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    • 5. 发明授权
    • Compounds useful in imaging and therapy
    • 用于成像和治疗的化合物
    • US08969546B2
    • 2015-03-03
    • US13805862
    • 2011-06-27
    • Piyush KumarLeonard WiebeAlexander McEwan
    • Piyush KumarLeonard WiebeAlexander McEwan
    • C07H19/052A61K51/00A61M36/14A61K51/04C08B37/00
    • C07H19/052A61K51/0453A61K51/0491C08B37/0057
    • Provided in the following specification are precursors or synthons that are useful for the synthesis of various arabinose based chemical and radiochemical derivatives of nitroimidazole-containing azomycin arabinosides, such as radioiodinated 1-#-D-(5-deoxy-5-[I*]-iodoarabinofuranosyl)-2-nitroimidazole (*IAZA), and radiofluorinated 1-#-D-(5-deoxy-5-[18F]-iodoarabinofuranosyl)-2-nitroimidazole (18FAZA). Such compounds are useful in imaging, therapy, or radiotherapy. Further, various syntheses of said precursors/synthons and the incorporation of said precursors/synthons into kits is provided. The precursors/synthons provided herein allow for an improved and facile manufacturing process for nitroimidazole-containing azomycin arabinosides.
    • 在以下说明书中提供了可用于合成基于阿拉伯糖的不同的含有阿拉伯糖的硝基咪唑的化学和放射化学衍生物的前体或合成子,例如放射性碘化的1-β-D-(5-脱氧-5- [I *] (* IAZA)和放射性氟化的1-#-D-(5-脱氧-5- [18 F] - 碘阿布霉素呋喃糖基)-2-硝基咪唑(18FAZA)。 这些化合物可用于成像,治疗或放射治疗。 此外,提供所述前体/合成子的各种合成以及所述前体/合成子掺入试剂盒中。 本文提供的前体/合成物允许用于含有硝基咪唑的阿拉伯糖苷的改良且易于制造的方法。
    • 6. 发明申请
    • COMPOUNDS USEFUL IN IMAGING AND THERAPY
    • 化合物可用于成像和治疗
    • US20130211066A1
    • 2013-08-15
    • US13805862
    • 2011-06-27
    • Piyush KumarLeonard WiebeAlexander McEwan
    • Piyush KumarLeonard WiebeAlexander McEwan
    • C07H19/052
    • C07H19/052A61K51/0453A61K51/0491C08B37/0057
    • Provided in the following specification are precursors or synthons that are useful for the synthesis of various arabinose based chemical and radiochemical derivatives of nitroimidazole-containing azomycin arabinosides, such as radioiodinated 1-#-D-(5-deoxy-5-[I*]-iodoarabinofuranosyl)-2-nitroimidazole (*IAZA), and radiofluorinated 1-#-D-(5-deoxy-5-[18F]-iodoarabinofuranosyl)-2-nitroimidazole (18FAZA). Such compounds are useful in imaging, therapy, or radiotherapy. Further, various syntheses of said precursors/synthons and the incorporation of said precursors/synthons into kits is provided. The precursors/synthons provided herein allow for an improved and facile manufacturing process for nitroimidazole-containing azomycin arabinosides.
    • 在以下说明书中提供了可用于合成基于阿拉伯糖的不同的含有阿拉伯糖的硝基咪唑的化学和放射化学衍生物的前体或合成子,例如放射性碘化的1-β-D-(5-脱氧-5- [I *] (* IAZA)和放射性氟化的1-#-D-(5-脱氧-5- [18 F] - 碘阿布霉素呋喃糖基)-2-硝基咪唑(18FAZA)。 这些化合物可用于成像,治疗或放射治疗。 此外,提供所述前体/合成子的各种合成以及所述前体/合成子掺入试剂盒中。 本文提供的前体/合成物允许用于含有硝基咪唑的阿拉伯糖苷的改良且易于制造的方法。