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1. 发明授权

US08473536B2 Algorithm for adiabatic pulse design using the Shinnar Le-Roux transform 有权
标题翻译：使用Shinnar Le-Roux变换的绝热脉冲设计算法
公开(公告)号：US08473536B2
公开(公告)日：2013-06-25
申请号：US12489285
申请日：2009-06-22
申请人： Priti Balchandani , John M. Pauly , Daniel M. Spielman
发明人： Priti Balchandani , John M. Pauly , Daniel M. Spielman
IPC分类号： G06F15/00 , G06F7/00
CPC分类号： G01R33/44 , G01R33/4833
摘要： A method for providing an adiabatic RF pulse that is an inversion or refocusing pulse for a RF pulse sequence is provided. A linear phase frequency profile (Flp(ω)) is determined for the adiabatic RF pulse. A quadratic phase is applied to the linear phase frequency profile for the adiabatic RF pulse to obtain F(ω), wherein the applying the quadratic phase comprises setting F(ω)=Flp(ω)eikω2. A polynomial β is set to equal a Fourier Transform (F(ω)). A corresponding minimum phase α polynomial is determined for the β polynomial. (α,β) are set as inputs to an inverse Shinnar Le-Roux transform to generate an adiabatic RF waveform. The adiabatic RF waveform is truncated to produce the adiabatic RF pulse, wherein k>0.03π/(ω5−ωp)/(N+1) and k
摘要翻译：提供了一种用于提供作为RF脉冲序列的反转或重聚焦脉冲的绝热RF脉冲的方法。确定绝热RF脉冲的线性相位频率分布（Flp（ω））。将二次相位施加到用于绝热RF脉冲的线性相位频率分布以获得F（ω），其中应用二次相位包括设置F（ω）= Flp（ω）eikomega2。多项式β被设置为等于傅里叶变换（F（ω））。对于β多项式确定相应的最小相位α多项式。（α，β）被设置为反向Shinnar Le-Roux变换的输入以产生绝热RF波形。绝热RF波形被截断以产生绝热射频脉冲，其中k> 0.03pi /（ω5-omegap）/（N + 1）和k

2. 发明授权

US07821263B2 Self-refocused spatial-spectral pulse 有权
标题翻译：自重聚焦空间光谱脉冲
公开(公告)号：US07821263B2
公开(公告)日：2010-10-26
申请号：US12136319
申请日：2008-06-10
申请人： Priti Balchandani , Daniel Spielman , John M. Pauly
发明人： Priti Balchandani , Daniel Spielman , John M. Pauly
IPC分类号： G01V3/00
CPC分类号： G01R33/5601 , G01R33/4833 , G01R33/4835
摘要： A method for frequency selective and slice selective magnetic resonance imaging (MRI) is provided. A B0 field is applied. A self-refocused spatial-spectral (SPSP) RF pulse is applied. A readout of a portion of k-space for the excited slice is performed. A second self-refocused SPSP excitation RF pulse is applied, wherein the second self-refocused SPSP excitation has an 180° echo phase difference from the self-refocused SPSP excitation. A second readout of a portion of k-space for the excited slice was performed. A difference between the readout and the second readout was found. The previous steps were repeated until k-space has been filled for the excited slice. The previous steps were repeated for a plurality of slices.
摘要翻译：提供了频率选择和切片选择性磁共振成像（MRI）的方法。应用B0字段。应用自重聚焦空间光谱（SPSP）RF脉冲。执行激励切片的k空间的一部分的读出。应用第二个自重新聚焦的SPSP激励RF脉冲，其中第二自重聚焦SPSP激发与自重新聚焦的SPSP激发具有180°的回波相位差。进行激发切片的k空间的一部分的第二次读出。发现读出和第二读数之间的差异。重复前面的步骤，直到激活切片填充k空间为止。对于多个切片重复前面的步骤。

3. 发明申请

US20090315558A1 SELF-REFOCUSED SPATIAL-SPECTRAL PULSE 有权
标题翻译：自反射空间光谱脉冲
公开(公告)号：US20090315558A1
公开(公告)日：2009-12-24
申请号：US12136319
申请日：2008-06-10
申请人： Priti Balchandani , Daniel Spielman , John M. Pauly
发明人： Priti Balchandani , Daniel Spielman , John M. Pauly
IPC分类号： G01R33/48
CPC分类号： G01R33/5601 , G01R33/4833 , G01R33/4835
摘要： A method for frequency selective and slice selective magnetic resonance imaging (MRI) is provided. A B0 field is applied. A self-refocused spatial-spectral (SPSP) RF pulse is applied. A readout of a portion of k-space for the excited slice is performed. A second self-refocused SPSP excitation RF pulse is applied, wherein the second self-refocused SPSP excitation has an 180° echo phase difference from the self-refocused SPSP excitation. A second readout of a portion of k-space for the excited slice was performed. A difference between the readout and the second readout was found. The previous steps were repeated until k-space has been filled for the excited slice. The previous steps were repeated for a plurality of slices.
摘要翻译：提供了频率选择和切片选择性磁共振成像（MRI）的方法。应用B0字段。应用自重聚焦空间光谱（SPSP）RF脉冲。执行激励切片的k空间的一部分的读出。应用第二个自重新聚焦的SPSP激励RF脉冲，其中第二自重聚焦SPSP激发与自重新聚焦的SPSP激发具有180°的回波相位差。进行激发切片的k空间的一部分的第二次读出。发现读出和第二读数之间的差异。重复前面的步骤，直到激活切片填充k空间为止。对于多个切片重复前面的步骤。

4. 发明授权

US5402067A Apparatus and method for rare echo imaging using k-space spiral coverage 失效
标题翻译：使用k空间螺旋覆盖的稀有回波成像的装置和方法
公开(公告)号：US5402067A
公开(公告)日：1995-03-28
申请号：US101865
申请日：1993-08-04
申请人： John M. Pauly , Daniel M. Spielman , Craig H. Meyer , Albert Macovski , Norbert J. Pelc
发明人： John M. Pauly , Daniel M. Spielman , Craig H. Meyer , Albert Macovski , Norbert J. Pelc
IPC分类号： G01R33/20 , A61B5/055 , G01R33/48 , G01R33/561 , G01V3/00
CPC分类号： G01R33/5615 , G01R33/446 , G01R33/5617
摘要： A long train of spin echoes is produced using a RARE excitation pulse sequence, and during each spin echo an annular segment of a long k-space spiral as determined by read-out magnetic gradients is detected. At the end of the echo train the entire k-space spiral will have been covered. Each of the segments can be a unique annular portion of the k-space spiral. Alternatively, fewer annular segments of the spiral can be provided, with the fewer annular segments rotated in k-space and replayed to cover interleaved paths in k-space. The imaging gradients are refocused at the time of each spin-echo pulse in order to permit the long echo pulse trains of RARE imaging. Each spiral segment is surrounded by gradient lobes that move out from the k-space origin to the beginning of the segment, and move back to the origin from the end of the segment. Advantageously, the magnetic gradient lobes can be produced concurrently with parasitic echo crusher gradients at the beginning and end of each spin-echo pulse. Further, off-resonance effects can be placed in sidelobes of the spin-echo signal to facilitate suppression in the detected signals.
摘要翻译：使用RARE激励脉冲序列产生长串自旋回波，并且在每个自旋回波期间，检测由读出磁梯度确定的长k空间螺旋的环形段。在回波列车的末端，整个k空间螺旋将被覆盖。每个段可以是k空间螺旋的独特的环形部分。或者，可以提供更少的螺旋环形段，其中较少的环形段在k空间中旋转并且重播以覆盖k空间中的交错路径。在每个自旋回波脉冲时，成像梯度被重新聚焦，以便允许RARE成像的长回波脉冲序列。每个螺旋段由从k空间原点移出到段的开头的梯度波瓣包围，并从段的末尾返回到原点。有利地，可以在每个自回波脉冲的开始和结束处与寄生回波破碎机梯度同时产生磁梯度波瓣。此外，离共振效应可以置于自旋回波信号的旁瓣中，以便于检测信号中的抑制。

5. 发明授权

US5283526A Method for performing single and multiple slice magnetic resonance spectroscopic imaging 失效
标题翻译：执行单片和多片磁共振光谱成像的方法
公开(公告)号：US5283526A
公开(公告)日：1994-02-01
申请号：US908098
申请日：1992-07-01
申请人： Daniel M. Spielman , John M. Pauly
发明人： Daniel M. Spielman , John M. Pauly
IPC分类号： G01R33/48 , G01R33/54 , G01R33/20
CPC分类号： G01R33/446 , G01R33/4828
摘要： A new pulse sequence which uses inversion recovery for lipid suppression and a spectral-spatial refocusing pulse for water suppression in spectroscopic imaging of the brain. In contrast to methods which eliminate fat by restricting the excited volume to lie completely within the brain, inversion recovery techniques allow imaging of an entire slice without such restrictions. A spectral-spatial pulse provides water suppression insensitive to a reasonable range of B.sub.0 and B.sub.1 inhomogeneities. Metabolite maps covering large volumes of the human brain can be produced with images from single and multiple slices obtained.
摘要翻译：一种新的脉冲序列，其使用用于脂质抑制的反转恢复和用于大脑光谱成像中的水抑制的光谱 - 空间重聚焦脉冲。与通过将激发体积限制在脑内完全消除脂肪的方法相反，反转恢复技术允许整个切片的成像而没有这种限制。光谱空间脉冲提供对B0和B1不均匀性的合理范围不敏感的水分抑制。覆盖大量人脑的代谢物图可以通过获得单片和多片的图像产生。

6. 发明授权

US08638096B2 Method of autocalibrating parallel imaging interpolation from arbitrary K-space sampling with noise correlations weighted to reduce noise of reconstructed images 有权
标题翻译：从任意K空间采样中自动校准平行成像插值的方法，加权噪声相关，以减少重构图像的噪声
公开(公告)号：US08638096B2
公开(公告)日：2014-01-28
申请号：US12907764
申请日：2010-10-19
申请人： Tao Zhang , Michael Lustig , John M. Pauly , Shreyas S. Vasanawala
发明人： Tao Zhang , Michael Lustig , John M. Pauly , Shreyas S. Vasanawala
IPC分类号： G01R33/56
CPC分类号： G01R33/5611 , G01R33/4824
摘要： A computer implemented method for magnetic resonance imaging is provided. A 3D Fourier Transform acquisition is performed with two phase encode directions, wherein phase code locations are chosen so that a total number of phase encodes is less than a Nyquist rate, and closest distances between phase encode locations takes on a multiplicity of values. Readout signals are received through a multi-channel array of a plurality of receivers. An autocalibrating parallel imaging interpolation is performed and a noise correlation is generated. The noise correlation is used to weight a data consistency term of a compressed sensing iterative reconstruction. An image is created from the autocalibration parallel imaging using the weighted data consistency term. The image is displayed.
摘要翻译：提供了一种用于磁共振成像的计算机实现方法。使用两个相位编码方向执行3D傅立叶变换采集，其中选择相位位置使得相位编码的总数小于奈奎斯特速率，并且相位编码位置之间的最近距离具有多个值。通过多个接收器的多通道阵列接收读出信号。执行自动校准并行成像内插，并产生噪声相关。噪声相关用于加权压缩感测迭代重建的数据一致性项。使用加权数据一致性项从自动校准并行成像创建图像。显示图像。

7. 发明授权

US07928729B2 Distortion-free magnetic resonance imaging near metallic implants 有权
标题翻译：在金属植入物附近的无畸变磁共振成像
公开(公告)号：US07928729B2
公开(公告)日：2011-04-19
申请号：US12188031
申请日：2008-08-07
申请人： Brian A. Hargreaves , Wenmiao Lu , John M. Pauly , Garry E. Gold , Kim B. Pauly
发明人： Brian A. Hargreaves , Wenmiao Lu , John M. Pauly , Garry E. Gold , Kim B. Pauly
IPC分类号： G01V3/00
CPC分类号： G01R33/4833 , G01R33/5611 , G01R33/5618 , G01R33/56536 , G01R33/56563
摘要： A method for 3D magnetic resonance imaging (MRI) with slice-direction distortion correction is provided. One or more selective cross-sections with a thickness along a first axis is excited using a RF pulse with a bandwidth, wherein a selective cross-section is either a selective slice or selective slab. A refocusing pulse is applied to form a spin echo. One or more 2D encoded image signals are acquired with readout along a second axis and phase encoding along a third axis. Slice-direction distortion is corrected by resolving the position by resolving the frequency offset.
摘要翻译：提供了一种具有切片方向失真校正的3D磁共振成像（MRI）方法。使用具有带宽的RF脉冲激发具有沿着第一轴的厚度的一个或多个选择性横截面，其中选择性截面是选择性切片或选择性板。应用重聚焦脉冲以形成自旋回波。一个或多个2D编码图像信号是沿第二轴读出并沿第三轴进行相位编码的。通过解析频率偏移来解决位置来校正切片方向失真。

8. 发明申请

US20100033179A1 DISTORTION-FREE MAGNETIC RESONANCE IMAGING NEAR METALLIC IMPLANTS 有权
标题翻译：无损磁性共振成像近金属植入物
公开(公告)号：US20100033179A1
公开(公告)日：2010-02-11
申请号：US12188031
申请日：2008-08-07
申请人： Brian A. Hargreaves , Wenmiao Lu , John M. Pauly , Garry E. Gold , Kim B. Pauly
发明人： Brian A. Hargreaves , Wenmiao Lu , John M. Pauly , Garry E. Gold , Kim B. Pauly
IPC分类号： G01R33/56
CPC分类号： G01R33/4833 , G01R33/5611 , G01R33/5618 , G01R33/56536 , G01R33/56563
摘要： A method for 3D magnetic resonance imaging (MRI) with slice-direction distortion correction is provided. One or more selective cross-sections with a thickness along a first axis is excited using a RF pulse with a bandwidth, wherein a selective cross-section is either a selective slice or selective slab. A refocusing pulse is applied to form a spin echo. One or more 2D encoded image signals are acquired with readout along a second axis and phase encoding along a third axis. Slice-direction distortion is corrected by resolving the position by resolving the frequency offset.
摘要翻译：提供了一种具有切片方向失真校正的3D磁共振成像（MRI）方法。使用具有带宽的RF脉冲激发具有沿着第一轴的厚度的一个或多个选择性横截面，其中选择性截面是选择性切片或选择性板。应用重聚焦脉冲以形成自旋回波。一个或多个2D编码图像信号是沿第二轴读出并沿第三轴进行相位编码的。通过解析频率偏移来解决位置来校正切片方向失真。

9. 发明申请

US20080150528A1 RF FIELD MAPPING FOR MAGNETIC RESONANCE IMAGING 有权
标题翻译：用于磁共振成像的射频场映射
公开(公告)号：US20080150528A1
公开(公告)日：2008-06-26
申请号：US11614798
申请日：2006-12-21
申请人： Charles H. Cunningham , Krishna S. Nayak , John M. Pauly
发明人： Charles H. Cunningham , Krishna S. Nayak , John M. Pauly
IPC分类号： G01V3/14
CPC分类号： G01R33/583 , G01R33/246 , G01R33/446 , G01R33/4824 , G01R33/4835 , G01R33/5607 , G01R33/561
摘要： For in vivo magnetic resonance imaging at high field (≧3 T) it is essential to consider the homogeneity of the active B1 field (B1+), particularly if surface coils are used for RF transmission. A new method is presented for highly rapid B1+ magnitude mapping. It combines the double angle method with a B1-insensitive magnetization-reset sequence such that the choice of repetition time (TR) is independent of T1 and with a multi-slice segmented (spiral) acquisition to achieve volumetric coverage with adequate spatial resolution in a few seconds.
摘要翻译：对于在高场（> = 3T）下的体内磁共振成像，必须考虑活性B 1区域（B 1 + 1）的均匀性，特别是如果表面线圈用于RF传输。提出了一种用于高度快速的B＆lt; 1＆gt; +幅度映射的新方法。它将双重角度方法与B 1敏感磁化复位序列相结合，使得重复时间（TR）的选择与T 1> 1不相关，切片分段（螺旋）采集，在几秒钟内实现足够的空间分辨率的体积覆盖。

10. 发明授权

US07276904B2 Method for generating T1-weighted magnetic resonance images and quantitative T1 maps 有权
标题翻译：用于产生T1加权磁共振图像和定量T1图的方法
公开(公告)号：US07276904B2
公开(公告)日：2007-10-02
申请号：US11136194
申请日：2005-05-24
申请人： Reed F. Busse , John M. Pauly , Greg Zaharchuk
发明人： Reed F. Busse , John M. Pauly , Greg Zaharchuk
IPC分类号： G01V3/00
CPC分类号： G01R33/50 , G01R33/5615 , G01R33/5617
摘要： Methods and systems for generating T1-weighted images are provided. The method includes acquiring a pair of single-shot fast-spin-echo (SSFSE) images S1 and S2. The method further includes generating a T1-weighted image ST1w based on S1 and S2.
摘要翻译：提供了生成T1加权图像的方法和系统。该方法包括获取一对单次快速自旋回波（SSFSE）图像S 1和S 2 2。该方法还包括基于S 1和S 2 2生成T1加权图像S T1W1。

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