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1. 发明申请

US20120134931A1 PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE 有权
标题翻译：细胞摄取的细胞是可控的
公开(公告)号：US20120134931A1
公开(公告)日：2012-05-31
申请号：US13384591
申请日：2010-07-15
申请人： Roger Tsien , Tood Aguilera , Emilia Olson , Tao Jiang , Quyen Nguyen
发明人： Roger Tsien , Tood Aguilera , Emilia Olson , Tao Jiang , Quyen Nguyen
IPC分类号： A61K49/06 , C07K9/00 , C07K7/02 , A61K49/00
CPC分类号： A61K47/64 , A61K47/595 , A61K47/60 , A61K47/62 , A61K47/6911 , A61K49/0032 , A61K49/0056 , C07K7/06
摘要： Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.
摘要翻译：在某些实施方案中，本文公开了具有增加的体内循环的选择性转运分子。在一些实施方案中，本文公开的选择性转运分子具有式（A-X-B-C）-M，其中C是货物部分; A是具有包含5至9个连续酸性氨基酸的序列的肽，其中所述氨基酸选自：天冬氨酸和谷氨酸; B是具有包含5至20个连续碱性氨基酸的序列的肽; X是一个连接子; M是大分子载体。

2. 发明授权

US09808532B2 Peptides whose uptake in cells is controllable 有权
公开(公告)号：US09808532B2
公开(公告)日：2017-11-07
申请号：US13384581
申请日：2010-07-15
申请人： Roger Tsien , Emilia Olson , Tao Jiang , Quyen Nguyen , Michael Whitney
发明人： Roger Tsien , Emilia Olson , Tao Jiang , Quyen Nguyen , Michael Whitney
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00 , A61K47/48 , A61K49/00 , C07K7/06
CPC分类号： A61K47/64 , A61K47/595 , A61K47/60 , A61K47/62 , A61K47/6911 , A61K49/0032 , A61K49/0056 , C07K7/06
摘要： Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)n-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutatmates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.

3. 发明申请

US20120134922A1 PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE 有权
标题翻译：细胞摄取的细胞是可控的
公开(公告)号：US20120134922A1
公开(公告)日：2012-05-31
申请号：US13384581
申请日：2010-07-15
申请人： Roger Tsien , Emilia Olson , Tao Jiang , Quyen Nguyen , Mike Whitney
发明人： Roger Tsien , Emilia Olson , Tao Jiang , Quyen Nguyen , Mike Whitney
IPC分类号： A61K51/00 , C07K7/02 , A61K49/00
CPC分类号： A61K47/64 , A61K47/595 , A61K47/60 , A61K47/62 , A61K47/6911 , A61K49/0032 , A61K49/0056 , C07K7/06
摘要： Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A—X—B—C)n—M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.
摘要翻译：在某些实施方案中，本文公开了具有增加的体内循环的选择性转运分子。在一些实施方案中，本文公开的选择性转运分子具有式（A-X-B-C）n-M，其中C是货物部分; A是具有包含5至9个连续酸性氨基酸的序列的肽，其中所述氨基酸选自：天冬氨酸和谷氨酸; B是具有包含5至20个连续碱性氨基酸的序列的肽; X是一个连接子; M是大分子载体。

4. 外观设计

USD632019S1 Interlocked v-shaped pointed eyelashes 有权
标题翻译：联锁v形指尖睫毛
公开(公告)号：USD632019S1
公开(公告)日：2011-02-01
申请号：US29366688
申请日：2010-07-28
申请人： Quyen Nguyen
设计人： Quyen Nguyen

5. 外观设计

USD670031S1 V-shaped two strands eyelash for adhesive interlocking 有权
标题翻译： V形双股睫毛用于粘合剂互锁
公开(公告)号：USD670031S1
公开(公告)日：2012-10-30
申请号：US29417919
申请日：2012-04-10
申请人： Quyen Nguyen
设计人： Quyen Nguyen

6. 外观设计

USD670030S1 Interlocked two V-shaped two strands eyelashes 有权
标题翻译：联锁两个V形双股睫毛
公开(公告)号：USD670030S1
公开(公告)日：2012-10-30
申请号：US29417912
申请日：2012-04-10
申请人： Quyen Nguyen
设计人： Quyen Nguyen

7. 发明申请

US20070041904A1 Peptides whose uptake by cells is controllable 审中-公开
标题翻译：细胞摄取的肽是可控的
公开(公告)号：US20070041904A1
公开(公告)日：2007-02-22
申请号：US11437095
申请日：2006-05-19
申请人： Tao Jiang , Emilia Olsen , Michael Whitney , Todd Aguilera , Quyen Nguyen , Edmund Wong , Roger Tsien
发明人： Tao Jiang , Emilia Olsen , Michael Whitney , Todd Aguilera , Quyen Nguyen , Edmund Wong , Roger Tsien
IPC分类号： A61K51/00 , A61K49/10 , C07K7/64 , C12N15/86
CPC分类号： C07K7/08 , A61K38/00 , A61K41/0095 , A61K47/64 , A61K47/645 , A61K47/65 , A61K49/0032 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/14 , A61K49/146 , A61K51/088 , C07K14/00 , C07K14/4728
摘要： A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
摘要翻译：本发明的肽的一般结构包括A-X-B-C，其中C是货物部分，B部分包括碱性氨基酸，X是可切割的接头序列，A部分包括酸性氨基酸。完整结构不被细胞所占据; 然而，在X的细胞外裂解时，B-C部分被吸收，将货物运送到靶细胞。货物可以是例如用于诊断成像的对比剂，化学治疗药物或用于治疗的放射线敏化剂。 X可能在细胞外或细胞内裂解。本发明的分子可以是直链，环状，支链或具有混合结构。

8. 发明授权

US09622527B2 Single section lift-up technique for eyelash extensions 有权
公开(公告)号：US09622527B2
公开(公告)日：2017-04-18
申请号：US14507436
申请日：2014-10-06
申请人： Quyen Nguyen
发明人： Quyen Nguyen
IPC分类号： A41G5/02
CPC分类号： A41G5/02
摘要： A single section lift-up technique for eyelash extensions with curved tweezers. Place three pieces of surgical tape over upper natural eyelashes to divide the eyelid into an outer corner, a middle and an inner corner section. Lift up the upper eyelashes one at a time from under the surgical tape on each section with a curved tweezers. Attach adhesive coated false eyelashes one at a time against the upper lashes of the each section with the curved tweezers. Attach adhesive coded false eyelashes one at a time against the upper eyelashes of each section with the curved tweezers.

9. 外观设计

USD632018S1 V-shape pointed eyelash 有权
标题翻译： V形尖睫毛
公开(公告)号：USD632018S1
公开(公告)日：2011-02-01
申请号：US29366684
申请日：2010-07-28
申请人： Quyen Nguyen
设计人： Quyen Nguyen

10. 发明申请

US20100170526A1 Interlocking process of V-shaped tapered flare-out synthetic eyelashes 有权
标题翻译： V型锥形开口合成睫毛的联锁过程
公开(公告)号：US20100170526A1
公开(公告)日：2010-07-08
申请号：US12318771
申请日：2009-01-08
申请人： Quyen Nguyen
发明人： Quyen Nguyen
IPC分类号： A41G5/02
CPC分类号： A41G5/02
摘要： A method to apply a V-shaped eyelash having four symmetric tapered strands attached at the mounting portion to natural eyelash's hair. The V-shaped eyelash has two strands on each side. The V flare corresponds to an angle can be less than or equal to 160° degrees. The thickness of each strand can be 0.10 mm to 0.30 mm thick at the base and tapered at the tips. The lengths can be from 7 mm to 17 mm giving the illusion of a natural long, beautiful and luscious eyelash. Because the eyelash extension is a V shape with the two strands on each side, the eyelash can distribute weight evenly on each side. The natural hair strand as the holder at center also making the eyelash extensions last longer. The eyelashes are made from synthetic fiber which is crimp free and can be permed to a C, and J curl.
摘要翻译：将具有四个对称锥形线的V形睫毛应用于在安装部分附接到天然睫毛的头发上的方法。 V形睫毛在每边都有两条线。 V型喇叭对应的角度可以小于或等于160度。每根绞线的厚度在底部为0.10mm至0.30mm，在尖端处为锥形。长度可以是7毫米到17毫米，给人以自然的长而美丽和美丽的睫毛的幻觉。因为睫毛延伸部是每侧两根股线的V形，所以睫毛可以在每边均匀分布重量。自然的发条作为中心的持有者，也使睫毛延长时间更长。睫毛由无卷曲的合成纤维制成，可以被卷曲成C和J卷曲。

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