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1. 发明申请

US20130089932A1 FET Sensor and Methods for Detecting Melamine 审中-公开
标题翻译： FET传感器和检测三聚氰胺的方法
公开(公告)号：US20130089932A1
公开(公告)日：2013-04-11
申请号：US13648396
申请日：2012-10-10
申请人： Qiang Wu , Wenchuang Hu , Ruhai Tian
发明人： Qiang Wu , Wenchuang Hu , Ruhai Tian
IPC分类号： H01L29/78 , G01N33/53
CPC分类号： G01N33/5438 , G01N33/552 , G01N2610/00
摘要： The present invention provides a device and methods for the detection and quantification melamine in a sample by rapid and specific electrochemical detection. The present invention includes using a field-effect transistor (FET) biosensor having an open Si channel with a melamine antigen, or hapten, or an antibody, anchored via a linker molecule such as self assembled monolayer to the surface of the gate dielectric of the said open Si channel. The anchoring molecule having the capability of detecting melamine directly or indirectly by selectively binding melamine antibodies, which changes a field-effect on a Si channel, causing a change in conductivity of the FET. This change in conductivity can be measured and is used to determine the presence or absence of melamine in a sample compared to a standard signal or pre-measured database.
摘要翻译：本发明提供了通过快速和特异性电化学检测在样品中检测和定量三聚氰胺的装置和方法。本发明包括使用具有三聚氰胺抗原的开放Si通道的场效应晶体管（FET）生物传感器，或通过诸如自组装单层的连接分子锚定到所述第一电极的栅电介质的表面的半抗原或抗体说开Si通道。锚定分子具有通过选择性结合三聚氰胺抗体来检测三聚氰胺的能力，三聚氰胺抗体改变了Si通道的场效应，导致了FET的导电性的变化。可以测量电导率的这种变化，并用于确定样品中与标准信号或预测量数据库相比存在或不存在三聚氰胺。

2. 发明授权

US09810660B2 Fin-FET sensor with improved sensitivity and specificity 有权
公开(公告)号：US09810660B2
公开(公告)日：2017-11-07
申请号：US13876958
申请日：2011-09-28
申请人： Wenchuang Hu , Ruhai Tian , Suresh Regonda , Krutarth B. Trivedi
发明人： Wenchuang Hu , Ruhai Tian , Suresh Regonda , Krutarth B. Trivedi
IPC分类号： H01L29/76 , G01N27/403 , G01N15/06 , G01N27/414 , H01L27/12 , H01L29/78
CPC分类号： G01N27/4145 , G01N27/4146 , H01L27/1211 , H01L29/785
摘要： The claimed invention is directed to a finFET biosensor with improved sensitivity and selectivity. Embodiments of the invention are also directed to finFET biosensor arrays, methods for operating finFET biosensors with improved sensitivity and selectivity, and methods of operating finFET biosensor arrays.

3. 发明申请

US20130291627A1 FIN-FET SENSOR WITH IMPROVED SENSITIVITY AND SPECIFICITY 有权
标题翻译： FIN-FET传感器具有提高的灵敏度和特异性
公开(公告)号：US20130291627A1
公开(公告)日：2013-11-07
申请号：US13876958
申请日：2011-09-28
申请人： Wenchuang Hu , Ruhai Tian , Suresh Regonda , Krutarth B. Trivedi
发明人： Wenchuang Hu , Ruhai Tian , Suresh Regonda , Krutarth B. Trivedi
IPC分类号： G01N27/414
CPC分类号： G01N27/4145 , G01N27/4146 , H01L27/1211 , H01L29/785
摘要： The claimed invention is directed to a fmFET biosensor with improved sensitivity and selectivity. Embodiments of the invention are also directed to finFET biosensor arrays, methods for operating fmFET biosensors with improved sensitivity and selectivity, and methods of operating finFET biosensor arrays.
摘要翻译：所要求保护的发明涉及具有改进的灵敏度和选择性的fmFET生物传感器。本发明的实施例还涉及finFET生物传感器阵列，用于操作具有改进的灵敏度和选择性的fmFET生物传感器的方法，以及操作finFET生物传感器阵列的方法。

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