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1. 发明申请

US20050147668A1 Quick release pharmaceutical compositions of drug substances 有权
标题翻译：药物快速释放药物组合物
公开(公告)号：US20050147668A1
公开(公告)日：2005-07-07
申请号：US10758233
申请日：2004-01-13
申请人： Poul Bertelsen , Niels Hansen , Hermann Ruckendorfer , Shigeru Itai
发明人： Poul Bertelsen , Niels Hansen , Hermann Ruckendorfer , Shigeru Itai
IPC分类号： A61K9/16 , A61K9/20
CPC分类号： A61K9/1617 , A61K9/1611 , A61K9/1652
摘要： The present invention relates to an oral modified release pharmaceutical composition for the administration of a therapeutically and/or prophylactically effective amount of an active substance (a drug substance) to obtain a relatively fast or quick onset of the therapeutic and/or prophylactic effect The drug substances contained in a modified release pharmaceutical composition according to the invention are suitably a drug substance which has a very low solubitity under acidic conditions, i.e. under conditions similar to those present in the stomach and/or drug substances which have a pKa value below about 5.5 such as in a range of from about 4 to about 5. The composition is based on a powder comprising a therapeutically and/or prophylactically active substance and has such a particle size that when the powder is subjected to a sieve analysis, then at least about 90% w/w of the particles passes through sieves 180 μm and the powder is contacted with an aqueous medium to form a particulate composition, which has such a particle size that when the particulate composition is subjected to a sieve analysis, then at least about 50% w/w of the particles passes through sieve 180 μm. Furthermore, the composition, when tested in accordance with the dissolution method (1) defined herein employing 0.07 N hydrochloric acid as dissolution medium, releases at least about 50% w/w of the active substance within the first 20 min of the test
摘要翻译：本发明涉及一种用于给予治疗和/或预防有效量的活性物质（药物）以获得相对快速或快速起效的治疗和/或预防效果的口服释放药物组合物。该药物根据本发明的改性释放药物组合物中所含的物质适宜地是在酸性条件下具有非常低的溶解性的药物物质，即在与胃和/或药物物质中存在pK < 低于约5.5，例如在约4至约5的范围内。该组合物基于包含治疗和/或预防活性物质的粉末，并且具有这样的粒径，即当粉末经受进行筛分分析，然后至少约90％w / w的颗粒通过筛子180μm，粉末与水性介质接触以形成颗粒组合物具有这样的颗粒尺寸，当颗粒组合物进行筛分分析时，至少约50％w / w的颗粒通过筛子180μm。此外，当根据本文定义的溶解方法（1）使用0.07N盐酸作为溶解介质测试时，组合物在试验的最初20分钟内释放至少约50％w / w的活性物质

2. 发明授权

US06713089B1 Quick release pharmaceutical compositions of drug substances 有权
标题翻译：药物快速释放药物组合物
公开(公告)号：US06713089B1
公开(公告)日：2004-03-30
申请号：US09786864
申请日：2001-07-10
申请人： Poul Bertelsen , Niels Gjørløv Hansen , Hermann Ruckendorfer , Shigeru Itai
发明人： Poul Bertelsen , Niels Gjørløv Hansen , Hermann Ruckendorfer , Shigeru Itai
IPC分类号： A61K914
CPC分类号： A61K9/2009 , A61K9/1611
摘要： The present invention relates to an oral modified release pharmaceutical composition for the administration of a therapeutically and/or prophylactically effective amount of an active substance (a drug substance), to obtain a relatively fast or quick onset of the therapeutic and/or prophylactic effect. The drug substances contained in a modified release pharmaceutical composition according to the invention are suitably a drug substance which has a pKa value below about 5, such as in a range of from about 4 to about 5. The composition is based on a powder comprising a therapeutically and/or prophylactically active substance and has such a particle size that: when the powder is subjected to a sieve analysis, then at least about 90% w/w of the particles pass through a 180 micron sieve, and when the powder is contacted with an aqueous medium to form a particulate composition, which as such a particle size that when the particulate composition is subjected to a sieve analysis, then at least about 50% w/w of the particles passes through a 180 micron sieve. Further more, the composition, when tested in accordance with the dissolution method (I) defines herein, employing 0.07 HCl as dissolution medium, release at least about 50% w/w of the active substance within the first 20 minutes of the test.
摘要翻译：本发明涉及用于给予治疗和/或预防有效量的活性物质（药物物质）的口服释放药物组合物，以获得治疗和/或预防效果的相对快速或快速的发作。包含在根据本发明的改性释放药物组合物中的药物物质合适地是pKa值低于约5，例如在约4至约5范围内的药物。该组合物基于包含治疗和/或预防活性物质，并且具有这样的粒度：当粉末进行筛分分析时，然后至少约90％w / w的颗粒通过180微米筛，并且当粉末接触时与水性介质形成颗粒组合物，其颗粒大小使得当颗粒组合物进行筛分分析时，至少约50％w / w的颗粒通过180微米筛。此外，当根据本文的溶解方法（I）测试时，组合物使用0.07HCl作为溶解介质，在测试的前20分钟内释放至少约50％w / w的活性物质。

3. 发明授权

US09814686B2 Rolled collagen carrier 有权
公开(公告)号：US09814686B2
公开(公告)日：2017-11-14
申请号：US14117882
申请日：2012-05-24
申请人： Wolfgang Schoenhofer , Pernille Dybendal Pedersen , Poul Bertelsen , Henrik Braender , Ingrid Blanka , Henrik Neuschaefer Larsen
发明人： Wolfgang Schoenhofer , Pernille Dybendal Pedersen , Poul Bertelsen , Henrik Braender , Ingrid Blanka , Henrik Neuschaefer Larsen
IPC分类号： A61B17/08 , A61D1/00 , A61K9/70 , A61F13/02 , A61K38/36 , A61K38/48 , A61K47/42 , A61L24/04 , A61L31/04
CPC分类号： A61K9/7007 , A61F13/0276 , A61K38/363 , A61K38/4833 , A61K47/42 , A61L24/043 , A61L31/041
摘要： The invention relates to a process for the preparation of a rolled compressed collagen carrier and a process for un-rolling said rolled compressed collagen carrier. Said rolled compressed collagen carrier is ready for use in minimally invasive surgery. The invention also relates to a rolled compressed collagen carrier for use in the prevention or treatment of injury associated with performing minimally invasive surgery.

4. 外观设计

USD578328S1 Dispenser 有权
标题翻译：分配器
公开(公告)号：USD578328S1
公开(公告)日：2008-10-14
申请号：US29289592
申请日：2007-07-25
申请人： Karsten Plum , Poul Bertelsen , Bo Winther Barkholt , Flemming Buch
设计人： Karsten Plum , Poul Bertelsen , Bo Winther Barkholt , Flemming Buch

5. 发明授权

US09351903B2 Eye wash device 有权
标题翻译：洗眼装置
公开(公告)号：US09351903B2
公开(公告)日：2016-05-31
申请号：US13321064
申请日：2010-05-19
申请人： Poul Bertelsen
发明人： Poul Bertelsen
IPC分类号： A61H33/04 , A61H35/02 , A61M35/00 , B05B15/04 , A61F9/00
CPC分类号： A61H35/02 , A61F9/0008 , A61F9/0026 , A61M2210/0612 , B05B12/36
摘要： An eye rinsing device for rinsing at least one eye is embodied as an attachable attachment, which can be connected to a container, wherein the attachment can be placed onto the eye of a person. The eye rinsing device is provided with at least one rinsing opening, which is directed towards the eye by means of which the washing of an eye is carried out in an improved manner. The attachment encompasses a device having wing-like spreading elements which pull the upper eyelid and the lower eyelid apart so as to support the opening of the eye during the rinsing process.
摘要翻译：用于冲洗至少一只眼睛的眼睛清洗装置被实施为可附接的附件，其可以连接到容器，其中附件可以放置在人的眼睛上。眼睛清洗装置设置有至少一个冲洗孔，该清洗开口指向眼睛，通过该清洗口以改进的方式进行眼睛的洗涤。附件包括具有翼状扩散元件的装置，其将上眼睑和下眼睑分开，以在漂洗过程中支撑眼睛的开口。

6. 发明授权

US06599529B1 Modified release multiple-units compositions of non-steroid anti-inflammatory drug substances (NSAIDs) 有权
标题翻译：非类固醇抗炎药物（NSAIDs）的改良释放多单元组合物
公开(公告)号：US06599529B1
公开(公告)日：2003-07-29
申请号：US09508594
申请日：2000-07-17
申请人： Annette Skinhøj , Poul Bertelsen
发明人： Annette Skinhøj , Poul Bertelsen
IPC分类号： A61K954
CPC分类号： A61K9/2081 , A61K9/5084 , A61K31/542 , A61K45/06
摘要： An oral pharmaceutical modified release multiple-units composition for the administration of a therapeutically and/or prophylactically effective amount of a non-steroid anti-inflammatory drug substance to obtain both a relatively fast onset of the therapeutic effect and the maintenance of a therapeutically active plasma concentration for a relatively long period of time is disclosed.
摘要翻译：一种用于施用治疗和/或预防有效量的非类固醇抗炎药物的口服药物改良释放多单元组合物，以获得治疗效果相对较快发作和维持治疗活性血浆浓度相对较长的时间被公开。

7. 发明授权

US5674529A Alkalinizing potassium salt controlled release preparations 失效
标题翻译：碱性钾盐控释制剂
公开(公告)号：US5674529A
公开(公告)日：1997-10-07
申请号：US472693
申请日：1995-06-06
申请人： Herman Marder , Lawrence Kirschner , John J. Steinke , Andrew D. Kurtz , Poul Bertelsen , Nils Gjerlov Hansen , Thyge Borup Hjorth
发明人： Herman Marder , Lawrence Kirschner , John J. Steinke , Andrew D. Kurtz , Poul Bertelsen , Nils Gjerlov Hansen , Thyge Borup Hjorth
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , A61K9/50 , A61K33/10
CPC分类号： A61K9/2081 , A61K33/10 , A61K9/5015 , A61K9/5047 , A61K9/5073
摘要： Multiparticulate controlled release preparations incorporating an alkalinizing potassium salt, preferably potassium bicarbonate, as an active ingredient, which are suitable for forming pharmaceutical dosage forms for oral administration. Such dosage forms are useful for potassium supplementation and for the treatment of degenerative bone or cardiovascular diseases, e.g., osteoporosis and hypertension.
摘要翻译：包含碱性钾盐，优选碳酸氢钾作为活性成分的多微粒控释制剂，其适于形成用于口服给药的药物剂型。这样的剂型可用于钾补充和治疗退行性骨或心血管疾病，例如骨质疏松症和高血压。

8. 发明授权

US09254229B2 Packaging unit and a dispenser for disposable articles 有权
公开(公告)号：US09254229B2
公开(公告)日：2016-02-09
申请号：US12304079
申请日：2007-02-28
申请人： Bo Winther Barkholt , Poul Bertelsen , Flemming Buch , Karsten Plum
发明人： Bo Winther Barkholt , Poul Bertelsen , Flemming Buch , Karsten Plum
IPC分类号： A61B19/00 , A61F15/00
CPC分类号： A61F15/002
摘要： A packaging unit for holding a plurality of articles, preferably disposable articles, such, as plasters, tissues, gauze, etc. The packaging unit comprises a holding member (2) comprising a first part (5) with at most fifteen spaced apart flaps (6), and a second part (7), the first and second parts being arranged oppositely each other. A plurality of articles are arranged and retained between the first and second parts in such a manner that an individual article can be removed from the packaging unit. The packaging unit is insertable in a dispenser (13) and may serve as a refill package. Furthermore, a dispenser for delivering disposable articles, the dispenser comprising a retaining part (14) for retaining a packaging unit and an opening (15) allowing a packaging unit to be inserted and allowing an individual article to be delivered. The opening is arranged in such a manner that an individual article may be delivered from the dispenser by pulling it in a substantially downwards direction. The dispenser improves the hygienic standard as compared to prior art dispensers because the position of the opening prevents dirt, blood, or various items from entering the dispenser due to the force of gravity, thereby contaminating the articles positioned in the dispenser.

9. 发明申请

US20120071840A1 EYE WASH DEVICE 有权
标题翻译：眼部洗发器
公开(公告)号：US20120071840A1
公开(公告)日：2012-03-22
申请号：US13321064
申请日：2010-05-19
申请人： Poul Bertelsen
发明人： Poul Bertelsen
IPC分类号： A61F9/00
CPC分类号： A61H35/02 , A61F9/0008 , A61F9/0026 , A61M2210/0612 , B05B12/36
摘要： To create an eye rinsing device (100) for rinsing at least one eye (12), which is embodied as an attachable attachment (11), which can be connected to a container (10), wherein the attachment (11) can be placed onto the eye (12) of a person, and is provided with at least one rinsing opening (15), which is directed towards the eye (12), by means of which the washing of an eye is carried out in an improved manner, it is proposed for the attachment (11) to encompass a device comprising wing-like spreading elements (16, 17), which pull the upper eyelid (13) and the lower eyelid (14) apart, so as to support the opening of the eye (12) during the rinsing process.
摘要翻译：为了创建用于冲洗至少一个眼睛（12）的眼睛漂洗装置（100），其被实施为可连接到容器（10）的可附接附件（11），其中所述附件（11）可以被放置在人的眼睛（12）上，并且设置有至少一个朝向眼睛（12）的冲洗开口（15），通过该清洁开口（15）以改进的方式进行眼睛的洗涤，建议附件（11）包括包括翼状扩散元件（16,17）的装置，其将上眼睑（13）和下眼睑（14）分开拉开，以支撑开口眼睛（12）在漂洗过程中。

10. 发明申请

US20090200192A1 PACKAGING UNIT AND A DISPENSER FOR DISPOSABLE ARTICLES 有权
标题翻译：包装单位和散装物品的分配者
公开(公告)号：US20090200192A1
公开(公告)日：2009-08-13
申请号：US12304079
申请日：2007-02-28
申请人： Bo Winther Barkholt , Poul Bertelsen , Flemming Buch , Karsten Plum
发明人： Bo Winther Barkholt , Poul Bertelsen , Flemming Buch , Karsten Plum
IPC分类号： A61B19/00
CPC分类号： A61F15/002
摘要： A packaging unit for holding a plurality of articles, preferably disposable articles, such, as plasters, tissues, gauze, etc. The packaging unit comprises a holding member (2) comprising a first part (5) with at most fifteen spaced apart flaps (6), and a second part (7), the first and second parts being arranged oppositely each other. A plurality of articles are arranged and retained between the first and second parts in such a manner that an individual article can be removed from the packaging unit. The packaging unit is insertable in a dispenser (13) and may serve as a refill package. Furthermore, a dispenser for delivering disposable articles, the dispenser comprising a retaining part (14) for retaining a packaging unit and an opening (15) allowing a packaging unit to be inserted and allowing an individual article to be delivered. The opening is arranged in such a manner that an individual article may be delivered from the dispenser by pulling it in a substantially downwards direction. The dispenser improves the hygienic standard as compared to prior art dispensers because the position of the opening prevents dirt, blood, or various items from entering the dispenser due to the force of gravity, thereby contaminating the articles positioned in the dispenser.
摘要翻译：一种包装单元，用于保持多个物品，优选一次性物品，例如膏药，纸巾，纱布等。包装单元包括保持构件（2），该保持构件包括具有至多十五个间隔开的翼片的第一部分（5） 6）和第二部分（7），第一和第二部分彼此相对地布置。多个物品被布置并保持在第一和第二部分之间，使得单独的物品可以从包装单元移除。包装单元可插入分配器（13）中并且可以用作再填充包装。此外，用于输送一次性物品的分配器，所述分配器包括用于保持包装单元的保持部分（14）和允许包装单元插入并允许单个物品被输送的开口（15）。开口以这样的方式布置，使得单个物品可以通过沿着基本上向下的方向拉动而从分配器传送。与现有技术的分配器相比，分配器改进了卫生标准，因为开口的位置由于重力而防止污垢，血液或各种物品进入分配器，从而污染位于分配器中的物品。

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