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1. 发明申请

US20180142024A1 ANTI-cMET ANTIBODY 审中-公开
公开(公告)号：US20180142024A1
公开(公告)日：2018-05-24
申请号：US15843636
申请日：2017-12-15
申请人： Pierre Fabre Medicament
发明人： Liliane Goetsch , Thierry Wurch , Cédric Bes
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , A61K47/68 , A61K39/00
CPC分类号： C07K16/2863 , A61K31/337 , A61K31/517 , A61K31/5377 , A61K31/555 , A61K31/7068 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6813 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , A61K2300/00
摘要： The invention relates to a novel antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor, with an improved antagonistic activity, said antibody comprising a modified hinge region.The invention also relates to a composition comprising such an antibody antagonist to c-Met and its use as a medicament for treating cancer.

2. 发明申请

US20160039935A1 NOVEL ANTI-cMET ANTIBODY 审中-公开
标题翻译：新型抗体抗体
公开(公告)号：US20160039935A1
公开(公告)日：2016-02-11
申请号：US14677032
申请日：2015-04-02
申请人： PIERRE FABRE MEDICAMENT
发明人： Liliane GOETSCH , Thierry Wurch , Cédric Bes
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/00 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , G01N33/5748 , G01N33/57492 , G01N2333/91205
摘要： The present invention relates to a novel divalent antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor, preferably both in a ligand-dependent and in a ligand-independent manner as well as the amino acid and nucleic acid sequences coding for said antibody. More preferably said antibody comprises a modified hinge region and exhibits an improved antagonistic activity. More particularly, the antibody according to the invention is capable of inhibiting the c-Met dimerization. The invention likewise comprises the use of said antibody as a medicament for the prophylactic and/or therapeutic treatment of cancers, preferably for cancer characterized by a ligand-independent activation of c-Met, or any pathology connected with the over expression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the over-expression of c-Met. The invention finally comprises products and/or compositions comprising such an antibody in combination with other antibodies and/or chemical compounds directed against other growth factors involved in tumor progression or metastasis and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.
摘要翻译：本发明涉及能够特异性结合人c-Met受体和/或能够特异性抑制所述受体的酪氨酸激酶活性的新型二价抗体，优选以配体依赖性和不依赖于配体的方式与以及编码所述抗体的氨基酸和核酸序列。更优选地，所述抗体包含修饰的铰链区并表现出改善的拮抗活性。更具体地，根据本发明的抗体能够抑制c-Met二聚化。本发明同样包括使用所述抗体作为预防和/或治疗癌症的药物，优选用特征在于与c-Met配体无关激活的癌症或与所述受体的过度表达相关的任何病理学以及用于诊断与c-Met过度表达相关的疾病的过程或试剂盒。本发明最终包含包含这种抗体与其它针对参与肿瘤进展或转移的其它生长因子的其它抗体和/或化合物组合的产品和/或组合物和/或与毒素偶联的化合物和/或抗癌剂或试剂及其用于预防和/或治疗某些癌症的用途。

3. 发明申请

US20170218071A1 ANTI-cMET ANTIBODY 审中-公开
公开(公告)号：US20170218071A1
公开(公告)日：2017-08-03
申请号：US15258232
申请日：2016-09-07
申请人： Pierre Fabre Medicament
发明人： Liliane Goetsch , Thierry Wurch , Cédric Bes
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395
CPC分类号： C07K16/2863 , A61K31/337 , A61K31/517 , A61K31/5377 , A61K31/555 , A61K31/7068 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6813 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , A61K2300/00
摘要： The invention relates to a novel antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor, with an improved antagonistic activity, said antibody comprising a modified hinge region.The invention also relates to a composition comprising such an antibody antagonist to c-Met and its use as a medicament for treating cancer.

4. 发明申请

US20150239958A1 PROCESS FOR THE MODULATION OF THE ANTAGONISTIC ACTIVITY OF A MONOCLONAL ANTIBODY 审中-公开
标题翻译：调节单克隆抗体拮抗活性的方法
公开(公告)号：US20150239958A1
公开(公告)日：2015-08-27
申请号：US14631301
申请日：2015-02-25
申请人： PIERRE FABRE MEDICAMENT
发明人： Thierry Wurch
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K1/107 , C07K16/2863 , C07K2317/24 , C07K2317/53 , C07K2317/73 , C07K2317/75 , C07K2317/76
摘要： The present disclosure relates to the antibody engineering field and, more particularly, to a process for the screening of antibodies and/or the modulation of the agonistic/antagonistic activity of antibodies. More particularly, the disclosure concerns a process of improving the antagonistic activity of a monoclonal antibody directed against a specific target molecule, or a divalent functional fragment or derivative thereof, the antibody being capable of inhibiting one or more of the biological activities of the target molecule, wherein the process comprises a stage of reconfiguration of the hinge region consisting of a modification of the amino acid sequence of the hinge region by the deletion, the addition or the substitution of at least one amino acid. The disclosure also relates to polypeptides useful for such a modulation method and the obtained antibodies.
摘要翻译：本公开涉及抗体工程领域，更具体地，涉及用于筛选抗体的方法和/或抗体的激动/拮抗活性的调节。更具体地，本公开涉及改善针对特异性靶分子或其二价功能片段或其衍生物的单克隆抗体的拮抗活性的方法，所述抗体能够抑制靶分子的一种或多种生物活性其中该方法包括通过缺失，至少一个氨基酸的添加或取代由铰链区的氨基酸序列修饰构成的铰链区域的重新配置的阶段。本公开还涉及可用于这种调节方法的多肽和获得的抗体。

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