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1. 发明授权

US11858937B2 Substituted pyrazolo[1,5-a]pyrimidines and pyrazolo[1,5-a][1,3,5]triazines as CDK inhibitors 有权
公开(公告)号：US11858937B2
公开(公告)日：2024-01-02
申请号：US17045009
申请日：2019-04-11
申请人： QURIENT CO., LTD. , LEAD DISCOVERY CENTER GMBH
发明人： Kiyean Nam , Jaeseung Kim , Yeejin Jeon , Donghoon Yu , Mooyoung Seo , Dongsik Park , Jan Eickhoff , Gunther Zischinsky , Uwe Koch
IPC分类号： A61K31/519 , A61K31/53 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to pyrazolo [1,5-a][1,3,5]triazine and pyrazolo [1,5-a]pyrimidine derivatives having Formula I:

and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferative diseases, inflammatory diseases, immunological diseases, cardiovascular diseases and infectious diseases. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof.

2. 发明授权

US11945822B2 Pyrazolo-triazine and/or pyrazolo-pxrimidine derivatives as selective inhibitor of cyclin dependent kinase 有权
公开(公告)号：US11945822B2
公开(公告)日：2024-04-02
申请号：US17045030
申请日：2019-04-11
申请人： QURIENT CO., LTD. , LEAD DISCOVERY CENTER GMBH
发明人： Kiyean Nam , Jaeseung Kim , Yeejin Jeon , Donghoon Yu , Mooyoung Seo , Dongsik Park , Jan Eickhoff , Gunther Zischinsky
IPC分类号： C07D487/04 , A61P35/00 , A61P35/02 , C07D519/00
CPC分类号： C07D487/04 , A61P35/00 , A61P35/02 , C07D519/00
摘要： The present invention relates to pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferative diseases, inflammatory diseases, immunological diseases, cardiovascular diseases and infectious diseases. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof.

3. 发明授权

US09096608B2 Pharmaceutically active pyrazolo-triazine derivatives 有权
标题翻译：药用活性吡唑并三嗪衍生物
公开(公告)号：US09096608B2
公开(公告)日：2015-08-04
申请号：US14389946
申请日：2013-03-01
申请人： LEAD DISCOVERY CENTER GMBH
发明人： Jan Eickhoff , Gunther Zischinsky , Uwe Koch , Gerd Rühter , Carsten Schultz-Fademrecht , Peter Nussbaumer
IPC分类号： C07D491/107 , C07D487/04
CPC分类号： C07D491/107 , C07D487/04
摘要： Pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.
摘要翻译：吡唑并[1,5-a] [1,3,5]三嗪衍生物和/或其药学上可接受的盐，使用这些衍生物作为药物活性剂，特别是用于预防和/或治疗感染性疾病，包括机会性疾病免疫疾病，自身免疫性疾病，心血管疾病，细胞增殖性疾病，炎症，勃起功能障碍和中风，以及包含至少一种所述吡唑并[1,5-a] [1,3,5]三嗪衍生物和/或其药学上可接受的盐。此外，本发明涉及所述吡唑并[1,5-a] [1,3,5]三嗪衍生物作为蛋白激酶的抑制剂的用途。

4. 发明授权

US09567345B2 Pharmaceutically active pyrazolo-triazine derivatives 有权
标题翻译：药用活性吡唑并三嗪衍生物
公开(公告)号：US09567345B2
公开(公告)日：2017-02-14
申请号：US14381146
申请日：2013-03-01
申请人： LEAD DISCOVERY CENTER GMBH
发明人： Jan Eickhoff , Gunther Zischinsky , Uwe Koch
IPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , A61K31/4162 , A61K31/5377 , C07D491/107 , C07D487/04 , C07D471/10
CPC分类号： C07D491/107 , C07D471/10 , C07D487/04
摘要： The present invention relates to pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.
摘要翻译：本发明涉及吡唑并[1,5-a] [1,3,5]三嗪衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，免疫疾病，自身免疫疾病，心血管疾病，细胞增殖性疾病，炎症，勃起功能障碍和中风，以及包含至少一种所述吡唑并[1,5-a] [1,3,5] 三嗪衍生物和/或其药学上可接受的盐。此外，本发明涉及所述吡唑并[1,5-a] [1,3,5]三嗪衍生物作为蛋白激酶的抑制剂的用途。

5. 发明申请

US20150111873A1 PHARMACEUTICALLY ACTIVE PYRAZOLO-TRIAZINE DERIVATIVES 有权
标题翻译：药用活性吡唑并吡啶衍生物
公开(公告)号：US20150111873A1
公开(公告)日：2015-04-23
申请号：US14389946
申请日：2013-03-01
申请人： LEAD DISCOVERY CENTER GMBH
发明人： Jan Eickhoff , Gunther Zischinsky , Uwe Koch , Gerd Rühter , Carsten Schultz-Fademrecht , Peter Nussbaumer
IPC分类号： C07D491/107 , C07D487/04
CPC分类号： C07D491/107 , C07D487/04
摘要： Pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.
摘要翻译：吡唑并[1,5-a] [1,3,5]三嗪衍生物和/或其药学上可接受的盐，使用这些衍生物作为药物活性剂，特别是用于预防和/或治疗感染性疾病，包括机会性疾病免疫疾病，自身免疫性疾病，心血管疾病，细胞增殖性疾病，炎症，勃起功能障碍和中风，以及包含至少一种所述吡唑并[1,5-a] [1,3,5]三嗪衍生物和/或其药学上可接受的盐。此外，本发明涉及所述吡唑并[1,5-a] [1,3,5]三嗪衍生物作为蛋白激酶的抑制剂的用途。

6. 发明申请

US20150018329A1 PHARMACEUTICALLY ACTIVE PYRAZOLO-TRIAZINE DERIVATIVES 有权
标题翻译：药用活性吡唑并吡啶衍生物
公开(公告)号：US20150018329A1
公开(公告)日：2015-01-15
申请号：US14381146
申请日：2013-03-01
申请人： LEAD DISCOVERY CENTER GMBH
发明人： Jan Eickhoff , Gunther Zischinsky , Uwe Koch
IPC分类号： C07D491/107 , C07D471/10 , C07D487/04
CPC分类号： C07D491/107 , C07D471/10 , C07D487/04
摘要： The present invention relates to pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.
摘要翻译：本发明涉及吡唑并[1,5-a] [1,3,5]三嗪衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，免疫疾病，自身免疫性疾病，心血管疾病，细胞增殖性疾病，炎症，勃起功能障碍和中风，以及包含至少一种所述吡唑并[1,5-a] [1,3,5] 三嗪衍生物和/或其药学上可接受的盐。此外，本发明涉及所述吡唑并[1,5-a] [1,3,5]三嗪衍生物作为蛋白激酶的抑制剂的用途。

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