专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07097995B2 Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes 有权
标题翻译：化学发光吖啶鎓化合物及其类似物作为水解酶的底物
公开(公告)号：US07097995B2
公开(公告)日：2006-08-29
申请号：US10928300
申请日：2004-08-27
申请人： Qingping Jiang , Anand Natrajan , David J. Sharpe , Wen-Jee Wong , Say-Jong Law
发明人： Qingping Jiang , Anand Natrajan , David J. Sharpe , Wen-Jee Wong , Say-Jong Law
IPC分类号： C12Q1/34
CPC分类号： C07D491/10 , C07D219/04 , C07F9/64 , C12Q1/42 , C12Q2334/00 , G01N33/533 , G01N33/582
摘要： A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-PFormula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.
摘要翻译：公开了具有以下通式I的水解酶的化学发光底物，如下：<？在线公式描述=“在线公式”末端=“铅”→> Lumi-M-PFormula I < -line-formula description =“In-line Formulas”end =“tail”？>其中“Lumi”是能够自身产生光的化学发光部分（a），（b）MP附着和（c）M附着。 Lumi的实例包括化学发光吖啶鎓化合物，苯并吖啶鎓化合物，喹啉鎓化合物，异喹啉鎓化合物，菲啶鎓化合物和光合精化合物，螺吡啶化合物，鲁米诺化合物和异鲁米诺化合物。 M是具有至少一个选自氧，氮和硫的孤对电子的多价杂原子，其一端直接连接到Lumi的发光部分，另一端直接附着于P。 P是可以通过水解酶容易地除去的基团。使用上述化合物的酶反应如下：其中HE是水解酶。 Lumi-M是具有与Lumi-M-P不同的物理和/或化学性质的化学发光产物。

2. 发明授权

US06783948B1 Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes 有权
标题翻译：化学发光吖啶鎓化合物及其类似物作为水解酶的底物
公开(公告)号：US06783948B1
公开(公告)日：2004-08-31
申请号：US09626566
申请日：2000-07-27
申请人： Qingping Jiang , Anand Natrajan , David J. Sharpe , Wen-Jee Wong , Say-Jong Law
发明人： Qingping Jiang , Anand Natrajan , David J. Sharpe , Wen-Jee Wong , Say-Jong Law
IPC分类号： C12Q134
CPC分类号： C07D491/10 , C07D219/04 , C07F9/64 , C12Q1/42 , C12Q2334/00 , G01N33/533 , G01N33/582
摘要： A chemiluminescent substrate of hydrolytic enzyme having the following general Formula I, as follows: Lumi-M-P Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P it a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.
摘要翻译：具有以下通式I的水解酶的化学发光底物如下：其中“Lumi”是能够自身产生光的化学发光部分（a），（b）MP附着的（c）和M连接的化合物发光部分。 Lumi的实例包括化学发光吖啶鎓化合物，苯并吖啶鎓化合物，喹啉鎓化合物，异喹啉鎓化合物，菲啶鎓化合物和光合精化合物，螺吡啶化合物，鲁米诺化合物和异鲁米诺化合物。 M是具有至少一个选自氧，氮和硫的孤对电子的多价杂原子，其一端直接连接到Lumi的发光部分，另一端直接附着于P。 P是可以通过水解酶容易地除去的基团。使用上述化合物的酶反应如下：其中HE是水解酶，Lumi-M是具有与Lumi-M-P不同的物理和/或化学性质的化学发光产物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式