会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 5. 发明授权
    • Methioninase gene therapy for tumor treatment
    • 甲硫氨酸酶基因治疗肿瘤治疗
    • US06524571B1
    • 2003-02-25
    • US09195055
    • 1998-11-18
    • Mingxu XuYuying Tan
    • Mingxu XuYuying Tan
    • A01N4304
    • G02B5/32A01K67/0271A61K38/51A61K48/00
    • A depletion method to inhibit tumor growth includes introducing a viral expression system capable of expressing methioninase or a fusion protein containing methioninase into a tumor contained in a vertebrate subject or cells thereof. The fusion protein may contain a fluorescent protein to permit monitoring of the completeness of the depletion method. The fusion protein can be used in vivo as well as in vitro screening protocols which employ the viral expression system. The expression system includes control sequences and means to integrate the nucleotide sequence into the genome of a host cell for expression. The method may also include treating the cells with isolated methioninase and/or with a therapeutic cell. The depletion method can be with other known therapies, such as maintaining the animal having the tumor on a methionine depleted diet.
    • 抑制肿瘤生长的消耗方法包括将能够表达蛋氨酸酶的病毒表达系统或含有蛋氨酸酶的融合蛋白引入到脊椎动物对象或其细胞中所含的肿瘤中。 融合蛋白可以含有荧光蛋白以允许监测耗尽方法的完整性。 融合蛋白可以在体内以及使用病毒表达系统的体外筛选方案中使用。 表达系统包括将核苷酸序列整合到宿主细胞的基因组中用于表达的控制序列和方法。 该方法还可以包括用分离的蛋氨酸酶和/或用治疗细胞处理细胞。 耗尽方法可以与其他已知的疗法一起使用,例如将具有肿瘤的动物维持在消耗蛋氨酸的饮食上。