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2. 发明申请

US20160033498A1 NANOSENSORS AND RELATED TECHNOLOGIES 有权
标题翻译：纳米传感器及相关技术
公开(公告)号：US20160033498A1
公开(公告)日：2016-02-04
申请号：US14788134
申请日：2015-06-30
申请人： President and Fellows of Harvard College
发明人： Charles M. Lieber , Ying Fang , Fernando Patolsky
IPC分类号： G01N33/551 , G01N33/553
CPC分类号： G01N33/551 , B82Y10/00 , C12Q1/6825 , C12Q2600/156 , G01N27/4145 , G01N27/4146 , G01N33/553 , H01L51/0049 , H01L51/0093 , C12Q2563/155
摘要： The present invention generally relates to nanotechnology and sub-microelectronic circuitry, as well as associated methods and devices, for example, nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample (for example, their presence and/or dynamical information), e.g., at the single molecule level. For example, a nanoscale wire device can be used in some cases to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between a nucleic acid or other analyte, and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances. Articles and devices of size greater than the nanoscale are also included in certain embodiments. Still other aspects of the invention include assays, sensors, kits, and/or other devices that include such nanoscale wires, methods of making and/or using such nanoscale wires, or the like.
摘要翻译：本发明通常涉及纳米技术和亚微电子电路，以及相关的方法和装置，例如纳米级线器件和用于确定疑似存在于样品中的核酸或其他分析物的方法（例如，它们的存在和/或动态信息），例如在单分子水平。例如，在一些情况下可以使用纳米级线器件来检测核酸内的单碱基错配（例如，通过确定缔合和/或解离速率）。在一个方面，可以在核酸或其他分析物与相对于纳米尺度线固定的结合对象之间确定动力学信息，例如结合常数，缔合速率和/或解离速率。在一些情况下，纳米尺寸线包括包含金属 - 半导体化合物的第一部分和不包括金属 - 半导体化合物的第二部分。在一些实施方案中，结合配偶体相对于纳米尺度线的至少第二部分是固定的，并且纳米级线的第二部分的尺寸可以在一些情况下被最小化和/或控制。尺寸大于纳米级的制品和装置也包括在某些实施方案中。本发明的其它方面包括测定，传感器，试剂盒和/或包括这种纳米线的其它装置，制造和/或使用这种纳米级线的方法等。

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