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1. 发明授权

US06988995B2 Method and system for detecting the effects of Alzheimer's disease in the human retina 失效
标题翻译：用于检测人类视网膜中阿尔茨海默病的影响的方法和系统
公开(公告)号：US06988995B2
公开(公告)日：2006-01-24
申请号：US10260927
申请日：2002-09-30
申请人： Qienyuan Zhou , Michael J. Sinai , John C. Moore , William Wong
发明人： Qienyuan Zhou , Michael J. Sinai , John C. Moore , William Wong
IPC分类号： A61B13/00
CPC分类号： A61B3/1225 , A61B3/1005
摘要： A system for the in vivo detection of the effects of AD in the interior of an eye. A scanning polarimeter, including a residual retardance canceling system and an improved anterior segment retardance compensator, produces an optical analysis signal representing the birefringence of the retinal nerve fiber layer (RNFL) structures of the eye. The birefringence data is more accurate because of compensation for anterior segment birefringence and residual birefringence of optical components, such as, for example, the beam splitters, lenses, scanners and retarders. An electrical analysis signal representing a large (20 by 40 degrees) retardance map is produced and evaluated by an artificial neural network to produce an analysis classification signal representing the contribution of Alzheimer's disease to the birefringence of the retinal layer corresponding to the relationship of the electrical analysis signal to an analysis signal database.
摘要翻译：用于体内检测眼睛内部AD的影响的系统。包括残余延迟消除系统和改进的前段延迟补偿器的扫描偏振计产生表示眼睛的视网膜神经纤维层（RNFL）结构的双折射的光学分析信号。双折射数据更准确，因为补偿光学部件的前段双折射和残余双折射，例如分束器，透镜，扫描器和延迟器。表示大（20×40度）延迟图的电分析信号由人工神经网络产生和评估，以产生表示阿尔茨海默病对视网膜层的双折射的贡献的分析分类信号，其对应于电气分析信号到分析信号数据库。

2. 发明授权

US07286227B2 Method and system for removing the effects of corneal birefringence from a polarimetric image of the retina 失效
标题翻译：用于从视网膜的偏振图像中去除角膜双折射的影响的方法和系统
公开(公告)号：US07286227B2
公开(公告)日：2007-10-23
申请号：US10260481
申请日：2002-09-30
申请人： Qienyuan Zhou , Xiangrun Huang
发明人： Qienyuan Zhou , Xiangrun Huang
IPC分类号： A61B3/10 , G01J4/00
CPC分类号： A61B3/1005
摘要： A scanning laser polarimetry (SLP) system that measures in vivo retinal nerve fiber layer (RNFL) retardance (δN, θN) in a single measurement without a variable corneal compensator (VCC). The diagnostic signal is biased so that the detected RNFL retardance orientation angles are sufficiently similar at adjacent pixels in the retinal polarimetric image to permit resolution of the orientation angle ambiguity in a single polarimetric image without repeating the measurement at another signal polarization state. With a simple bias retarder, the effects of anterior segment retardance (δC, θC) can be removed from a single polarimetric image of the retina without a VCC. Alternatively, from two single polarimetric images obtained at two different bias retarder positions, the anterior segment retardance magnitude δC and orientation θC and the RNFL retardance magnitude δN and orientation θN can all be determined from the peripapillary RNFL image region alone.
摘要翻译：扫描激光偏振法（SLP）系统，其在单个测量中测量体内视网膜神经纤维层（RNFL）延迟（N N N N，N N N N），而没有可变角膜补偿器（VCC）。诊断信号被偏置，使得检测到的RNFL延迟取向角在视网膜偏振图像中的相邻像素处足够相似，以允许在单个偏振图像中解决定向角模糊，而不重复在另一个信号偏振状态的测量。使用简单的偏置延迟器，可以从没有VCC的视网膜的单个极化图像中去除前段延迟（delta C，θC）的影响。或者，从在两个不同的偏置延迟器位置处获得的两个单个极化图像，前段延迟幅度增量和取向θC和RNFL延迟量值ΔN 和/或取向均可以从单独的peripapillary RNFL图像区域确定。

3. 发明申请

US20080312552A1 Method to detect change in tissue measurements 审中-公开
标题翻译：检测组织测量变化的方法
公开(公告)号：US20080312552A1
公开(公告)日：2008-12-18
申请号：US12157850
申请日：2008-06-13
申请人： Qienyuan Zhou , Pak-Wai Lo , Koenraad A. Vermeer
发明人： Qienyuan Zhou , Pak-Wai Lo , Koenraad A. Vermeer
IPC分类号： A61B3/00
CPC分类号： G06K9/00617 , G06T7/0012 , G06T2207/30041
摘要： The present invention relates to the detection of statistically significant changes in tissue characteristics within the eye. Change in a tissue characteristic is statistically significant when the magnitude of the change exceeds the test-retest measurement variability. One embodiment of the present invention analyzes the data using more than one statistic in order to capture global, regional, and/or local changes that are essential to clinical interpretation of changes in a tissue characteristic. In one embodiment of the present invention, the tissue characteristic tested is RNFL thickness.
摘要翻译：本发明涉及眼睛内组织特征的统计学显着变化的检测。当变化幅度超过测试重测测量变异性时，组织特征的变化是统计学上显着的。本发明的一个实施例使用多于一个的统计量来分析数据，以便捕获临床解释组织特征变化所必需的全局，区域和/或局部变化。在本发明的一个实施例中，测试的组织特征是RNFL厚度。

4. 发明授权

US06704106B2 Method and system for canceling system retardance error in an ophthalmological polarimeter 失效
标题翻译：用于消除眼科偏振计系统延迟误差的方法和系统
公开(公告)号：US06704106B2
公开(公告)日：2004-03-09
申请号：US10160808
申请日：2002-05-31
申请人： Michael Anderson , Qienyuan Zhou , William Papworth
发明人： Michael Anderson , Qienyuan Zhou , William Papworth
IPC分类号： G01J400
CPC分类号： A61B3/1005 , A61B3/14 , G01J4/04
摘要： A polarimeter system that averages multiple retardance measurement samples to cancel the effects of system birefringence in the diagnostic path. The retardance measurement errors arising from system birefringence have a symmetry that repeats over each complete cycle of optical signal rotation cycle. This symmetry is such that averaging the four retardance measurements collected over one complete rotation cycle cancels the effects of system birefringence, leaving a mean retardance measurement free of residual polarization bias. Apparatus is provided for determining the birefringence, thickness, and fiber orientation of the nerve fiber layer at the fundus of the eye by measuring the polarization bias induced in a return beam of polarized light that is reflected at the ocular fundus from an incident beam of a known polarization state. A corneal polarization compensator cancels the birefringent effects of the cornea and other portions of the eye anterior to the fundus.
摘要翻译：平衡多个延迟测量样本以消除诊断路径中系统双折射的影响的偏振计系统。由系统双折射引起的延迟测量误差具有在光信号旋转周期的每个完整周期上重复的对称性。这种对称性使得在一个完整的旋转周期上收集的四个延迟测量的平均取消了系统双折射的影响，留下了没有残余偏振偏移的平均延迟测量。提供了一种设备，用于通过测量在从眼睛的眼底反射的偏振光的反射光束中感应的偏振偏移，从眼睛的眼睛的入射光束来测定神经纤维层在眼底的双折射，厚度和纤维取向已知的极化状态。角膜偏振补偿器抵消了角膜和眼底前部眼部的双折射效应。

5. 发明授权

US06356036B1 System and method for determining birefringence of anterior segment of a patient's eye 有权
标题翻译：用于确定患者眼睛前段的双折射的系统和方法
公开(公告)号：US06356036B1
公开(公告)日：2002-03-12
申请号：US09727992
申请日：2000-12-01
申请人： Qienyuan Zhou
发明人： Qienyuan Zhou
IPC分类号： A61B310
CPC分类号： A61B3/1225 , A61B3/1005
摘要： The magnitude and axial orientation of birefringence of the anterior and the posterior segments of the human eye are determined. The anterior segment includes essentially the combined birefringence of the cornea and the crystalline lens, and the posterior segment includes regions at the fundus. The optical axis and the magnitude of the birefringence of the anterior segment is first determined, then the birefringence of the posterior segment is nulled by a variable retarder. The birefringence of the posterior segment is then determined without interference of the birefringence of the anterior segment. The apparatus and method are applicable to the measurement of the birefringence of the retinal nerve fiber layer at the peripapillary region and the birefringence of the Henle fiber layer at the macular region of the retina.
摘要翻译：确定人眼前段和后段的双折射的大小和轴向取向。前段基本上包括角膜和晶状体的组合双折射，并且后段包括眼底的区域。首先确定光轴和前段双折射的大小，然后通过可变延迟器将后段的双折射置零。然后确定后段的双折射，而不干扰前段的双折射。该装置和方法适用于测量视网膜神经纤维层在周围毛细血管区域的双折射和Henle纤维层在视网膜黄斑区域的双折射。

6. 发明授权

US07287855B2 Method and system for removing the effects of corneal birefringence from a polarimetric image of the retina 失效
标题翻译：用于从视网膜的偏振图像中去除角膜双折射的影响的方法和系统
公开(公告)号：US07287855B2
公开(公告)日：2007-10-30
申请号：US10855196
申请日：2004-05-26
申请人： Qienyuan Zhou , Xiangrun Huang
发明人： Qienyuan Zhou , Xiangrun Huang
IPC分类号： A61B3/10 , G01J4/00
CPC分类号： A61B3/1005
摘要： A scanning laser polarimetry (SLP) system that measures retinal nerve fiber layer (RNFL) retardance in a single scan image with improved sensitivity. An external bias retarder in combination with the anterior segment retardance forms a nonzero joint retardance adapted to enhance the signal-to-noise ratio (SNR) of the SLP system. With such a simple bias retarder, the effects of anterior segment retardance (δC, θC) may be removed from a single polarimetric image of the retina without a direct cancellation by a variable corneal compensator (VCC) by the method of this invention. Using a single polarimetric image is particularly advantageous for simplicity and accurate corneal compensation. The simple bias retarder may be embodied as a VCC or any useful external retarder, for example.
摘要翻译：一种扫描激光偏光法（SLP）系统，可以提高灵敏度的单次扫描图像中的视网膜神经纤维层（RNFL）延迟。与前段延迟相结合的外部偏置阻尼器形成适于增强SLP系统的信噪比（SNR）的非零关节延迟。使用这种简单的偏置延迟器，可以从视网膜的单个极化图像中去除前段延迟（delta C，θC）的影响，而不需要直接消除视网膜的直接消除通过本发明的方法可变角膜补偿器（VCC）。使用单个极化图像对于简单和准确的角膜补偿特别有利。例如，简单的偏置延迟器可以被实现为VCC或任何有用的外部延迟器。

7. 发明授权

US08770753B2 Scanning and processing using optical coherence tomography 有权
标题翻译：使用光学相干断层扫描进行扫描和处理
公开(公告)号：US08770753B2
公开(公告)日：2014-07-08
申请号：US13310626
申请日：2011-12-02
申请人： Michael Hee , Jay Wei , David Huang , Qienyuan Zhou , Yonghua Zhao , Ben Jang , Tony Ko
发明人： Michael Hee , Jay Wei , David Huang , Qienyuan Zhou , Yonghua Zhao , Ben Jang , Tony Ko
IPC分类号： A61B3/14 , A61B3/10 , A61B3/12
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/107 , A61B3/1225 , A61B3/14
摘要： In accordance with some embodiments, a method of eye examination includes acquiring OCT data with a scan pattern centered on an eye cornea that includes n radial scans repeated r times, c circular scans repeated r times, and n* raster scans where the scan pattern is repeated m times, where each scan includes a A-scans, and where n is an integer that is 0 or greater, r is an integer that is 1 or greater, c is an integer that is 0 or greater, n* is an integer that is 0 or greater, m is an integer that is 1 or greater, and a is an integer greater than 1, the values of n, r, c, n*, and m being chosen to provide OCT data for a target measurement, and processing the OCT data to obtain the target measurement.
摘要翻译：根据一些实施例，眼睛检查的方法包括以包括眼睛角膜为中心的扫描图案来获取OCT数据，该扫描图案包括重复r次的n个径向扫描，c次循环扫描重复r次，以及扫描模式为重复m次，其中每个扫描包括A扫描，并且其中n是0或更大的整数，r是1或更大的整数，c是0或更大的整数，n *是整数 0或更大，m是1或更大的整数，a是大于1的整数，n，r，c，n *和m的值被选择为提供用于目标测量的OCT数据，并处理OCT数据以获得目标测量。

8. 发明申请

US20050030475A1 Method and system for removing the effects of corneal birefringence from a polarimetric image of the retina 失效
标题翻译：用于从视网膜的偏振图像中去除角膜双折射的影响的方法和系统
公开(公告)号：US20050030475A1
公开(公告)日：2005-02-10
申请号：US10855196
申请日：2004-05-26
申请人： Qienyuan Zhou , Xiangrun Huang
发明人： Qienyuan Zhou , Xiangrun Huang
IPC分类号： A61B3/10 , A61B3/12
CPC分类号： A61B3/1005
摘要： A scanning laser polarimetry (SLP) system that measures retinal nerve fiber layer (RNFL) retardance in a single scan image with improved sensitivity. An external bias retarder in combination with the anterior segment retardance forms a nonzero joint retardance adapted to enhance the signal-to-noise ratio (SNR) of the SLP system. With such a simple bias retarder, the effects of anterior segment retardance (δC, θC) may be removed from a single polarimetric image of the retina without a direct cancellation by a variable corneal compensator (VCC) by the method of this invention. Using a single polarimetric image is particularly advantageous for simplicity and accurate corneal compensation. The simple bias retarder may be embodied as a VCC or any useful external retarder, for example.
摘要翻译：一种扫描激光偏光法（SLP）系统，可以提高灵敏度的单次扫描图像中的视网膜神经纤维层（RNFL）延迟。与前段延迟相结合的外部偏置阻尼器形成适于增强SLP系统的信噪比（SNR）的非零关节延迟。使用这种简单的偏置延迟器，可以通过本发明的方法通过可变角膜补偿器（VCC）直接消除来自视网膜的单个极化图像的前段延迟（deltaC，thetaC）的影响。使用单个极化图像对于简单和准确的角膜补偿特别有利。例如，简单的偏置延迟器可以被实现为VCC或任何有用的外部延迟器。

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