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1. 发明授权

US4271160A Substituted morpholine derivatives and pharmaceutical compositions 失效
标题翻译：取代的吗啉衍生物和药物组合物
公开(公告)号：US4271160A
公开(公告)日：1981-06-02
申请号：US161509
申请日：1980-06-20
申请人： Piero Melloni , Arturo Della Torre , Giovanni C. Carniel , Alessandro Rossi
发明人： Piero Melloni , Arturo Della Torre , Giovanni C. Carniel , Alessandro Rossi
IPC分类号： A61K31/13 , A61K31/135 , A61K31/165 , A61K31/335 , A61K31/357 , A61K31/535 , A61K31/5375 , A61P25/24 , A61P25/26 , C07C41/16 , C07C43/215 , C07C45/41 , C07C59/68 , C07C67/00 , C07C205/32 , C07C213/00 , C07C217/48 , C07D265/30 , C07D265/32 , C07D265/33 , C07D295/092 , C07D303/24 , C07D317/58 , C07D317/64 , C07D321/10 , C07D413/12
CPC分类号： C07D265/30 , C07C205/32 , C07C205/37 , C07C41/16 , C07C45/41 , C07C59/68 , C07D265/32 , C07D265/33 , C07D303/24 , C07D317/58
摘要： Substituted morpholine derivatives, such as, for instance the compound 2-[.alpha.-(3,4-methylendioxy-phenoxy)-benzyl]-morpholine are disclosed.The claimed compounds are active on the central nervous system, and may be used as antidepressant agents.
摘要翻译：公开了取代的吗啉衍生物，例如化合物2- [α-（3,4-亚甲二氧基 - 苯氧基） - 苄基] - 吗啉。要求保护的化合物在中枢神经系统上是有活性的，并且可以用作抗抑郁剂。

2. 发明授权

US4123527A N-tricyclic derivatives of azetidine and process for their preparation 失效
标题翻译：氮杂环丁烷的N-三环衍生物及其制备方法
公开(公告)号：US4123527A
公开(公告)日：1978-10-31
申请号：US647980
申请日：1976-01-09
申请人： Piero Melloni , Arturo Della Torre , Francesco Lauria , Norina Passerini , Alessandro Rossi , Raffaele Tommasini
发明人： Piero Melloni , Arturo Della Torre , Francesco Lauria , Norina Passerini , Alessandro Rossi , Raffaele Tommasini
IPC分类号： C07D205/04 , C07D409/04 , A61K31/395
CPC分类号： C07D205/04
摘要： Novel N-tricyclic derivatives of azetidine are disclosed of the general formula ##STR1## where A is a C.sub.1 -C.sub.3 alkylene group, a C.sub.2 -C.sub.3 alkenylene group or a cyclopropylene group, the remaining substituents being defined in the specification. Such compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities. The compound 1-[5-(10, 11-dihydro-5H-dibenzo [a,d]cyclopheptenyl)]-3-methyl-amino-azetidine is illustrative.
摘要翻译：公开了氮杂环丁烷的新型N-三环衍生物，其通式为：其中A为C1-C3亚烷基，C2-C3亚链烯基或亚环丙基，其余取代基在本说明书中定义。这些化合物可用于其抗抑郁，抗惊厥和抗焦虑活性。化合物1- [5-（10,11-二氢-5H-二苯并[a，d]环庚烯基）] - 3-甲基 - 氨基 - 氮杂环丁烷是说明性的。

3. 发明授权

US4078073A N-tricyclic derivatives of azetidine 失效
标题翻译：氮杂环丁烷的N-三环衍生物
公开(公告)号：US4078073A
公开(公告)日：1978-03-07
申请号：US738373
申请日：1976-11-02
申请人： Piero Melloni , Arturo Della Torre , Francesco Lauria , Norina Passerini , Alessandro Rossi , Raffaele Tommasini
发明人： Piero Melloni , Arturo Della Torre , Francesco Lauria , Norina Passerini , Alessandro Rossi , Raffaele Tommasini
IPC分类号： C07D205/04 , C07D313/12
CPC分类号： C07D205/04
摘要： Novel N-tricyclic derivatives of azetidine of the formula: ##STR1## wherein A is a --CH.sub.2 --O-- or an --O--CH.sub.2 group, and the remaining substituents being defined in the specification are disclosed. An illustrative compound is 1-[11-(6,11-dihydro-dibenzo [b,e] oxepinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
摘要翻译：新颖的下式的氮杂环丁烷N-三环衍生物：其中A是-CH 2 -O-或-O-CH 2基团，其余取代基在说明书中定义。示例性化合物是1- [11-（6,11-二氢 - 二苯并[b，e]氧代乙烯基）] - 3-甲基氨基 - 氮杂环丁烷。该化合物可用于其抗抑郁，抗惊厥和抗焦虑活性。

4. 发明授权

US4078072A N-tricyclic derivatives of azetidine and pharmaceutical compositions and methods containing them 失效
标题翻译：氮杂环丁烷的N-三环衍生物和含有它们的药物组合物和方法
公开(公告)号：US4078072A
公开(公告)日：1978-03-07
申请号：US738375
申请日：1976-11-02
申请人： Piero Melloni , Arturo Della Torre , Francesco Lauria , Norina Passerini , Alessandro Rossi , Raffaele Tommasini
发明人： Piero Melloni , Arturo Della Torre , Francesco Lauria , Norina Passerini , Alessandro Rossi , Raffaele Tommasini
IPC分类号： C07D205/04 , C07D409/04 , A61K31/39
CPC分类号： C07D205/04
摘要： Novel N-tricyclic derivatives of azetidine are disclosed of the general formula: ##STR1## WHERE A is a --CH.sub.2 --S-- or --S--CH.sub.2 -- group, the remaining substituents being defined in the specification. Illustrative is the compound 1-[11-(6,11-dihydro-dibenzo [b,e] thiopinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
摘要翻译：公开了氮杂环丁烷的新型N-三环衍生物，具有以下通式：其中A是-CH 2 -S-或-S-CH 2 - 基团，其余取代基在说明书中定义。示例性的是化合物1- [11-（6,11-二氢 - 二苯并[b，e]硫代基）] - 3-甲基氨基 - 氮杂环丁烷。该化合物可用于其抗抑郁，抗惊厥和抗焦虑活性。

5. 发明授权

US4229449A Substituted morpholine derivatives and compositions 失效
标题翻译：取代的吗啉衍生物和组合物
公开(公告)号：US4229449A
公开(公告)日：1980-10-21
申请号：US1604
申请日：1979-01-08
申请人： Piero Melloni , Arturo D. Torre , Giovanni C. Carniel , Alessandro Rossi
发明人： Piero Melloni , Arturo D. Torre , Giovanni C. Carniel , Alessandro Rossi
IPC分类号： A61K31/13 , A61K31/135 , A61K31/165 , A61K31/335 , A61K31/357 , A61K31/535 , A61K31/5375 , A61P25/24 , A61P25/26 , C07C41/16 , C07C43/215 , C07C45/41 , C07C59/68 , C07C67/00 , C07C205/32 , C07C213/00 , C07C217/48 , C07D265/30 , C07D265/32 , C07D265/33 , C07D295/092 , C07D303/24 , C07D317/58 , C07D317/64 , C07D321/10 , C07D413/12
CPC分类号： C07D265/30 , C07C205/32 , C07C205/37 , C07C41/16 , C07C45/41 , C07C59/68 , C07D265/32 , C07D265/33 , C07D295/088 , C07D303/24 , C07D317/58
摘要： Substituted morpholine derivatives, such as, for instance, the compound 2-[.alpha.-(2-methoxy-phenoxy)-benzyl]-morpholine are disclosed.The claimed compounds are active on the central nervous system, and may be used as antidepressant agents.
摘要翻译：公开了取代的吗啉衍生物，例如化合物2- [α-（2-甲氧基 - 苯氧基） - 苄基] - 吗啉。要求保护的化合物在中枢神经系统上是有活性的，并且可以用作抗抑郁剂。

6. 发明授权

US4134974A Imidazo[5,1-c][1,4]benzoxazin-1-one 失效
标题翻译：咪唑并[{5,1-c {9 {8,1,4-苯并恶嗪-1-酮
公开(公告)号：US4134974A
公开(公告)日：1979-01-16
申请号：US749031
申请日：1976-12-08
申请人： Piero Melloni , Nicola Mongelli , Francesco Lauria , Alessandro Rossi , Raffaele Tommasini
发明人： Piero Melloni , Nicola Mongelli , Francesco Lauria , Alessandro Rossi , Raffaele Tommasini
IPC分类号： A61K31/535 , A61K31/5383 , A61K31/54 , A61K31/542 , A61P25/24 , A61P25/26 , C07D207/40 , C07D207/404 , C07D265/36 , C07D498/04 , C07D498/14 , C07D513/04 , C07D513/14
CPC分类号： C07D207/404 , C07C205/37 , C07C317/00 , C07D265/36 , C07D513/04
摘要： Cyclic derivatives of 1,4-benzoxazine and 1,4-benzothiazine are disclosd, such as, for instance, 1H,2,3,3a,4-tetrahydro-2-carbamoylmethyl-imidazo[5,1-c][1,4]benzoxazin-1-one and 1H,2,3,3a,4-tetrahydro-2-carbamoylmethyl-8-chloro-imidazo[5,1-c][1,4]benzoxazin-1-one. These compounds are active on the central nervous system, and function as antidepressant agents.
摘要翻译：公开了1,4-苯并恶嗪和1,4-苯并噻嗪的环状衍生物，例如1H，2,3,3a，4-四氢-2-氨基甲酰基甲基 - 咪唑并[5,1-c] [1,3] 4]苯并恶嗪-1-酮和1H，2,3,3a，4-四氢-2-氨基甲酰基甲基-8-氯 - 咪唑并[5,1-c] [1,4]联苯并恶嗪-1-酮。这些化合物在中枢神经系统上是活性的，并且作为抗抑郁剂起作用。

7. 发明授权

US08733131B2 Apparatus and method for chemical deposition on a rod member in an optical fibre manufacturing process 有权
标题翻译：在光纤制造工艺中在杆件上进行化学沉积的装置和方法
公开(公告)号：US08733131B2
公开(公告)日：2014-05-27
申请号：US10496866
申请日：2001-11-29
申请人： Franco Cocchini , Antonio Schiaffo , Alessandro Rossi
发明人： Franco Cocchini , Antonio Schiaffo , Alessandro Rossi
IPC分类号： C03B37/027
CPC分类号： C03B37/01486 , Y02P40/57
摘要： An apparatus and method for chemical deposition on a rod member having a support structure for supporting the rod member substantially coaxial to a deposition axis; a burner for depositing chemical substances on the rod member; and a rotation device for imparting a rotation motion to the rod member. The rotation device has a joint member of a type suitable to transmit torque between two misaligned members, for example, a double universal joint or a flexible joint, positioned between a motor and a rod gripping member.
摘要翻译：一种用于化学沉积在杆构件上的装置和方法，所述杆构件具有用于支撑所述杆构件的支撑结构，所述支撑结构基本上与沉积轴线同轴; 用于在所述杆构件上沉积化学物质的燃烧器; 以及用于向杆构件施加旋转运动的旋转装置。旋转装置具有适于在位于马达和杆夹持构件之间的两个不对准构件（例如，双万向接头或柔性接头）之间传递扭矩的接头构件。

8. 发明授权

US07574875B2 Method for vapour deposition on an elongated substrate 有权
标题翻译：在细长基板上气相沉积的方法
公开(公告)号：US07574875B2
公开(公告)日：2009-08-18
申请号：US10108364
申请日：2002-03-29
申请人： Alessandro Rossi , Franco Cocchini , Stefano Grieco
发明人： Alessandro Rossi , Franco Cocchini , Stefano Grieco
IPC分类号： C03B37/018
CPC分类号： C03B37/01486 , C03B19/1484 , C03B37/01884
摘要： Device and method for chemical deposition on an elongated member of vitreous material in which a rotating gripping member causes a first end portion of the elongated member to rotate. The second end portion of the elongated member is borne by a pair of supporting members which are axially spaced apart (L1) and are capable of permitting angular rotational movement and axial sliding of the second end portion. Each supporting member also applies a radial constraint preventing the second end portion from moving away from the axis of rotation, thus forcing the second portion and the elongated member to lie with a longitudinal axis coaxial with the axis of rotation. Any curvature of the elongated member is corrected and recovered in this way.
摘要翻译：在玻璃质材料的细长构件上进行化学沉积的装置和方法，其中旋转夹持构件使细长构件的第一端部旋转。细长构件的第二端部由轴向间隔开的一对支撑构件（L1）承载，并且能够允许第二端部的角度旋转运动和轴向滑动。每个支撑构件还施加径向约束，以防止第二端部远离旋转轴线移动，从而迫使第二部分和细长构件与与旋转轴线同轴的纵向轴线位于其中。以这种方式校正和恢复细长构件的任何曲率。

9. 发明授权

US4728649A 3-oxo-piperazin-1-yl-ergolines exhibiting antidopaminergic activity 失效
标题翻译：具有抗癌剂活性的3-氧代 - 哌嗪-1-基 - 麦角酰胺
公开(公告)号：US4728649A
公开(公告)日：1988-03-01
申请号：US817135
申请日：1986-01-08
申请人： Sergio Mantegani , Aldemio Temperilli , Gabriella Traquandi , Alessandro Rossi , Lorenzo Pegrassi
发明人： Sergio Mantegani , Aldemio Temperilli , Gabriella Traquandi , Alessandro Rossi , Lorenzo Pegrassi
IPC分类号： A61K31/48 , A61P9/12 , A61P25/00 , A61P25/20 , C07D457/02 , C07D457/12 , A61K31/445
CPC分类号： C07D457/02
摘要： The invention relates to ergoline derivatives having the general formula (I): ##STR1## where R=H, CH.sub.3 ; R.sub.1 =H, halogen, CH.sub.3, phenylthio, C.sub.1 -C.sub.4 alkylthio; R.sub.2 =H, CH.sub.3 O, and R.sub.3 =H or R.sub.2 +R.sub.3 =chemical bond; R.sub.4 =C.sub.1 -C.sub.4 hydrocarbon; R.sub.5, R.sub.6, R.sub.8, R.sub.9 independently=H, C.sub.1 -C.sub.4 alkyl, or R.sub.5, R.sub.8 independently=H, C.sub.1 -C.sub.4 alkyl and R.sub.6 +R.sub.9 =CH.sub.2 CH.sub.2, CH.sub.2 CH.sub.2 CH.sub.2 ; R.sub.7 =H, C.sub.1 -C.sub.4 alkyl, phenyl, NR'R"; R',R" independently=H, C.sub.1 -C.sub.4 alkyl, acyl or NR'R"=heterocyclic ring; W=0, H.sub.2 ; n=0, 1, 2, and their pharmaceutically acceptable salts, these compounds exhibiting antihypertensive activity making them useful anxiolytic and antipsychotic agents. A process for their preparation and pharmaceutical compositions containing them are also described.
摘要翻译：本发明涉及具有通式（I）的麦角灵衍生物：其中R = H，CH 3; R1 = H，卤素，CH3，苯硫基，C1-C4烷硫基; R2 = H，CH3O，R3 = H或R2 + R3 =化学键; R4 = C1-C4烃; R5，R6，R8，R9独立地为H，C1-C4烷基或R5，R8独立地为H，C1-C4烷基和R6 + R9 = CH2CH2，CH2CH2CH2; R7 = H，C1-C4烷基，苯基，NR'R“ R'，R“独立地为H，C 1 -C 4烷基，酰基或NR'R”=杂环; W = 0，H2; n = 0,1,2及其药学上可接受的盐，这些具有抗高血压活性的化合物使它们成为抗焦虑药和抗精神病药。还描述了其制备方法和含有它们的药物组合物。

10. 发明授权

US08695379B2 Apparatus and method for applying traction to an elongate element produced by fusing a preform of glass material and usable in a process for producing an optical fibre 有权
标题翻译：用于将牵引力施加到通过熔化玻璃材料的预制件而产生并可用于制造光纤的工艺中的细长元件的装置和方法
公开(公告)号：US08695379B2
公开(公告)日：2014-04-15
申请号：US10169125
申请日：2000-12-21
申请人： Marco Antonio Caiata , Franco Cocchini , Giuseppe Ferri , Andrea Mazzotti , Alessandro Rossi , Antonio Schiaffo
发明人： Marco Antonio Caiata , Franco Cocchini , Giuseppe Ferri , Andrea Mazzotti , Alessandro Rossi , Antonio Schiaffo
IPC分类号： C03B23/045
CPC分类号： C03B37/01242 , C03B23/047 , C03B37/0124 , C03B37/01251
摘要： Apparatus for applying traction to an elongate cylindrical element produced by fusion of an end portion of a preform of glass material, in which a traction device is capable of being connected to a portion of the elongate cylindrical element to provide traction of the elongate cylindrical element along an axis. A device for the rotation of the elongate cylindrical element applies a twist to the elongate cylindrical element about the axis simultaneously with the traction.
摘要翻译：用于将牵引力施加到通过熔化玻璃材料预成型件的端部而产生的细长圆柱形元件的装置，其中牵引装置能够连接到细长圆柱形元件的一部分以提供细长圆柱形元件沿着一个轴。用于旋转细长圆柱形元件的装置在与牵引力同时围绕轴线对细长圆柱形元件施加扭曲。

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