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1. 发明授权

US08343911B2 Methods of inhibiting and treating bacterial biofilms by metal chelators 有权
标题翻译：金属螯合剂抑制和治疗细菌生物膜的方法
公开(公告)号：US08343911B2
公开(公告)日：2013-01-01
申请号：US12288449
申请日：2008-10-20
申请人： Pradeep K. Singh , Michael J. Welsh , E. Peter Greenberg
发明人： Pradeep K. Singh , Michael J. Welsh , E. Peter Greenberg
IPC分类号： A61K38/00 , A61K38/40
CPC分类号： A61K38/40 , A01N61/00 , A01N63/02 , A23B4/20 , A23B4/22 , A23L3/34635 , A23L3/3526 , A23L3/3571 , A61L2/0082 , A61L2/16 , A61L2/186 , A61L2202/24
摘要： The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm.
摘要翻译：本发明提供了用于预防和治疗细菌感染的方法和组合物。这些方法是基于发现生物可利用的铁的消耗刺激细菌中的表面运动，从而抑制细菌群体发展成生物膜的能力。

2. 发明授权

US07446089B2 Methods of inhibiting and treating bacterial biofilms by metal chelators 失效
标题翻译：金属螯合剂抑制和治疗细菌生物膜的方法
公开(公告)号：US07446089B2
公开(公告)日：2008-11-04
申请号：US10958923
申请日：2004-10-04
申请人： Pradeep K. Singh , Michael J. Welsh , Everett P. Greenberg
发明人： Pradeep K. Singh , Michael J. Welsh , Everett P. Greenberg
IPC分类号： A61K38/00 , A61K39/40
CPC分类号： A61K38/40 , A01N61/00 , A01N63/02 , A23B4/20 , A23B4/22 , A23L3/34635 , A23L3/3526 , A23L3/3571 , A61L2/0082 , A61L2/16 , A61L2/186 , A61L2202/24
摘要： The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm.
摘要翻译：本发明提供了用于预防和治疗细菌感染的方法和组合物。这些方法是基于发现生物可利用的铁的消耗刺激细菌中的表面运动，从而抑制细菌群体发展成生物膜的能力。

3. 发明申请

US20120142583A1 Methods of inhibiting and treating bacterial biofilms by metal chelators 有权
标题翻译：金属螯合剂抑制和治疗细菌生物膜的方法
公开(公告)号：US20120142583A1
公开(公告)日：2012-06-07
申请号：US12288449
申请日：2008-10-20
申请人： Pradeep K. Singh , Michael J. Welsh , Everett P. Greenberg
发明人： Pradeep K. Singh , Michael J. Welsh , Everett P. Greenberg
IPC分类号： A61K38/40 , A61P31/04 , A61K38/38
CPC分类号： A61K38/40 , A01N61/00 , A01N63/02 , A23B4/20 , A23B4/22 , A23L3/34635 , A23L3/3526 , A23L3/3571 , A61L2/0082 , A61L2/16 , A61L2/186 , A61L2202/24
摘要： The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm.
摘要翻译：本发明提供了用于预防和治疗细菌感染的方法和组合物。这些方法是基于发现生物可利用的铁的消耗刺激细菌中的表面运动，从而抑制细菌群体发展成生物膜的能力。

4. 发明申请

US20120209867A1 VERIFYING CONSISTENCY AMONG DEVICE CONFIGURATIONS BASED ON COMPARING CONFIGURATION FILES 审中-公开
标题翻译：基于比较配置文件的设备配置中的验证一致性
公开(公告)号：US20120209867A1
公开(公告)日：2012-08-16
申请号：US13454050
申请日：2012-04-23
申请人： Ankit Agarwal , Mahesh Lavannis , Pradeep K. Singh
发明人： Ankit Agarwal , Mahesh Lavannis , Pradeep K. Singh
IPC分类号： G06F17/30
CPC分类号： G06F16/10
摘要： A scalable comparison structure and methodology is provided that is suitable for comparing the configuration of devices in an efficient manner. In the configuration files, section delimiters are defined to identify the sections of the files within which the select data content is located, and differences in the sections are identified based on the select data content within the section. Thereafter, comparisons and reports are based on these unique content sections. Groups of devices are optionally defined, and different sets of select data content can be compared based on these groups. The result of the comparison may be presented in multiple hierarchical forms, including an identification of which configuration files are different from each other, and an identification of the differences among the unique content in these configuration files.
摘要翻译：提供了一种可扩展的比较结构和方法，适用于以有效的方式比较设备的配置。在配置文件中，定义了分段定界符，以标识选择数据内容所在的文件部分，并根据部分中的选择数据内容识别部分中的差异。此后，比较和报告是基于这些独特的内容部分。可选择地定义设备组，并且可以基于这些组来比较不同组的选择数据内容。比较的结果可以以多种分层形式呈现，包括哪些配置文件彼此不同的标识以及这些配置文件中的唯一内容之间的差异的标识。

5. 发明申请

US20070282981A1 AGGREGATING POLICY CRITERIA PARAMETERS INTO RANGES FOR EFFICIENT NETWORK ANALYSIS 有权
标题翻译：将政策标准参数纳入有效网络分析范围
公开(公告)号：US20070282981A1
公开(公告)日：2007-12-06
申请号：US11735474
申请日：2007-04-15
申请人： Alain J. Cohen , Pradeep K. Singh , Ankit Agarwal , Venuprakash Barathan
发明人： Alain J. Cohen , Pradeep K. Singh , Ankit Agarwal , Venuprakash Barathan
IPC分类号： G06F15/16
CPC分类号： H04L47/10 , H04L41/0853 , H04L41/0893 , H04L41/5003 , H04L43/50 , H04L47/127 , H04L47/20 , H04L47/2441
摘要： A network configuration is processed to identify each policy and the criteria associated with each policy. The criteria of the policies are processed to identify a non-overlapping set of ranges of the criteria parameter, each range being associated with a particular policy or set of policies. In a preferred embodiment, the criteria include the protocol, the source and destination IP addresses, and the source and destination ports, and a default range is defined for each criteria parameter.
摘要翻译：处理网络配置以识别每个策略和与每个策略相关联的标准。处理策略的标准以识别标准参数的不重叠的范围集合，每个范围与特定策略或策略集相关联。在优选实施例中，标准包括协议，源和目的地IP地址以及源端口和目的端口，并且为每个标准参数定义默认范围。

6. 发明授权

US09539367B2 Gallium inhibits biofilm formation 有权
标题翻译：镓抑制生物膜形成
公开(公告)号：US09539367B2
公开(公告)日：2017-01-10
申请号：US11004049
申请日：2004-12-03
申请人： Bradley E. Britigan , Pradeep K. Singh
发明人： Bradley E. Britigan , Pradeep K. Singh
IPC分类号： A61L27/54 , A61K31/28 , A61K33/24 , A01N59/16 , A61L27/30 , A61L29/10 , A61L29/16
CPC分类号： A61L27/54 , A01N59/16 , A61K31/28 , A61K33/24 , A61L27/306 , A61L29/106 , A61L29/16 , A61L2300/102 , A61L2300/404
摘要： The present invention provides a gallium-containing composition for coating/impregnating a device or device surface to prevent biofilm growth formation. The present invention also provides a method of preventing or inhibiting biofilm growth formation. The present invention also provides methods for killing established biofilms.
摘要翻译：本发明提供了一种用于涂覆/浸渍装置或装置表面以防止生物膜生长形成的含镓组合物。本发明还提供了预防或抑制生物膜生长形成的方法。本发明还提供了杀死已建立的生物膜的方法。

7. 发明授权

US08898734B2 Analyzing security compliance within a network 有权
标题翻译：分析网络中的安全合规性
公开(公告)号：US08898734B2
公开(公告)日：2014-11-25
申请号：US11505171
申请日：2006-08-16
申请人： Pradeep K. Singh , Ankit Agarwal , Alain J. Cohen , Venuprakash Barathan , Vinod Jeyachandran
发明人： Pradeep K. Singh , Ankit Agarwal , Alain J. Cohen , Venuprakash Barathan , Vinod Jeyachandran
IPC分类号： H04L29/06 , H04L12/26 , H04L12/24
CPC分类号： H04L41/28 , H04L12/2697 , H04L41/0866 , H04L41/0893 , H04L41/145 , H04L41/22 , H04L43/50 , H04L63/1433 , H04L63/20
摘要： A security policy database identifies the intended security policies within a network, a traffic generator provides test traffic that is configured to test each defined security policy, and a simulator simulates the propagation of this traffic on a model of the network. The model of the network includes the configuration data associated with each device, and thus, if devices are properly configured to enforce the intended security policies, the success/failure of the simulated test traffic will conform to the intended permit/deny policy of each connection. Differences between the simulated message propagation and the intended security policies are reported to the user, and diagnostic tools are provided to facilitate identification of the device configuration data that accounts for the observed difference. Additionally, if a network's current security policy is unknown, test traffic is generated to reveal the actual policy in effect, to construct a baseline intended security policy.
摘要翻译：安全策略数据库标识网络中的预期安全策略，流量生成器提供被配置为测试每个定义的安全策略的测试流量，并且模拟器模拟该流量在网络模型上的传播。网络模型包括与每个设备相关联的配置数据，因此，如果设备被正确配置以实施预期的安全策略，则模拟测试流量的成功/失败将符合每个连接的预期允许/拒绝策略。向用户报告模拟消息传播与预期安全策略之间的差异，并提供诊断工具以便于识别出所观察到的差异的设备配置数据。此外，如果网络当前的安全策略未知，则生成测试流量以显示实际的实际策略，以构建基准预期的安全策略。

8. 发明授权

US08130759B2 Routing validation 有权
标题翻译：路由验证
公开(公告)号：US08130759B2
公开(公告)日：2012-03-06
申请号：US11494441
申请日：2006-07-27
申请人： Alain J. Cohen , Pradeep K. Singh , Vinod Jeyachandran , Nitin Gupta
发明人： Alain J. Cohen , Pradeep K. Singh , Vinod Jeyachandran , Nitin Gupta
IPC分类号： H04L12/28
CPC分类号： H04L45/28 , H04L41/0631 , H04L41/08 , H04L41/0866 , H04L41/14 , H04L41/145 , H04L45/02 , H04L45/124
摘要： A simulator simulates routing system protocols to build routing tables corresponding to a modeled network, and a comparator compares the routing tables in the actual network to these simulator-created routing tables. Because the modeled system represents a fault-free version of the actual system, and assuming that the modeled routing system protocols are representative of the algorithms used in the actual routers, these simulator-produced routing tables will represent the ‘ideal’ routing tables that should be present in the routers of the actual network. By querying each router in the actual network for its routing table and comparing each routing table to the corresponding simulator-produced routing table, any differences from the ‘ideal’ can be identified.
摘要翻译：模拟器模拟路由系统协议以构建与建模网络相对应的路由表，并且比较器将实际网络中的路由表与这些模拟器创建的路由表进行比较。因为建模的系统代表了实际系统的无故障版本，并且假设建模的路由系统协议代表实际路由器中使用的算法，则这些模拟器生成的路由表将表示应该应用的“理想”路由表存在于实际网络的路由器中。通过查询实际网络中的每个路由器的路由表，并将每个路由表与相应的模拟器生成的路由表进行比较，可以识别与“ideal”的任何差异。

9. 发明授权

US07843840B2 Traffic independent survivability analysis 有权
标题翻译：交通独立生存能力分析
公开(公告)号：US07843840B2
公开(公告)日：2010-11-30
申请号：US12195393
申请日：2008-08-20
申请人： Vanko Vankov , Arun Pasupathy , Vinod Jeyachandran , Pradeep K. Singh , Alain J. Cohen , Yonghuan Cao
发明人： Vanko Vankov , Arun Pasupathy , Vinod Jeyachandran , Pradeep K. Singh , Alain J. Cohen , Yonghuan Cao
IPC分类号： G06F11/30
CPC分类号： H04L43/50
摘要： First-order effects of hypothesized fault conditions are determined by propagating discrete test packets between select nodes and noting the change of path, if any, taken by the test packet under each condition relative to the fault-free path. Tools are provided to create classes of node pairs of interest, and test packets are created only for select classes. The network is analyzed to identify fault conditions that are likely to impact system performance, and only these fault conditions are simulated. By providing a methodology for selecting classes of node pairs to test, and prioritizing the faults to simulate, a first-order survivability analysis of large networks can be performed efficiently and effectively. The efficiency of this technique is also enhanced by providing test packets that are representative of a wide range of possible source-destination combinations, and by evaluating only the source-destination combinations that may be directly affected by each fault condition.
摘要翻译：通过在选择节点之间传播离散的测试包，并注意到每个条件下相对于无故障路径，由测试包采取的路径（如果有的话）的变化来确定假设故障条件的一阶影响。提供工具来创建感兴趣的节点对类，并且只为选择类创建测试包。分析网络以识别可能影响系统性能的故障状况，并且仅模拟这些故障条件。通过提供一种选择要测试的节点对的类别并对故障进行优先级模拟的方法，可以有效和高效地执行大型网络的一阶生存性分析。通过提供表示广泛范围的可能的源 - 目的地组合的测试分组以及通过仅评估可能由每个故障状况直接影响的源 - 目的地组合来增强该技术的效率。

10. 发明授权

US07693699B2 Incremental update of virtual devices in a modeled network 有权
标题翻译：模拟网络中虚拟设备的增量更新
公开(公告)号：US07693699B2
公开(公告)日：2010-04-06
申请号：US11503553
申请日：2006-08-11
申请人： Pradeep K. Singh , Raymond Onley , Nishant Gupta , Alain J. Cohen
发明人： Pradeep K. Singh , Raymond Onley , Nishant Gupta , Alain J. Cohen
IPC分类号： G06F17/50
CPC分类号： G06F17/30286
摘要： In a network simulation system, a compiler is provided to support incremental updates to the configuration data associated with the modeled network. Each incremental change is identified and logged, to facilitate configuration management and select roll-backs to prior configurations. Because each update is processed and managed individually, and integrated automatically into the overall system configuration, the overhead associated with keeping a configuration database up-to-date is substantially reduced, thereby increasing the likelihood that all configuration changes will be reflected in the modeled network. In a preferred embodiment, the same data is used to incrementally update the configuration model and to execute the change in the actual system, thereby further reducing the overhead and assuring a correspondence between the modeled network and the actual network.
摘要翻译：在网络仿真系统中，提供编译器来支持与建模网络相关联的配置数据的增量更新。识别和记录每个增量更改，以便于配置管理，并选择回滚到以前的配置。由于每个更新被单独处理和管理，并且自动整合到整个系统配置中，所以与保持配置数据库的最新状态相关联的开销大大减少，从而增加了所有配置更改将反映在建模网络中的可能性。在优选实施例中，相同的数据用于递增地更新配置模型并执行实际系统中的改变，从而进一步降低开销并确保建模网络与实际网络之间的对应关系。

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