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1. 发明公开

US20240091330A1 Anti-Microbial Immunomodulation 审中-公开
公开(公告)号：US20240091330A1
公开(公告)日：2024-03-21
申请号：US18379422
申请日：2023-10-12
申请人： Qu Biologics Inc.
发明人： Harold David Gunn , Salim Dhanji , David W. Mullins
IPC分类号： A61K39/108
CPC分类号： A61K39/0266 , A61K39/0258 , A61K2039/521
摘要： The invention provides methods of modulating an immune system in a vertebrate host for the therapeutic or prophylactic treatment of infection by a first microbial pathogen in a target tissue, comprising administration at an administration site of an effective amount of an antigenic formulation comprising antigenic determinants specific for a second heterologous microbial pathogen.

2. 发明授权

US09320787B2 Tissue targeted antigenic activation of the immune response to treat cancers 有权
标题翻译：组织靶向抗原激活治疗癌症的免疫反应
公开(公告)号：US09320787B2
公开(公告)日：2016-04-26
申请号：US13894343
申请日：2013-05-14
申请人： Qu Biologics Inc.
发明人： Harold David Gunn
IPC分类号： A61K39/108 , A61K39/00 , G01N33/50 , A61K45/06
CPC分类号： A61K39/0258 , A61K39/0011 , A61K45/06 , A61K2039/521 , A61K2039/5252 , G01N33/5011 , G01N33/5047 , G01N33/5082 , G01N2333/24 , G01N2333/31 , A61K2300/00
摘要： The invention provides in part methods for treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated. The compositions may for example include killed or attenuated microbial pathogens, such as whole killed bacterial cells, and may be administered at sites distant from the cancer, for example the skin. In selected embodiments, the invention provides methods for treating a cancer situated in the colon, using formulations of E. coli cells. The administration of the immunogenic compositions may be repeated relatively frequently over a relatively long period of time. In embodiments for intradermal or subcutaneous injection, dosages may be adjusted so that injections reproduce a consistent, visible, inflammatory immune reaction at the site of administration.
摘要翻译：本发明部分提供了通过给予在癌症所在的特定器官或组织中具有致病性的一种或多种微生物具有抗原性特异性的组合物来治疗特定器官或组织的癌症的方法。组合物可以例如包括灭活或减毒的微生物病原体，例如完全杀死的细菌细胞，并且可以在远离癌症的位置（例如皮肤）施用。在选择的实施方案中，本发明提供了使用大肠杆菌细胞的制剂治疗位于结肠中的癌症的方法。免疫原性组合物的施用可以在相当长的时间内相对频繁地重复。在皮内或皮下注射的实施方案中，可以调节剂量，使得注射在给药部位再现一致的，可见的炎性免疫反应。

3. 发明申请

US20140010844A1 Tissue Targeted Antigenic Activation of the Immune Response to Treat Cancers 有权
标题翻译：组织靶向抗原激活免疫反应治疗癌症
公开(公告)号：US20140010844A1
公开(公告)日：2014-01-09
申请号：US13923211
申请日：2013-06-20
申请人： Qu Biologics Inc.
发明人： Harold David Gunn
IPC分类号： A61K39/108 , A61K45/06
CPC分类号： A61K39/0258 , A61K39/0011 , A61K45/06 , A61K2039/521 , A61K2039/5252 , G01N33/5011 , G01N33/5047 , G01N33/5082 , G01N2333/24 , G01N2333/31 , A61K2300/00
摘要： The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated. The formulations of the invention thereby facilitate activation of an immune response to a cancer in a particular tissue or organ. The compositions may for example include killed or attenuated microbial pathogens, such as whole killed bacterial cells, and may be administered at sites distant from the cancer, for example the skin. In some embodiments, microbial species of endogenous flora that are known to cause infection in the relevant organ or tissue may be used in the formulation of the antigenic compositions. In alternative embodiments, exogenous microbial pathogens that are known to cause infection in the relevant organ or tissue may be used in the formulation of the antigenic compositions. The administration of the immunogenic compositions may be repeated relatively frequently over a relatively long period of time. In embodiments for intradermal or subcutaneous injection, dosages may be adjusted so that injections reproduce a consistent, visible, delayed inflammatory immune reaction at the successive site or sites of administration.
摘要翻译：本发明部分地通过给予在癌症所在的特定器官或组织中具有致病性的一种或多种微生物具有抗原性特异性的组合物来治疗特定器官或组织的癌症的方法。因此，本发明的制剂有助于激活对特定组织或器官中的癌症的免疫应答。组合物可以例如包括灭活或减毒的微生物病原体，例如完全杀死的细菌细胞，并且可以在远离癌症的位置（例如皮肤）施用。在一些实施方案中，已知在相关器官或组织中引起感染的内源性菌群的微生物物种可用于抗原组合物的制剂中。在替代实施方案中，已知在相关器官或组织中引起感染的外源微生物病原体可用于抗原组合物的制剂中。免疫原性组合物的施用可以在相当长的时间内相对频繁地重复。在皮内注射或皮下注射的实施方案中，可以调整剂量，使得注射在连续的施用位点或再生部位再现一致的，可见的，延迟的炎性免疫反应。

4. 发明授权

US11819543B2 Anti-microbial immunomodulation 有权
公开(公告)号：US11819543B2
公开(公告)日：2023-11-21
申请号：US17154536
申请日：2021-01-21
申请人： Qu Biologics Inc.
发明人： Harold David Gunn , Salim Dhanji , David W. Mullins
IPC分类号： A61K39/02 , A61K39/108 , A61K39/00
CPC分类号： A61K39/0266 , A61K39/0258 , A61K2039/521 , A61K2039/54 , A61K2039/541 , A61K2039/545 , A61K2039/55 , A61K2039/57 , A61K2039/58 , Y02A50/30
摘要： The invention provides methods of modulating an immune system in a vertebrate host for the therapeutic or prophylactic treatment of infection by a first microbial pathogen in a target tissue, comprising administration at an administration site of an effective amount of an antigenic formulation comprising antigenic determinants specific for a second heterologous microbial pathogen.

5. 发明申请

US20210138057A1 Anti-Microbial Immunomodulation 有权
公开(公告)号：US20210138057A1
公开(公告)日：2021-05-13
申请号：US17154536
申请日：2021-01-21
申请人： Qu Biologics Inc.
发明人： Harold David Gunn , Salim Dhanji , David W. Mullins
IPC分类号： A61K39/108
摘要： The invention provides methods of modulating an immune system in a vertebrate host for the therapeutic or prophylactic treatment of infection by a first microbial pathogen in a target tissue, comprising administration at an administration site of an effective amount of an antigenic formulation comprising antigenic determinants specific for a second heterologous microbial pathogen.

6. 发明申请

US20130337012A1 Tissue Targeted Antigenic Activation of the Immune Response to Treat Cancers 有权
标题翻译：组织靶向抗原激活免疫反应治疗癌症
公开(公告)号：US20130337012A1
公开(公告)日：2013-12-19
申请号：US13894343
申请日：2013-05-14
申请人： Qu Biologics Inc.
发明人： Harold David Gunn
IPC分类号： A61K39/108 , A61K45/06
CPC分类号： A61K39/0258 , A61K39/0011 , A61K45/06 , A61K2039/521 , A61K2039/5252 , G01N33/5011 , G01N33/5047 , G01N33/5082 , G01N2333/24 , G01N2333/31 , A61K2300/00
摘要： The invention provides in part methods for treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated. The compositions may for example include killed or attenuated microbial pathogens, such as whole killed bacterial cells, and may be administered at sites distant from the cancer, for example the skin. In selected embodiments, the invention provides methods for treating a cancer situated in the colon, using formulations of E. coli cells. The administration of the immunogenic compositions may be repeated relatively frequently over a relatively long period of time. In embodiments for intradermal or subcutaneous injection, dosages may be adjusted so that injections reproduce a consistent, visible, inflammatory immune reaction at the site of administration.
摘要翻译：本发明部分提供了通过给予在癌症所在的特定器官或组织中具有致病性的一种或多种微生物具有抗原性特异性的组合物来治疗特定器官或组织的癌症的方法。组合物可以例如包括灭活或减毒的微生物病原体，例如完全杀死的细菌细胞，并且可以在远离癌症的位置（例如皮肤）施用。在选择的实施方案中，本发明提供了使用大肠杆菌细胞的制剂治疗位于结肠中的癌症的方法。免疫原性组合物的施用可以在相当长的时间内相对频繁地重复。在皮内或皮下注射的实施方案中，可以调节剂量，使得注射在给药部位再现一致的，可见的炎性免疫反应。

7. 发明公开

US20240189409A1 Personalized Site-Specific Immunomodulation 审中-公开
公开(公告)号：US20240189409A1
公开(公告)日：2024-06-13
申请号：US18224769
申请日：2023-07-21
申请人： Qu Biologics Inc.
发明人： Harold David Gunn , Salim Dhanji , Brett Anthony Premack , Michael Tak Huai Chow
IPC分类号： A61K39/108 , A61K39/00 , A61K39/05 , A61K39/085 , A61K39/09 , A61K39/095 , A61K39/102 , A61K39/112
CPC分类号： A61K39/0258 , A61K39/0008 , A61K39/0266 , A61K39/0275 , A61K39/05 , A61K39/085 , A61K39/092 , A61K39/095 , A61K39/102 , A61K2039/521 , A61K2039/5252 , A61K2039/542 , A61K2039/545 , A61K2039/58 , A61K2039/585 , A61K2039/70 , Y02A50/30
摘要： The invention provides methods of treating inflammation in a specific organ or tissue of an individual. The method involves determining whether the individual has previously been infected with at least one pathogen that is pathogenic in the specific organ or tissue; and administering to the individual an anti-inflammatory composition comprising antigenic determinants, the antigenic determinants selected or formulated so that together they are specific for the at least one pathogen. The pathogen may be an endogenous or exogenous pathogen, and may further be a bacterial pathogen, a viral pathogen, a fungal pathogen, a protozoan pathogen, or a helminth pathogen.

8. 发明申请

US20210052645A1 Innate Targeting of Adoptive Cellular Therapies 有权
公开(公告)号：US20210052645A1
公开(公告)日：2021-02-25
申请号：US16957505
申请日：2018-12-28
申请人： Qu Biologics Inc.
发明人： Harold David Gunn , David W. Mullins , Mark Bazett , Shirin Kalyan
IPC分类号： A61K35/17 , A61K9/00 , A61K39/00 , A61P35/00 , A61P37/04
摘要： Therapeutic modalities are provided for targeting adoptive cellular therapies to specific sites of disease, involving the use of specific repertoirs of PRR ligands. In effect, innate immune system signaling is provoked so as to facilitate the homing of adoptive immune cells to sites of disease, for example to the site of a solid tumor.

9. 发明授权

US10251946B2 Anti-microbial immunomodulation 有权
公开(公告)号：US10251946B2
公开(公告)日：2019-04-09
申请号：US15308302
申请日：2015-05-01
申请人： Qu Biologics Inc.
发明人： Harold David Gunn , Salim Dhanji , David W. Mullins
IPC分类号： A61K39/00 , A61K39/108
摘要： The invention provides methods of modulating an immune system in a vertebrate host for the therapeutic or prophylactic treatment of infection by a first microbial pathogen in a target tissue, comprising administration at an administration site of an effective amount of an antigenic formulation comprising antigenic determinants specific for a second heterologous microbial pathogen.

10. 发明授权

US09775896B2 Tissue targeted antigenic activation of the immune response to treat cancers 有权
公开(公告)号：US09775896B2
公开(公告)日：2017-10-03
申请号：US14800314
申请日：2015-07-15
申请人： Qu Biologics Inc.
发明人： Harold David Gunn
IPC分类号： A61K39/00 , A61K39/085 , A61K39/09 , A61K39/235 , A61K31/405 , A61K31/635 , A61K31/192 , A61K39/108 , A61K39/112 , A61K39/104 , A61K33/24 , A61K39/02 , A61K39/102 , A61K39/145 , A61K39/155 , G01N33/50 , C12R1/445
CPC分类号： A61K39/235 , A61K31/192 , A61K31/405 , A61K31/635 , A61K33/24 , A61K39/0011 , A61K39/0241 , A61K39/0258 , A61K39/0266 , A61K39/0275 , A61K39/085 , A61K39/092 , A61K39/102 , A61K39/1045 , A61K39/145 , A61K39/155 , A61K2039/521 , A61K2039/522 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , A61K2039/575 , A61K2039/585 , A61K2039/70 , C12N2710/10032 , C12N2760/16032 , C12N2760/18532 , C12N2760/18632 , C12R1/445 , G01N33/5055 , G01N33/5088 , Y02A50/474 , Y02A50/482 , A61K2300/00
摘要： The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated.

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