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1. 发明申请

US20100217176A1 METERED GEL DISPENSER 审中-公开
标题翻译：计量凝胶分配器
公开(公告)号：US20100217176A1
公开(公告)日：2010-08-26
申请号：US12775053
申请日：2010-05-06
申请人： R. Dario Norberto Carrara , Arnaud Grenier , Holger Kraus , Peter L. Sadowski , Paul Greenhalgh , Matthew Young , Dominic Reber , Martin Murphy
发明人： R. Dario Norberto Carrara , Arnaud Grenier , Holger Kraus , Peter L. Sadowski , Paul Greenhalgh , Matthew Young , Dominic Reber , Martin Murphy
IPC分类号： A61M35/00 , A61N1/30
CPC分类号： A45D40/26 , A45D34/04 , A45D40/04 , G01F11/025
摘要： The invention relates to a dermal flowable-composition dispenser that includes a body for retaining a supply of the composition, an application portion having an application surface, and a conduit connecting the supply chamber with the application surface for facilitating the reproducible delivery of a predetermined dose of the composition to the application surface. The application surface includes a concave application surface and a front side having an upper rim enclosing the application surface and forming a depression that has a volume that is greater than or equal to the volume of the predetermine dose. Also, the application surface is configured and dimensioned such it can receive the patient's skin to allow for removal of the predetermined dose of the composition, and wherein the concave application surface is shaped such that the entire application surface contacts the patient's skin when the application surface is pressed thereagainst.
摘要翻译：本发明涉及一种真皮可流动组合物分配器，其包括用于保持组合物供应的本体，具有施用表面的施用部分和将供应室与施用表面连接的导管，以便于可再现地递送预定剂量的组合物到应用表面。施加表面包括凹入的施加表面和前侧，其具有封闭施加表面的上边缘并形成具有大于或等于预定剂量的体积的凹陷的凹陷。此外，施用表面被构造和定尺寸使得其可以接收患者的皮肤以允许去除组合物的预定剂量，并且其中凹形施用表面成形为使得整个施用表面在使用表面接触患者的皮肤时被压在那里

2. 发明授权

US07387788B1 Pharmaceutical compositions of nicotine and methods of use thereof 有权
标题翻译：尼古丁的药物组合物及其使用方法
公开(公告)号：US07387788B1
公开(公告)日：2008-06-17
申请号：US11492568
申请日：2006-07-24
申请人： R. Dario Norberto Carrara , Arnaud Grenier , Celine Besse
发明人： R. Dario Norberto Carrara , Arnaud Grenier , Celine Besse
IPC分类号： A61K13/00 , A61K31/465
CPC分类号： A61K31/465 , A61K9/0014 , A61K47/10 , A61K47/14 , A61K47/186 , A61K47/24 , A61K47/38
摘要： The present invention comprises non occlusive compositions for transdermal delivery of nicotine, and more particularly pharmaceutically acceptable salts thereof, and methods of making same. The composition may, for example, be a gel suitable for transdermal or transmucosal applications. The compositions of the present invention typically comprise a mixture of water and alcohol, and a solvent system having a mono alkyl ether of diethylene glycol and a glycol present in specified ratios and in specific amounts, wherein the pH of the gel is usually between a pH of 5.5 and 7. The compositions may include further components, for example, the hydroalcoholic vehicle may further comprise additional penetration enhancer(s), buffering agent(s), antioxidant(s), stabilizer(s) and/or gelling agent(s). The invention also relates to a method for the sustained delivery of nicotine pharmaceutically acceptable salts to treat a variety of conditions and disorders.
摘要翻译：本发明包括用于经皮递送尼古丁的非闭塞组合物，更具体地是其药学上可接受的盐，以及制备它们的方法。组合物可以例如是适合于透皮或经粘膜应用的凝胶。本发明的组合物通常包含水和醇的混合物，以及具有二甘醇单体烷基醚和二醇以特定比例和特定量存在的溶剂体系，其中凝胶的pH通常在pH 组合物可以包括另外的组分，例如，水醇载体可以进一步包含另外的渗透增强剂，缓冲剂，抗氧化剂，稳定剂和/或胶凝剂（s））。本发明还涉及一种用于持续递送尼古丁药学上可接受的盐以治疗多种病症和病症的方法。

3. 发明授权

US07335379B2 Transdermal pharmaceutical formulation for minimizing skin residues 有权
标题翻译：用于最小化皮肤残留物的透皮药物制剂
公开(公告)号：US07335379B2
公开(公告)日：2008-02-26
申请号：US11371042
申请日：2006-03-07
申请人： R. Dario Norberto Carrara , Arnaud Grenier , Celine Besse
发明人： R. Dario Norberto Carrara , Arnaud Grenier , Celine Besse
IPC分类号： A61F13/00
CPC分类号： A61K9/7007 , A61K9/0014 , A61K9/006 , A61K9/06 , A61K31/025 , A61K31/435 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/38 , Y10S514/946 , Y10S514/947
摘要： This invention relates to novel transdermal or transmucosal pharmaceutical formulation which reduces the occurrences of contamination of other individuals and the transference to clothing of the user. The novel formulation includes at least one pharmacologically active ingredient, and a solvent system having a monoalkylether of diethylene glycol and a glycol present in specified ratios, and a mixture of water and alcohol. The invention also relates to a method for inhibiting or delaying crystallization of an active agent in a pharmaceutical formulation.
摘要翻译：本发明涉及新型透皮或透粘膜药物制剂，其减少其他个体的污染的发生以及使用者的衣服的转移。该新型制剂包括至少一种药理学活性成分，和具有二乙二醇的单烷基醚和特定比例的二醇的溶剂体系，以及水和醇的混合物。本发明还涉及抑制或延迟药物制剂中活性剂结晶的方法。

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