专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09050373B2 Pharmaceutical compositions comprising antisense oligonucleotides and methods of using same 有权
标题翻译：包含反义寡核苷酸的药物组合物及其使用方法
公开(公告)号：US09050373B2
公开(公告)日：2015-06-09
申请号：US12800376
申请日：2010-05-13
申请人： Qi Long Lu , Bo Wu
发明人： Qi Long Lu , Bo Wu
IPC分类号： C07H21/04 , C12N15/11 , A61K47/48
CPC分类号： A61K47/48315 , A61K47/549 , A61K47/61 , A61K47/645 , A61K47/6455 , C12N2310/3233
摘要： The invention provides compositions and associated methods for the antisense treatment of genetic disorders, infections and various other medical conditions. In particular, embodiments of the present invention are directed to pharmaceutical compositions comprising a combination of an antisense oligonucleotide compound conjugated with a positively charged polymer (“ON-PCP”) and a negatively charged polymer. Pharmaceutical compositions in accordance with the present invention have demonstrated improved antisense efficiency and reductions in cell toxicity compared to compositions that contain an oligonucleotide compound conjugated with a positively charged polymer.
摘要翻译：本发明提供了用于遗传疾病，感染和各种其他医学病症的反义治疗的组合物和相关方法。特别地，本发明的实施方案涉及包含与带正电荷的聚合物（“ON-PCP”）缀合的反义寡核苷酸化合物和带负电荷的聚合物的组合的药物组合物。与含有与带正电聚合物共轭的寡核苷酸化合物的组合物相比，根据本发明的药物组合物已经证明改进的反义效力和细胞毒性降低。

2. 发明申请

US20110281787A1 Pharmaceutical compositions comprising antisense oligonucleotides and methods of using same 有权
标题翻译：包含反义寡核苷酸的药物组合物及其使用方法
公开(公告)号：US20110281787A1
公开(公告)日：2011-11-17
申请号：US12800376
申请日：2010-05-13
申请人： Qi Long Lu , Bo Wu
发明人： Qi Long Lu , Bo Wu
IPC分类号： A61K38/14 , A61P35/00 , A61P31/12 , A61K31/7088 , A61P31/04
CPC分类号： A61K47/48315 , A61K47/549 , A61K47/61 , A61K47/645 , A61K47/6455 , C12N2310/3233
摘要： The invention provides compositions and associated methods for the antisense treatment of genetic disorders, infections and various other medical conditions. In particular, embodiments of the present invention are directed to pharmaceutical compositions comprising a combination of an antisense oligonucleotide compound conjugated with a positively charged polymer (“ON-PCP”) and a negatively charged polymer. Pharmaceutical compositions in accordance with the present invention have demonstrated improved antisense efficiency and reductions in cell toxicity compared to compositions that contain an oligonucleotide compound conjugated with a positively charged polymer.
摘要翻译：本发明提供了用于遗传疾病，感染和各种其他医学病症的反义治疗的组合物和相关方法。特别地，本发明的实施方案涉及包含与带正电荷的聚合物（“ON-PCP”）缀合的反义寡核苷酸化合物和带负电荷的聚合物的组合的药物组合物。与含有与带正电聚合物共轭的寡核苷酸化合物的组合物相比，根据本发明的药物组合物已经证明改进的反义效力和细胞毒性降低。

3. 发明申请

US20100322911A1 USE OF MICROWAVE IRRADIATION FOR DELIVERY OF MACROMOLECULES 有权
标题翻译：使用微波辐射来分送大分子
公开(公告)号：US20100322911A1
公开(公告)日：2010-12-23
申请号：US12712580
申请日：2010-02-25
申请人： Qi Long Lu , Pei Juan Lu
发明人： Qi Long Lu , Pei Juan Lu
IPC分类号： A61K48/00 , C12N13/00 , C12N15/87 , A61K35/18 , A61K35/14 , A61P43/00
CPC分类号： C12N15/87 , A61K48/0083 , C12M35/02 , C12N13/00
摘要： The present invention is directed to methods of delivering macromolecules to a target cell or tissue by microwave irradiation. A target cell or tissue is exposed to one or more macromolecules to be delivered into the desired cell or tissue and irradiated with microwave radiation. The strength or power of the microwave radiation is such that the macromolecules are delivered into the target cell or tissue. Preferably, the strength of the microwave radiation does not significantly impact cell viability in a negative manner (e.g., apoptosis).
摘要翻译：本发明涉及通过微波辐射将大分子递送至靶细胞或组织的方法。将靶细胞或组织暴露于一个或多个大分子以递送至所需的细胞或组织中并用微波辐射照射。微波辐射的强度或功率使得大分子被递送到靶细胞或组织中。优选地，微波辐射的强度不以负面的方式显着地影响细胞活力（例如细胞凋亡）。

4. 发明申请

US20120309825A1 Nitrate Esters And Their Use For The Treatment Of Muscle And Muscle Related Diseases 有权
标题翻译：硝酸酯及其用于治疗肌肉和肌肉相关疾病的用途
公开(公告)号：US20120309825A1
公开(公告)日：2012-12-06
申请号：US13485185
申请日：2012-05-31
申请人： Guqi Wang , Qi Long Lu
发明人： Guqi Wang , Qi Long Lu
IPC分类号： A61K31/21 , A61P21/00 , A61Q19/08 , A61K8/40 , C07C203/04 , A61K31/27 , A61P17/00
CPC分类号： A61K8/40 , A61K31/21 , A61K31/27 , A61K45/06 , A61Q19/08 , A61K2300/00
摘要： Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, CH3, CH2CH3, CH2CH2CH3, or H; R2 is ONO2, CH2ONO2, Cn′H2n′+1OH, Cn′H2n′+1OH, CH3, CH2CH3, CH2CH2CH3, or H; R3 is ONO2, CH2ONO2, Cn′″H2n″+1OH, Cn″H2n″+1OH, CH3, CH2CH3, CH2CH2CH3, or H; and R4 is ONO2, CH2ONO2, Cn′″H2n″+1OH, Cn″H2n″+1OH, CH3, CH2CH3, CH2CH2CH3, or H; wherein n is an integer from 0 to 9, n′ is an integer from 0 to 9, and n″ is an integer from 0 to 9, and n+n′+n″≦9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof.
摘要翻译：提供了硝酸烷基酯化合物用于将一氧化氮递送到目标肌肉组织，特别是正常和营养不良的肌肉。在一方面，提供具有下式的硝酸酯化合物：其中，R1是ONO2，CH2ONO2，CnH2n + 1OH，CnH2n + 1OH，CH3，CH2CH3，CH2CH2CH3或H; R2是ONO2，CH2ONO2，Cn'H2n'+ 1OH，Cn'H2n'+ 1OH，CH3，CH2CH3，CH2CH2CH3或H; R3是ONO2，CH2ONO2，Cn'“H2n”+ 1OH，Cn“H2n”+ 1OH，CH3，CH2CH3，CH2CH2CH3或H; 并且R 4是ONO 2，CH 2 ONO 2，C n“H 2 n”+ 1 OH，C n“H 2n”+ 1 OH，CH 3，CH 2 CH 3，CH 2 CH 2 CH 3或H; 其中n为0至9的整数，n'为0至9的整数，n“为0至9的整数，n + n'+ n”＆nlE; 9，并且其中R 1 ，R2和R3是选自ONO2，CH2ONO2及其组合的酯硝酸酯。

5. 发明申请

US20120202752A1 Antisense Oligonucleotides 有权
标题翻译：反义寡核苷酸
公开(公告)号：US20120202752A1
公开(公告)日：2012-08-09
申请号：US13369050
申请日：2012-02-08
申请人： Qi Long Lu
发明人： Qi Long Lu
IPC分类号： A61K31/7088 , A61P21/00 , A61K38/14 , C07H21/04 , C07H21/02
CPC分类号： A61K31/7088 , A61K31/7105 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/3233 , C12N2310/346 , C12N2320/33 , C12N2310/321 , C12N2310/3521
摘要： Embodiments of the present invention are directed generally to antisense compounds and compositions for the treatment of muscular dystrophy, and in particular, Duchenne muscular dystrophy (DMD). In one embodiment, the invention is directed to antisense oligonucleotide molecules, pharmaceutical compositions and formulations comprising antisense oligonucleotide molecules, and methods of treating muscular dystrophy related diseases and disorders wherein the antisense oligonucleotide molecules comprises a base sequence selected from the group consisting of SEQ ID NO: 5-8, 10, 12, 14, 16, 24, 27, 28, 34, 35, 37, 40, 42, 44-46, 79, 97, 100, 101, and 116, and combinations thereof.
摘要翻译：本发明的实施方案一般涉及用于治疗肌营养不良症，特别是杜氏肌营养不良症（DMD）的反义化合物和组合物。在一个实施方案中，本发明涉及反义寡核苷酸分子，药物组合物和包含反义寡核苷酸分子的制剂，以及治疗肌营养不良症相关疾病和病症的方法，其中所述反义寡核苷酸分子包含选自SEQ ID NO ：5-8,10,12,14,16,24,27,28,34,35,37,40,42,44-46,79,97,100,101和116及其组合。

6. 发明授权

US09452117B2 Nitrate esters and their use for the treatment of muscle and muscle related diseases 有权
标题翻译：硝酸酯及其用于治疗肌肉和肌肉相关疾病的用途
公开(公告)号：US09452117B2
公开(公告)日：2016-09-27
申请号：US13485185
申请日：2012-05-31
申请人： Guqi Wang , Qi Long Lu
发明人： Guqi Wang , Qi Long Lu
IPC分类号： A61K31/21 , A61K31/27 , A61K45/06 , C07C203/04 , A61K8/40 , A61Q19/08
CPC分类号： A61K8/40 , A61K31/21 , A61K31/27 , A61K45/06 , A61Q19/08 , A61K2300/00
摘要： Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, CH3, CH2CH3, CH2CH2CH3, or H; R2 is ONO2, CH2ONO2, Cn′H2n′+1OH, Cn′H2n′+1OH, CH3, CH2CH3, CH2CH2CH3, or H; R3 is ONO2, CH2ONO2, Cn′″H2n″+1OH, Cn″H2n″+1OH, CH3, CH2CH3, CH2CH2CH3, or H; and R4 is ONO2, CH2ONO2, Cn′″H2n″+1OH, Cn″H2n″+1OH, CH3, CH2CH3, CH2CH2CH3, or H; wherein n is an integer from 0 to 9, n′ is an integer from 0 to 9, and n″ is an integer from 0 to 9, and n+n′+n″≦9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof.

7. 发明授权

US09078911B2 Antisense oligonucleotides 有权
标题翻译：反义寡核苷酸
公开(公告)号：US09078911B2
公开(公告)日：2015-07-14
申请号：US13369050
申请日：2012-02-08
申请人： Qi Long Lu
发明人： Qi Long Lu
IPC分类号： C12N15/11 , A61K31/7088 , A61K31/7105 , C12N15/113
CPC分类号： A61K31/7088 , A61K31/7105 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/3233 , C12N2310/346 , C12N2320/33 , C12N2310/321 , C12N2310/3521
摘要： Embodiments of the present invention are directed generally to antisense compounds and compositions for the treatment of muscular dystrophy, and in particular, Duchenne muscular dystrophy (DMD). In one embodiment, the invention is directed to antisense oligonucleotide molecules, pharmaceutical compositions and formulations comprising antisense oligonucleotide molecules, and methods of treating muscular dystrophy related diseases and disorders wherein the antisense oligonucleotide molecules comprises a base sequence selected from the group consisting of SEQ ID NO: 5-8, 10, 12, 14, 16, 24, 27, 28, 34, 35, 37, 40, 42, 44-46, 79, 97, 100, 101, and 116, and combinations thereof.
摘要翻译：本发明的实施方案一般涉及用于治疗肌营养不良症，特别是杜氏肌营养不良症（DMD）的反义化合物和组合物。在一个实施方案中，本发明涉及反义寡核苷酸分子，包含反义寡核苷酸分子的药物组合物和制剂，以及治疗肌营养不良症相关疾病和病症的方法，其中所述反义寡核苷酸分子包含选自SEQ ID NO ：5-8,10,12,14,16,24,27,28,34,35,37,40,42,44-46,79,97,100,101和116及其组合。

8. 发明授权

US09023890B2 Nitrate esters and their use for the treatment of muscle and muscle related diseases 有权
标题翻译：硝酸酯及其用于治疗肌肉和肌肉相关疾病的用途
公开(公告)号：US09023890B2
公开(公告)日：2015-05-05
申请号：US12629230
申请日：2009-12-02
申请人： Guqi Wang , Qi Long Lu
发明人： Guqi Wang , Qi Long Lu
IPC分类号： A61K31/21 , C07C203/08 , A61K31/27 , A61K45/06 , C07C203/04
CPC分类号： A61K31/21 , A61K31/27 , A61K45/06 , C07C203/04 , A61K2300/00
摘要： Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, or CH2CH2CH3, or H; R2 is ONO2, CH2ONO2, Cn′H2n′+1OH, Cn′H2n′+1OH, CH2CH2CH3 or H; and R3 is ONO2, CH2ONO2, Cn′″H2n″+1OH, Cn″H2n″+1OH, CH2CH2CH3 or H; wherein n is an integer from 0 to 9, n′ is an integer from 0 to 9, and n″ is an integer from 0 to 9, and n+n′+n″≦9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof.
摘要翻译：提供了硝酸烷基酯化合物用于将一氧化氮递送到目标肌肉组织，特别是正常和营养不良的肌肉。在一个方面，提供具有下式的硝酸酯化合物：其中，R1是ONO2，CH2ONO2，CnH2n + 1OH，CnH2n + 1OH或CH2CH2CH3，或H; R2是ONO2，CH2ONO2，Cn'H2n'+ 1OH，Cn'H2n'+ 1OH，CH2CH2CH3或H; 并且R3是ONO2，CH2ONO2，Cn'“H2n”+ 1OH，Cn“H2n”+ 1OH，CH2CH2CH3或H; 其中n为0至9的整数，n'为0至9的整数，n“为0至9的整数，n + n'+ n”＆nlE; 9，并且其中R 1 ，R2和R3是选自ONO2，CH2ONO2及其组合的酯硝酸酯。

9. 发明申请

US20110130455A1 Nitrate Esters and Their Use For The Treatment of Muscle and Muscle Related Diseases 有权
标题翻译：硝酸酯及其用于治疗肌肉和肌肉相关疾病的用途
公开(公告)号：US20110130455A1
公开(公告)日：2011-06-02
申请号：US12629230
申请日：2009-12-02
申请人： Guqi Wang , Qi Long Lu
发明人： Guqi Wang , Qi Long Lu
IPC分类号： A61K31/21 , C07C203/04 , A61P21/00
CPC分类号： A61K31/21 , A61K31/27 , A61K45/06 , C07C203/04 , A61K2300/00
摘要： Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: wherein,R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, or CH2CH2CH3, or H;R2 is ONO2, CH2ONO2, Cn′H2n′+1OH, Cn′H2n′+1OH, CH2CH2CH3 or H; andR3 is ONO2, CH2ONO2, Cn′″H2n″+1OH, Cn″H2n″+1OH, CH2CH2CH3 or H;wherein n is an integer from 0 to 9, n′ is an integer from 0 to 9, and n″ is an integer from 0 to 9, and n+n′+n″≦9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof.
摘要翻译：提供了硝酸烷基酯化合物用于将一氧化氮递送到目标肌肉组织，特别是正常和营养不良的肌肉。在一个方面，提供具有下式的硝酸酯化合物：其中，R1是ONO2，CH2ONO2，CnH2n + 1OH，CnH2n + 1OH或CH2CH2CH3，或H; R2是ONO2，CH2ONO2，Cn'H2n'+ 1OH，Cn'H2n'+ 1OH，CH2CH2CH3或H; 并且R3是ONO2，CH2ONO2，Cn'“H2n”+ 1OH，Cn“H2n”+ 1OH，CH2CH2CH3或H; 其中n为0至9的整数，n'为0至9的整数，n“为0至9的整数，n + n'+ n”＆nlE; 9，并且其中R 1 ，R2和R3是选自ONO2，CH2ONO2及其组合的酯硝酸酯。

10. 发明授权

US08569251B2 Use of microwave irradiation for delivery of macromolecules 有权
标题翻译：使用微波辐射传递大分子
公开(公告)号：US08569251B2
公开(公告)日：2013-10-29
申请号：US12712580
申请日：2010-02-25
申请人： Qi Long Lu , Pei Juan Lu
发明人： Qi Long Lu , Pei Juan Lu
IPC分类号： A61K48/00
CPC分类号： C12N15/87 , A61K48/0083 , C12M35/02 , C12N13/00
摘要： The present invention is directed to methods of delivering macromolecules to a target cell or tissue by microwave irradiation. A target cell or tissue is exposed to one or more macromolecules to be delivered into the desired cell or tissue and irradiated with microwave radiation. The strength or power of the microwave radiation is such that the macromolecules are delivered into the target cell or tissue. Preferably, the strength of the microwave radiation does not significantly impact cell viability in a negative manner (e.g., apoptosis).
摘要翻译：本发明涉及通过微波辐射将大分子递送至靶细胞或组织的方法。将靶细胞或组织暴露于一个或多个大分子以递送至所需的细胞或组织中并用微波辐射照射。微波辐射的强度或功率使得大分子被递送到靶细胞或组织中。优选地，微波辐射的强度不以负面的方式显着地影响细胞活力（例如细胞凋亡）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式