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1. 发明申请

US20060229447A1 Constrained compounds as CGRP-receptor antagonists 有权
公开(公告)号：US20060229447A1
公开(公告)日：2006-10-12
申请号：US11417326
申请日：2006-05-03
申请人： Prasad Chaturvedula , Stephen Mercer , Haiquan Fang
发明人： Prasad Chaturvedula , Stephen Mercer , Haiquan Fang
IPC分类号： A61K31/55 , C07D403/14 , C07D487/10
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

2. 发明申请

US20060094707A1 Constrained compounds as CGRP-receptor antagonists 有权
公开(公告)号：US20060094707A1
公开(公告)日：2006-05-04
申请号：US11247697
申请日：2005-10-11
申请人： Prasad Chaturvedula , Stephen Mercer , Haiquan Fang
发明人： Prasad Chaturvedula , Stephen Mercer , Haiquan Fang
IPC分类号： A61K31/55 , C07D487/02
CPC分类号： C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

3. 发明申请

US20060117302A1 Type propagation for automatic casting of output types in a data flow program 有权
公开(公告)号：US20060117302A1
公开(公告)日：2006-06-01
申请号：US11269217
申请日：2005-11-08
申请人： Stephen Mercer , Steven Rogers
发明人： Stephen Mercer , Steven Rogers
IPC分类号： G06F9/44
CPC分类号： G06F9/4484 , G06F9/4492
摘要： System and method for implicit downcasting at compile time in a data flow program. A first data flow function in an object-oriented dataflow program is identified, where the first function includes an input of a parent data type and an output of the parent data type. The first function is analyzed to determine if the output preserves the run-time data type of the input. A second dataflow function in the object-oriented data flow program is identified, where the second function includes a program element that calls the first function, passing an input parameter of a child data type of the parent data type as input. If the analysis determines that an output parameter returned by the output of the first function will always be of the child data type, the program element is automatically configured at compile time to always downcast the output parameter from the parent data type to the child data type at run-time.

4. 发明申请

US20060036656A1 Automatic versioning and data mutation of user-defined data types 有权
标题翻译：用户自定义数据类型的自动版本和数据变异
公开(公告)号：US20060036656A1
公开(公告)日：2006-02-16
申请号：US11047198
申请日：2005-01-31
申请人： Stephen Mercer
发明人： Stephen Mercer
IPC分类号： G06F17/30
CPC分类号： G06F17/30309 , G06F8/71
摘要： System and method for automatic versioning and data mutation for user-defined data types. A program development environment may be operable to: create a first version of a data type definition in response to user input; instantiate and store an object of the first version of the data type, optionally including a version identifier indicating the version of the object; modify the first version of the data type definition in response to user input, thereby creating a second version of the data type definition; load the object from storage; and automatically (without user intervention) modify the object to conform to the second version of the data type definition. Successive modifications of the data type definition may generate successive versions of the data type. Objects instantiated and stored according to a previous version of the data type may be loaded from storage and automatically modified to conform to a specified subsequent version.
摘要翻译：用户自定义数据类型的自动版本控制和数据变异的系统和方法。程序开发环境可以用于：响应于用户输入创建数据类型定义的第一版本; 实例化和存储数据类型的第一版本的对象，可选地包括指示对象的版本的版本标识符; 响应于用户输入修改数据类型定义的第一版本，从而创建数据类型定义的第二版本; 从存储加载对象; 并自动（无用户干预）修改对象以符合数据类型定义的第二个版本。数据类型定义的连续修改可能会生成数据类型的连续版本。根据数据类型的先前版本实例化和存储的对象可以从存储器加载并被自动修改以符合指定的后续版本。

5. 发明申请

US20050215576A1 Novel therapeutic agents for the treatment of migraine 有权
标题翻译：用于治疗偏头痛的新型治疗剂
公开(公告)号：US20050215576A1
公开(公告)日：2005-09-29
申请号：US11091429
申请日：2005-03-28
申请人： Andrew Degnan , Xiaojun Han , Gene Dubowchik , John Macor , Stephen Mercer
发明人： Andrew Degnan , Xiaojun Han , Gene Dubowchik , John Macor , Stephen Mercer
IPC分类号： A61K31/4709 , A61K31/517 , C07D401/14 , C07D43/14
CPC分类号： C07D401/14
摘要： The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
摘要翻译：本发明涉及作为降钙素基因相关肽受体（“CGRP受体”）拮抗剂的式（I）化合物，包含它们的药物组合物，鉴定它们的方法，使用它们的治疗方法及其在治疗治疗中的用途神经源性血管舒张，神经源性炎症，偏头痛和其他头痛，热损伤，循环休克，与更年期相关的潮红，气道炎症性疾病如哮喘和慢性阻塞性肺疾病（COPD）以及其他治疗可以通过 CGRP受体的拮抗作用。

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