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1. 发明授权

US07192611B2 Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors 有权
标题翻译：鉴定游离B环类黄酮作为有效的COX-2抑制剂
公开(公告)号：US07192611B2
公开(公告)日：2007-03-20
申请号：US10469275
申请日：2003-02-28
申请人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
发明人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
IPC分类号： A01N65/00
CPC分类号： A61K31/7048 , A61K31/353 , A61K36/18
摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供抑制环加氧酶COX-2的新方法。该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物和药学上可接受的载体。

2. 发明授权

US08535735B2 Identification of free-B-ring flavonoids as potent COX-2 inhibitors 有权
标题翻译：鉴定游离B环类黄酮作为有效的COX-2抑制剂
公开(公告)号：US08535735B2
公开(公告)日：2013-09-17
申请号：US13493820
申请日：2012-06-11
申请人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
发明人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
IPC分类号： A01N65/00
CPC分类号： A61K31/7048 , A61K31/353 , A61K36/539
摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供抑制环加氧酶COX-2的新方法。该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物和药学上可接受的载体。

3. 发明授权

US08568799B2 Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia 有权
标题翻译：从阿拉伯胶中分离双重COX-2和5-脂氧合酶抑制剂
公开(公告)号：US08568799B2
公开(公告)日：2013-10-29
申请号：US13355362
申请日：2012-01-20
申请人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
发明人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
IPC分类号： A01N65/00
CPC分类号： A61K31/353 , A61K31/33 , A61K36/00 , A61K36/48
摘要： The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.
摘要翻译：本公开提供了用于减轻炎症相关疾病和病症的组合物和方法。这些方法包括给予分离自植物单个或多个相思树属的多种黄烷的个体和/或混合物。本公开还包括从植物相思属分离和纯化具有环氧合酶（COX-2）和5-脂肪氧合酶（5-LO）酶的双重特异性的黄酮组合物的方法。

4. 发明申请

US20130012463A1 IDENTIFICATION OF FREE-B-RING FLAVONOIDS AS POTENT COX-2 INHIBITORS 有权
标题翻译：作为COCO-2抑制剂的自由B环氟虫酯的鉴定
公开(公告)号：US20130012463A1
公开(公告)日：2013-01-10
申请号：US13493820
申请日：2012-06-11
申请人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
发明人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
IPC分类号： A61K31/352 , A61P19/02 , A61P29/00 , A61K31/7048
CPC分类号： A61K31/7048 , A61K31/353 , A61K36/539
摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供抑制环加氧酶COX-2的新方法。该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物和药学上可接受的载体。

5. 发明申请

US20120329863A1 ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA 有权
标题翻译：从ACACIA分离双COX-2和5-LIPOXYGENASE抑制剂
公开(公告)号：US20120329863A1
公开(公告)日：2012-12-27
申请号：US13355362
申请日：2012-01-20
申请人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
发明人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
IPC分类号： A61K31/353 , A61P25/00
CPC分类号： A61K31/353 , A61K31/33 , A61K36/00 , A61K36/48
摘要： The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.
摘要翻译：本公开提供了用于减轻炎症相关疾病和病症的组合物和方法。这些方法包括给予分离自植物单个或多个相思树属的多种黄烷的个体和/或混合物。本公开还包括从植物相思属分离和纯化具有环氧合酶（COX-2）和5-脂肪氧合酶（5-LO）酶的双重特异性的黄酮组合物的方法。

6. 发明申请

US20110245333A1 IDENTIFICATION OF FREE-B-RING FLAVONOIDS AS POTENT COX-2 INHIBITORS 审中-公开
标题翻译：作为COCO-2抑制剂的自由B环氟虫酯的鉴定
公开(公告)号：US20110245333A1
公开(公告)日：2011-10-06
申请号：US13084419
申请日：2011-04-11
申请人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Walte
发明人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Walte
IPC分类号： A61K31/352 , A61P29/00
CPC分类号： A61K31/7048 , A61K31/353 , A61K36/539
摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供抑制环加氧酶COX-2的新方法。该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物和药学上可接受的载体。

7. 发明授权

US07108868B2 Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia 有权
标题翻译：从阿拉伯胶中分离双重cox-2和5-脂氧合酶抑制剂
公开(公告)号：US07108868B2
公开(公告)日：2006-09-19
申请号：US10104477
申请日：2002-03-22
申请人： Qi Jia , Timothy C. Nichols , Eric Rhoden , Scott Waite
发明人： Qi Jia , Timothy C. Nichols , Eric Rhoden , Scott Waite
IPC分类号： A61K36/00
CPC分类号： A61K31/353 , A61K31/33 , A61K36/00 , A61K36/48
摘要： The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.
摘要翻译：本发明提供了同时抑制环氧合酶COX-2和5-脂氧合酶（5-LO）酶的新方法。同时双重抑制COX-2和5-LO的方法包括将含有单个植物或多种植物的多种黄烷的个体和/或混合物的组合物施用于植物相思树属植物中的宿主需要。本发明还包括预防和治疗COX-2和5-LO介导的疾病和病症的新方法。预防和治疗COX-2和5-LO介导的疾病和病症的方法包括向有需要的宿主施用有效量的组合物，其包含从单一植物分离的个体和/或多种黄烷的混合物或植物相思树属植物多种植物和药学上可接受的载体。本发明包括分离和纯化来自植物相思树属的COX-2和5-LO双重特异性的黄烷组合物的方法。

8. 发明授权

US08124134B2 Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia 有权
标题翻译：从相思树中分离双重COX-2和5-脂氧合酶抑制剂
公开(公告)号：US08124134B2
公开(公告)日：2012-02-28
申请号：US11457388
申请日：2006-07-13
申请人： Qi Jia , Timothy C. Nichols , Eric Rhoden , Scott Waite
发明人： Qi Jia , Timothy C. Nichols , Eric Rhoden , Scott Waite
IPC分类号： A01N65/00
CPC分类号： A61K31/353 , A61K31/33 , A61K36/00 , A61K36/48
摘要： The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.
摘要翻译：本发明提供了同时抑制环氧合酶COX-2和5-脂氧合酶（5-LO）酶的新方法。同时双重抑制COX-2和5-LO的方法包括将含有单个植物或多种植物的多种黄烷的个体和/或混合物的组合物施用于植物相思树属植物中的宿主需要。本发明还包括预防和治疗COX-2和5-LO介导的疾病和病症的新方法。预防和治疗COX-2和5-LO介导的疾病和病症的方法包括向有需要的宿主施用有效量的组合物，其包含从单一植物分离的个体和/或多种黄烷的混合物或植物相思树属植物多种植物和药学上可接受的载体。本发明包括分离和纯化来自植物相思树属的COX-2和5-LO双重特异性的黄烷组合物的方法。

9. 发明申请

US20150066671A1 MERCHANT POINT OF SALE SECURITY SYSTEM 有权
标题翻译：销售安全系统的销售点
公开(公告)号：US20150066671A1
公开(公告)日：2015-03-05
申请号：US14012793
申请日：2013-08-28
申请人： Timothy C. Nichols , Ramaneek Khanna , Geoffrey W. Chatterton
发明人： Timothy C. Nichols , Ramaneek Khanna , Geoffrey W. Chatterton
IPC分类号： G06Q20/20
CPC分类号： G06Q20/20 , G06Q20/4016 , G07G3/00
摘要： A point of sale (POS) security system includes a POS device including a non-transitory memory, one or more hardware processors, and one or more environment sensors. A plurality of POS instructions are located on the non-transitory memory in the POS device and executable by the one or more hardware processors in the POS device to provide a POS engine that is configured to receive and transmit payment information for conducting a payment transaction associated with a purchase. A plurality of security instructions are located on the non-transitory memory in the POS device and are executable by the one or more hardware processors in the POS device to provide a security engine that is configured to receive environment signals from the one or more environment sensors in the POS device and analyze those environment signals to determine a security breach.
摘要翻译：销售点（POS）安全系统包括包括非暂时性存储器，一个或多个硬件处理器以及一个或多个环境传感器的POS设备。多个POS指令位于POS设备中的非暂时性存储器上，并且可由POS设备中的一个或多个硬件处理器执行，以提供POS引擎，该POS引擎被配置为接收和发送支付信息，用于执行相关联的支付交易购买。多个安全指令位于POS设备中的非暂时存储器上，并且可由POS设备中的一个或多个硬件处理器执行，以提供被配置为从一个或多个环境传感器接收环境信号的安全引擎在POS设备中分析这些环境信号以确定安全漏洞。

10. 发明授权

US08572304B2 Systems and methods for configuring mobile devices for printing to wireless printers 失效
标题翻译：用于配置移动设备以打印到无线打印机的系统和方法
公开(公告)号：US08572304B2
公开(公告)日：2013-10-29
申请号：US12960740
申请日：2010-12-06
申请人： Timothy C. Nichols , Geoffrey W. Chatterton , Ramaneek Khanna , Eric D. Bauswell , Anthony R. Chvala
发明人： Timothy C. Nichols , Geoffrey W. Chatterton , Ramaneek Khanna , Eric D. Bauswell , Anthony R. Chvala
IPC分类号： G06F13/00 , G06F3/00
CPC分类号： G06F3/1204 , G06F3/1228 , G06F3/1292
摘要： The present disclosure is directed to systems and methods for configuring mobile communication devices to identify and communicate with wireless printing devices. These systems and methods may include determining available wireless printing devices, selecting a desired wireless printing device, attempting to establish communication between the mobile communication device and the wireless printing device using a first communication protocol, prompting a user to indicate the successfulness of the first communication protocol, and configuring the mobile communication device for printing to the wireless printing device using the first communication protocol if the first communication protocol successfully communicated with the wireless printing device. The systems and methods may further include prompting the user to indicate that the first communication protocol was not successful if the first communication protocol did not successfully communicate with the wireless printing device and repeating the method using another available communication protocol.
摘要翻译：本公开涉及用于配置移动通信设备以识别和与无线打印设备通信的系统和方法。这些系统和方法可以包括确定可用的无线打印设备，选择所需的无线打印设备，尝试使用第一通信协议在移动通信设备和无线打印设备之间建立通信，促使用户指示第一通信的成功并且如果第一通信协议与无线打印设备成功通信，则使用第一通信协议将移动通信设备配置为用于打印到无线打印设备。所述系统和方法还可以包括：如果第一通信协议没有成功地与无线打印设备通信并且使用另一可用通信协议重复该方法，则提示用户指示第一通信协议不成功。

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