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1. 发明授权

US5962667A Pharmaco-gene delivery in human breast cancer cells 失效
标题翻译：人乳腺癌细胞中的药物基因递送
公开(公告)号：US5962667A
公开(公告)日：1999-10-05
申请号：US962613
申请日：1997-11-03
申请人： Pramod Jain , David Gewirtz
发明人： Pramod Jain , David Gewirtz
IPC分类号： A61K48/00 , C07J1/00 , C12N15/12 , C12N15/33
CPC分类号： A61K48/0083 , A61K48/0008 , C07J1/00
摘要： Estradiol facilitates non-viral gene delivery to breast tumor cells. The effect is dose dependent, and is independent of the gene construct, temperature, and tumor cell line. Thus, compositions and treatment regimens that use estradiol, or other estrogen pharmacologic agents, in combination with genes of interest can be used to provide targeted delivery and expression of genetic products in target cells and tissues of estrogen, such as breast cells. The compositions and treatment regimens have particular application to the enhanced delivery of genetic constructs useful in killing breast tumor cells and preventing tumor recurrence.
摘要翻译：雌二醇促进非病毒基因递送到乳腺肿瘤细胞。该效应是剂量依赖性的，并且与基因构建体，温度和肿瘤细胞系无关。因此，使用雌二醇或其它雌激素药物剂与目的基因组合的组合物和治疗方案可用于在雌激素例如乳腺细胞的靶细胞和组织中提供靶向递送和表达遗传产物。组合物和治疗方案特别适用于增强了用于杀死乳腺肿瘤细胞和预防肿瘤复发的遗传构建体。

2. 发明申请

US20050060077A1 Coasting downshift control for automatic transmissions 有权
标题翻译：自动变速箱的降档控制
公开(公告)号：US20050060077A1
公开(公告)日：2005-03-17
申请号：US10661954
申请日：2003-09-12
申请人： Joseph Slayton , Bradley Riedle , Pramod Jain , Balaram Sankpal , Steven Meisner , David Bidner , Armand Giannamore
发明人： Joseph Slayton , Bradley Riedle , Pramod Jain , Balaram Sankpal , Steven Meisner , David Bidner , Armand Giannamore
IPC分类号： B60W10/06 , B60W30/18 , F16H59/36 , F16H59/38 , F16H59/44 , F16H61/04 , F16H63/50 , G06F7/00
CPC分类号： B60W10/06 , B60W10/04 , B60W10/11 , B60W10/115 , B60W30/18 , B60W30/1819 , B60W2510/0652 , B60W2510/1015 , B60W2510/104 , B60W2710/0605 , B60W2710/0616 , B60W2710/0622 , B60W2710/0666 , F16H59/36 , F16H59/44 , F16H61/0437 , F16H63/502 , F16H2059/363 , F16H2059/366 , F16H2059/385 , F16H2061/0496 , Y02T10/76 , Y10T477/6403 , Y10T477/693636
摘要： An automatic transmission ratio shift control system and method for a powertrain having an engine and multiple-ratio gearing controlled by friction elements actuated by hydraulic pressure, an electronic controller for establishing torque transitions among the friction elements as the gear ratio changes, the engine speed being controlled by an electronic throttle control. The strategy employs an electronic throttle and closed loop engine speed control and uses fuel and air as an energy source to increase engine speed during a power-off downshift. The engine speed is boosted to a level close to the synchronous speed in conjunction with release of the off-going friction element. The on-coming friction element is then applied as the engine speed approaches a desired speed. The engine speed increase is timed to lead an increase in torque converter speed.
摘要翻译：一种用于具有由液压致动的摩擦元件控制的发动机和多级传动装置的动力系的自动变速比变速控制系统和方法，用于在齿轮比变化时在摩擦元件之间建立转矩转换的电子控制器，发动机转速为由电子节气门控制控制。该策略采用电子节气门和闭环发动机转速控制，并且在断电降档期间使用燃料和空气作为能源来提高发动机转速。发动机转速提高到接近同步速度的水平，同时释放离去的摩擦元件。然后随着发动机速度接近期望的速度而应用即将到来的摩擦元件。发动机转速提高的时间是引起变矩器转速的增加。

3. 发明申请

US20060041564A1 Graphical Annotations and Domain Objects to Create Feature Level Metadata of Images 审中-公开
标题翻译：图形注释和域对象来创建图像的特征级元数据
公开(公告)号：US20060041564A1
公开(公告)日：2006-02-23
申请号：US10711061
申请日：2004-08-20
申请人： Pramod Jain , Hoai Nguyen
发明人： Pramod Jain , Hoai Nguyen
IPC分类号： G06F7/00
CPC分类号： G06F16/50 , G06F16/907
摘要： Disclosed is a method, system and program for creating an annotation resource and feature-level metadata for images. Annotation resource is a collection of feature-specific domain objects. A domain object contains geometry of the feature and plurality of attributes. Geometry of feature is created by graphically annotating with freeform drawing tools on a transparent layer placed on top of the image. Attribute values may be computed automatically, manually entered or hyperlinked to a resource. The annotation resource will be stored in a database separate from the image, and cataloged in a metadata repository. This will allow users to perform search based on feature-level attributes to retrieve and display the annotation resource with the associated image.
摘要翻译：公开了一种用于创建用于图像的注释资源和特征级元数据的方法，系统和程序。注释资源是特征域对象的集合。域对象包含要素的几何和多个属性。通过在放置在图像顶部的透明图层上以自由形式绘图工具进行图形注释来创建特征的几何。属性值可以自动计算，手动输入或超链接到资源。注释资源将存储在与图像分开的数据库中，并在元数据存储库中编目。这将允许用户根据特征级属性执行搜索，以检索和显示带有关联图像的注释资源。

4. 发明授权

US10269066B2 Automated collateral risk and business performance assessment system 有权
公开(公告)号：US10269066B2
公开(公告)日：2019-04-23
申请号：US16014120
申请日：2018-06-21
申请人： Pramod Jain
发明人： Pramod Jain
IPC分类号： G06Q40/02 , G06N20/00
摘要： A system that automatically manages a collateral risk and a business performance of an entity is provided. The system generates a customizable database to store critical accounting and ancillary business information. The system automatically updates the customized database at predefined time periods based on new accounting and ancillary business information. The system automatically enables the customized database for scalable assessment of a collateral risk and a business performance of an entity. The system determines the collateral risk and business performance of an entity and provides the collateral risk, and business performance of the entity and an analytical summary of the accounting and the ancillary business information to a machine learning model. The system recommends actions to be performed to reduce the collateral risk and to improve the business performance based on the accounting and ancillary business information. The system enables a user to perform the actions to reduce the collateral risk and to improve the business performance of the entity.

5. 发明授权

US07089102B2 Coasting downshift control for automatic transmissions 有权
标题翻译：自动变速箱的降档控制
公开(公告)号：US07089102B2
公开(公告)日：2006-08-08
申请号：US10661954
申请日：2003-09-12
申请人： Joseph Slayton , Bradley Riedle , Pramod Jain , Balaram Sankpal , Steven Meisner , David Bidner , Armand Giannamore
发明人： Joseph Slayton , Bradley Riedle , Pramod Jain , Balaram Sankpal , Steven Meisner , David Bidner , Armand Giannamore
IPC分类号： G06F17/00 , B60W10/04
CPC分类号： B60W10/06 , B60W10/04 , B60W10/11 , B60W10/115 , B60W30/18 , B60W30/1819 , B60W2510/0652 , B60W2510/1015 , B60W2510/104 , B60W2710/0605 , B60W2710/0616 , B60W2710/0622 , B60W2710/0666 , F16H59/36 , F16H59/44 , F16H61/0437 , F16H63/502 , F16H2059/363 , F16H2059/366 , F16H2059/385 , F16H2061/0496 , Y02T10/76 , Y10T477/6403 , Y10T477/693636
摘要： An automatic transmission ratio shift control system and method for a powertrain having an engine and multiple-ratio gearing controlled by friction elements actuated by hydraulic pressure, an electronic controller for establishing torque transitions among the friction elements as the gear ratio changes, the engine speed being controlled by an electronic throttle control. The strategy employs an electronic throttle and closed loop engine speed control and uses fuel and air as an energy source to increase engine speed during a power-off downshift. The engine speed is boosted to a level close to the synchronous speed in conjunction with release of the off-going friction element. The on-coming friction element is then applied as the engine speed approaches a desired speed. The engine speed increase is timed to lead an increase in torque converter speed.
摘要翻译：一种用于具有由液压致动的摩擦元件控制的发动机和多级传动装置的动力系的自动变速比变速控制系统和方法，用于在齿轮比变化时在摩擦元件之间建立转矩转换的电子控制器，发动机转速为由电子节气门控制控制。该策略采用电子节气门和闭环发动机转速控制，并且在断电降档期间使用燃料和空气作为能源来提高发动机转速。发动机转速提高到接近同步速度的水平，同时释放离去的摩擦元件。然后随着发动机速度接近期望的速度而应用即将到来的摩擦元件。发动机转速提高的时间是引起变矩器转速的增加。

6. 发明申请

US20060020908A1 Unified Approach to Building Web Applications that can be deployed as stand-alone and in Web Portals 审中-公开
标题翻译：统一的构建Web应用程序的方法，可以作为独立的Web Portal部署
公开(公告)号：US20060020908A1
公开(公告)日：2006-01-26
申请号：US10710576
申请日：2004-07-21
申请人： Pramod Jain , Yayati Kasralikar , Satya Komatineni , Hoai Nguyen
发明人： Pramod Jain , Yayati Kasralikar , Satya Komatineni , Hoai Nguyen
IPC分类号： G06F9/44
CPC分类号： G06F9/44505 , G06F8/60 , G06F16/958
摘要： Disclosed is a method, system and program for creating web applications that can be deployed as standalone or in a web portal with no changes to the server side pages and no changes to backend business components. This method consists of two aspects: method for developing server side pages that enables presentation logic and associated data retrieval logic to be written only once, and a broker class that enables the backend business components to be written only once. Another aspect of the present invention is a single action class for portlet applications that connects the portlet container to backend business components that use data sources, applications and web services.
摘要翻译：公开了一种用于创建Web应用程序的方法，系统和程序，该应用程序可以单独部署或在Web门户中部署，而不会更改服务器端页面，也不会对后端业务组件进行任何更改。该方法包括两个方面：用于开发服务器端页面的方法，其使表示逻辑和相关联的数据检索逻辑仅被写入一次，以及允许后端业务组件仅写入一次的代理类。本发明的另一方面是将portlet应用程序连接到使用数据源，应用程序和Web服务的后端业务组件的portlet应用程序的单个动作类。

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