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1. 发明公开

US20230146476A1 NANOSWITCH CALIPER TRAINS FOR HIGH-THROUGHPUT, HIGH-RESOLUTION STRUCTURAL ANALYSIS OF BIOMOLECULES 审中-公开
公开(公告)号：US20230146476A1
公开(公告)日：2023-05-11
申请号：US17907763
申请日：2021-02-26
申请人： President and Fellows of Harvard College , Children's Medical Center Corporation , Dana-Farber Cancer Institute, Inc.
发明人： James I. MacDonald , Michael H. Raez , William M. Shih , Wesley Philip Wong
IPC分类号： G01N33/68 , G01N33/53 , G01N33/543 , C12Q1/6811
CPC分类号： G01N33/6803 , G01N33/5308 , G01N33/54346 , C12Q1/6811
摘要： Provided herein are compositions and methods for determining the structure of individual targets by determining long-range distances within such targets.

2. 发明申请

US20180364225A1 HIGH THROUGHPUT SCREENING OF SMALL MOLECULES 审中-公开
公开(公告)号：US20180364225A1
公开(公告)日：2018-12-20
申请号：US16060392
申请日：2016-12-07
申请人： President and Fellows of Harvard College , Children's Medical Center Corporation , Dana-Farber Cancer Institute, Inc.
发明人： Bhavik Nathwani , Darren Yang , Wesley Philip Wong , William M. Shih , Andrew Ward
IPC分类号： G01N33/552 , G01N33/543
摘要： Provided herein, in some embodiments, are methods of high-throughput screening of small molecules and related compositions and articles of manufacture.

3. 外观设计

USD846755S1 Holder 有权
公开(公告)号：USD846755S1
公开(公告)日：2019-04-23
申请号：US29586798
申请日：2016-12-07
申请人： President and Fellows of Harvard College , Children's Medical Center Corporation , Dana-Farber Cancer Institute, Inc.
设计人： Bhavik Nathwani , William M. Shih , Wesley Philip Wong , Darren Yang
摘要： FIG. 1 is a top, front perspective view of a first embodiment of a holder;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a top view thereof; and
FIG. 7 is a bottom view thereof.
FIG. 8 is a top, front perspective view of a second embodiment of a holder;
FIG. 9 is a front view thereof;
FIG. 10 is a rear view thereof;
FIG. 11 is a left side view thereof;
FIG. 12 is a right side view thereof;
FIG. 13 is a top view thereof; and
FIG. 14 is a bottom view thereof.
FIG. 15 is a top, front perspective view of a third embodiment of a holder;
FIG. 16 is a front view thereof;
FIG. 17 is a rear view thereof;
FIG. 18 is a left side view thereof;
FIG. 19 is a right side view thereof;
FIG. 20 is a top view thereof; and,
FIG. 21 is a bottom view thereof.
The dashed lines shown illustrate portions of the holder that form no part of the claimed design. The dot-dash-dot lines immediately adjacent the shaded areas represent the bounds of the claimed design.

4. 外观设计

USD844805S1 Holder 有权
公开(公告)号：USD844805S1
公开(公告)日：2019-04-02
申请号：US29556273
申请日：2016-02-29
申请人： President and Fellows of Harvard College , Dana-Farber Cancer Institute, Inc. , Children's Medical Center Corporation
设计人： Bhavik Nathwani , William M. Shih , Wesley Philip Wong , Darren Yang
摘要： This invention was made with U.S. Government support under Contract No. ONR BAA15-001 awarded by the Office of Naval Research and Contract No. DGE1144152 awarded by the National Science Foundation. The Government has certain rights in the invention.
FIG. 1 is a top, front perspective view of a first embodiment of a holder;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a top view thereof; and
FIG. 7 is a bottom view thereof.
FIG. 8 is a top, front perspective view of a second embodiment of a holder;
FIG. 9 is a front view thereof;
FIG. 10 is a rear view thereof;
FIG. 11 is a left side view thereof;
FIG. 12 is a right side view thereof;
FIG. 13 is a top view thereof; and
FIG. 14 is a bottom view thereof.
FIG. 15 is a top, front perspective view of a third embodiment of a holder;
FIG. 16 is a front view thereof;
FIG. 17 is a rear view thereof;
FIG. 18 is a left side view thereof;
FIG. 19 is a right side view thereof;
FIG. 20 is a top view thereof; and
FIG. 21 is a bottom view thereof.
FIG. 22 is a top, front perspective view of a fourth embodiment of a holder;
FIG. 23 is a front view thereof;
FIG. 24 is a rear view thereof;
FIG. 25 is a left side view thereof;
FIG. 26 is a right side view thereof;
FIG. 27 is a top view thereof; and,
FIG. 28 is a bottom view thereof.
The dashed lines shown illustrate portions of the holder that form no part of the claimed design. The dot-dash-dot lines immediately adjacent the shaded areas represent the bounds of the claimed design.

5. 发明申请

US20180291434A1 NUCLEIC ACID-BASED LINKERS FOR DETECTING AND MEASURING INTERACTIONS 审中-公开
公开(公告)号：US20180291434A1
公开(公告)日：2018-10-11
申请号：US15888941
申请日：2018-02-05
申请人： President and Fellows of Harvard College , Children's Medical Center Corporation
发明人： Wesley Philip Wong , Kenneth Anders Halvorsen
IPC分类号： C12Q1/6816 , G01N33/53 , C12Q1/6813 , C12Q1/6804
摘要： The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double- stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first and/or a second oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other.

6. 发明申请

US20170369935A1 NUCLEIC ACID-BASED LINKERS FOR DETECTING AND MEASURING INTERACTIONS 审中-公开
公开(公告)号：US20170369935A1
公开(公告)日：2017-12-28
申请号：US15533473
申请日：2015-11-16
申请人： Children's Medical Center Corporation , President and Fellows of Harvard College
发明人： Mounir Ahmad Koussa , Kenneth Anders Halvorsen , Andrew Ward , Wesley Philip Wong
IPC分类号： C12Q1/68 , C12P19/34 , G01N27/447
CPC分类号： C12Q1/6818 , C12P19/34 , C12Q2563/131 , C12Q2565/125 , G01N27/447 , C12Q2565/133
摘要： The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics, detecting analytes including low concentration analytes, and screening library members. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first, a second, a third, and optionally a fourth oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other or of interacting with a common moiety such as an analyte. Changes in topology of the complex are used to determine the binding interactions of the various binding partners.

7. 发明授权

US11913872B2 Spinning apparatus for measurement of characteristics relating to molecules 有权
公开(公告)号：US11913872B2
公开(公告)日：2024-02-27
申请号：US17167847
申请日：2021-02-04
申请人： President and Fellows of Harvard College , Children's Medical Center Corporation
发明人： Darren Yang , Andrew Ward , Wesley Philip Wong , Kenneth Anders Halvorsen
IPC分类号： G01N21/07 , G01N33/53 , C12Q1/68 , C12Q1/6816 , G01N33/543 , G01N15/14 , G01N33/557 , G01N15/00 , G01N15/10 , B82Y15/00 , B04B13/00 , B04B15/02
CPC分类号： G01N21/07 , B82Y15/00 , C12Q1/68 , C12Q1/6816 , G01N15/1434 , G01N33/53 , G01N33/543 , G01N33/557 , B04B13/00 , B04B15/02 , G01N2015/0038 , G01N2015/0065 , G01N2015/1006 , G01N2201/021 , G01N2201/0423 , G01N2201/0693 , G01N2203/0089 , C12Q1/68 , C12Q2523/303 , C12Q2525/30
摘要： An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

8. 发明申请

US20210239602A1 SPINNING APPARATUS FOR MEASUREMENT OF CHARACTERISTICS RELATING TO MOLECULES 有权
公开(公告)号：US20210239602A1
公开(公告)日：2021-08-05
申请号：US17167847
申请日：2021-02-04
申请人： President and Fellows of Harvard College , Children's Medical Center Corporation
发明人： Darren Yang , Andrew Ward , Wesley Philip Wong , Kenneth Anders Halvorsen
IPC分类号： G01N21/07 , B82Y15/00 , G01N33/53 , C12Q1/68 , C12Q1/6816 , G01N33/543 , G01N15/14 , G01N33/557
摘要： An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

9. 发明授权

US09914958B2 Nucleic acid-based linkers for detecting and measuring interactions 有权
公开(公告)号：US09914958B2
公开(公告)日：2018-03-13
申请号：US14356282
申请日：2012-11-05
申请人： President and Fellows of Harvard College , Children's Medical Center Corporation
发明人： Wesley Philip Wong , Kenneth Anders Halvorsen
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6816 , C12Q1/6804 , C12Q1/6813 , G01N33/5308 , C12Q2525/313 , C12Q2563/107 , C12Q2565/601
摘要： The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics with or without force, detecting analytes, screening aptamers, and encoding/encrypting information. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first and/or a second oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other.

10. 发明授权

US10948401B2 Spinning apparatus for measurement of characteristics relating to molecules 有权
公开(公告)号：US10948401B2
公开(公告)日：2021-03-16
申请号：US16079995
申请日：2017-02-24
申请人： Children's Medical Center Corporation , President and Fellows of Harvard College
发明人： Darren Yang , Andrew Ward , Wesley Philip Wong , Kenneth Anders Halvorsen
IPC分类号： G01N21/07 , B04B15/00 , G01N33/557 , B82Y15/00 , G01N33/53 , C12Q1/68 , C12Q1/6816 , G01N33/543 , G01N15/14 , G01N15/00 , G01N15/10 , B04B13/00 , B04B15/02
摘要： An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

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