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1. 发明授权

US10223905B2 Mobile device and system for detection and communication of information received from an ingestible device 有权
公开(公告)号：US10223905B2
公开(公告)日：2019-03-05
申请号：US15612955
申请日：2017-06-02
申请人： Proteus Digital Health, Inc.
发明人： Mark Zdeblick , Arna Ionescu Stoll , William McAllister , Kit Yee Au-Yeung
IPC分类号： G08C17/02 , A61B5/00 , A61B5/07 , G06F19/00
摘要： A mobile device for detecting an electrical signal generated by an ingestible event marker is disclosed. The mobile device includes a detection subsystem to receive an electrical signal generated by an ingestible event marker from a detection arrangement. A processing subsystem is coupled to the detection subsystem to decode the electrical signal. A radio subsystem is configured to transmit the decoded electrical signal to a wireless node. A system includes the mobile device and the detection arrangement. A method includes receiving the electrical signal generated by the ingestible event marker at the mobile device, decoding the electrical signal to extract information associated with the ingestible event marker, and transmitting the information to a wireless node.

2. 发明申请

US20180279910A1 INGESTION-RELATED BIOFEEDBACK AND PERSONALIZED MEDICAL THERAPY METHOD AND SYSTEM 审中-公开
公开(公告)号：US20180279910A1
公开(公告)日：2018-10-04
申请号：US15880085
申请日：2018-01-25
申请人： Proteus Digital Health, Inc.
发明人： Marc Jensen , Robert Leichner , Patrick Beaulieu , Kit Yee Au-Yeung , Lawrence Arne , Mark Zdeblick , Andrew Thompson , George Savage , Timothy Robertson , Yashar Behzadi
IPC分类号： A61B5/07 , G16H10/60 , G06F19/00 , H04B13/00 , A61B5/00 , G16H50/20 , G16H20/00 , G16H20/10 , A61B5/021 , A61B5/11 , A61B5/024
摘要： A system including a sensor, a mobile device, and a computer system is disclosed. The sensor is configured to detect physiologic data from the body of the patient. The mobile device includes a patient data input device. The computer system, communicatively coupled to the mobile device, includes a patient record indicating: patient data comprising a plurality of patient activities, and detected physiological data received from the sensor via the mobile device. The computer system is configured to identify an unhealthy physiological data value from the detected physiological data of the patient record, correlate the unhealthy physiological data value to a patient activity of the patient data, select a therapeutic recommendation to address the unhealthy physiological data value, and transmit the selected therapeutic recommendation to the patient, via the mobile device, at a future time associated with the patient activity correlated to the unhealthy physiological data value.

3. 发明申请

US20170265813A1 COMMUNICATION SYSTEM WITH PARTIAL POWER SOURCE 审中-公开
公开(公告)号：US20170265813A1
公开(公告)日：2017-09-21
申请号：US15474811
申请日：2017-03-30
申请人： Proteus Digital Health, Inc.
发明人： Mark Zdeblick , Timothy Robertson , Aleksandr Pikelny , Hooman Hafezi
IPC分类号： A61B5/00 , A61B5/07 , A61B5/1473 , A61J3/00 , G06K7/10 , H01Q1/27
摘要： The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can be used in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharmainformatics enabled pharmaceutical compositions.

4. 发明申请

US20160324442A1 LOOSE WEARABLE RECEIVER SYSTEMS 审中-公开
标题翻译：松散可接收接收系统
公开(公告)号：US20160324442A1
公开(公告)日：2016-11-10
申请号：US15147593
申请日：2016-05-05
申请人： Proteus Digital Health, Inc.
发明人： Mark Zdeblick
IPC分类号： A61B5/07 , A61B5/00 , A61B5/11
CPC分类号： A61B5/073 , A61B5/021 , A61B5/02405 , A61B5/02416 , A61B5/0402 , A61B5/0537 , A61B5/1112 , A61B5/1118 , A61B5/112 , A61B5/6824 , A61B5/7455 , A61B2503/10 , A61B2560/0219 , A61B2560/0242 , A61B2560/045
摘要： A loose wearable receiver system is disclosed. A loose wearable receiver system is a body-associated personal communicator capable of detecting, monitoring, analyzing, and/or transmitting information about a wearer. The loose wearable system may be operable to detect an electrical current signature from an ingestible device indicator system. The loose wearable system may store and/or access data on a remote system. The loose wearable system may comprise a wearable component configured to be removably worn, such as on a limb. The loose wearable system comprises a compartment and optionally a battery-powered electronics module configured to be removably attached to the compartment or a charging station for charging a battery within the wearable system.
摘要翻译：公开了一种松散的可戴式接收机系统。松散佩戴的接收器系统是能够检测，监视，分析和/或发送关于佩戴者的信息的身体相关个人通信器。松散佩戴系统可以可操作以从可摄取装置指示器系统检测电流特征。松散佩戴系统可以存储和/或访问远程系统上的数据。松散的可穿戴系统可以包括构造成可移除地穿着的可穿戴部件，例如在肢体上。松散的可穿戴系统包括隔室和可选地电池供电的电子模块，其被配置为可移除地附接到隔室或用于对可穿戴系统内的电池充电的充电站。

5. 发明授权

US09439582B2 Communication system with remote activation 有权
标题翻译：通讯系统具有远程激活功能
公开(公告)号：US09439582B2
公开(公告)日：2016-09-13
申请号：US14552218
申请日：2014-11-24
申请人： Proteus Digital Health, Inc.
发明人： Jeffrey Berkman , Mark Zdeblick , Patricia Johnson , Hooman Hafezi , Jonathan Withrington
IPC分类号： A61B5/07 , A61B5/053 , A61J3/00 , H01Q1/27 , A61B5/00 , A61B5/03 , A61B5/145
CPC分类号： A61B5/073 , A61B5/0002 , A61B5/0008 , A61B5/036 , A61B5/0538 , A61B5/14539 , A61B5/4839 , A61B5/7285 , A61B2560/0214 , A61B2562/18 , A61J3/007 , H01Q1/273
摘要： The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.
摘要翻译：本发明的系统包括不同材料形式的导电元件，电子元件和部分电源。当与导电流体接触时，产生电压电势并且电源完成，这激活了系统。电子部件控制不同材料之间的电导，以产生独特的当前签名。该系统还可以测量系统周围环境的状况。

6. 发明申请

US20150318901A1 MULTI-MODE COMMUNICATION INGESTIBLE EVENT MARKERS AND SYSTEMS, AND METHODS OF USING THE SAME 有权
标题翻译：多模式通信无效的标记和系统及其使用方法
公开(公告)号：US20150318901A1
公开(公告)日：2015-11-05
申请号：US14699809
申请日：2015-04-29
申请人： Proteus Digital Health, Inc.
发明人： Timothy Robertson , Mark Zdeblick
IPC分类号： H04B5/00 , A61B5/00 , A61B5/07
CPC分类号： H04B5/0062 , A61B5/0031 , A61B5/073 , A61B5/4833 , A61B5/4839 , A61B5/4848 , A61B5/6861 , A61B2562/08 , A61B2562/162 , G06K7/10297
摘要： A device including an integrated circuit, a partial power source, including first and second materials associated with the integrated circuit is disclosed. The first and second materials are configured to provide a voltage potential difference when in contact with a conductive fluid to power up the device. A signal amplification element secured around the integrated circuit relative to the first and second materials is configured to facilitate extension of a current flow path between the first and second materials. A modulator is configured to control conductance between the first and second materials to generate a detectable signal that is partially defined by the current flow extending through the conductive fluid. A communication module is coupled to the partial power source and is configured to communicate with a receiver and an antenna electrically coupled to the communication module, which uses the antenna to communicate with the receiver.
摘要翻译：公开了一种包括集成电路，部分电源的装置，包括与集成电路相关联的第一和第二材料。第一和第二材料配置成当与导电流体接触时提供电压电位差，以使设备加电。围绕集成电路相对于第一和第二材料固定的信号放大元件构造成有助于在第一和第二材料之间扩展电流流动路径。调制器被配置为控制第一和第二材料之间的电导，以产生由延伸穿过导电流体的电流部分地限定的可检测信号。通信模块耦合到部分电源，并且被配置为与接收器和电连接到通信模块的天线进行通信，所述通信模块使用天线与接收机进行通信。

7. 发明申请

US20150182463A1 CONTROLLED ACTIVATION INGESTIBLE IDENTIFIER 审中-公开
标题翻译：控制不活动识别器
公开(公告)号：US20150182463A1
公开(公告)日：2015-07-02
申请号：US14570673
申请日：2014-12-15
申请人： Proteus Digital Health, Inc.
发明人： Hooman Hafezi , Timothy Robertson , Olivier Colliou , Mark Zdeblick
IPC分类号： A61K9/20 , A61B5/00
CPC分类号： A61K9/2072 , A61B5/073 , A61B5/14539 , A61B5/1473 , A61B5/4238 , A61B5/4833 , A61B5/4839 , A61B5/6861 , A61B2560/0214 , A61J3/007 , A61K49/00 , H01M10/0436
摘要： Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.
摘要翻译：提供了用于可摄取组合物的受控激活标识符，例如制药信息学组合物。标识符包括受控激活元件，其响应于感兴趣的目标位置处的预定刺激的存在而提供对标识符的激活。本发明可用于各种不同的应用，包括但不限于监测治疗方案依从性，跟踪药剂的历史等。

8. 发明授权

US09008761B2 Two-wrist data gathering system 有权
标题翻译：双腕数据采集系统
公开(公告)号：US09008761B2
公开(公告)日：2015-04-14
申请号：US13670339
申请日：2012-11-06
申请人： Proteus Digital Health, Inc.
发明人： Mark Zdeblick
IPC分类号： A61B5/0408 , H04B13/00 , A61B5/06 , A61B5/00 , A61J7/04 , G06F19/00 , A61K9/20 , A61B5/07
CPC分类号： A61B5/0408 , A61B5/061 , A61B5/07 , A61B5/681 , A61J7/0481 , A61J2200/30 , A61J2205/60 , A61K9/20 , G06F19/00 , G06F19/3456 , H04B13/005
摘要： Sensing is carried out from locations considerably removed from the stomach. Cooperating sensor electronics are placed at each of two wrists of the patient. The potential discomfort and inconvenience of an abdominal patch are reduced or eliminated, and alternative power sources become available.
摘要翻译：感觉是从显着从胃中除去的位置进行的。合作的传感器电子设备放置在患者的两只手腕的每一个上。减少或消除腹部贴片的潜在不适和不便，并且替代电源变得可用。

9. 发明申请

US20200259691A1 METHODS, DEVICES AND SYSTEMS FOR RECEIVING AND DECODING A SIGNAL IN THE PRESENCE OF NOISE USING SLICES AND WARPING 审中-公开
公开(公告)号：US20200259691A1
公开(公告)日：2020-08-13
申请号：US16600174
申请日：2019-10-11
申请人： Proteus Digital Health, Inc.
发明人： Robert Fleming , Cherie Kushner , William H. McAllister , Mark Zdeblick
IPC分类号： H04L27/148 , H04B1/00 , H04L29/06 , H04L25/08 , H04L7/04 , H04L27/144 , H04L27/00
摘要： A method may comprise receiving and sampling a signal. The signal may encode a data packet. A slice may be generated and stored comprising a pair of values for each of a selected number of samples of the signal representing a correlation of the signal to reference functions in the receiver. The presence of the data packet may then be detected and the detected packet decoded from the stored slices. The generating and storing slices may be carried out as the received signal is sampled. The sampled values of the signal may be discarded as the slices are generated and stored. The slice representation of the signal can be manipulated to generate filters with flexible bandwidth and center frequency.

10. 发明授权

US10610128B2 Pharma-informatics system 有权
公开(公告)号：US10610128B2
公开(公告)日：2020-04-07
申请号：US15788968
申请日：2017-10-20
申请人： Proteus Digital Health, Inc.
发明人： Mark Zdeblick , Andrew Thompson , Aleksandr Pikelny , Timothy L. Robertson , Hooman Hafezi
IPC分类号： A61B5/07 , A61B5/00 , H01Q1/27 , A61J3/00 , G06K7/10 , A61B5/1473
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/07 , A61B5/076 , A61B5/1473 , A61B5/4833 , A61B5/4839 , A61B5/681 , A61B5/6861 , A61B5/7282 , A61J3/007 , G06K7/10168 , H01Q1/273 , A61B2560/0214 , A61B2560/0462 , A61B2562/08 , A61B2562/162 , Y10T29/49117
摘要： A system for administering prescription medications including a composition and a receiver. The composition may include an active agent, an identifier, and a pharmaceutically acceptable carrier. The active agent may include a controlled pharmaceutical. The identifier may include: a partial power source having a first material and a second material configured to generate a voltage in contact with a conductive fluid within a body of a patient, and a signal generation component configured to use at least a portion of the generated voltage to transmit a signal through the body of the patient. The receiver may be positioned near the body of the patient, wherein the receiver is configured to: receive the signal transmitted through the body of the patient, and automatically report the signal for at least one of identification of the controlled pharmaceutical or tracking physical administration of the controlled pharmaceutical to the body of the patient.

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