localize in the synovial membrane, and then applying an external stimulus that interacts with the material to provide therapy. The materials of this invention are preferably particles, which are either magnetic or contain a heavy element. The external stimuli of this invention includes an alternating magnetic field to heat magnetic particles, infrared laser to heat heavy elements, or electromagnetic ionizing radiation (X- or gamma-radiation) that interacts with heavy elements to produce a localized radiation dose.
摘要翻译：本发明的一个方面是提供一种安全有效的滑膜切除治疗方法。该方法包括向受影响的关节施用材料，允许材料定位在滑膜中，然后施加与材料相互作用以提供治疗的外部刺激。本发明的材料优选是磁性的或含有重元素的颗粒。本发明的外部刺激包括用于加热磁性颗粒的交变磁场，加热重元素的红外激光或与重元素相互作用以产生局部辐射剂量的电磁离子辐射（X-或γ-辐射）。

7. 发明授权

US06315979B1 Radioiodinated sulfonated phenols for brachytherapy 有权
标题翻译：用于近距离放射治疗的放射碘化磺化酚
公开(公告)号：US06315979B1
公开(公告)日：2001-11-13
申请号：US09323359
申请日：1999-06-01
申请人： Jaime Simon , R. Keith Frank , Alan D. Strickland
发明人： Jaime Simon , R. Keith Frank , Alan D. Strickland
IPC分类号： A61K5100
CPC分类号： A61K51/04 , A61K51/0406
摘要： The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2 and R3 are independently hydrogen, C1-C4 alkyl, or a carboxyl group, and I* is 123I, 131I or 125I, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.
摘要翻译：本发明涉及糠醛的放射性碘化酚类化合物的用途：m和n独立地为0,1,2或3，X为在生理pH下为负或带正电的基团，R，R 1，R 2和R 3为独立地是氢，C 1 -C 4烷基或羧基，I *为123 I，131 I或125 I及其药学上可接受的盐。该化合物在可植入导管中的近距离放射治疗的动物体内被配制和使用。此外，由于这些化合物的肾脏清除速度快，因此可用于研究肾功能。还公开了制备这些化合物的方法。

8. 发明授权

US08263112B2 In vivo use of water absorbent polymers 失效
标题翻译：体内使用吸水性聚合物
公开(公告)号：US08263112B2
公开(公告)日：2012-09-11
申请号：US10840112
申请日：2004-05-06
申请人： Jaime Simon , Alan D. Strickland
发明人： Jaime Simon , Alan D. Strickland
IPC分类号： A61K9/16
CPC分类号： A61K31/78 , A61K9/00 , A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/716 , A61K31/74 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.
摘要翻译：本发明是用于从宿主的肠道中除去流体的方法和材料，并且可用于治疗患有流体过载状态的动物或人类患者。在一个实施方案中，本发明方法涉及摄取肠道内涂覆的非全身性，无毒性，不可消化的吸水聚合物，其在通过肠道时吸收流体。聚合物在粪便中排出，其中聚合物和吸收的流体从身体移除。优选的聚合物包括优选以珠粒形式提供的超吸收性丙烯酸聚合物。聚合物可以包括用于选择性地去除血液传播的废物的功能基团，例如。尿素，来自G.I. 道。

9. 发明授权

US06908609B2 In vivo use of water absorbent polymers 失效
公开(公告)号：US06908609B2
公开(公告)日：2005-06-21
申请号：US10036989
申请日：2001-11-06
申请人： Jaime Simon , Alan D. Strickland
发明人： Jaime Simon , Alan D. Strickland
IPC分类号： A61K9/50 , A61K9/16 , A61K9/52 , A61K31/715 , A61K31/716 , A61K31/74 , A61K31/78 , A61K31/785 , A61K47/32 , A61K47/38 , A61P3/00 , A61P7/00 , A61P7/10 , A61P9/04 , A61P9/10 , A61P13/12 , A61K31/765
CPC分类号： A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/716 , A61K31/74 , A61K31/78 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.

10. 发明申请

US20130195975A1 IN VIVO USE OF WATER ABSORBENT POLYMERS 审中-公开
标题翻译：吸水聚合物在血液中的使用
公开(公告)号：US20130195975A1
公开(公告)日：2013-08-01
申请号：US13589699
申请日：2012-08-20
申请人： Jaime Simon , Alan D. Strickland
发明人： Jaime Simon , Alan D. Strickland
IPC分类号： A61K31/78 , A61K9/00
CPC分类号： A61K31/78 , A61K9/00 , A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/716 , A61K31/74 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.
摘要翻译：本发明是用于从宿主的肠道中除去流体的方法和材料，并且可用于治疗患有流体过载状态的动物或人类患者。在一个实施方案中，本发明方法涉及摄取肠道内涂覆的非全身性，无毒性，不可消化的吸水聚合物，其在通过肠道时吸收流体。聚合物在粪便中排出，其中聚合物和吸收的流体从身体移除。优选的聚合物包括优选以珠粒形式提供的超吸收性丙烯酸聚合物。聚合物可以包括用于选择性地去除血液传播的废物的功能基团，例如。尿素，来自G.I. 道。

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